Clinical trials: Bone Injury
Ankle Fractures
Vertical Distance Between Medial and Lateral Malleolus in Normal Population
Determine variation in vertical distance between the medial and lateral malleolus in the normal population subjected to X-rays for any other causes than ankle fracture Determine the effect of weight bearing on this variation
- Trial name
- NCT04826289
- Testing
- X rays
- Where
- Egypt
- Volunteers
- 580 people
- Sponsor
- Assiut University
Bone Fractures
Naringenin Supplementation in Bone Fracture Patients
Fractures of the lower extremities represent a significant proportion of injuries sustained by polytrauma patients, with a notable association with prolonged hospitalization, chronic disability, and impaired physical functioning.
- Trial name
- NCT06612762
- Testing
- The daily ingestion of capsules containing naringenin
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Hip Fractures
What Laxative Should be Used After Hip Fracture Surgery?
To conduct a randomized clinical trial to determine how best to prevent constipation after hip fracture surgery using laxatives.
- Trial name
- NCT06455813
- Testing
- Bisacodyl, Macrogol 3350 and electrolytes, A combination of macrogol 3350 and electrolytes and bisacodyl
- Where
- 2 sites in Denmark
- Volunteers
- 375 people
- Sponsor
- Odense University Hospital
Vertebral Fracture, Multiple Myeloma
Examination of Vertebroplasty in Addition to Regular Treatment of Patients With Multiple Myeloma.
Patients with newly diagnosed or known multiple myeloma with newly diagnosed vertebral lesion(s) will be invited to participate in a cross-sectoral randomized controlled trial.
- Trial name
- NCT04533217
- Testing
- Vertebroplasty
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Spine Centre of Southern Denmark
Hip Fractures
Patients With Acute Hip Fractures Will Receive Either the PENG Block or no Block Respectively.
Hip fracture pain is often severe and traditionally managed by systemic opioids which have increased risk of side effects in frail elderly patients.
- Trial name
- PENGBlock (NCT04996979)
- Testing
- Ropivacaine 0.5% Injectable Solution
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- Singapore General Hospital
Transplant Bone Disease
Pamidronate, Vitamin D, and Calcium for the Bone Disease of Kidney and Heart Transplantation
Bone is lost rapidly and fractures occur in 10-20% of patients who receive organ transplants within 2 years. The purpose of this study is to evaluate long-term effects of a pamidronate-vitamin D-calcium regimen on bone loss…
- Trial name
- NCT00302627
- Testing
- Pamidronate, vitamin D, Calcium Carbonate
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Providence Health & Services
Proximal Femoral Fracture
Risk Factors for Cut-out After Internal Fixation of Trochanteric Fractures in Elderly Subjects.
Proximal femoral fracture is associated with severe morbidity and mortality and high socioeconomic costs. The main mechanical complication of internal fixation in trochanteric fracture is lag-screw cut-out through the femoral…
- Trial name
- NCT03975868
- Testing
- Analysis of associated factors for cut-out in internal fixation of extracapsular proximal femoral fracture.
- Volunteers
- 228 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Trauma
Screw Versus Tightrope Syndesmotic Injury Fixation in Weber C Ankle Fractures
The aim of our study is to compare two different syndesmosis transfixation methods in AO/OTA Weber C ankle fractures. Our hypothesis is that 50% of screw fixed fibulas but only 5% of suture-button fixed fibulas are in…
- Trial name
- NCT01742650
- Testing
- Screw fixation, TightRope
- Where
- Finland
- Volunteers
- 38 people
- Sponsor
- University of Oulu
Risk of Bone Fracture Occurrences
Efficacy and Safety Study of Toremifene Citrate for the Reduction in the Risk of New Bone Fracture Occurrences in Men With Prostate Cancer
The purpose of this study is to determine whether Toremifene Citrate is effective in reducing the risk of bone fractures in men with prostate cancer who are on Androgen Deprivation Therapy.
- Trial name
- TREAT2 (NCT01214291)
- Testing
- Toremifene
- Where
- United States
- Sponsor
- GTx
Rib Fractures
Early Percutaneous Cryoablation for Pain Control After Rib Fractures Among Elderly Patients
The purpose of this study is to provide long-term pain control for elderly patients with rib fractures in order to minimize their risk of complications and return them to baseline functional capacity
- Trial name
- EPERC (NCT04482582)
- Testing
- Cryoneurolysis, Standard of Care
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Stanford University
Lateral Malleolus Fracture
A Noninferiority RCT Comparing Operative vs Nonoperative Treatment for ER-stress Positive Weber-B Unimalleolar Fractures
Current gold standard treatment for unstable (those found unstable in external rotation (ER) stress testing Weber B-type, Lauge-Hansen supination-external rotation type IV) ankle fractures is open reduction and internal fixation…
- Trial name
- NCT01758796
- Testing
- Non-operative treatment, Surgery
- Where
- Finland
- Volunteers
- 126 people
- Sponsor
- University of Oulu
Fracture Healing
A Phase IIa Study Of Men And Post-Menopausal Women With A Fractured Distal Radius
This is a study designed to test the safety and effectiveness of SB-751689 in the treatment of a distal radius fracture in post-menopausal women and men in comparison to placebo to determine if healing time of the fracture can be…
- Trial name
- NCT00548496
- Testing
- SB-751689
- Where
- 37 sites in Argentina, Australia and 11 more
- Volunteers
- 86 people
- Sponsor
- GlaxoSmithKline
Orbital Fractures, Blow Out Fracture of Orbit
Orbital Fractures Registry
Approximately 300 patients presenting orbital blow-out fracture will be enrolled prospectively in this registry. All patients, surgically and nonsurgically treated as per standard (routine) of care will be followed-up (FU) within…
- Trial name
- OFx (NCT03887988)
- Testing
- Primary "early" reconstruction, Nonsurgical, Primary "delayed" reconstruction
- Where
- 14 sites in United States, Germany and 10 more
- Volunteers
- 300 people
- Sponsor
- AO Innovation Translation Center
Fracture of Shaft of Humerus
Acute Management of Humeral Shaft Fractures: Sling vs. Splint
When people break their arm and arrive at Oregon Health and Science University's Emergency Department (OHSU ED), they are treated with a short-term means of immobilizing their broken arm.
- Trial name
- NCT01869322
- Testing
- Sling and Swathe, Coaptation Splint
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Rib Fractures
Comparison of Lung Function Based on Electrical Impedance Tomography and CT Lung Volume in Patients With Rib Fractures
Our research uses the electrical impedance tomography system (EIT), which can use the applied current and measurement voltage through the body surface electrode group, and use the reconstruction algorithm to construct an image…
- Trial name
- EIT (NCT04946331)
- Testing
- Electrical impedance tomography system
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Otitis Media Chronic, Temporal Bone
Efficacy of Platelet- and Extracellular Vesicle-rich Plasma in Chronic Postsurgical Temporal Bone Inflammations
This clinical study evaluates the efficacy of the autologous blood-derived product called platelet- and extracellular vesicle-rich plasma (PVRP) for the treatment of chronically inflamed post-surgical temporal bone cavities.
- Trial name
- PvRP-ear (NCT04281901)
- Testing
- Platelet- and extracellular vesicle-rich plasma, Standard conservative treatment
- Where
- Slovenia
- Volunteers
- 25 people
- Sponsor
- University Medical Centre Ljubljana
Periprosthetic Fractures, Periprosthetic Fracture Around Prosthetic Joint Implant
Periprosthetic Fracture Registry (PPFx)
This registry supports international data collection and research on PPFx treatments after hip and knee arthroplasty. A registry such as this ultimately aims to provide far-reaching benefits to society including reduced morbidity…
- Trial name
- PPFx (NCT03378557)
- Where
- 13 sites in United States, Belgium and 4 more
- Volunteers
- 600 people
- Sponsor
- AO Innovation Translation Center
ACL - Anterior Cruciate Ligament Rupture
Influence of the Different Types of Tibial Fixation in the Reconstruction of the Anterior Cruciate Ligament of the Knee: Osseous Integration, Ligament Maturation and Clinical Results.
Influence of different tibial fixation methods in anterior cruciate ligament (ACL) reconstruction: bone integration, graft maturation, and clinical outcomes.
- Trial name
- NCT07753707
- Testing
- Anterior cruciate ligament (ACL) reconstruction
- Where
- Spain
- Volunteers
- 111 people
- Sponsor
- Institut Català de Traumatologia i Medicina de l'Esport
Femoral Fractures, Tibial Fractures
Intra-op Monitoring With NIRS and NICOM, and Surgical Outcome in Elderly Patients With Fractures of Lower Limbs
In Taiwan, about 75.92% of the elderlies above 65 years old suffered from chronic diseases or major diseases, especially in circulatory system. Thus, dramatic hemodynamic change is often observed in surgeries in this population.
- Trial name
- NCT02280512
- Testing
- elderly with fractures
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Fractures, Open, Wounds and Injuries--Infections
Acute Application of Antibiotic Powder in Open Fracture Wounds
The purpose of this study is to help determine the best treatment for severe injures like open fracture wounds. Some broken bone injuries can be more likely to get an infection. It is mostly due to the way they were injured.
- Conditions
- Fractures, Open, Wounds and Injuries--Infections, Anti-Bacterial Agents, Fractures, Bone
- Trial name
- APOW (NCT04872400)
- Testing
- Vancomycin, Tobramycin
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver