Clinical trials: Bone Mass
Periprosthetic Osteolysis
Assessment of Periprosthetic Bone Mineral Density in Patients Undergoing Total Knee Prosthesis of Different Design
compare changes in BMD via DXA at the level of the femoral and tibial periprosthetic bone between two groups of patients undergoing cemented TKA of different design (posterior stabilization vs posterior cruciate preservation)…
- Trial name
- DXA-TKA (NCT06309433)
- Testing
- dual energy x-ray absorptiometry
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Ortopedico Rizzoli
Physical Activity, Nutrition
Physical Activity, Calcium, and Bone in Children
Doctors recommend that young children participate in daily physical activity to promote bone health. However, studies in adults show that physical activity and increased calcium intake cause noticeable benefits for bone health…
- Trial name
- NCT00000415
- Testing
- Physical activity, Calcium supplement
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Coronary Artery Bypass Graft, Chronic Kidney Disease
Evaluation of the Bone Mineral Density and Muscle Mass in Patients Post Coronary Artery Bypass Graft Surgery With Chronic Kidney Disease
The purposes of this study are: (1) to compare the body composition, physical activity, physical function, and quality of life between patients with and without CKD after CABG; and (2) to analyze the relationships among body…
- Trial name
- NCT01932008
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Breast Cancer
Effectiveness of Zoledronic Acid in the Prevention of Osteoporosis in Early Breast Cancer Patients Receiving Letrozole
The purpose of this study is to determine whether zoledronic acid given intravenously every 6 months can prevent reduction in bone mineral density in women with early stage breast cancer receiving adjuvant therapy with the…
- Trial name
- NCT00376740
- Testing
- zoledronic acid
- Where
- 2 sites in Israel
- Volunteers
- 90 people
- Sponsor
- Soroka University Medical Center
Renal Dialysis
Effect of Whole-body Vibration Training in Patients With Renal Dialysis
To show the effect of whole-body vibration in physical performance in patients with renal dialysis.
- Trial name
- NCT07049718
- Testing
- whole body vibration
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Osteoarthritis, Hip
Femoral Remodeling Following Total Hip Arthroplasty With OMNI Apex Modular™ and OMNI Apex ARC™ Stem Compared to Competitive Designs
This study compares the change in bone density which occurs after hip replacement with different femoral stem devices.
- Trial name
- NCT01359540
- Testing
- OMNI Apex Modular™ Hip Device, OMNI Apex ARC™ Hip Device
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Spokane Joint Replacement Center
Low Bone Density
Age Related Changes in Calciotropic Hormones and Their Impact on Male Osteoporosis
The purpose of this pilot study is to generate preliminary data regarding the skeletal effects of age-related changes in calcium and vitamin D metabolism in older men.
- Trial name
- NCT00588874
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yale University
Osteoporosis
PTH And Calcium Responses to Exercise (PACE) in Older Adults
Exercise that causes a decline in serum Calcium (Ca) as a result of dermal Ca loss stimulates bone resorption via an increase in Parathyroid Hormone (PTH).
- Trial name
- NCT02468817
- Testing
- Treadmill Exercise, Magnitude of Ca loss during Exercise at 26 degrees Celcius
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Vasomotor Symptoms (VMS)
Dose Escalation Study in Female Subjects With Breast Cancer Receiving Aromatase Inhibitor or Tamoxifen
Open-label, two dose study of Q-122, over a 4 week treatment period to explore the effects of Q-122 in a population of women with a history of breast cancer taking an aromatase inhibitor or tamoxifen.
- Trial name
- NCT04080297
- Testing
- oral capsule of Q-122
- Volunteers
- 21 people
- Sponsor
- Que Oncology
Osteoporosis, Renal Osteodystrophy
The Effects of 12-months of Denosumab on Bone Density in Prevalent Kidney Transplant Recipients
This is a Phase 2 Multi-Center Clinical Trial (safety and effectiveness trial) in 60 patients (40 denosumab; 20 placebo) who have had a kidney transplant for 12-months or longer with more than 30% of kidney function.
- Conditions
- Osteoporosis, Renal Osteodystrophy, Kidney Transplant; Complications
- Trial name
- ProliaKTx (NCT03960554)
- Testing
- Denosumab Inj 60 mg/ml
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- Thomas Nickolas, MD MS
Knee Osteoarthritis
Evaluation of Bone Mineral Density Changes Using Two Tibial Base Plate Designs in Primary Total Knee Arthroplasty in Young Patient
Arthritic disease in people less than 60 years old is increasingly common. Younger, active individuals often present now to orthopaedic surgeons requiring treatment of knee osteoarthritis.
- Trial name
- NCT03970460
- Testing
- Primary TKA with cemented modular metal-backed tibial implant, Primary TKA with uncemented trabecular metal
- Volunteers
- 88 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Bone Density, Low, Bone Mineral Density in Children With Graves' Disease
Bone Mineral Density in Children With Graves' Disease
to evaluate bone mineral density in children with graves' disease
- Trial name
- NCT06375096
- Testing
- evaluate bone mineral density
- Volunteers
- 100 people
- Sponsor
- Assiut University
Revision, Joint
Evaluation of the Trabecular Metal™ Revision Hip Cup Using Bone Mineral Density (DEXA)
In 1997, the FDA approved the use of Trabecular Metal™ (Zimmer, Trabecular Metal Technology, Inc., Parsippany, NJ) for acetabular cups, a porous tantalum structural biomaterial that was developed to address the limitations of…
- Trial name
- NCT01183260
- Testing
- Trabecular Metal Revision Cup, Trabecular Metal Modular Cup
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Chronic Kidney Diseases, Fracture
Denosumab Treatment in CKD Patients at High Risk of Fracture
Objective: To verify the efficacy and safety of denosumab in the prevention and treatment of CKD-MBD in CKD patients with high risk of fracture.
- Conditions
- Chronic Kidney Diseases, Fracture, Bone Density, Low, End Stage Renal Disease
- Trial name
- NCT05692297
- Testing
- Denosumab, Non-denosumab
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Capital Medical University
Osteopenia
Study to Evaluate the Safety and Efficacy of Seasonale for Treatment of Low Bone Mineral Density
This is a randomized, multicenter, placebo-controlled study to evaluate the effects of Seasonale, an extended-regimen oral contraceptive, on bone mineral density in adolescent females who have had their menstrual period but now…
- Trial name
- NCT00117260
- Testing
- Seasonale (levonorgestrel and ethinyl estradiol)
- Sponsor
- Duramed Research
Osteopenia, Bone Metabolism Disorders
Effects of Aerobic Versus Resistance Training on Bone Metabolism in Stage 3-4 Chronic Kidney Disease
This randomized controlled trial investigates the comparative effects of aerobic versus resistance training on bone mineral density (BMD) and bone metabolism markers in patients with stage 3 or 4 chronic kidney disease (CKD).
- Conditions
- Osteopenia, Bone Metabolism Disorders, Chronic Kidney Disease (Stage 3-4), Mineral and Bone Disorder (CKD-MBD)
- Trial name
- CKD-BONE-EX (NCT07133256)
- Testing
- Resistance Exercise, Aerobic Training
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sinai University
Postmenopausal
Safety, Pharmacokinetics, and Efficacy of 100, 150, and 200 mg Risedronate Administered to Women With Low BMD
A Multi-center, Active-controlled (5 mg daily risedronate), Double-blind, Randomized, Sequential Escalating Dose Study to Assess Safety, Pharmacokinetics and Efficacy of 100, 150, and 200 mg Oral Risedronate Administered Monthly…
- Trial name
- NCT00577837
- Testing
- risedronate, experimental
- Where
- 14 sites in United States, Canada and 3 more
- Volunteers
- 370 people
- Sponsor
- Warner Chilcott
Parathyroid Hormone, Tenofovir Disoproxil Fumarate
The Effects of Vitamin D and Calcium Supplementation to Parathyroid Hormone in CHB Patients Treated With TDF
Nucleot(s)ide is an antiviral drug that can reduce the number of viruses, reduce the risk of HCC, regress hepatic fibrosis and reduce death from Hepatitis B viral infection.
- Conditions
- Parathyroid Hormone, Tenofovir Disoproxil Fumarate, Chronic Hepatitis B Virus, Vitamin D
- Trial name
- TDF (NCT05313477)
- Testing
- Ergocalciferol Capsules, Calcium carbonate
- Where
- Thailand
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Marfan's Syndrome
Generation of Marfan Syndrome and Fontan Cardiovascular Models Using Patient-specific Induced Pluripotent Stem Cells
Medical researchers of National Heart Centre Singapore will carry out a state-of-the-art study that examines the possibility of changing patients' own cells into multi-functional and potent stem cells called iPS cells.
- Trial name
- NCT02815072
- Testing
- Skin biopsy
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- National Heart Centre Singapore
Primary Osteoarthritis, Cartilage Degeneration
DEXA Bone Density Analysis of the CoreHip® Prosthesis System
The goal of this interventional post-market follow-up study is to evaluate radiological changes in the diaphyseal bone density (Gruen Zones 3 and 4) within 24 months postoperative in patients treated with CoreHip® primary…
- Conditions
- Primary Osteoarthritis, Cartilage Degeneration, Osteoarthritis, Hip, Inflammatory Arthritis
- Trial name
- CODEX (NCT06632301)
- Testing
- Primary hip replacement with cementless stem
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Aesculap AG
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