Clinical trials: Bone Diseases, Endocrine
Adult Growth Hormone Deficiency
A Non-inferiority Phase 2 Study to Evaluate the Safety and Efficacy of PEG-rhGH in the Treatment of AGHD
This study aims to explore the optimal dose of PEG-rhGH injection in the treatment of AGHD, preliminarily evaluate its safety and efficacy, to provide scientific and reliable evidence for the medication dosage in Phase 2 clinical…
- Trial name
- NCT03104010
- Testing
- Somatropin Injection
- Where
- 9 sites in China
- Volunteers
- 180 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Breast Cancer
Efficacy of RAD001 in Breast Cancer Patients With Bone Metastases
The purpose of this study is to determine wether RAD001 can inhibit growth of tumour cells and/or stop the formation and activity of bone degrading osteoclasts.
- Trial name
- RADAR (NCT00466102)
- Testing
- RAD001
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- GBG Forschungs GmbH
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Social Health, Activity Behaviors, and Quality of Life Among Young Adult Cancer Survivors
This longitudinal observational study examines how social health, including social support, social roles, loneliness, social anxiety, and social network characteristics, relates to physical activity, sedentary time, and quality…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT07259304
- Testing
- Medical Device Usage and Evaluation, Quality-of-Life Assessment, Survey Administration
- Where
- 3 sites in United States
- Volunteers
- 173 people
- Sponsor
- University of Southern California
Chronic Disease, Frail
Functional Exercise and Nutrition Education Program for Older Adults
There is strong evidence that specific types of exercise can improve health and physical function in older adults. While community exercise classes exist, many older adults with chronic conditions may need guidance from…
- Conditions
- Chronic Disease, Frail, Diabetes Mellitus, Cancer
- Trial name
- MoveStrong (NCT04037436)
- Testing
- Strength and Balance Training & Nutrition Education, Usual Care
- Where
- 5 sites in Canada
- Volunteers
- 44 people
- Sponsor
- University of Waterloo
Type 2 Diabetes Mellitus
Efficacy Of Autologous Bone Marrow Derived Stem Cell Transplantation In Patients With Type 2 Diabetes Mellitus
India is the "Diabetes Capital of the World" with 41 million Indians having diabetes i.e. every fifth diabetic in the world is an Indian1.
- Trial name
- SCT (NCT00644241)
- Testing
- stem cell harvest, angiographic transplantation of stem cells
- Where
- India
- Volunteers
- 10 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Osteomyelitis, Prosthetic Joint Infection
Short or Long Antibiotic Regimes in Orthopaedics
Research question: If adults with bone or joint infection have local antibiotic therapy, can they do without prolonged treatment with antibiotics by mouth (oral) or injection? Adults with bone or joint infections are usually…
- Conditions
- Osteomyelitis, Prosthetic Joint Infection, Diabetic Foot
- Trial name
- SOLARIO (NCT03806166)
- Testing
- Shorter Systemic Antibiotics, Standard treatment
- Where
- 23 sites in Germany, Portugal and 2 more
- Volunteers
- 500 people
- Sponsor
- Oxford University Hospitals NHS Trust
Parathyroid Cancer, Primary Hyperparathyroidism
Natural History Study of Parathyroid Disorders
Background: Parathyroid disorders are very common in the general population and include disorders of parathyroid excess, deficiency, or defects in parathyroid hormone (PTH) signaling.
- Conditions
- Parathyroid Cancer, Primary Hyperparathyroidism, Pseudohypoparathyroidism, Inheritable Bone Diseases
- Trial name
- NCT04969926
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes Mellitus, Bone Remodeling
Changes in Bone Turnover With Exposure to a GLP-1 Receptor Agonist
The purpose of this study is to determine changes in bone turnover markers and calcitonin following the initiation of exenatide compared to placebo in postmenopausal women wtih type 2 diabetes.
- Trial name
- CMBD (NCT01381926)
- Testing
- exenatide, Saline
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Puberty, Precocious, McCune-Albright Syndrome
Faslodex in McCune-Albright Syndrome
The purpose of this study is to evaluate the safety, effectiveness and pharmacokinetics of a study drug called Faslodex (fulvestrant) in the treatment of progressive precocious puberty (PPP) (early puberty) in girls with…
- Trial name
- FMAS (NCT00278915)
- Testing
- Fulvestrant
- Where
- 16 sites in United States, France and 4 more
- Volunteers
- 30 people
- Sponsor
- AstraZeneca
Congenital Hypothyroidism
Congenital Hypothyroidism in Children With Eutopic Gland or Thyroid Hemiagenesis: Predictive Factors for Transient vs Permanent Hypothyroidism.
In France, the incidence of congenital hypothyroidism has increased significantly since the newborn screening program was introduced in 1978. The largest increase is seen in children with eutopic thyroid gland.
- Trial name
- NCT04712760
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Chronic Kidney Diseases, Chronic Kidney Disease-Mineral and Bone Disorder
Chinese CKD-MBD Prevalence Survey (CRISS-MBD)
This is a multi-center cross sectional epidemiological study. The purpose of this study is to investigate the prevalence of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) in Chinese population.
- Trial name
- NCT04714918
- Where
- 40 sites in China
- Volunteers
- 10,254 people
- Sponsor
- Limeng Chen
Adenocarcinoma, Adenocystic Carcinoma
The Registry of Oncology Outcomes Associated With Testing and Treatment
This study is to collect and validate regulatory-grade real-world data (RWD) in oncology using the novel, Master Observational Trial construct. This data can be then used in real-world evidence (RWE) generation.
- Conditions
- Adenocarcinoma, Adenocystic Carcinoma, Anal Cancer, Appendix Cancer
- Trial name
- ROOT (NCT04028479)
- Testing
- Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P)
- Where
- 2 sites in United States
- Volunteers
- 167 people
- Sponsor
- Taproot Health
Peripheral Vascular Disease, Ischemia
A Clinical Study Using Autologous Bone Marrow Stem Cell for Diabetes Related Vascular Complications
Stem cell therapy has been a new and effective therapy in recent years for diabetic foot.This study intends to establish an optimal clinical research program, and attempts to break the technical bottleneck in the stem cell…
- Conditions
- Peripheral Vascular Disease, Ischemia, Diabetic Foot
- Trial name
- NCT02796079
- Testing
- mesenchymal stem cells, saline
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Jie Shen
Healthy, Growth Hormone Deficiency
Effects of GH and Lirglutide on AgRP
This is a randomized, placebo-controlled, cross-over study with 4 arms. Healthy and GH deficient adults ages 18-45 years will be studied. Arms will consist of 21-day treatment periods and be separated by 8-week washout periods.
- Trial name
- NCT05681299
- Testing
- growth hormone and lirglutide, growth hormone, liraglutide
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Acromegaly
Predictive Factors Study
This is a long term study to evaluate common therapeutic algorithms and possible predictive parameters for Somatuline Autogel treatment in patients with Acromegaly.
- Trial name
- TAPAS (NCT02020499)
- Testing
- Somatuline Autogel® (lanreotide) 60, 90, 120 mg.
- Where
- 6 sites in Australia
- Volunteers
- 5 people
- Sponsor
- Ipsen
Pancreas Cancer
A Single-center Clinical Study to Evaluate the Safety and Efficacy of Autologous Bone Marrow-derived DCs(CellgramDC-WT1) and Immune Checkpoint Inhibitors in Patients With Metastatic Pancreatic Cancer Who Have Failed First-line or More Standard Chemotherapy
To evaluate the safety and effectiveness of immune cell therapy using autologous bone marrow-derived dendritic cells and immune checkpoint inhibitors in patients with metastatic pancreatic cancer who have failed at least one…
- Trial name
- DICI_PC (NCT06172634)
- Testing
- dentritic cell infusion and immunecheckpoint inhibitor
- Volunteers
- 10 people
- Sponsor
- Soonchunhyang University Hospital
Diabetes Mellitus Type 1, Diabetes Mellitus Type 2
Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals
Patients with diabetes have high blood sugar levels (hyperglycemia) because pancreatic beta-cells no longer produce sufficient insulin.
- Trial name
- NCT00813228
- Testing
- Sitagliptin (Januvia)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pituitary Tumor
PITUItary Carcinoma or Aggressive Tumors REgistry -Lyon
The purpose of this study is to observe predictors of pituitary tumor recurrence and markers of persistent disease activity through computerized collection of comprehensive demographic, therapeutic, pathologic and outcome…
- Trial name
- PITUICARE-Lyon (NCT02854228)
- Where
- France
- Volunteers
- 1,300 people
- Sponsor
- Hospices Civils de Lyon
Growth Hormone Deficiency
Exploring Interactions Between Growth Hormone and the Microbiome
The goal of this study is to characterize the microbiome and metabolomics of children with Growth Hormone (GH) deficiency, prior GH treatment initiation and compare it to healthy children
- Trial name
- NCT03327207
- Testing
- Non Interventional
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Bone Metabolism
The Effect of Testosterone Replacement on Bone Mineral Density in Boys and Men With Anorexia Nervosa
Decreased bone strength is a common and serious medical problem present in many people with anorexia nervosa. Men with anorexia nervosa have lower levels of gonadal steroids such as testosterone.
- Trial name
- NCT00853502
- Testing
- testosterone cypionate
- Where
- United States
- Sponsor
- Massachusetts General Hospital