Clinical trials: Bone Mass
Osteoporosis
Denosumab Sequential Therapy
Denosumab is a potent anti-resorptive agent and is now widely used in the treatment of osteoporosis. Although denosumab has excellent effect to increase bone mass and prevent fracture in FREEDOM study with very low complications…
- Trial name
- DST (NCT03868033)
- Testing
- Zoledronic Acid, Denosumab
- Where
- Taiwan
- Volunteers
- 101 people
- Sponsor
- National Taiwan University Hospital
Rehabilitation, Physical Fitness
The Effect of Baduanjin on Physical Fitness and Bone Density in Maintenance Hemodialysis Patients
The aim of this study is to examine the effect of 18-month Baduanjin exercise on physical fitness and bone density in maintenance hemodialysis (MHD) patients.
- Conditions
- Rehabilitation, Physical Fitness, Bone Density, Hemodialysis Complication
- Trial name
- NCT06346379
- Testing
- Baduanjin exercise
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Affiliated Hospital of Nantong University
Osteoporosis, Postmenopausal, Statin Therapy
Therapeutic Prospects of HMG-CoA Reductase Inhibitors, Atorvastatin and Rosuvastatin, in Osteoporotic Patients
Osteoporosis is one of the most common chronic skeletal disorders, particularly among postmenopausal women, and is associated with an increased risk of fragility fractures, disability, and reduced quality of life.
- Trial name
- statins on BMD (NCT07717788)
- Testing
- Alendronate 70 mg tablets, Atorvastatin, Rosuvastatin
- Where
- Iraq
- Volunteers
- 65 people
- Sponsor
- Alkufa university\\collage of pharmacy
Bone Density, Bone Loss, Alveolar
Evaluation of Immediately Placed Dental Implants With Local Application of Injectable PRF in Periodontally Compromised Sites
The present study is a human, prospective, parallel, randomised controlled clinical trial conducted to explore the efficacy of injectable PRF around dental implants.
- Trial name
- PRF (NCT04029779)
- Testing
- I-PRF
- Where
- India
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Bone Density, Bone Loss
Effects of Denosumab on Bone Mineral Density in Women With Anorexia Nervosa: A Pilot Study
This protocol is a randomized, double-blind, placebo-controlled clinical trial which aims to investigate the effect of denosumab on BMD in women with anorexia nervosa.
- Conditions
- Bone Density, Bone Loss, Anorexia Nervosa, Eating Disorder
- Trial name
- NCT03292146
- Testing
- Denosumab 60 MG [Prolia], Alendronate 70Mg Tab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Osteoporosis
HIV UPBEAT: Understanding the Pathology of Bone Disease in HIV-infected Patients.
Despite the prevalence of osteopenia and osteoporosis in the HIV positive population, relatively little is known about the underlying pathology.
- Trial name
- UPBEAT (NCT01778361)
- Where
- Ireland
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Weight Loss
The Effect of Severe Weight Loss and Protein Intake on Bone
The purpose of this study is to learn whether the amount of dietary protein can influence bone health during the weight loss after weight loss surgery.
- Trial name
- NCT00472680
- Testing
- Caloric restriction, high protein, Caloric restriction; normal protein, Nutrition Education
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Rutgers University
Bone Demineralization
Alendronate for Prevention of AntiRetroviral Therapy-associated Bone Loss
Antiretroviral therapy (ART) initiation is associated with a significant loss of bone mineral density (BMD), characterised by increases in bone turnover, which is largely limited to the first 48 weeks of therapy.
- Trial name
- APART (NCT02322099)
- Testing
- Alendronate, calcium carbonate and colecalciferol, Tenofovir disoproxil
- Where
- 2 sites in Ireland
- Volunteers
- 53 people
- Sponsor
- University College Dublin
Fracture
Evaluation of Treatment of Fractures of the Humerus With a Plate.
The purpose of this study is to study with the use of clinical and radiological parameters the treatment of three-part and four-part fractures with the Winsta PH osteosynthesis device (Fischer Medical).
- Trial name
- NCT00408291
- Testing
- Winsta PH osteosynthesis device
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- University of Aarhus
Ankylosing Spondylitis, Osteoporosis
Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS)
This prospective study will assess the effects of treatment with alendronate in osteoporotic patients with ankylosing spondylitis.
- Trial name
- NCT01104987
- Testing
- alendronate
- Where
- Sweden
- Volunteers
- 16 people
- Sponsor
- Göteborg University
Osteoporosis
Frequency of Zoledronic Acid to Prevent Further Bone Loss in Osteoporotic Patients Requiring Androgen Deprivation Therapy for Prostate Cancer
The aim of this study is to determine if 3 monthly infusions of zoledronic acid, given over one year, improves the bone mineral density in osteoporotic patients undergoing androgen deprivation therapy for prostate cancer
- Trial name
- NCT00520052
- Testing
- zoledronic acid
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- Wirral University Teaching Hospital NHS Trust
Age-Related Osteoporosis
Genetic Regulators of Bone Health That Are Unique to Vertebral Bone
Osteoporosis is an age related disease in which a person's bone slowly becomes weaker with time. The bones may become so weak that they break easily such as a fall from standing height.
- Trial name
- NCT05946278
- Testing
- Sample collection for gene expression
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- University of Colorado, Denver
Osteoporosis
Examination How the Administration Period of Teriparatide Affects Bone Metabolism and Bone Mineral Density Prior to Denosumab Therapy
The aim of this study is to examine the efficacy and adverse events in the following 3 groups in osteoporosis patients: 1. The administration period of teriparatide is less than 6 months and thereafter, denosumab for 24 months.
- Trial name
- NCT03702140
- Testing
- "Teriparatide", "Forteo® or Teribon"
- Where
- Japan
- Volunteers
- 90 people
- Sponsor
- Shinshu University
Multiple Myeloma
Effect of Combination of Bortezomib/Dexamethasone/Zoledronic Acid on Bone Disease in Patients With Multiple Myeloma Relapsed After 1-3 Prior Lines of Therapy
The aim of this study is to evaluate the effect of bortezomib in combination with dexamethasone and zoledronic acid on bone mineral density (BMD) and skeletal related events (SREs) in Patients with Multiple Myeloma who Have…
- Trial name
- NCT00972959
- Testing
- Bortezomib, Zoledronic Acid, Dexamethasone
- Where
- 3 sites in Greece
- Volunteers
- 17 people
- Sponsor
- University of Athens
Prostate Cancer
Open-label Trial on the Effect of I.V. Zoledronic Acid 4 mg on Bone Density in Hormone Sensitive Prostate Cancer Patients With Bone Metastasis
The purpose of this trial with Zometa is to investigate the effect ZOMETA 4 mg (zoledronic acid for injection in 100mg solution ) has in preventing associated bone loss in prostate cancer patients with bone metastasis when…
- Trial name
- NCT00035997
- Testing
- Zometa
- Where
- 56 sites in United States
- Volunteers
- 261 people
- Sponsor
- Novartis Pharmaceuticals
Recurrent Spontaneous Abortion
Prospective Study of BMD and Ca-P Metabolism in RSA Patients: LMWH Use Versus Control
The goal of this prospective observational study is to learn about the effect of low molecular weight heparin (LMWH) application on bone mineral density (BMD) and on calcium-phosphorus metabolism in patients with recurrent…
- Trial name
- NCT05878574
- Testing
- Low molecular weight heparin
- Where
- China
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- Aimin Zhao
Osteoporosis
Osteoporosis Prevention in Preadolescent Girls
This study will test an osteoporosis prevention program aimed at preadolescent girls between the ages of 10 and 12 who have not yet started their menstrual periods.
- Trial name
- NCT00000413
- Testing
- Psychoeducational program
- Where
- United States
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Aging Well
Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly
Due to age-related effects, the bone and cardiovascular health are damaged. Physical exercise and in particular the strength training has been proposed as a fundamental tool to these pathologies, especially in the elderly.
- Trial name
- NCT04281264
- Testing
- Passive Hypoxia, Normoxia Circuit Training with Elastic Bands, Hypoxia Circuit Training with Elastic Bands
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
Rheumatoid Arthritis, Osteoporosis
Evaluation of the Role of Adalimumab on Extraarticular Manifestation - Bone Metabolism and Bone Mineral Density in Patients With Active Rheumatoid Arthritis
This post marketing observational study will be conducted in a prospective, single country, multicenter format to assess the prevention of generalized bone loss in patients with active rheumatoid arthritis (RA) treated with…
- Trial name
- NCT01078155
- Volunteers
- 131 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Healthy Volunteers
Effects of DHEA and Exercise in the Elderly
DHEA or dehydroepiandrosterone is a naturally occurring hormone secreted by tghe adrenal galnds. The secretion of HDEA declines with aging. DHEA is considered a food supplement and it is not regulated by the FDA.
- Trial name
- NCT00205686
- Testing
- DHEA, exercise
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
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