Clinical trials: Body Weight Control
Obesity
Combined Physical-cognitive Exercise and Dietary Intervention for Postmenopausal Obese Women
This study aims to examine the effects of dietary intervention combined with physical-cognitive exergaming on cognitive performance and circulating biomarkers of obese postmenopausal women.
- Trial name
- NCT04768725
- Testing
- Dietary intervention combined with physical-cognitive exergaming, Dietary intervention, Physical-cognitive intervention
- Where
- Thailand
- Volunteers
- 92 people
- Sponsor
- Chiang Mai University
Obesity and Overweight
Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity
This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D. This trial will last for a duration of 84 weeks.
- Trial name
- VESPER-4 (NCT07311850)
- Testing
- MET097
- Where
- 161 sites in United States, Bulgaria and 8 more
- Volunteers
- 3,578 people
- Sponsor
- Pfizer
Obesity, Obesity, Childhood
A Novel Obesity Prevention Program for High-Risk Infants in Primary Care
The goal of this clinical trial is to test a responsive parenting obesity prevention program with infants and caregivers of color (e.g., non-White; Hispanic/Latinx) and/or who are economically marginalized (i.e., publicly…
- Conditions
- Obesity, Obesity, Childhood, Weight Gain, Weight Gain Trajectory
- Trial name
- THRIVE (NCT06028113)
- Testing
- THRIVE 2.0
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Obesity and Overweight, Obese Adolescents
Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity
The goal of this clinical trial is to learn if the drug semaglutide changes markers of disease risk as it relates to weight in children ages 12-15 years old who are obese (class 2 or 3).
- Conditions
- Obesity and Overweight, Obese Adolescents, Weight Management, Weight Loss
- Trial name
- MODERN (NCT06967389)
- Testing
- Ozempic®
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- John Bauer
Morbid Obesity, Noninvasive Ventilation
Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite
This study evaluates the ability of high flow nasal cannula versus nasal cannula to oxygenate morbidly obese patients undergoing moderate to deep sedation for gastrointestinal procedures.
- Conditions
- Morbid Obesity, Noninvasive Ventilation, Deep Sedation
- Trial name
- NCT02859597
- Testing
- High flow nasal cannula, Nasal Cannula
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Non-Alcoholic Fatty Liver Disease, Non-alcoholic Steatohepatitis
Structured Mobile Technology Based Lifestyle Program vs Usual Care for Patients With Non-alcoholic Fatty Liver Disease
This study will look at physical activity and nutrition in patients with non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).
- Trial name
- NCT03839082
- Testing
- Usual Care then FitBit, FitBit then Usual Care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Michigan
Impaired Glucose Tolerance, Overweight
Acupuncture for Impaired Glucose Tolerance in Overweight/Obese Population
This is a prospective, multicenter, parallel-group, participants- and assessors-blinded randomized trial aiming to evaluate the effectiveness and safety of acupuncture in improving glucose metabolism for overweight/obese…
- Conditions
- Impaired Glucose Tolerance, Overweight, Obese, Prediabetic State
- Trial name
- NCT05347030
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Yan Yan
Morbid Obesity, Labor Pain
DPE Technique in Labor Epidural for Morbidly Obese Women
The primary purpose of this study is to determine differences in block quality between the "dural-puncture epidural" (DPE) and standard epidural (EPL) techniques for labor analgesia in the morbidly obese patient.
- Trial name
- NCT03074695
- Testing
- Dural puncture epidural (DPE), Standard Epidural (EPL)
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Duke University
Anorexia, Cachexia
Treatment of Cancer-anorexia Using Megestrol Acetate Concentrated Suspension in Lung or Pancreatic Cancer Patients
Purpose of the study is to compare the effects of megestrol acetate concentrated suspension and placebo on caloric intake for the treatment of cancer-associated anorexia in patients with lung or pancreatic cancer
- Conditions
- Anorexia, Cachexia, Weight Loss
- Trial name
- NCT00637728
- Testing
- Megestrol acetate concentrated suspension 110 mg/mL
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Par Pharmaceutical, Inc.
Obesity, Metabolic Disease
Xla1 Christensenella Minuta, Phase I, Randomized, Partially Placebo-controlled Double-blind Protocol, Evaluating Safety, Tolerability and Impact on the Gut Microbiota in Healthy Volunteers, Overweight and Obese Adults
Xla1 Christensenella minuta, phase I, randomized, placebo-controlled double-blind protocol, evaluating safety, tolerability and impact on the gut microbiota in healthy volunteers, overweight and obese adults.
- Trial name
- CAUSALITY (NCT04663139)
- Testing
- Xla1
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- YSOPIA Bioscience
Obesity, Overweight
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities
The main purpose of this phase 3b study is to evaluate the efficacy and safety of tirzepatide compared with semaglutide in adult participants who have obesity or overweight with weight related comorbidities without Type 2…
- Trial name
- SURMOUNT-5 (NCT05822830)
- Testing
- Tirzepatide, Semaglutide
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 751 people
- Sponsor
- Eli Lilly and Company
Prediabetes, Obesity & Overweight
Human Pilot Study for the Investigation of the Role of Bilberry and Olive Bioactives on Oxidative Stress Parameters and Inflammatory Markers.
Numerous plant-based foods contain bioactive compounds, in particular polyphenols, which have antioxidant, anti-inflammatory, and metabolic regulatory effects.
- Conditions
- Prediabetes, Obesity & Overweight, Inflamation, Oxidative Stress
- Trial name
- BIOTRANSFORM (NCT07659028)
- Testing
- supplementation, food
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Obesity
A Study to Test Different Doses of BI 456906 in Patients With Obesity
Main objective is to investigate the tolerability of different titration schemes of BI 456906 in otherwise healthy patients with obesity/overweight, and to determine a titration scheme for future studies.
- Trial name
- NCT03591718
- Testing
- BI 456906
- Where
- 2 sites in Germany
- Volunteers
- 131 people
- Sponsor
- Boehringer Ingelheim
Overweight and Obesity, Body Weight
Evaluation of the Effectiveness of Standard and Innovative Products That Represent a Substitute Meal for Weight Management in a Reduction Diet
Randomized stratified controlled clinical study for evaluate the effectiveness of a diet program designed for reduce body weight through standard and innovative products that are a substitute meal for weight management in a…
- Trial name
- NCT05733871
- Testing
- meal replacement product- STANDARD PRODUCT, Meal replacement product- INNOVATIVE PRODUCT
- Where
- Croatia
- Volunteers
- 36 people
- Sponsor
- Children's Hospital Srebrnjak
Pneumoperitoneum, Morbid Obesity
Ultrasonography Guided Pneumoperitoneum for Laparoscopic Surgery in Morbidly Obese Patients
Bariatric Surgery for morbid obesity is indicated when BMI > 40 kg/m2 without comorbidities or BMI > 35 kg/m2 with co-morbidities.
- Conditions
- Pneumoperitoneum, Morbid Obesity, Bariatric Surgery Candidate
- Trial name
- USP (NCT06413264)
- Testing
- Ultrasonography guided Veress needle insertion for creating pneumoperitoneum, Veress needle will be inserted blindly as a closed technique for creating pneumoperitoneum
- Where
- India
- Volunteers
- 40 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Obesity, Obesity, Abdominal
Acupoint Catgut Embedding With Laser Acupuncture for Weight Loss in Adults With Obesity
Acupoint catgut embedding and laser acupuncture have each been studied as treatments for obesity in adults, but the two have not been evaluated in combination, and few trials have measured anthropometric, biochemical, and blood…
- Conditions
- Obesity, Obesity, Abdominal, Overweight
- Trial name
- NCT07770893
- Testing
- Acupoint catgut embedding, Active laser acupuncture, Dietary and exercise counseling
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei City Hospital
Obesity-related Male Infertility
Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm Health
Why is this study being done? Obesity can harm men's fertility by lowering sperm quality and hormone levels, making it harder to have children. Weight loss through diet and exercise helps, but it's often hard to stick with.
- Trial name
- NCT07179120
- Testing
- Semaglutide (Rybelsus®), Tirzepatide, Standardized Lifestyle Intervention
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Insulin Resistance
Cacao Consumption in Patients With Insulin Resistance
Metabolic syndrome (MS) is a clinical entity that includes several disorders that predispose to imbalance in lipid metabolism: hypertension, insulin resistance, hypertriglyceridemia, obesity and low levels of high density…
- Trial name
- NCT03034291
- Testing
- Cacao 70%, White chocolate
- Volunteers
- 92 people
- Sponsor
- Universidad de Antioquia
Obesity, Weight Loss
Effects of Adding L-BAIBA to Exercising Adult Overweight and Obese Men and Women
Beta-amino isobutyric acid (BAIBA) is a myokine produced in skeletal muscle and has been shown to impact how our body metabolizes fuel.
- Conditions
- Obesity, Weight Loss, Weight, Body, Cardiometabolic Syndrome
- Trial name
- LBC (NCT05775016)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Obesity and Overweight
Neurological Impact of Weight Reduction and Fitness Interventions
This study will test how significant weight loss through bariatric surgery, combined with a personalised exercise program, affects brain inflammation.
- Trial name
- NeuroFit (NCT06830252)
- Testing
- Exercise
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- University of Sydney
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