Clinical trials: Bone Marrow Transplant Complications
Sinusoidal Obstruction Syndrome, Veno-occlusive Disease
5-day Defibrotide Treatment for Hepatic SOS/VOD
Sinusoidal Obstruction Syndrome (SOS), also referred to as hepatic veno-occlusive disease (VOD), is rare but serious complication of allogeneic stem cell transplantation (allo-SCT).
- Conditions
- Sinusoidal Obstruction Syndrome, Veno-occlusive Disease, Bone Marrow Transplant Complications
- Trial name
- NCT04313036
- Testing
- Defibrotide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Loyola University
Bone Marrow Transplant Infection, Bone Marrow Transplant Complications
Feasibility and Efficacy of Modified Donor Lymphocytes Infusion (CD45RA Negative Selected) After Haploidentical Transplantation With Post-transplantation Cyclophosphamide in Patients With Hematological Malignancies (ONC-2016-002).
Interventional non-randomized trial. The duration of study will be 47 months. After haploidentical transplantation, patients without complications, mainly a GVHD ≥ grade 2, will receive mDLI.
- Conditions
- Bone Marrow Transplant Infection, Bone Marrow Transplant Complications, Graft Vs Host Disease, Infection
- Trial name
- NCT04687982
- Testing
- modified donor lymphocytes infusion (mDLI)
- Where
- Italy
- Volunteers
- 19 people
- Sponsor
- Istituto Clinico Humanitas
Sinusoidal Obstruction Syndrome, Veno Occlusive Disease, Hepatic
Validating Ultrasound Biomarkers for Hepatic Sinusoidal Obstruction Syndrome in Pediatric Hematopoietic Cell Transplant Patients
Hepatic veno-occlusive disease/sinusoidal obstructive syndrome (VOD/SOS) is a potentially fatal complication of hematopoietic cell transplant (HCT).
- Conditions
- Sinusoidal Obstruction Syndrome, Veno Occlusive Disease, Hepatic, Bone Marrow Transplant Complications, Stem Cell Transplant Complications
- Trial name
- NCT03963999
- Testing
- Ultrasound Elastography, Contrast Enhanced Ultrasound (CEUS)
- Where
- United States
- Sponsor
- Children's Mercy Hospital Kansas City
Cancer, Effects of Chemotherapy
Ovarian Tissue Cryopreservation in Females Undergoing Procedures That Will Potentially Lead To Loss of Ovarian Function
The purpose of this study is to retrieve and cryopreserve ovarian tissue from females undergoing a treatment that may lead to irreversible loss of ovarian function.
- Conditions
- Cancer, Effects of Chemotherapy, Unspecified Complication of Bone Marrow Transplant, Auto Immune Disease
- Trial name
- NCT01993732
- Testing
- Retrieval and Cryopreservation
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Medical College of Wisconsin
Bone Marrow Transplant Complications, Graft Versus Host Disease
Post Transplant Cyclophosphamide in Matched Unrelated Donor Stem Cell Transplantation for Hematological Malignancies
This study aims to evaluate the clinical efficacy of cyclophosphamide in patients receiving a bone marrow graft from a matched unrelated donor in overall survival, progression free survival and cumulative incidence of acute and…
- Conditions
- Bone Marrow Transplant Complications, Graft Versus Host Disease, Infection Viral, Engraft Failure
- Trial name
- NCT03818334
- Testing
- Cyclophosphamide, ATG
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital Israelita Albert Einstein
Complications of Bone Marrow Transplant, Hematologic Neoplasms
Study of FOND Versus FOND+O for the Prevention of CINV in Hematology Patients Receiving Highly Emetogenic Chemotherapy Regimens
The objective of this study is to compare the effectiveness of olanzapine added to standard triplet therapy (fosaprepitant, ondansetron, and dexamethasone) versus triplet therapy alone in preventing chemotherapy-induced nausea…
- Trial name
- FOND-O (NCT02635984)
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Augusta University
Unspecified Complication of Bone Marrow Transplant
School Reintegration After Pediatric Hematopoietic Stem Cell Transplant
This is a qualitative study that will explore the experiences of school reentry following Hematopoietic Stem Cell Transplant (HSCT) in children ages 10-16 years of age, their parents, teachers and primary PBMT(Pediatric Bone…
- Trial name
- NCT02052570
- Where
- United States
- Sponsor
- Duke University
Cognition Disorders, Fatigue
Phase II Early Behavioral Intervention in BMT w/ Sleep Disturbance-Assess QOL+Fatigue+Cognitive f(x)
This pilot clinical trial studies early brief behavioral intervention in treating sleep disturbance and improving quality of life in patients undergoing bone marrow transplant (BMT).
- Conditions
- Cognition Disorders, Fatigue, Sleep Disorders, Other Complications of Bone Marrow Transplant
- Trial name
- NCT01536977
- Testing
- quality-of-life assessment, questionnaire administration, management of therapy complications
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Stanford University