Clinical trials: Bone Mass
Low Bone Mineral Density
Determine the Efficacy, Safety and Tolerability of Denosumab (AMG 162) in the Treatment of Postmenopausal Women With Low Bone Mineral Density
To determine the effect of denosumab treatment compared with placebo over 12 months on bone mineral density (BMD) of the lumbar spine in postmenopausal women with low BMD.
- Trial name
- NCT00043186
- Testing
- Denosumab, Alendronate
- Volunteers
- 412 people
- Sponsor
- Amgen
Neurodevelopment Outcome, Linear Growth
Micronutrient Enhancement for Development and Health in Adolescents - The MEDHA Study
MEDHA is a randomized controlled trial among 10-18 year old girls to examine the use-case of the United Nations International Multiple Micronutrient Antenatal Preparation (UNIMMAP) multiple micronutrient supplement (MMS)…
- Conditions
- Neurodevelopment Outcome, Linear Growth, Micronutrient Status, Bone Mineral Density
- Trial name
- MEDHA (NCT07695883)
- Testing
- Iron (60 mg)- folic acid (400 ug) [IFA], Multiple micronutrient supplement [MMS], Multiple micronutrient supplement Plus [MMS+]
- Where
- Bangladesh
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Diabetes Mellitus, Type 2
Statin and Bone Health
This study aims to evaluate the impact of simvastatin on the bone density of postmenopausal women with type 2 diabetes over a duration of 18 months, using a randomized controlled trial design.
- Trial name
- NCT05613400
- Testing
- Simvastatin 10mg, Ezetimibe 10mg
- Where
- Hong Kong
- Volunteers
- 240 people
- Sponsor
- The University of Hong Kong
Osteoporosis
Radiological Biological Genetic and Micro-architectural Bone Determinants of Fractures in Men With Low Bone Mineral Density
Rational: Osteoporosis in men is responsible for one third of fragility fractures. However the definition and especially the determinants of fracture in humans are less well known than in women.
- Trial name
- OSTEHOM (NCT01250314)
- Testing
- Radiology, Biological, biochemical and genetic samples
- Where
- France
- Volunteers
- 79 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Burn, Growth
Bone Mineral Density, Body Composition and Growth Following Severe Burn Injury
The purpose of this study is two-fold. The first is to establish that bone mineral density is diminished among children admitted to this regional burn center as compared to healthy non-burned children.
- Conditions
- Burn, Growth, Malnutrition
- Trial name
- NCT00285090
- Testing
- Calcium, Vitamin D, Calcium,Vitamin D, Calcium, VitaminD
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kathy Prelack, PhD, RD
Kidney Transplant; Complications, Bone Loss
Bone Density and Vascular Calcifications Evolution After Renal Transplant
The investigators project is based on: Assessment of bone architecture by high resolution peripheral scanner (HRpQCT) and bone densitometry (DEXA); The non-invasive detection of vascular calcifications (by abdominal CT scanner)…
- Trial name
- NCT04713774
- Testing
- High-resolution peripheral quantitative CT scanner (HRpQCT)
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University of Liege
Primary Osteoporosis
Community Smart Aging Model - Resistance Training
This clinical trial aims to evaluate the effectiveness of a smart community-based resistance training program in older adults aged 60 and older with primary osteoporosis.
- Trial name
- NCT07506538
- Testing
- Smart Community-Based Resistance Training, Routine Health Education
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Lingshu Sun
Acute Lymphoblastic Leukemia
Pharmacokinetics of Dexamethasone in Childhood ALL and Reduction in Bone Mineral Density
The goal of this observational study is to learn about systemic and central nervous system (CNS) exposure to dexamethasone in childhood acute lymphoblastic leukaemia (ALL).
- Trial name
- NCT06367725
- Where
- 4 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Overweight, Glucose Metabolism Disorders
The Physical Activity and Nutrition in Children (PANIC) Study
The Physical Activity and Nutrition in Children (PANIC) Study is a single-centre controlled trial on the effects of a combined physical activity and dietary intervention on cardiometabolic risk factors and other health outcomes…
- Conditions
- Overweight, Glucose Metabolism Disorders, Lipid Metabolism Disorders, Blood Pressure
- Trial name
- PANIC (NCT01803776)
- Testing
- lifestyle counseling
- Where
- Finland
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Pulmonary Disease, Chronic Obstructive
Study Evaluating the Effect of Fluticasone Furoate/ Vilanterol (FF/VI) Inhalation Powder Compared With Vilanterol (VI) Inhalation Powder on Bone Mineral Density (BMD) in Subjects With Chronic Obstructive Pulmonary Disease (COPD).
This is a multi-center, randomized, double-blind, parallel-group study. The FF/VI inhalation powder once daily and VI inhalation powder once daily will be evaluated in subjects with COPD over 156 weeks.
- Trial name
- NCT01957150
- Testing
- Fluticasone Furoate/Vilanterol, Vilanterol
- Where
- 45 sites in United States, Canada and 3 more
- Volunteers
- 283 people
- Sponsor
- GlaxoSmithKline
Lymphoblastic Leukemia, Cancer Survivors
Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors
This will be a randomized, placebo-controlled trial with a 2x2 factorial design testing the effects of an NAD+ precursor (NR) and exercise on skeletal muscle quality and VO2max in AYA HCT survivors.
- Conditions
- Lymphoblastic Leukemia, Cancer Survivors, Aplastic Anemia, Myelodysplastic Syndromes
- Trial name
- IAMFIT (NCT05194397)
- Testing
- Nicotinamide Riboside, Exercise Intervention
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Children's Hospital of Philadelphia
Breast Cancer, Osteoporosis
Bone Density and Bone Loss in Postmenopausal Women With Breast Cancer Receiving Treatment in Clinical Trial IBCSG-1-98
RATIONALE: Diagnostic procedures, such as bone mineral density testing and x-ray, help measure bone loss in women receiving treatment for breast cancer. The test results may help doctors plan better treatment.
- Trial name
- NCT00369850
- Testing
- laboratory biomarker analysis, Dual energy X-ray absorptiometry (DEXA), Spine X-ray
- Where
- 16 sites in Australia, France and 6 more
- Volunteers
- 458 people
- Sponsor
- ETOP IBCSG Partners Foundation
Idiopathic Parkinson's Disease
Volumetric Bone Mineral Density and it's Relationship With Osteoporotic Fractures in Parkinson's Disease
Idiopathic Parkinson's disease (IPD) is the second most frequent neurodegenerative disease. Its association with osteroporosis and fragility fracture is now clearly demonstrated, but the determinants of this osteoporosis are yet…
- Trial name
- DOPPA (NCT03095690)
- Testing
- High resolution peripheral scanner (HRpQCT).
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Osteoporosis, Postmenopausal
Effects of Arzoxifene on Bone Fractures and Incidence of Breast Cancer
The purpose of this trial is to study: Effects of arzoxifene on bone fractures and bone mass. Effects of arzoxifene on getting breast cancer.
- Trial name
- NCT00088010
- Testing
- Arzoxifene
- Where
- United States
- Volunteers
- 9,369 people
- Sponsor
- Eli Lilly and Company
Graves' Disease
D-vitamin And Graves' Disease; Morbidity And Relapse Reduction
The purpose of this study is to investigate the effects of vitamin D supplementation on morbidity and risk of relapse in patients with Graves' disease.
- Trial name
- DAGMAR (NCT02384668)
- Testing
- Cholecalciferol
- Where
- 8 sites in Denmark
- Volunteers
- 278 people
- Sponsor
- University of Aarhus
Osteoporosis, Osteopenia
Effects of Hesperidin on Bone Mineral Density and Bone Metabolism of Postmenopausal Women
Fruits and vegetables are rich in a variety of flavonoids with antioxidant properties. These compounds may be partially responsible for some of the positive links found between fruits and vegetables intake and higher bone mineral…
- Trial name
- NCT00330096
- Testing
- Hesperidin
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Periodontitis
Impact of SRP on Bone Resorption and Systemic Inflammatory Markers in Postmenopausal Women With Periodontitis
This study is designed to determine the effect of treating postmenopausal women and using non-surgical techniques on biomarkers of systemic inflammation (IL-6 ) and systemic bone resorption (C-terminal collagen cross-links, CTX).
- Trial name
- NCT04261491
- Testing
- scaling and root planing
- Where
- 2 sites in India
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Cognitive Decline, Sleep
Fish Oil for Cognitive Function, Sleep Quality, and Bone Density
The Precision Nutritional Management for Diabetes trial (PNMD; NCT03708887) is a randomized clinical trial in 415 diabetic patients investigating whether taking daily dietary supplements of omega-3 fatty acids (1.5 or 3 grams)…
- Conditions
- Cognitive Decline, Sleep, Bone Mineral Density
- Trial name
- NCT06614374
- Testing
- Low-dose fish oil capsules, High-dose fish oil capsules, Refined olive oil
- Where
- China
- Volunteers
- 415 people
- Sponsor
- Jingjing Jiao
Type 1 Diabetes Mellitus
Type 1 Diabetes Mellitus Bone Mineral Density in Childhood and Adolescence
Type 1 Diabetes Mellitus is a disease that has an effect on bone mineral density. It is unclear how and when it effects the bone density.
- Trial name
- NCT01605149
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Creighton University
Hypocalcemia, Postoperative Parathormone
Early Prediction of Hypocalcemia After Thyroidectomy Using Postoperative Second Hour Parathormone
Hypocalcemia is the most frequent complication in thyroid surgeries. Diagnosing this complication earlier will reduce longer hospital stay and will lead to an earlier intervention.
- Trial name
- NCT03717116
- Testing
- parathormone level
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Istanbul University
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