Clinical trials: Bone Loss
Guided Tissue Regeneration, Periodontal / Methods, Dental Enamel Proteins* / Therapeutic Use
Flapless Periodontal Regeneration Using Hyaluronic Acid Versus Enamel Matrix Derivative
The goal of this clinical trial is to radiographically assess the effectiveness of minimally invasive non-surgical technique (MINST) combined with local administration of sodium hypochlorite gel (Perisolv®) and 1.6% cross-linked…
- Conditions
- Guided Tissue Regeneration, Periodontal / Methods, Dental Enamel Proteins* / Therapeutic Use, Alveolar Bone Loss* / Therapy, Hyaluronic Acid* / Therapeutic Use
- Trial name
- NCT07339605
- Testing
- Flapless instrumentation of the defect following MINST in conjuction with NaOCl and hyaluronic acid application, Flapless instrumentation of the defect following MINST, root conditioning with EDTA and EMD application, Flapless instrumentation of the defect and product application simulation
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Valencia
Alveolar Bone Loss
Demineralized Dentin Allograft Versus Demineralized Dentin Autograft for Socket Preservation
This study is designed to evaluate and compare clinically and radiographically the effectiveness of Demineralized Dentin Allograft (DDA) versus Demineralized Dentin Autograft (Auto-DD) for preservation of alveolar ridge…
- Trial name
- NCT06457373
- Testing
- Demineralized Dentin Allograft, Demineralized Dentin Autograft
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Horus University
Metformin Gel, Bone Healing
Effect of Metformin Gel on Guided Bone Regeneration Around Immediate Dental Implant at Posterior Maxillary Region
To evaluate, by standardized radiographic follow-up, whether locally delivered 1% metformin gel improves bone healing around immediately placed dental implants augmented with GBR.
- Conditions
- Metformin Gel, Bone Healing, Guided Bone Regeneration, Crestal Bone Loss
- Trial name
- MET-GBR (NCT07770087)
- Testing
- Metformin 1% Topical Gel, immediate Dental Implant Placement With Guided Bone Regeneration
- Where
- 2 sites in Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss
Early Dental Implant Installation in Regeneration Sites: a Prof of Concept Prospective Case Study
This study will evaluate bone healing after tooth extraction and alveolar ridge preservation, a common procedure used to maintain the bone volume needed for future dental implant placement.
- Trial name
- NCT07766057
- Testing
- Alveolar Ridge preservation and early implant placement
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- Franco Cavalla
Marginal Bone Loss Around Implants
Radiographic and Retention Evaluation Over Seven Years for Four Implant Retained Overdenture
ABSTRACT Statement of the problem: Insufficient long-term retrospective data is evaluating marginal bone loss and retention of four-implant Locator-retained mandibular overdentures.
- Trial name
- NCT07536776
- Testing
- implant retained overdenture, four dental implant with locator attachment
- Where
- Egypt
- Volunteers
- 27 people
- Sponsor
- Mansoura University
Maxillary Sinus Disease, Alveolar Bone Loss
Crestal Sinus Lifting in Periodontally-Compromised Patients Utilizing Autologous Dentin Graft
The integration of artificial intelligence and computer-guided technology offers the potential for improving surgical accuracy, reducing complications, and enhancing outcomes.
- Trial name
- NCT06887582
- Testing
- Free-hand sinus lift augmanted by particulate autologous dentin graft + free-hand implant placement, AI-assisted/computer-guided sinus lift augmanted by particulate autologous dentin graft + computer-guided implant placement, Free-hand sinus lift with autologous dentin block graft +free-hand immediate implant placement
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Osseodensification, Bone Expansion
Osseodensification for Narrow Alveolar Ridge Expansion
This prospective, single-arm, non-randomized interventional clinical study was designed to evaluate the immediate horizontal dimensional change in narrow alveolar ridges following osseodensification-assisted dental implant-site…
- Conditions
- Osseodensification, Bone Expansion, Alveolar Bone Loss, Jaw, Edentulous, Partially
- Trial name
- OD-RridgeExp (NCT07436533)
- Testing
- Densah burs (Osseodensification Technique)
- Where
- Yemen
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Science and Technology, Yemen
Tooth Loss / Rehabilitation, Tooth Extraction
Ovate Pontic Versus Essix Provisional After Tooth Extraction and Alveolar Ridge Preservation (Pontic-Essix)
This randomized controlled trial compares two provisional socket-sealing concepts following single non-molar tooth extraction and alveolar ridge preservation: a fixed, tooth-supported, 3D-printed ovate pontic provisional…
- Conditions
- Tooth Loss / Rehabilitation, Tooth Extraction, Alveolar Bone Loss, Alveolar Ridge Augmentation
- Trial name
- Pontic-Essix (NCT07748871)
- Testing
- Bio-Oss Collagen, Mucograft Seal, Fixed 3D-printed ovate pontic provisional restoration
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Bern
Chronic Periodontitis, Periodontal Bone Loss
Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and Enamel Matrix Derivative in Periodontal Regeneration.
The aim of this study is to compare the effectiveness in periodontal regeneration of cross-linked hyaluronic acid at 1.8% (Hyadent BG®) with enamel matrix derivative (Emdogain®) in periodontal bone defects evaluating their…
- Trial name
- NCT04274244
- Testing
- Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML, Enamel Matrix Proteins (Active comparator group)
- Where
- Spain
- Volunteers
- 53 people
- Sponsor
- Andres Lopez Roldan
Clift Lip, Cleft Palate
Description of Pain in Pediatric Patients With Cleft Lip and Palate Undergoing Alveolar Grafting Using Two Surgical Strategies: Stem Cells and Autogenous Iliac Crest Bone (Pain Evaluation in Children Undergoing Alveolar Grafting: Stem Cells vs. Iliac Crest Bone)
Study Objective The objective of this study was to evaluate and compare postoperative pain and hospital costs in pediatric patients with cleft lip and palate undergoing alveolar bone grafting surgery.
- Conditions
- Clift Lip, Cleft Palate, Alveolar Bone Loss, Postoperative Pain
- Trial name
- NCT07734974
- Testing
- Autogenous Iliac Crest Bone Grafting, Bioengineered Alveolar Grafting (SHED + Scaffold)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital Sirio-Libanes
Chronic Kidney Diseases, Bone Loss
Bone in CKD Alkali Response (BICARb Pilot Trial)
The goal of this clinical trial is to test whether potassium citrate improves skeletal health in adults and children with chronic kidney disease.
- Trial name
- BICARb (NCT05918029)
- Testing
- Potassium Citrate Extended Release Oral Tablet, Potassium Citrate and Citric Acid Oral Solution
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Albert Einstein College of Medicine
Alveolar Bone Loss, Periodontal Pocket
Regenerative Gel (Emdogain®) for Healing After Wisdom Tooth Extraction
This study investigates whether the intraoperative application of a specialized regenerative gel (Emdogain®) can improve the periodontal health of the mandibular second molar by preventing or reducing the formation of tissue…
- Conditions
- Alveolar Bone Loss, Periodontal Pocket, Impacted Tooth With Abnormal Positioning
- Trial name
- NCT07718932
- Testing
- Enamel Matrix Derivative (Emdogain®)
- Where
- 2 sites in Greece
- Volunteers
- 70 people
- Sponsor
- Aristotle University Of Thessaloniki
Dental Crowding, Alveolar Bone Loss
Bone Level Changes Using Clear Aligners Compared to Fixed Appliances in Non-Extraction Treatment of Adults
This study compares two common ways of straightening teeth in adults who have mild-to-moderate crowding of the lower front teeth and do not need any teeth removed: clear aligners and traditional fixed braces.
- Conditions
- Dental Crowding, Alveolar Bone Loss, Malocclusion
- Trial name
- NCT07716007
- Testing
- Fixed orthodontic appliance, Clear aligners
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Bone Substitutes, Alveolar Bone Grafting
Bone Augmentation Techniques in the Mandible Posterior Region
This study will compare three methods to rebuild lost bone in the back part of the lower jaw (posterior mandible) before dental implant placement.
- Trial name
- NCT06661447
- Testing
- Cortical Shell Bone Grafting
- Where
- Ecuador
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Universidad de Especialidades Espiritu Santo
Alveolar Bone Loss, Posterior Mandible
Khoury's Bone Shell Technique Versus Titanium-Reinforced Polytetrafluoroethylene for Augmentation of Horizontal Deficiency in Posterior Mandible (Histomorphometry Analysis)
The purpose of the study is the comparison of bone gained histologically from the Bone Shell Khoury's Technique in comparison with the usage of non-resorbable membrane polytetrafluoroethylene and discussing its eligibility for…
- Trial name
- NCT07669792
- Testing
- GBR using Ti based PTFE, Bone Shell Khoury's Technique
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Tooth Loss in the Anterior Maxilla, Alveolar Bone Loss* / Therapy
Beta-Tricalcium Phosphate Grafting of Peri-implant Jumping Gaps Greater Than 2 mm in Immediate Implants
This randomized controlled trial evaluated whether grafting the peri-implant "jumping gap" with injectable β-tricalcium phosphate (β-TCP) improves outcomes after immediate implant placement in sites where the horizontal gap…
- Trial name
- NCT07709676
- Testing
- Experimental: Test: beta-tricalcium phosphate grafting
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Minia University
Alveolar Ridge Deficiency, Alveolar Bone Loss
Novel Synthetic Membrane for Horizontal Bone Augmentation: A Case Series
The goal of this clinical study is to learn if the Inox Nanoksa G-Plus membrane works to rebuild bone in the upper or lower jaw (ridge augmentation) for adults who need dental implants but do not have enough bone width or height.
- Trial name
- NCT07701473
- Testing
- Inox Nanoksa G-Plus Membrane, Particulate Bone Graft
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Bone Loss, Alveolar, Dental Implant Failed
Clinical, Radiological and Microbiological Outcomes of Implants With Two Different Connection Configurations, a Split-mouth RCT.
This study designed as a randomized controlled split-mouth trial will be conducted at the Dental Clinic of the University of Valencia.
- Trial name
- NCT03528330
- Testing
- Rehabilitation with dental implant with internal hexagon connection, Rehabilitation with dental implant with conical connection
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Bone Loss
Comparison Between High-speed Drilling With Irrigation and Low-speed Drilling With Irrigation
A randomized controlled clinical trial was conducted in the Oral Surgery Unit, Faculty of Medicine and Dentistry, University of Valencia.
- Trial name
- NCT05286866
- Testing
- Dental implant bed preparation
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Bone Loss, Bacterium; Agent
Impact of Transepithelial Abutment Connection and Disconnection in Dental Implants
Over the past decade, implant research has focused on maintaining the health and stability of peri-implant tissues. A key factor is platform switching at the bone level, where a narrower abutment than the implant is used.
- Conditions
- Bone Loss, Bacterium; Agent, Satisfaction, Patient
- Trial name
- NCT06629961
- Testing
- abutment placement, Ti-base placement
- Where
- 2 sites in Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Valencia