Clinical trials: Bone Health, open to volunteers
Rheumatoid Arthritis
GenAI-Assisted Rheumatoid Arthritis Bone Erosion Risk Assessment and DMARD Selection
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive joint damage and bone erosion. Accurate assessment of RA bone erosion risk (RABER) and appropriate disease-modifying antirheumatic drug…
- Trial name
- RABER (NCT07914907)
- Testing
- GenAI-Assisted Clinical Decision Support for RABER Assessment and DMARD Selection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Adolescence Idiopathic Scoliosis, AIS
Smartphone App for Adolescents With Idiopathic Scoliosis
This study aims to evaluate a smartphone application (DinSkoliose) designed to support adolescents with idiopathic scoliosis (AIS) in managing their condition and following their treatment.
- Trial name
- NCT07686848
- Testing
- DinSkoliose smartphone application
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oslo Metropolitan University
Autism Spectrum Disorder, Bone Health
Oxytocin Effects on Bone in Children With Autism Spectrum Disorder
This is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin on bone health in children with autism spectrum disorder, ages 6-18 years old.
- Trial name
- BOX (NCT05754073)
- Testing
- 1. Intranasal oxytocin spray, 3. Intranasal Oxytocin spray
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- Elizabeth Austen Lawson
Inflammatory Bowel Disease, Crohn Disease
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls.
- Trial name
- NCT04508088
- Testing
- Coronal T1 weighted spin echo images, Spin-lattice relaxation (T1), Magnetic resonance spectroscopy
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Case Series/Case Note Review
The Assessment of Bone Health in a Clinical Setting
The study will use data already obtained through the metabolic clinical service to improve diagnosis and management of our patients.
- Trial name
- NCT05216185
- Volunteers
- 5,000 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Hodgkin Lymphoma in Remission, Leukemia in Remission
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment
This clinical trial studies the effects of dexrazoxane hydrochloride on biomarkers associated with cardiomyopathy and heart failure after cancer treatment.
- Conditions
- Hodgkin Lymphoma in Remission, Leukemia in Remission, Lymphoblastic Lymphoma, Osteosarcoma
- Trial name
- NCT01790152
- Testing
- Assessment of Therapy Complications, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- 79 sites in United States, Australia and 2 more
- Volunteers
- 420 people
- Sponsor
- Children's Oncology Group
Alveolar Bone Atrophy, Alveolar Bone Grafting
Digital Planning and Clinical Assessment of the Treated Atrophic Posterior Maxilla With a Sinus Lift Procedure: a Cross-sectional Study.
Maxillary posterior area is the most challenging site for dental implant placement. Indeed, complex remodeling processes, resulting in changes of the maxillary sinus and shape of the alveolar ridge will cause difficulties in…
- Conditions
- Alveolar Bone Atrophy, Alveolar Bone Grafting, Peri-Implant Health, Sinus Floor Augmentation
- Trial name
- NCT07526337
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Cystic Fibrosis, Hypoestrogenism
Estrogen Supplementation and Bone Health in Women With CF
The goal of this study is to learn about the role of estrogen and other hormones in bone development in adolescent and young adult women with cystic fibrosis (CF).
- Trial name
- STURDY (NCT05704036)
- Testing
- Transdermal estrogen, Progesterone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Johns Hopkins University
Medium-/Long-segment Spinal Fusion Patients, Spine Surgeons
Evaluation of an Online Peri-operative Health Education Platform for Patients Undergoing Spine Surgery: Ready Set Recover
Chronic back pain is the world's leading cause of disability, with spine surgery being a common yet costly intervention. However, many patients experience suboptimal recovery, with persistent pain and functional limitations…
- Conditions
- Medium-/Long-segment Spinal Fusion Patients, Spine Surgeons, Chronic Low Back Pain, Scoliosis Patients
- Trial name
- NCT07766824
- Testing
- Ready Set Recover
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National University of Natural Medicine
Health Behavior, Quality of Life
The Lake Nona Life Project
The Lake Nona Life Project aims to examine the health and wellness of participants over the course of multiple years, focusing on the links between health and wellness, longevity, quality of life, and human performance.
- Conditions
- Health Behavior, Quality of Life, Aging
- Trial name
- NCT02533804
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Osteoporosis
Health ImprOvement Program of Bone in China
Fracture risk factors have long been identified as key factors in osteoporosis and fragility fractures. The WHO recommended Fracture risk assessmenttool (FRAX) applies clinical risk factors to assess the absolute risk of…
- Trial name
- NCT05906147
- Testing
- Regular follow-up
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Second Xiangya Hospital of Central South University
Orthopaedic Fractures, Socioeconomic Factors
Trial of Social Work Services in Fracture Clinic Setting
Every year, many Canadians sustain a fracture that requires surgical treatment and results in a long recovery period. During this recovery period, patients may experience new or worsening mental health issues including…
- Trial name
- SWRCT (NCT06973655)
- Testing
- Social Work support
- Where
- 2 sites in United States, Canada
- Volunteers
- 2,000 people
- Sponsor
- Sheila Sprague
Myeloproliferative Neoplasms (MPNs)
WELL-MPN: A Digital Lifestyle App for Patients With MPNs
The goal of this clinical trial is to learn whether a digital lifestyle app can help improve diet, physical activity, symptoms, emotional well-being, and quality of life in adults with myeloproliferative neoplasms (MPNs).
- Trial name
- WELL-MPN (NCT07349134)
- Testing
- WELL-MPN Digital App
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Brigham and Women's Hospital
Sarcoma, Giant Cell Tumor of Bone
Activation Sarcoma: PROMIS and Mobility Evaluation in Sarcoma Patients
Sarcoma is a rare form of bone and soft tissue cancer, making up about 1% of all adult cancers. Management typically involves radiation therapy, chemotherapy, and surgical resection.
- Trial name
- NCT07227961
- Testing
- Surgery
- Where
- 4 sites in United States, Canada
- Volunteers
- 800 people
- Sponsor
- University of Calgary
Premature Ovarian Insufficiency
Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency
Background: Premature ovarian insufficiency (POI) is a condition in which women under the age of 40 years have absent or irregular menstrual cycles. POI can cause infertility, signs of menopause, osteoporosis, and other symptoms.
- Trial name
- NCT06851754
- Testing
- Progesterone, Estrogen Patch
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Prostate Cancer (Adenocarcinoma)
Effect of ADT and ARPI on Bone Loss of Patients with Prostate Cancer
This study aims to assess the impact of Androgen Deprivation Therapy (ADT) and Androgen Receptor Pathway Inhibitors (ARPI) on bone quality in patients with prostate cancer.
- Trial name
- NCT06838520
- Testing
- Bone health assessment
- Where
- 4 sites in China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Nutrition, Health and Wellbeing
Early Time-Restricted Eating Combined With Exercise in Older Adults
This randomized controlled trial aims to investigate the effects of Early Time-Restricted Eating (eTRE) combined with a multicomponent exercise program on bone health, physical function, and fall risk in healthy older adults.
- Conditions
- Nutrition, Health and Wellbeing, Aging, Time Restricted Eating
- Trial name
- NCT07695961
- Testing
- Early Time-Restricted Eating (eTRE)+Exercise Intervention
- Where
- Tunisia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Manouba
Hearing Loss, Conductive, Hearing Loss, Mixed
Pilot Study to Evaluate the Long-term Chronic Care of Patients Who Could or do Utilize an Osseointegrated Device (OID)
The primary objective of the study is to evaluate OID hearing intervention on cognition among patients who could vs. do utilize an OID.
- Conditions
- Hearing Loss, Conductive, Hearing Loss, Mixed, Deafness, Unilateral
- Trial name
- NCT04899037
- Testing
- No intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of South Florida
Osteoporosis, Fracture
Fragility Fracture Liaison Service and Anti-osteoporosis Medication Monitoring Service Study
Aims: (1) to Establish the FLS services at the National Taiwan University Hospital Jinshan Branch. (2) To establish a anti-osteoporosis medication management service at Jinshan Branch.
- Trial name
- NCT02635022
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital