Clinical trials: Bone Marrow Lesions
Oral Mucosal Ulceration, Oral Mucositis
Phototherapy for the Management of Oral Ulcers in Bone Marrow Recipients
Study hypothesis: light therapy may prevent oral ulcers in bone marrow recipients. Methods: patients will be treated with either active light-emitting device or inactive light-emitting device.
- Conditions
- Oral Mucosal Ulceration, Oral Mucositis, Oral Lesion
- Trial name
- NCT01307540
- Testing
- phototherapy
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome
Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy
This phase I trial studies the side effects and the best dose of sunitinib malate in treating human immunodeficiency virus (HIV)-positive patients with cancer receiving antiretroviral therapy.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
- Trial name
- NCT00890747
- Testing
- sunitinib malate, pharmacological study, laboratory biomarker analysis
- Where
- 11 sites in United States
- Volunteers
- 42 people
- Sponsor
- National Cancer Institute (NCI)
High Grade Myelodysplastic Syndrome Lesions
Idarubicin Combined to Azacitidine in Int-2 or High Risk Myelodysplastic Syndromes
Patients will receive escalating doses of ldarubicin combined to Azacitidine given at the FDA/EMEA approved Schedule and dosing.
- Trial name
- NCT01305135
- Testing
- azacitidine and idarubicin
- Where
- 32 sites in France, Tunisia
- Volunteers
- 41 people
- Sponsor
- Groupe Francophone des Myelodysplasies
Meniscus Lesion
Does Wrapping With Bone Marrow Injection Enhance Healing of Meniscal Sutures Into the Avascular Area
This study will compare meniscal healing of non-vascularised area augmented or not by bone marrow injected under a protective collagen membrane (meniscal wrapping)
- Trial name
- NCT03968029
- Testing
- suturing meniscal augmented, suturing meniscal
- Where
- 2 sites in Switzerland
- Volunteers
- 96 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Knee Bone Marrow Lesions
New Topographic Classification of Knee Bone Marrow Lesions
the investigator are studying a new topographic classification of bone marrow lesion in the knee and validating it.
- Trial name
- ncbe (NCT03976141)
- Testing
- mri
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Milan
Osteoarthritis, Knee
Efficacy Study of Neridronate to Treat Painful Osteoarthritis of the Knee With Bone Marrow Lesions.
The purpose of this study is to determine whether neridronate is effective in the treatment of pain related to bone marrow oedema in patients with osteoarthritis of the knee.
- Trial name
- NCT01803360
- Testing
- Neridronate
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- ASST Gaetano Pini-CTO
Meniscus Lesion
Augmentation of Meniscal Repair With Marrow Stimulation Techniques (Microfractures)
This study will compare meniscal healing augmented or without augmentation with bone marrow stimulation techniques The assessments will include validated, disease specific, patient oriented outcome measures, second look…
- Trial name
- men_micro (NCT02323490)
- Testing
- with microfractures, without microfractures
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Centre of Postgraduate Medical Education
Women (Between 18 to 50 Years Old), Sacro-iliac Joints
Incidence of MRI Sacro-Iliac Joint Anomalies in Young Women
Prospective multicenter study assessing the incidence of inflammatory and structural lesions seen on MRI of the SI joints in a consecutive population of women aged 18-50 years old.
- Conditions
- Women (Between 18 to 50 Years Old), Sacro-iliac Joints, Inflammatory Lesions, Structural Lesions
- Trial name
- MISIA (NCT02956824)
- Testing
- Standard care
- Where
- France
- Volunteers
- 512 people
- Sponsor
- University Hospital, Montpellier
Rotator Cuff Tear
Clinical Study on Mesenchymal Stem Cells Used in the Reconstruction Surgery of the Supraspinatus Muscle Lesions
The prospective randomized clinical study investigating the effect of mesenchymal stem cells on tendon healing. The objective of the study is to demonstrate the effect of concentrated bone marrow stem cells ( MSCs ) to the…
- Trial name
- NCT03068988
- Testing
- mesenchymal stem cells, without mesenchymal stem cells
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Hospital Znojmo
Bone Demineralization Lesions in the Injured Marrow
Bone Demineralization Lesions in the Injured Marrow: Efficacy and Tolerability of Administration Early and Repeated the Zoledronic Acid. Comparative Study, Prospective, Double-blind Controlled (DBMZol)
Subjects with lesion bone marrow are at risk of fracture by fragility bone. The median time to onset of fracture was 8.5 years. Fracture increases costs of care, dependency.
- Trial name
- DBMZol (NCT01802658)
- Testing
- Zoledronic acid, NA Cl
- Where
- 9 sites in France
- Volunteers
- 12 people
- Sponsor
- Nantes University Hospital
Osteochondral Lesion
Evaluation of the Osteointegrative and Regenerative Capacity of a Scaffold Enriched With Bone Marrow-Derived Cells at the Subchondral Level, Associated With Retrograde Drilling
Osteochondral lesions of the ankle (OsteoChondral Lesions - OCLs) are defects of the subchondral bone and the overlying articular cartilage that commonly affect young and active patients.
- Trial name
- NCT07555899
- Testing
- Osteochondral lesions treated with a scaffold enriched with bone marrow-derived cells at the subchondral level combined with retrograde drilling.
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteochondral Lesions of Talus
Bone Marrow Aspirate Concentrate (BMAC) Supplementation for Osteochondral Lesions
The purpose of this study is to determine the clinical efficacy of the application of bone marrow aspirate concentrate (BMAC) as a supplement to microfracture in the treatment of osteochondral lesions of the talus (OLTs).
- Trial name
- BMAC (NCT02011295)
- Testing
- ankle arthroscopy with debridement and microfracture of the OLT, Bone Marrow Aspirate injection
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Monoclonal Gammopathy of Undetermined Significance (MGUS), Myelodysplastic Syndromes
Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome
Blood cancers occur when the molecules that control normal cell growth are damaged. Many of these changes can be detected by directly examining parts of the cancer or cells in blood.
- Conditions
- Monoclonal Gammopathy of Undetermined Significance (MGUS), Myelodysplastic Syndromes, Hematological Malignancies, B-cell Malignancy, Low-grade
- Trial name
- NCT02269592
- Where
- 7 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Dana-Farber Cancer Institute
Myelodysplastic Syndrome With Low-grade Lesions, Iron Overload Due to Repeated Red Blood Cell Transfusions
Effect of Deferiprone on Oxidative-Stress and Iron-Overload in Low Risk Transfusion-Dependent MDS Patients
The effect oral iron chelator Deferiprone on the Oxidative stress and on Iron Overload status in transfusion dependent, iron-overloaded low risk MDS patients; Primary Objective: To evaluate the effect of Deferiprone on oxidative…
- Trial name
- NCT02477631
- Testing
- Deferiprone
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Sheba Medical Center
Knee Injuries
Trial Comparing BST-CarGel and Microfracture in Repair of Articular Cartilage Lesions in the Knee
This study will investigate whether the treatment of damaged cartilage in the knee with BST-CarGel will increase the amount and quality of cartilage repair tissue when compared with microfracture alone.
- Trial name
- NCT00314236
- Testing
- BST-CarGel with Microfracture, Microfracture without BST-CarGel
- Where
- 18 sites in Canada, South Korea and 1 more
- Volunteers
- 80 people
- Sponsor
- Piramal Healthcare Canada Ltd
Osteochondritis
"One-step" Bone Marrow Mononuclear Cell Transplantation in Talar Osteochondral Lesions
BACKGROUND Osteochondral lesions are defects of the cartilaginous surface and underlying subchondral bone of the talar dome. The use of concentrated bone marrow derived cells has been gaining successful results with arthroscopic…
- Trial name
- BMDC (NCT02005861)
- Testing
- bone marrow cells transplantation on collagen scaffold
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Istituto Ortopedico Rizzoli
Bone Diseases
Comparing Synthetic Bone Alone Versus Synthetic Bone With Bone Marrow in Bone Lesions
This is a prospective randomized study comparing Vitoss alone versus Vitoss with bone marrow aspirate in benign bone lesions.
- Trial name
- NCT00147823
- Testing
- Vitoss Alone, Vitoss with Bone Marrow Aspirate
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- State University of New York - Upstate Medical University
Vertebral Lesion
Vertebral Bone Marrow Lesions by DWI and ADC Values
The aim of the work is to assess the utility of apparent diffusion coefficient obtained in diffusion-weighted MR imaging for the differentiation between benign and malignant vertebral lesions.
- Trial name
- NCT04431739
- Testing
- MRI including conventional MRI, DWI with multiple ADC values
- Volunteers
- 50 people
- Sponsor
- Mohamed Ibrahim Abbas
Graft Versus Host Disease
Transdermal Patch to Monitor Inflammatory Biomarkers of GVHD
The aim of this study is to measure local inflammatory responses in patients undergoing an allogeneic stem cell transplant and attempt to define any set of biomarkers that are significantly altered in acute or chronic skin graft…
- Trial name
- NCT02511782
- Testing
- D-SQUAME Skin Sampling Discs
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Fanconi Anemia
MRI as Noninvasive Innovative Approach in Detection and Monitoring of Malignant Oral Lesions in Fanconi Anemia Patients
This study being done to learn more about the use of medical Magnetic Resonance Imaging (mMRI) and dedicated dental MRI (ddMRI) as a non-invasive diagnosing tool when evaluating potential oral cancerous and precancerous lesions…
- Trial name
- NCT07649031
- Testing
- MRIs
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Minnesota