Clinical trials: Bone Defects, open to volunteers
Osteochondral Defects of Talus, Gait Analysis
Gait Pattern Analysis After Arthroscopic Treament of Osteochondral Defects of Talus
The study will investigate alterations in post-surgical gait patterns among patients who have undergone all arthroscopic microfracture and biological scaffold implementation surgery for the osteochondral lesions of talus.
- Conditions
- Osteochondral Defects of Talus, Gait Analysis, Microfracture Procedure, Biological Scaffold
- Trial name
- NCT07161128
- Testing
- arthroscopic microfracture and biological scaffold implementation for osteochondral defects of talus
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gazi University
Sticky Bone
Guided Bone Regeneration Using a Mixture of Autogenous and Xenograft Particulate Versus Patient-Specific Sticky Bone for Horizontal Anterior Maxillary Defect
This study aims to enhance healing while minimizing invasiveness and restoring tissues to their proper structure and function by using patient specific sticky bone that will enhance the soft tissue reaction and maintain the graft…
- Trial name
- NCT07113886
- Testing
- Mixture of Autogenous and Xenograft Particulates, Patient-Specific Sticky Bone
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Cartilage Injury, OA Knee
Tissue Engineered Cartilage to Repairing Articular Cartilage Defects
The joint cartilage constructed by combining bone marrow mesenchymal stem cells with three-dimensional materials has achieved the goal of repairing joint cartilage.
- Trial name
- NCT07094100
- Testing
- Tissue engineered cartilage
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Adolescent Idiopathic Scoliosis, 22q11.2 Deletion Syndrome
Early Scoliotic Changes in Children at Increased Risk for Scoliosis Development
Rationale: Despite several decades of research, the exact etiology of adolescent idiopathic scoliosis (AIS) remains unclear. In AIS, spine curvature begins with and progresses during the adolescent growth spurt.
- Trial name
- EARLYBIRD (NCT05924347)
- Testing
- MRI, Scolioscan, Skeletal maturity assessment
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- UMC Utrecht
Dental Implants, Single-tooth, Alveolar Ridge Preservation
Alveolar Ridge Preservation Versus Spontaneous Healing
Rationale: To determine the effect of alveolar ridge preservation (ARP) versus spontaneous healing (SH) in large buccal bone defects in the posterior mandible.
- Conditions
- Dental Implants, Single-tooth, Alveolar Ridge Preservation, Guided Bone Regeneration
- Trial name
- ARP versus SH (NCT07001345)
- Testing
- Alveolar Ridge Reconstruction
- Where
- Netherlands
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Marfan Syndrome
Marfan Syndrome Moderate Exercise Trial II
Marfan syndrome (MFS) is a distinctive connective tissue disorder that affects multiple organ systems including the heart, bones, ligaments, and eyes, and is associated with significant risk of aortic dissection.
- Trial name
- NCT05809323
- Testing
- Exercise Intervention Group, Control Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Intra-Bony Defects in Periodontitis Patients
The Efficacy of Exosomes Combined With Synthetic Bone Graft for the Treatment of Periodontal Intra-bony Defects
The aim of this study will be to evaluate clinically, radiographically and biochemically the efficacy of exosomes combined with synthetic bone graft for the treatment of periodontal intra-bony defects.
- Trial name
- NCT07897292
- Testing
- single flap approach, single flap approach combined with nanocrystalline hydroxyapatite bone substitute, Exosomes
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Khoshoe Al-mokhtar Mohammed
Marfan Syndrome
Clinical and Psychosocial Factors Associated With Physical Activity Level in Adults With Marfan Syndrome
Background. Marfan syndrome is a genetic connective tissue disorder with cardiovascular and musculoskeletal involvement. Despite clinical advances, many patients exhibit low levels of physical activity, influenced by clinical and…
- Trial name
- NCT07419386
- Testing
- Adults with Marfan syndrome
- Where
- Spain
- Volunteers
- 118 people
- Sponsor
- University of Oviedo
Periodontitis, Bone Defects
The Use of Two Bone Substitutes in Adjunct to EMD for the Treatment of One- and Two-wall Intrabony Defects.
The main aim will be to evaluate the difference in PD changes at 12-month follow-up, measured from the gingival margin to the base of the pocket, comparing periodontal regeneration using two different bone substitutes, that is…
- Trial name
- OSSIXPERIO (NCT07546279)
- Testing
- EMD + collagenated DBBM, EMD + hydroxyapatite collagen matrix
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Peri-implantitis
Reconstructive Treatment of Peri-implantitis With Combined Defects
The aim of this randomized clinical study is to assess the additional clinical benefit of incorporating a resorbable collagen membrane (CM) alongside a xenogeneic bone graft-specifically, deproteinized bovine bone mineral with…
- Trial name
- NCT06957652
- Testing
- DBMM-C plus Resorbable collagen membrane, DBMM-C
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Chondral Lesion of the Knee, Meniscal Injuries
Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy
This study will examine whether using bone marrow aspirate (BMA) during knee arthroscopy surgery can improve patient outcomes. The investigators will enroll 50 patients who need knee arthroscopy surgery for meniscus injuries or…
- Conditions
- Chondral Lesion of the Knee, Meniscal Injuries, Cartilage Defects of the Knee, Osteoarthritis (OA) of the Knee
- Trial name
- BMA (NCT06893302)
- Testing
- Bone Marrow Aspirate (BMA), Arthroscopic Debridement Surgery, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Vascular Anomaly, Osler Rendu Disease
Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 Study
There are no prospective studies of pregnancies for the diseases studied here in (Heredity Hemorrhagic Telangiectasia, Marfan syndrome or related, primary lower limb lymphedema, superficial arteriovenous malformations, and…
- Conditions
- Vascular Anomaly, Osler Rendu Disease, Marfan Syndrome or Related, Lymphedema Primary
- Trial name
- COGRare5 (NCT04194619)
- Testing
- Questionnaire
- Where
- 37 sites in France
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon
Impacted Mandibular Third Molar Extraction, Dentin Graft
Autologous Dentine Graft Compared to Xenograft in Managing Periodontally Compromised Second Molar After Third Molar Removal
The goal of this study is to evaluate the efficacy of autologous dentin graft (ADG) in treating periodontal defects on the distal aspect of mandibular 2nd molar (M2) after surgical removal of impacted mandibular 3rd molar (M3) by…
- Conditions
- Impacted Mandibular Third Molar Extraction, Dentin Graft, Xenograft, Bone Defects
- Trial name
- NCT07362394
- Testing
- Autologous dentin graft, Xenograft
- Where
- Malaysia
- Volunteers
- 34 people
- Sponsor
- National University of Malaysia
Bone Defects
Multi-center Study on Comprehensive Diagnosis and Treatment of Lower Limb Bone Defect Based on Three-dimensional Printing Technology
The clinical diagnosis and treatment of lower limb bone defect is a difficult problem in orthopedics. The traditional treatment has the shortcomings of long treatment period, no weight bearing in the early stage of the limb, weak…
- Trial name
- NCT06269354
- Testing
- 3D printed prostheses
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Orthopedic Disorder, Trauma Injury
X-BS Ortho Bone Graft Study
Randomised investigation of the osteoconductive performance and safety of CE-marked FDBS bone graft (GraftR3®), with contextual reference to CE-marked IBS (MBCP® Putty), in the filling of orthopaedic bone defects.
- Conditions
- Orthopedic Disorder, Trauma Injury, Extremity Injury
- Trial name
- NCT06326827
- Testing
- FDBS (GraftR3®), IBS (MBCP® Putty)
- Volunteers
- 200 people
- Sponsor
- Advanced Medical Solutions Ltd.
Peri-implantitis
Implant Survival After Surgical Treatment of Peri-implantitis of Infra-bony Defects
To report the 10 years outcomes of a reconstructive surgical protocol for peri-implantitis defects with different morphologies, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC).
- Trial name
- Bony defects (NCT07809334)
- Testing
- Reconstructive therapy
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Degradation of Magnesium Alloy Prosthesis and New Bone Regeneration
The Clinical Study of 3D-printed Magnesium Alloy Prosthesis With Controllable Degradation Rate in the Repair of Periarticular Bone Defects
Perimarticular fracture bone defect is a common and complicated clinical disease. The current treatment for this type of injury is anatomical reduction of the fracture, where the bone defect is filled with artificial, autologous…
- Trial name
- NCT06349629
- Testing
- 3D printed WE43 magnesium alloy
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Guided Tissue Regeneration, Periodontal / Methods, Dental Enamel Proteins* / Therapeutic Use
Flapless Periodontal Regeneration Using Hyaluronic Acid Versus Enamel Matrix Derivative
The goal of this clinical trial is to radiographically assess the effectiveness of minimally invasive non-surgical technique (MINST) combined with local administration of sodium hypochlorite gel (Perisolv®) and 1.6% cross-linked…
- Conditions
- Guided Tissue Regeneration, Periodontal / Methods, Dental Enamel Proteins* / Therapeutic Use, Alveolar Bone Loss* / Therapy, Hyaluronic Acid* / Therapeutic Use
- Trial name
- NCT07339605
- Testing
- Flapless instrumentation of the defect following MINST in conjuction with NaOCl and hyaluronic acid application, Flapless instrumentation of the defect following MINST, root conditioning with EDTA and EMD application, Flapless instrumentation of the defect and product application simulation
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Valencia
Bone Regeneration, Periodontal Bone Loss
Effect of Nitroglycerin Hydrogel on Repairing Critical Bone Defects
Due to their osteoconductive, osteoinductive, and osteogenic qualities, autologous bone grafts are the gold standard for augmenting bone, (1).
- Conditions
- Bone Regeneration, Periodontal Bone Loss, Healing Fracture of Bone
- Trial name
- Nitro- Bone (NCT06925763)
- Testing
- Nitroglycerin
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Minia University
Bone Defects, Orthopaedic Surgery (30 Minutes or Longer)
Evaluation of the Safety and Performance of the Neocement®
This study aims to collect real-world clinical data to gather information on the performance and safety of the Neocement® when used according to its intended purpose and current clinical applications.
- Trial name
- Neocement01 (NCT06973226)
- Where
- Portugal
- Volunteers
- 80 people
- Sponsor
- Bioceramed