Clinical trials: Body Weight Control
Severe Obesity
Mazdutide as Adjuvant Therapy Following Sleeve Gastrectomy in Severe Obesity
The SMART study is a 96-week, multicenter, randomized, double-blind, placebo-controlled superiority clinical trial. A total of 256 severe obesity patients are randomized 1:1 to either receive the bariatric surgery plus GCG/GLP-1…
- Trial name
- SMART (NCT07135141)
- Testing
- Sleeve gastrectomy plus early mazdutide initiation
- Where
- 14 sites in China
- Volunteers
- 256 people
- Sponsor
- Beijing Friendship Hospital
Obesity
Safety, Tolerability and Efficacy Study of PP1420 in HV
Obesity is a growing pandemic which affects 1 in 4 adults in the UK, and shortens life by increasing cardiovascular disease, diabetes and cancer.
- Trial name
- PP14201b1c (NCT02221765)
- Testing
- PP1420
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obesity & Overweight
A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With Obesity
This study investigates the Topical-Lingual (T-L) delivery of semaglutide, a GLP-1 receptor agonist (GLP-1RA), via an oral liquid emulsion formulation as a Proof-of-Concept for the T-L delivery of metabolic hormones in general.
- Trial name
- NCT07728383
- Testing
- Semaglutide 6 mg liquid emulsion formulation, Wegovy® (semaglutide) Tablet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Gila Therapeutics, Inc.
Transplant-Related Disorder, Overweight and Obesity
Nutrigenomics, Overweight/Obesity and Weight Management Trial (NOW Trial)
The investigators hypothesize that compared to the provision of population-based lifestyle advice, providing DNA-based lifestyle advice via personalized nutrigenomics testing (PNT) to two distinct patient populations (Family…
- Trial name
- NOW (NCT03015012)
- Testing
- Personalized Nutrigenomics Testing (PNT), Standard Nutrition Intervention (SNI)
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Western University, Canada
Weight Change, Body, Obesity
Digital Health Weight Management Among Public Housing Residents
This research will test the efficacy of a weight management intervention through a three-group randomized trial: mHealth only, mHealth+Community Health Worker (CHW) support, versus control group, among residents of Boston's…
- Trial name
- NCT04852042
- Testing
- mHealth, CHW support
- Where
- United States
- Volunteers
- 316 people
- Sponsor
- Tufts Medical Center
Obesity and Type 2 Diabetes, NAFLD - Non-Alcoholic Fatty Liver Disease
OneSTOP (One-Stop Telehealth Obesity Program) for Multidisciplinary Weight Management and Related Comorbidities
The goal of this clinical trial is to learn if the use of a care model including teleconsults and the EMPOWER app can induce clinically significant weight loss and metabolic improvements in obese adults with diabetes and…
- Conditions
- Obesity and Type 2 Diabetes, NAFLD - Non-Alcoholic Fatty Liver Disease, Hypertension, Dyslipidaemia
- Trial name
- OneSTOP (NCT06890169)
- Testing
- OneSTOP program, Standard of care weight management program
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Changi General Hospital
Weight Loss
Personalized Lifestyle Intervention and Weight Control
This trial aims to investigate whether tailored lifestyle consultation through SNP testing leads to more effective weight loss among overweight or obese individuals compared to general lifestyle guidance for weight control.
- Trial name
- NCT04079972
- Testing
- Obesity-related genetic information disclosure with tailored lifestyle recommendations, Non-obesity-related genetic information disclosure
- Where
- South Korea
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- NaNa Keum
Obesity, NAFLD
Vigorous- Versus Moderate-intensity Exercise to Reduce Liver Fat in Adults With Obesity and NAFLD
Non-alcoholic fatty liver disease (NAFLD) arising from obesity has become a global health concern. Although exercise is a cornerstone approach for managing NAFLD, detailed exercise prescription guidelines are unavailable.
- Trial name
- NCT06124456
- Testing
- Usual Care Control Group, Moderate-intensity Exercise Intervention, Vigorous-intensity Exercise Intervention
- Where
- Hong Kong
- Volunteers
- 330 people
- Sponsor
- The University of Hong Kong
Loss of Control Eating
Loss of Control Eating Following Weight Loss Surgery
This study will test the effectiveness of two distinct behavioral treatments for loss of control eating following bariatric surgery: 1. Behavioral Weight Loss Treatment 2.
- Trial name
- NCT02259322
- Testing
- Standard-of-Care, Behavioral Weight Loss Treatment, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Yale University
Schizophrenia
A Placebo-Controlled, Cross-Over Trial of Aripiprazole
This study is a ten-week, placebo-controlled, double-blind, cross-over, randomized trial of the novel antipsychotic agent, aripiprazole, added to 20 obese stable olanzapine-treated patients with schizophrenia or schizoaffective…
- Trial name
- NCT00351936
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- North Suffolk Mental Health Association
Diabetes, Nonalcoholic Fatty Liver Disease
Effects of Exercise on Patients With Nonalcoholic Fatty Liver Disease- A Comparative Randomized Controlled Trial
background: Obesity, diabetes mellitus type II and fatty liver disease combining with low levels of physical activity are prominent health risks for mortality and morbidity.
- Conditions
- Diabetes, Nonalcoholic Fatty Liver Disease, Obesity, Exercise
- Trial name
- [PTREC] (NCT03774511)
- Testing
- High-Intensity Interval Exercise & Moderate Intensity Interval Exercise
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Ahlia University
Physical Activity
Exploring the Effect of an Intervention on Women's Physical Activity Behaviour
Physical activity has been shown to reduce the risk of chronic diseases and promote physical and mental health and wellbeing, yet few women are active enough to see these benefits.
- Trial name
- NCT03601663
- Testing
- Physical Activity Information, Physical Activity Monitoring, Autonomy-support
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Weight Management
Tolerance and Appetite Reduction of a Nutritional Solution With Intragastric Gelation Properties
The physical properties of a food product, such as its gelling properties in the stomach can influence how full a person may feel after its consumption.
- Trial name
- NCT07127198
- Testing
- Beverage Variant 1 (low gelation properties), Beverage Variant 2 (medium gelation properties), Beverage Variant 3 (high gelation properties)
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Physical Activity, Obesity
Change in Physical Activity Levels in Women at Working Place
The purpose of this study is to evaluate the impact of different types of intervention on physical activity level and co-morbidities in women workers aged between 40 and 50 years.
- Trial name
- NCT01567007
- Testing
- individual counseling, group counseling, aerobic training
- Where
- Brazil
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Obesity and Overweight, Overweight or Obese
Innovative Functional Product for Overweight and Obesity
The aim of this randomized, parallel, two-arm, placebo-controlled, quadruple-blind clinical trial is to evaluate the efficacy of a polyphenol-enriched functional product in individuals with overweight or obesity, focusing…
- Conditions
- Obesity and Overweight, Overweight or Obese, Overweight or Obese Adults, Obese Subjects
- Trial name
- NCT07044167
- Testing
- Polyphenol-enriched functional product, Control without active polyphenols
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Carmen Lucas Abellán
Micronutrient Deficiencies
This Randomized Trial Aims to Investigate the Efficacy of Balanced Nutritional Tablets-Comprehensive Multivitamin and Mineral Supplements- in Preventing Micronutrient Deficiencies Among Patients Utilizing GLP-1 RAs for Weight Loss in Comparison to a Placebo Control
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), including Ozempic (semaglutide) and Saxenda (liraglutide), are gaining traction in treating obesity and its associated diseases due to their capacity to facilitate…
- Trial name
- NCT06981936
- Testing
- Balance Tablet
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Weight, Body
Time Restricted Eating With or Without a Fiber Supplement for Weight Management in Pediatric Cancer Survivors
This study aims to address a critical gap in pediatric oncology survivorship care by exploring innovative solutions to addressing obesity and its comorbidities in pediatric cancer survivors.
- Trial name
- NCT05826184
- Testing
- Time restircted eating, Time restricted eating + prebiotic
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Metabolic Syndrome
ENDOBARRIER® and Conventional Therapy in the Management of Metabolic Syndrome in Obese Patients
Obesity and metabolic syndrome (MS) are closely interrelated leading to increased mortality, mainly due to cardiovascular disease. In addition, some cancers are much higher when obesity is associated with metabolic syndrome.
- Trial name
- ENDOMETAB (NCT02297555)
- Testing
- ENDOBARRIER®
- Where
- 10 sites in France
- Volunteers
- 82 people
- Sponsor
- University Hospital, Lille
Obesity
Effects of the GOLO Weight Management Program With and Without Release Supplement on Weight and Metabolic Parameters in Subjects With Obesity
This randomized, double-blind placebo-controlled study was intended to measure the effects of the GWMP with Release supplement versus GWMP with placebo supplement in a representative group of obese subjects with or without…
- Trial name
- NCT03842501
- Testing
- Release Supplement
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Golo
Overweight and Obesity
Attentive Eating for Weight Loss
This trial examined whether a smartphone application designed to encourage a more attentive eating style could help people to lose weight, compared to a control group.
- Trial name
- NCT03602001
- Testing
- Attentive eating smartphone application., Standard dietary advice and text tips.
- Where
- United Kingdom
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
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