Clinical trials: Bone Markers
Osteoporosis, Osteoporosis, Postmenopausal
Bone Turnover Markers and Treatment Efficacy in Postmenopausal Osteoporosis
This study investigates the use of blood tests known as Bone Turnover Markers (BTMs) to quickly monitor the effectiveness of osteoporosis treatment in postmenopausal women.
- Trial name
- NCT07242612
- Testing
- Alendronate, Ibandronate; Risedronate, Teriparatide
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Khyber Medical University Peshawar
Chronic Kidney Disease, Bee Venom
Effect of Bee Venom on Chronic Kidney Disease-Mineral Bone Disorders in Hemodialysis Patients: a Randomized Controlled Trial
This study aims to evaluate the effectiveness of bee venom injections as a treatment for chronic kidney disease (CKD)-mineral bone disorder (MBD) in patients undergoing hemodialysis.
- Conditions
- Chronic Kidney Disease, Bee Venom, Hemodialysis
- Trial name
- BeeVenom-CKD (NCT06901102)
- Testing
- Bee Venom Injection, Standard Care for CKD-MBD
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Metabolic Bone Disease
Markers of Bone Disease in Children on Parenteral Nutrition
Parenteral nutrition (PN) is the provision of nutrients via the intravenous route. Parenteral nutrition associated metabolic bone disease (MBD) was first described in children in the 1980s.
- Trial name
- NCT01603472
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Intestinal Failure, Osteoporosis
Bone Markers in Pediatric IF
Poor bone health is a well-recognized but poorly understood complication in children with intestinal failure (IF) who are dependent on parenteral nutrition (PN).
- Conditions
- Intestinal Failure, Osteoporosis, Metabolic Bone Disease
- Trial name
- NCT05909228
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- The Hospital for Sick Children
Rubinstein-Taybi Syndrome
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.
Rubinstein-Taybi syndrome (RSTS) is a rare and severe congenital developmental disorder characterized by congenital anomalies and intellectual disability with a long term memory deficit.
- Trial name
- GENEPI (NCT04122742)
- Testing
- skin biopsy for the primary fibroblast culture and a 15 ml blood sample (3 unnamed samples of 5ml) in each of the 4 SRT patients included., Generation of Induced Pluripotent Stem Cells (iPSC) from fibroblasts obtained by skin biopsy, Histone acetylation profiles of cells of SRT patients with CREBBP mutations
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University Hospital, Bordeaux
Osteoporosis, Postmenopausal, Statin Therapy
Therapeutic Prospects of HMG-CoA Reductase Inhibitors, Atorvastatin and Rosuvastatin, in Osteoporotic Patients
Osteoporosis is one of the most common chronic skeletal disorders, particularly among postmenopausal women, and is associated with an increased risk of fragility fractures, disability, and reduced quality of life.
- Trial name
- statins on BMD (NCT07717788)
- Testing
- Alendronate 70 mg tablets, Atorvastatin, Rosuvastatin
- Where
- Iraq
- Volunteers
- 65 people
- Sponsor
- Alkufa university\\collage of pharmacy
Osteoporosis
Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis
Denosumab is an antibody against receptor-activator of nuclear factor kappa-B ligand that prevents recruitment and differentiation of mature osteoclasts.
- Trial name
- ZOLARMAB (NCT03087851)
- Testing
- Zoledronic Acid
- Where
- Denmark
- Volunteers
- 61 people
- Sponsor
- Aarhus University Hospital
Multiple Myeloma, Breast Cancer
Comparison of Zometa Retention and Effect in Multiple Myeloma and Breast Cancer
The investigators major aim is to determine whether there is a difference in the retention of zoledronic acid in multiple myeloma patients, compared to patients with breast cancer metastasis to bone.
- Trial name
- NCT00760370
- Testing
- Zoledronic Acid
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Vejle Hospital
Bone Metastasis
Biomolecular Markers of Bone Metastasis
The goal of this clinical trial is to characterize the biomolecular profile of bone metastases to define the predisposing profiles of bone metastasis, in patients with breast or lung or renal carcinomas or of the gastroenteric or…
- Trial name
- NCT06806462
- Testing
- Biomolecular profile of bone metastases
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Osteoporosis
Effects of Clinical Pilates and Whole Body Vibration Exercises in Postmenopausal Osteoporotic Women
The aim is to compare the effects of clinical pilates and whole body vibration exercises in postmenopausal osteoporotic women on strength, flexibility, balance, bone turnover markers and quality of life.
- Trial name
- NCT04259697
- Testing
- Clinical pilates, Whole body vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Dokuz Eylul University
Osteoporosis
Efficacy and Safety of Brand Versus Generic Alendronate for Osteoporosis Treatment
Osteoporosis is a common disease defined as a decrease in bone mass and strength which increases risk of fragility fractures. This disorder may affecting health in many adults which causing disability, morbidity, and mortality.
- Trial name
- NCT02371252
- Testing
- Generic alendronate
- Where
- Thailand
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hematopoietic/Lymphoid Cancer
Stress Management Intervention for Caregivers of Patients Undergoing Bone Marrow Transplant (BMT)
RATIONALE: A stress management intervention may be more effective than usual care in improving quality of life in caregivers of patients undergoing bone marrow transplant.
- Trial name
- NCT00833898
- Testing
- Paced respiration as part of PEPRR, PEPRR
- Where
- 2 sites in United States
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Disorders of Calcium and Bone Metabolism
Markers of Metabolism and Vascular Access in ESRD
Aim of the study is to determine the association of markers of mineral metabolism with vascular access out come (maturation, patency of vascular access[AVF,AVG])To verify the relationship between vascular access complication…
- Trial name
- NCT05854576
- Testing
- vascular acess
- Volunteers
- 60 people
- Sponsor
- Soad Elsayed Abu douh
Type 2 Diabetes Mellitus, Bone Fractures
Microarchitecture, Bone Strength and Fracture Risk in Type 2 Diabetes
This multicenter, prospective, observational cohort study will assess bone differences in women and men with type 2 diabetes mellitus (T2DM) with and without fragility fractures.
- Trial name
- DiabOS (NCT02551315)
- Where
- 5 sites in Switzerland
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Osteopenia, Arterial Hypertension
Comparative Effects of Moxonidine on Bone Metabolism, Vascular and Cellular Aging in Hypertensive Postmenopausal Women
This study evaluates the effect of moxonidine versus bisoprolol on collagen type 1 C-telopeptide in postmenopausal female patients with arterial hypertension and osteopenia.
- Trial name
- COMPASS (NCT02355821)
- Testing
- Moxonidine, Bisoprolol
- Where
- Russia
- Volunteers
- 114 people
- Sponsor
- National Research Center for Preventive Medicine
Healthy
Evaluation of Consumption Safety and Effect of Mulberry Leaves and Vietnamese Coriander Based Instant Polyherbal Porridge on Working Memory and Bone Formation Markers
This study the investigators aimed to determine the effect of the herbal porridge containing the combined extract of mulberry and Vietnamese coriander (MP) on cognitive function and bone formation markers of menopausal women.
- Trial name
- NCT02562274
- Testing
- MP 50 mg/day, MP 1500 mg/day
- Where
- Thailand
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Premenstrual Syndrome
Altered Calcium and Vitamin D in PMDD or Severe PMS
Osteoporosis has become one of the most widely recognized disorders of our times affecting an estimated 25 million women in this country.
- Trial name
- NCT00005119
- Testing
- Measures of calcium and bone turnover
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Postmenopausal Osteoporosis
BEATRIS Study: A Study of Adherence to Bonviva (Ibandronate) Once Monthly in Women With Post-Menopausal Osteoporosis
This 2 arm study will assess the impact of Bone Marker Feedback (BMF), using blood sampling and communication of the results at 2 months, on adherence to monthly Bonviva (150mg po) in women with post-menopausal osteoporosis.
- Trial name
- NCT00545909
- Testing
- ibandronate [Bonviva/Boniva]
- Where
- 57 sites in Austria, Belgium and 3 more
- Volunteers
- 585 people
- Sponsor
- Hoffmann-La Roche
Osteoporosis
The Change of Bone Markers After Low Dose Alendronate in Postmenopausal Women With Bone Loss
High bone turnover with the bone resorption exceeding bone formation is a major mechanism of postmenopausal osteoporosis. Therefore, inhibition of bone resorption is a rational approach for the prevention.
- Trial name
- NCT00460057
- Testing
- Alendronate
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Eulji University Hospital
Abdominal Obesity, Metabolic Syndrome
The Effect of Whey Protein and Dietary Fibers on Risk Markers of the Metabolic Syndrome and Bone Health
The prevalence of overweight and lifestyle related diseases such as cardiovascular disease (CVD) and type 2 diabetes (T2D) is increasing world wide.
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- MERITS (NCT02931630)
- Testing
- Whey protein powder, Maltodextrin powder, High fiber bread
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital