Clinical trials: Bone Marrow Lesions, active
HIV, Kaposi's Sarcoma
Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer
BACKGROUND: A number of important scientific advances can be made through the study of blood, bone marrow, tumor, or other tissue samples from patients with HIV infection, infection with Kaposi s sarcoma associated herpesvirus…
- Conditions
- HIV, Kaposi's Sarcoma, Lymphomas, Multicentric Castleman's Disease
- Trial name
- NCT00006518
- Where
- United States
- Volunteers
- 1,029 people
- Sponsor
- National Cancer Institute (NCI)
Osteochondral Lesion
Evaluation of the Osteointegrative and Regenerative Capacity of a Scaffold Enriched With Bone Marrow-Derived Cells at the Subchondral Level, Associated With Retrograde Drilling
Osteochondral lesions of the ankle (OsteoChondral Lesions - OCLs) are defects of the subchondral bone and the overlying articular cartilage that commonly affect young and active patients.
- Trial name
- NCT07555899
- Testing
- Osteochondral lesions treated with a scaffold enriched with bone marrow-derived cells at the subchondral level combined with retrograde drilling.
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
Diffusion MRI, Bone Marrow Disease
Role of Diffusion MRI in Differentiation of Various Bone Marrow Lesions
Bone marrow lesions are common, and imaging findings are associated with various aetiologies, as compared to conventional radiography and computed tomography (CT), MRI is a better non-invasive imaging modality to evaluate…
- Trial name
- NCT06703138
- Volunteers
- 70 people
- Sponsor
- Assiut University
Erythroplakia, Fanconi Anemia
Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at Risk for Developing Oral Cancer
This clinical trial studies widefield fluorescence and reflectance imaging, fluorescence spectroscopy, and tissue samples in regularly examining (monitoring) participants at risk for developing oral cancer.
- Conditions
- Erythroplakia, Fanconi Anemia, Lichen Planus, Oral Cavity and Lip Precancerous Condition
- Trial name
- NCT00542373
- Testing
- Cytology Specimen Collection Procedure, Diagnostic Microscopy, Diagnostic Procedure
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- M.D. Anderson Cancer Center
Fanconi Anemia, Inherited Bone Marrow Failure Syndrome
Defining the Natural History of Squamous Cell Carcinoma in Fanconi Anemia
Background: Fanconi anemia (FA) is an inherited disorder. People with FA are more likely to get certain cancers, especially squamous cell carcinoma (SCC).
- Trial name
- NCT05687149
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Cancer Institute (NCI)
Bone Marrow Edema, Knee Osteoarthritis
Focused Extracorporeal Shockwave Therapy for Knee Arthritis
Subchondral bone marrow lesions (BMLs) in knee osteoarthritis (OA) are strongly associated with presence and severity of knee pain, structural deterioration, disease progression with an increased risk of total knee arthroplasty.
- Conditions
- Bone Marrow Edema, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NCT05596591
- Testing
- Focused extracorporeal shockwave therapy
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Kessler Foundation
FemoroAcetabular Impingement
Arthroscopic Treatment of Acetabular Labral Lesions: Intrarticular Injection of Bone Marrow vs Hip Arthroscopy Alone
The BoneMarrowHip study is a single-blind, randomized, single-center trial. Through this study, the clinical results of patients treated during hip arthroscopy surgery with autologous bone marrow infiltration taken from the…
- Trial name
- NCT07422662
- Testing
- Hip arthroscopy + BMAC injection, Hip arthroscopy
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituto Ortopedico Rizzoli
Fanconi Anemia
MRI as Noninvasive Innovative Approach in Detection and Monitoring of Malignant Oral Lesions in Fanconi Anemia Patients
This study being done to learn more about the use of medical Magnetic Resonance Imaging (mMRI) and dedicated dental MRI (ddMRI) as a non-invasive diagnosing tool when evaluating potential oral cancerous and precancerous lesions…
- Trial name
- NCT07649031
- Testing
- MRIs
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Minnesota
Knee Chondral Lesion
PRP vs AD-SVF in Addition to Marrow Stimulation for Knee Chondral Lesion
The goal of this clinical trial is to learn if PRP and adipose-derived stem cells (AD-SVF) enhance healing after knee microfracture for chondral lesions. It will also learn about the safety of the procedure.
- Trial name
- NCT07255547
- Testing
- Bone Marrow Stimulation, stromal vascular fraction (SVF), PRP injection
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Università degli Studi dell'Aquila
Chondral Lesion of the Knee, Meniscal Injuries
Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy
This study will examine whether using bone marrow aspirate (BMA) during knee arthroscopy surgery can improve patient outcomes. The investigators will enroll 50 patients who need knee arthroscopy surgery for meniscus injuries or…
- Conditions
- Chondral Lesion of the Knee, Meniscal Injuries, Cartilage Defects of the Knee, Osteoarthritis (OA) of the Knee
- Trial name
- BMA (NCT06893302)
- Testing
- Bone Marrow Aspirate (BMA), Arthroscopic Debridement Surgery, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Monoclonal Gammopathy of Undetermined Significance (MGUS), Myelodysplastic Syndromes
Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome
Blood cancers occur when the molecules that control normal cell growth are damaged. Many of these changes can be detected by directly examining parts of the cancer or cells in blood.
- Conditions
- Monoclonal Gammopathy of Undetermined Significance (MGUS), Myelodysplastic Syndromes, Hematological Malignancies, B-cell Malignancy, Low-grade
- Trial name
- NCT02269592
- Where
- 7 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Dana-Farber Cancer Institute