Clinical trials: Body Weight Control
Obesity, Overweight
A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss Program
This is a study of tirzepatide in participants with obesity. The purpose of this study is to learn more about how tirzepatide maintains body weight or adds to weight loss after an intensive lifestyle modification program.
- Trial name
- SURMOUNT-3 (NCT04657016)
- Testing
- Tirzepatide
- Where
- 65 sites in United States, Argentina and 2 more
- Volunteers
- 579 people
- Sponsor
- Eli Lilly and Company
Weight Loss, Body Composition
Effect of a Low-carbohydrate, High-protein Energy-restricted Diet on Weight and Body Composition Using DXA
People often choose certain diets to lose weight or to change their habits or lifestyle. The Dukan diet was created in the '70s and took on importance in the last decade. It is a 4 phase diet similar to the Atkins diet.
- Trial name
- NCT04646733
- Testing
- High Protein Diet Group, No High Protein Diet Group
- Where
- Mexico
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Erik Ramirez Lopez
Overweight, Lipid Metabolism
Effects of Concurrent Training on Serum PCSK9 Levels in Adults With Overweight
Being overweight can increase the risk of heart disease. PCSK9 is a protein that helps regulate cholesterol levels in the blood. Exercise may affect PCSK9 levels, but previous studies have reported conflicting results.
- Conditions
- Overweight, Lipid Metabolism, Cholesterol Metabolism
- Trial name
- NCT07910916
- Testing
- Concurrent Aerobic and Resistance Training
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Kastamonu University
Gestational Weight Gain, Overweight and Obesity
Healthy Gestational Weight Gain Programme
This study aims to evaluate the efficacy of a multi-component lifestyle interventions during pregnancy on promoting appropriate gestational weight gain, preventing GDM, and improving pregnancy, delivery, and neonatal outcomes…
- Trial name
- NCT06370533
- Testing
- behavioral interventions
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking University
Sleep, Inadequate, Overweight and Obesity
Improving Metabolic & Mental Health in Female Healthcare Shift Workers
Circadian rhythm disruption caused by shift work alters metabolic and hormonal pathways, which accelerates chronic disease onset, leading to decreased quality and quantity of life.
- Conditions
- Sleep, Inadequate, Overweight and Obesity, Work Related Stress, Healthy Lifestyle
- Trial name
- NCT06158204
- Testing
- Lifestyle Intervention
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Auburn University
Obesity, Overweight
A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight
The main purpose of this study is to find out how significantly Eloralintide slows stomach emptying in participants who are overweight or obese.
- Trial name
- NCT07738614
- Testing
- Eloralintide, Acetaminophen
- Where
- 2 sites in United States, Singapore
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Obesity
Study to Evaluate Methods That Assess the Effect of AZD4017 in Adipose Tissue
The primary purpose of this study is to investigate different methods to evaluate the effect of AZD4017 in adipose tissue after single and multiple doses of AZD4017 in abdominally obese but otherwise healthy subjects.
- Trial name
- NCT01096004
- Testing
- AZD4017
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Sedentary Behavior, Mild Cognitive Impairment
The DURATION Study: reDUcing sedentaRy behAviour to Maintain cogniTIve functiON.
Rationale: Older adults spend the majority of their time in sedentary behaviours (SB). High amounts of SB have been correlated with reduced cognitive performance.
- Conditions
- Sedentary Behavior, Mild Cognitive Impairment, Glucose Intolerance, Overweight and Obesity
- Trial name
- NCT04323423
- Testing
- interrupting sedentary behaviour with light physical activity
- Where
- Canada
- Sponsor
- Western University, Canada
Motor Activity, Weight Loss
Effect of a Technology-Based Intervention on Weight Change Post-Bariatric Surgery
The primary aim of this study is to examine the effect of applying a minimal contact technology-based intervention (TECH) at 1-year post-bariatric surgery on weight change compared to Standard Care.
- Trial name
- NCT02867696
- Testing
- Standard Care, Technology-based Intervention (TECH)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Obesity
To Evaluate the Safety, Tolerability, PK, PK-PD Relation of KD101 in the Fed State in Obese or Overweight Subjects
To Evaluate the safety, tolerability and pharmacokinetic property after KD101 multiple oral dosing in the fed state in obese or overweight subjects.
- Trial name
- NCT02462031
- Testing
- KD101
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Kwang Dong Pharmaceutical co., ltd.
Obesity, Morbid Obesity
Long Term Effect of Very-low-calories Ketogenic Diet on Weight Control and Cardiovascular Brisk Factors (KETOHEART)
The growing obesity pandemic has a major impact on global cardiovascular (CVD)-related morbidity and premature mortality, severely compromising the quality of life of those affected and significantly increasing costs for the…
- Trial name
- KETOHEART (NCT05781269)
- Testing
- VLCKD, r-MedDiet
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Obesity
Daytime vs. Delayed Eating Among Obese Individuals
The randomized, cross-over design study is designed to determine how timing of eating affects weight, adiposity, energy metabolism, and gene expression.
- Trial name
- NCT03354169
- Testing
- Eating Condition, No Intervention; withdrawn before randomization
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease
Biomarker Panel for PCOS-Associated Liver Steatosis in Adolescent Girls (COMPASS-pedPCOS)
This single-center, prospective, observational, cross-sectional mechanistic pilot study will evaluate whether polycystic ovary syndrome (PCOS) contributes to hepatic steatosis in adolescent girls independently of adiposity.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity, Hyperandrogenism
- Trial name
- COMPASSpedPCOS (NCT07731373)
- Testing
- Extended Serum Biomarker and Hormonal Panel, Liver Elastography with Controlled Attenuation Parameter, Targeted Genotyping of PNPLA3 rs738409 and HSD17B13 rs72613567
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Obesity, Cardiometabolic Syndrome
A Study Comparing the Health Effects of Two Diets Following UK Dietary Guidance in People Living With Overweight or Obesity
There are two parts to this study: 1. The investigators will study if the benefit from eating a healthy, balanced diet depends on the types of food processing in the diet.
- Conditions
- Obesity, Cardiometabolic Syndrome, Overweight
- Trial name
- UPDATE (NCT05627570)
- Testing
- Healthy, balanced Diet A, Healthy, balanced Diet B, Behavioural support intervention
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University College, London
Overweight and Obesity
Electrical Vestibular Stimulation (VeNS): Assessment of AMPK & SIRT1 Following Repeated Usage
The vestibular system which is responsible for balance and equilibrium constitutes our sixth sense. Metabolic Syndrome is a constellation of metabolic abnormalities characterized by obesity, insulin resistance (diabetes…
- Trial name
- NCT04433273
- Testing
- Electrical vestibular nerve stimulation
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Neurovalens Ltd.
Diabetes Mellitus, Obesity
Single Loop DJB Sleeve Gastrectomy for Poorly Controlled T2DM
Type 2 diabetes mellitus (T2DM) is a chronic progressive illness affecting a substantial percentage of the general population. While pharmacotherapy remains the mainstay of treatment, around 60% of patients cannot achieve the…
- Conditions
- Diabetes Mellitus, Obesity, Bariatric Surgery Candidate, Weight Loss
- Trial name
- NCT03125369
- Testing
- Sleeve gastrectomy + duodeno-jejunal bypass, Roux-Y gastric bypass
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Weight Change, Body, Behavior, Health
Increased Monitoring of Physical Activity and Calories With Technology
Since severe obesity in youth has been steadily increasing. Specialized pediatric obesity clinics provide programs to aid in reducing obesity.
- Conditions
- Weight Change, Body, Behavior, Health, Obesity, Childhood, Parent-Child Relations
- Trial name
- IMPACT (NCT03961061)
- Testing
- Brenner mFIT (standard care), Brenner mFIT (standard care plus mobile health components)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Weight Gain
Growth Study Using Else Toddler Nutritional Drink vs. a. Dairy Based Toddler Drink (Control) in Healthy Toddlers
The aim of the study is to investigate the growth of healthy toddlers fed with Toddler almond based nutritional drink (test) vs. a. formula that has been shown to support growth (control) in Healthy Toddlers
- Trial name
- NCT05576870
- Testing
- Plant based toddler nutrition, Dairy based toddler nutrition
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Else Nutrition GH Ltd
Obesity
A Study of RAY1225 in Participants With Obesity
The main purpose of this study is to learn more about the Tolerability of RAY1225 in participants with Obesity. The study will also explore the efficacy of RAY1225. The study will last about six months for each participant.
- Trial name
- NCT06254261
- Testing
- RAY1225
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Guangdong Raynovent Biotech Co., Ltd
Obesity, Weight Control
ASCEND-1: Lifestyle Intervention Plus Mazdutide for Weight Management
Obesity is a chronic, progressive, and relapsing disease. Although lifestyle interventions and anti-obesity medications are effective for inducing weight loss, evidence regarding their role in long-term weight maintenance after…
- Trial name
- NCT07517042
- Testing
- Mazdutide, Intensive Lifestyle Intervention, Usual Lifestyle Counseling
- Where
- 13 sites in China
- Volunteers
- 420 people
- Sponsor
- Shanghai Zhongshan Hospital
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