Clinical trials: Bone Mass
Uterine Fibroids, Endometriosis
A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet in Women With Uterine Fibroids or Endometriosis
The purpose of this clinical trial to characterize changes in bone mineral density during continuous treatment with relugolix combination tablet for up to 48 months (4 years) and 1 year of post-treatment follow-up in…
- Trial name
- NCT05862272
- Testing
- Relugolix Combination Tablet
- Where
- 120 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
Osteoporosis, Osteopenia
Study to Evaluate Effect of Intranasal Teriparatide on Serum P1NP, a Biomarker of Bone Formation, in Postmenopausal Women With Low Bone Mass
This study is being conducted to evaluate the effect treatment has on serum P1NP levels, a biomarker of bone formation in postmenopausal women with low bone mass.
- Trial name
- NCT01604057
- Testing
- ZT-034 Low Dose Nasal Spray, ZT-034 Mid Dose Nasal Spray, ZT-034 High Dose Nasal Spray
- Volunteers
- 130 people
- Sponsor
- Azelon Pharmaceuticals
Postmenopausal Osteoporosis, Hypovitaminosis D
Antiresorptive Effect of Treatment With Risedronate and Vitamin D in Postmenopausal Patients
Osteoporosis is defined as a systemic disease of bone mineralization, characterized by a decrease in bone mineral density that causes bone fragility and increases the risk of fractures during menopause.
- Conditions
- Postmenopausal Osteoporosis, Hypovitaminosis D, Hyperparathyroidism
- Trial name
- NCT05346419
- Testing
- Risedronate, Vitamin D
- Where
- Mexico
- Volunteers
- 33 people
- Sponsor
- Hospital Regional 1o de Octubre
Type 2 Diabetes Mellitus, Inflammation
Effects of Resveratrol on Inflammation in Type 2 Diabetic Patients
This research will investigate the effect of resveratrol on inflammatory mediators in type 2 diabetic patients in vivo. The investigators will also investigate the hypothesis that resveratrol has an antioxidant activity, improves…
- Conditions
- Type 2 Diabetes Mellitus, Inflammation, Insulin Resistance, Other Disorders of Bone Density and Structure
- Trial name
- NCT02244879
- Testing
- resveratrol
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- University of Turin, Italy
Aortopathies, Thoracic Aortic Aneurysm
Pathogenetic Basis of Aortopathy and Aortic Valve Disease
The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by…
- Conditions
- Aortopathies, Thoracic Aortic Aneurysm, Aortic Valve Disease, Thoracic Aortic Disease
- Trial name
- TAA (NCT03440697)
- Where
- 2 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Yale University
Osteoporosis
Acetaminophen or Fluvastatin Compared to Placebo on the Transient Post-Dose Symptoms (PDS) Following an Intravenous (i.v.) Infusion of a Single Dose of Zoledronic Acid 5mg, in Post-menopausal Women With Low Bone Mass
This study will evaluate the efficacy of acetaminophen or fluvastatin in reducing the rate of occurrence and the severity of post dose symptoms that may occur during the 3 day period following a zoledronic acid infusion in post…
- Trial name
- NCT00489424
- Testing
- Acetaminophen, Fluvastatin
- Where
- United States
- Volunteers
- 793 people
- Sponsor
- Novartis Pharmaceuticals
Low Bone Density
Comparing Between Osseodensification Burs Versus Osteotome in Low Bone Density Areas.
The objective of this study is to compare the primary stability of implant sites prepared using conventional drilling, osseodensification (Densah bur), and osteotome preparation techniques, and to evaluate the influence of these…
- Trial name
- NCT07378020
- Testing
- Conventional Osteotomy, Densah Bur drilling, osteotome bone condensation
- Where
- Egypt
- Volunteers
- 13 people
- Sponsor
- Future University in Egypt
Bone Mineral Density Quantitative Trait Locus 7
Antidepressants and Bone Mineral Density
The aim of this five arm randomized trial was thus to compare selective serotonin reuptake inhibitor (SSRI)sertraline and citalopram to a dual reuptake inhibitor venlafaxine, a nor-adrenaline reuptake inhibitor reboxetine and a…
- Trial name
- NCT02179268
- Testing
- sertraline, citalopram, venlafaxine
- Volunteers
- 203 people
- Sponsor
- Guiyang Medical University
Birth Weight, Vitamin D Deficiency
Effects of Vitamin D Supplement Before and During Pregnancy on Birth Weight
The purpose of this study is to determine whether a daily supplement of vitamin D, taking before and during pregnancy, effects child birth weight, pre- and postpartum complication and bone mineral density during lactation.
- Conditions
- Birth Weight, Vitamin D Deficiency, Pregnancy
- Trial name
- Gravita (NCT01038453)
- Testing
- Cholecalciferol 35 µg per day, Cholecalciferol (Vitamin D3) 70 µg
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Postmenopausal Osteoporosis
Zoledronic Acid to Maintain Bone Mass After Denosumab Discontinuation
In contrast with bisphosphonates,discontinuation of denosumab results in gradual loss of bone mineral density gains. The investigators aim to evaluate whether in patients treated with denosumab, a single zoledronic acid infusion…
- Trial name
- AfterDmab (NCT02499237)
- Testing
- Denosumab, Zoledronic acid
- Where
- 2 sites in Greece
- Volunteers
- 57 people
- Sponsor
- 424 General Military Hospital
Aortic Diseases, Aortic Dissection
Proximal Aortopathy in Scotland - Epidemiology and Surgical Outcomes
The aorta is the principal arterial vessel arising from the left heart that transfers blood to the body. Certain genetic and familial disease processes are known to weaken the aortic wall resulting in dilation and potential…
- Conditions
- Aortic Diseases, Aortic Dissection, Aortic Aneurysm, Thoracic, Aortic Ectasia
- Trial name
- NCT05389865
- Testing
- Surgery on the proximal aorta (aortic root +/- ascending aorta), Patients diagnosed with thoracic aortopathy but not operated upon
- Where
- United Kingdom
- Volunteers
- 1,662 people
- Sponsor
- Golden Jubilee National Hospital
Improving the Early Diagnosis of Osteoporosis in Adults and Children Living in the Abay Region of Kazakhstan
Identification and Assessment of Risk Factors for the Development of Osteoporosis in Adults and Children Living in the Abay Region of the Republic of Kazakhstan Using the Method of Dual-energy X-ray Absorptiometry and Clinical and Epidemiological Research
A survey of people to identify risk factors for osteoporosis, which include age, gender, lifestyle, diet, physical activity, the presence or absence of somatic pathology.
- Trial name
- NCT06344598
- Where
- Kazakhstan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Semey State Medical University
Bone Density
Occlusal Balance Effect on Mandibular Trabecular Bone by Using Fractal Analysis in Complete Denture Patients (Split-Mouth Study)
Although the number of individuals who are edentulous is declining, a sizable fraction still needs a complete denture for their oral rehabilitation.Tooth loss is an issue in public health that determines quality of life since it…
- Trial name
- NCT06320704
- Testing
- Prepolymerized milled PMMA with light-cured 3D-printed denture teeth.
- Where
- Egypt
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Badr University
Menopause Related Conditions, Sarcopenia
Effects of Time-restricted Eating and Exercise Training on Skeletal Muscle Mass Quantity, Quality and Function in Postmenopausal Women With Overweight and Obesity
The goal of this randomized controlled trial] is to investigate the effects of a 12-week time restricted eating (TRE) and exercise combined intervention, as compared to (i) TRE alone, and to (ii) Caloric Restriction (CR) plus the…
- Conditions
- Menopause Related Conditions, Sarcopenia, Osteoporosis Postmenopausal, Obesity
- Trial name
- NCT05912309
- Testing
- Time Restricted Eating (TRE), Exercise, Caloric Restriction
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Idoia Labayen
Spinal Muscular Atrophy Type 3
Whole Body Vibration Therapy in Children With Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) are one of the common physical disabilities in childhood. For SMA, progressive muscle weakness and early fatigue hamper the mobility of the sufferers.
- Trial name
- NCT03056144
- Testing
- whole body vibration therapy
- Where
- Hong Kong
- Volunteers
- 1 people
- Sponsor
- The Hong Kong Polytechnic University
Phenylketonuria
Nutritional and Neurotransmitter Changes in PKU Subjects on BH4
HYPOTHESIS: The investigators hypothesize that KuvanTM therapy could influence nutritional and body composition parameters and neurotransmitter concentrations in pediatric and adult PKU subjects.
- Trial name
- BH4&PKU (NCT00688844)
- Testing
- KuvanTM Therapy
- Where
- 2 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Emory University
Osteoporosis, Osteoarthritis
Resistance Exercise Training to Improve Bone and Articular Cartilage Health in Women
Osteoarthritis (degenerative joint disease) and osteoporosis (weak and fragile bones) are common conditions, particularly in women after menopause, and become even more common as we get older.
- Trial name
- REPROOF (NCT05889598)
- Testing
- Ballistic Resistance Lower Body Strength Training, Conventional Resistance Lower Body Strength Training
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Study on Mass Balance of [14C]HSK39297 in Healthy Chinese Adult Male Subjects
To evaluate the absorption, metabolism and excretion in healthy Chinese male subjects after a single oral dose of [14C]HSK39297
- Trial name
- NCT06852092
- Testing
- Carbon-14 labeled HSK39297
- Where
- China
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Hereditary Breast and Ovarian Cancer Syndrome, Osteoporosis
Zoledronate or Observation in Maintaining Bone Mineral Density in Patients Who Are Undergoing Surgery to Remove Both Ovaries
This randomized phase II trial is studying zoledronate to see how well it works compared to observation in maintaining bone mineral density in patients who are undergoing surgery to remove both ovaries.
- Conditions
- Hereditary Breast and Ovarian Cancer Syndrome, Osteoporosis, Ovarian Carcinoma
- Trial name
- NCT00305695
- Testing
- Laboratory Biomarker Analysis, Zoledronic Acid
- Where
- 95 sites in United States
- Volunteers
- 160 people
- Sponsor
- Gynecologic Oncology Group
Bone Mineral Density
The Role of Impact Activity in Peripubertal Bone Accrual
Osteoporosis has been established as a major public health problem, primarily effecting women. The attainment of maximal peak bone mass is crucial in the prevention of osteoporosis, yet little is known about the specifics of bone…
- Trial name
- NCT00619047
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
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