Clinical trials: Bone Cancer Surgery
Spinal Stenosis, Disc Herniation
Effects of Cognitive Intervention Therapy on Postoperative Delirium
This study is a prospective, single-center, randomized controlled trial to compare whether applying cognitive intervention therapy before and after surgery in elderly patients aged 65 years or older undergoing non-cardiac surgery…
- Conditions
- Spinal Stenosis, Disc Herniation, Lung Neoplasms, Carcinoma, Hepatocellular
- Trial name
- NCT06178939
- Testing
- control group, intervention group
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Bone Cancer, Bone Metastases
Focused Ultrasound Surgery in the Treatment of Pain Resulting From Metastatic Bone Tumors With the ExAblate 2100 Conformal Bone System
The goal of this prospective, non-randomized, single-arm, phase 2 study is to evaluate the safety and effectiveness of this treatment using this ExAblate conformal system in the treatment of pain resulting from metastatic bone…
- Conditions
- Bone Cancer, Bone Metastases, Pain
- Trial name
- NCT01085565
- Testing
- ExAblate 2100
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- InSightec
Skull Base Neoplasms
Surgical Outcomes of Extended Endoscopic Endonasal Approach for Skull Base Lesions.
Aim of this study is to evaluate the surgical and functional outcomes of the extended endoscopic endonasal approach (EEEA) in the management of skull base lesions, including extent of resection, postoperative complications, and…
- Trial name
- NCT07788300
- Testing
- Endoscopic Endonasal Approach for Skull Base Lesions.
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Osteosarcoma
Adjuvant High-Dose Thiotepa and Stem Cell Rescue Associated With Conventional Chemotherapy in Relapsed Osteosarcoma
Approximately 150 new cases of osteosarcoma are reported each year in France, of which 15 to 20% are metastatic. Further to the initial standard care, about 45% of the patients relapse within a median duration of 20 months.
- Trial name
- OSII-TTP (NCT00978471)
- Testing
- Thiotepa
- Where
- 23 sites in France
- Volunteers
- 44 people
- Sponsor
- Centre Leon Berard
Childhood Malignant Fibrous Histiocytoma of Bone, Sarcoma
Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one chemotherapy drug with surgery and/or radiation therapy may kill more tumor cells.
- Trial name
- NCT00002898
- Testing
- dactinomycin, carboplatin, cyclophosphamide
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Societe Internationale d'Oncologie Pediatrique
Osteosarcoma in Children
Long-term Evaluation of the Quality of Life of Former Patients Treated With Orthopedic Surgery, With or Without Radiotherapy
Surgery and radiation therapy play a major role in the treatment of bone and soft tissue tumors. Osteosarcomas, rhabdomyosarcomas, and Ewing tumors are the most common histologic types.
- Trial name
- STARTos (NCT04644913)
- Testing
- Quality of life questionnaire
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Institut Cancerologie de l'Ouest
Adult Spinal Cord Neoplasm, Spinal Bone Metastases
Robotic-Assisted Surgery in Treating Patients With Spine Tumors
This pilot clinical trial studies robotic-assisted surgery in treating patients with spine tumors. Robotic-assisted surgery is a less invasive type of surgery for spine tumors and may have fewer side effects and improve recovery
- Conditions
- Adult Spinal Cord Neoplasm, Spinal Bone Metastases, Spinal Cord Metastases
- Trial name
- NCT01345903
- Testing
- therapeutic conventional surgery
- Sponsor
- City of Hope Medical Center
Stomach Neoplasms, Colonic Neoplasms
Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients
Postoperative delirium（POD）is a common complication that can directly affect important clinical outcomes, and exert an enormous burden on patients, their families, hospitals, and public resources.
- Conditions
- Stomach Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Sigmoid Neoplasms
- Trial name
- NCT05068180
- Testing
- low-dose neuroleptanalgesia
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Intervertebral Disc Degeneration, Intervertebral Disc Displacement
Protection of Autonomic Nervous System During Lower Spine Surgical Procedures: A Safety and Feasibility Study
A safety and feasibility study of free-run and stimulated corporal electromyography (EMG) to assess autonomic neural function during spinal and/or pelvic surgery in women and men.
- Conditions
- Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Stenosis
- Trial name
- NCT02873182
- Testing
- Autonomic nervous system monitoring
- Volunteers
- 20 people
- Sponsor
- Stanley Skinner
Soft Tissue Sarcoma (STS), Bone Cancer Tumor
Development of a Radiomics Model With MR to Predict the Occurence of a Infiltration of Muscoskeletal Tumor
The goal of this observational study is to evaluate the feasibility and clinical utility of radiomics to diagnose peri-lesion tumour infiltration of tumours in participants with a suspect of Bone Cancer Tumor or Soft Tissue…
- Trial name
- NCT06774729
- Where
- Italy
- Volunteers
- 122 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Skull Base Neoplasms, Skull Neoplasms
Proposal for Intraoperative Administration of Intravenous Indocyanine Green to Evaluate Position of the Optic Canal, Position of the Internal Carotid Arteries, Tumor Vascularization, and Vessel Encasement in Endoscopic Endonasal Cranial Base Surgery
This study is being done to demonstrate the feasibility of using a nasal endoscope to perform intraoperative angiography of surgical field, with the goals to evaluate anatomical landmarks and tumor characteristics during skull…
- Conditions
- Skull Base Neoplasms, Skull Neoplasms, Bone Neoplasm, Neoplasms
- Trial name
- ICG2 (NCT03072186)
- Testing
- near-infrared light nasal endoscope used with ICG
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Ohio State University
Bone Cyst Aneurysmal, Pathological Fracture
Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts
The efficacy of traditional therapeutic approaches for aneurysmal bone cysts (ABC), such as surgery, embolization, sclerotherapy and radiotherapy, are often compromised for lesions in axial skeletons and adolescents complicated…
- Conditions
- Bone Cyst Aneurysmal, Pathological Fracture, Recurrent Disease, Refractory Tumor
- Trial name
- Deno-ABC (NCT03415477)
- Testing
- Denosumab (Xgeva)
- Volunteers
- 6 people
- Sponsor
- Peking University People's Hospital
Immunonutrition, Surgical Outcome
Perioperative Supplementation With Immunonutrition and Its Impact on Surgical Outcome and Pain in Oral Cavity or Mandibular Tumours
The aim of this study was to investigate the effect of adding omega 3 and dipeptiven to standard feeding in head and neck patients who will undergo oral cavity tumour resection or mandibular tumour resection (immunonutrrition…
- Conditions
- Immunonutrition, Surgical Outcome, Pain, Oral Cavity
- Trial name
- NCT06339372
- Testing
- Standard feeding, Omega 3 and dipeptiven
- Where
- Egypt
- Volunteers
- 176 people
- Sponsor
- Cairo University
Total Hip Replacement, Thromboelastometry
Impact of Surgical Injury on Haemostatic Tests in Patients Undergoing Total Hip Replacement With Subgroup Analysis of Patients With Neoplasm
Total hip replacement (THR) is associated with extensive tissue injury and considerable blood loss that can be complicated by hyperfibrinolysis with an increased need for blood transfusion.
- Conditions
- Total Hip Replacement, Thromboelastometry, Bone Neoplasm of Hip
- Trial name
- I-SIGHT-THR (NCT04442373)
- Testing
- Rotational thromboelastometry
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Bone Metastases, Cancer Survivor
Telemonitoring After Surgery to Preserve Limb Function in Optimizing Mobility in Cancer Survivors With Skeletal Metastases
This randomized pilot trial studies telemonitoring after surgery to preserve limb function in optimizing mobility in cancer survivors with cancer spread to the bone.
- Conditions
- Bone Metastases, Cancer Survivor, Metastatic Malignant Neoplasm in the Bone
- Trial name
- NCT02715856
- Testing
- Monitoring Device, Physical Activity Measurement, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- M.D. Anderson Cancer Center
Mandibular Neoplasms
Inferior Alveolar Nerve Block for Intraoperative Analgesia for Maxillofacial Cancer Surgery - RCT
Mandibular resection which is an important component of maxillofacial cancer surgery is an extremely painful procedure associated with severe sympathetic response needing high doses of opioids.
- Trial name
- NCT02745288
- Testing
- inferior alveolar nerve block
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Tata Memorial Centre
Infection, Bone Neoplasms
Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY)
The Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial is the first ever international multi-center randomized controlled trial in bone cancer surgery.
- Trial name
- PARITY (NCT01479283)
- Testing
- 24-Hour Prophylactic Cefazolin* Antibiotic Regimen, 5-Days Prophylactic Cefazolin* Antibiotic Regimen
- Where
- 54 sites in United States, Argentina and 10 more
- Volunteers
- 602 people
- Sponsor
- McMaster University
Trigeminocardiac Reflex, Jaw Cysts
Assessing the Frequency of Trigeminocardiac Reflex in Maxillary and Mandibular Cyst Operations
The goal of this clinical trial is to investigate the frequency of trigeminocardiac reflex development during the surgical removal of large cystic structures within the maxillary and mandibular bones in healthy adults.
- Conditions
- Trigeminocardiac Reflex, Jaw Cysts, Hemodynamic Instability
- Trial name
- NCT06605716
- Testing
- Enucleation of cysts
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Giant Cell Tumor of Bone
Accuracy of Indocyanine Green (ICG) Fluorescence Imaging in Giant Cell Tumor of Bone Surgery
This study evaluates the diagnostic accuracy of Indocyanine Green (ICG) fluorescence imaging in visualizing residual lesions of Giant Cell Tumor of Bone (GCTB) in the tumor cavity during surgery.
- Trial name
- ICG-GCTB (NCT07315828)
- Testing
- Indocyanine Green
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Maxillary Neoplasms
Prevalence of Trismus in Patients With Maxillary Cancer With and Without Radiation Therapy in the Egyptian Population.
This study aims at evaluating the prevalence of trismus among maxillary cancer patients in the Egyptian population and the effect of radiotherapy on the occurrence of trismus.
- Trial name
- NCT05091814
- Testing
- radiotherapy
- Where
- Egypt
- Volunteers
- 360 people
- Sponsor
- Cairo University