Clinical trials: Bone Mass
Osteoporosis
Soy and Isoflavones Effect on Bone
The purpose of this study is to test the effect of 1 year of added dietary soy protein and/or soy isoflavones on bone mineral density in late postmenopausal women.
- Trial name
- NCT00668447
- Testing
- Soy Isolate, Control protein, Novasoy isoflavones
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- United States Department of Agriculture (USDA)
Marfan Syndrome
Comparison of Medical Therapies in Marfan Syndrome.
The investigators are looking at the different impacts of atenolol, verapamil and perindopril on large artery and lv function in marfan syndrome. It is a double-blind, randomised cross-over trial.
- Trial name
- NCT01295047
- Testing
- Atenolol, VERAPAMIL, Perindopril
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Cardiff University
Osteoporosis
Treatment of Calcium Deficiency in Young Women
This study looks at the effects of calcium supplementation on bone density in women in their third decade of life. We placed women aged 19-27 who take in low amounts of calcium in their diets in one of two groups.
- Trial name
- NCT00000426
- Testing
- Calcium supplement
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Creighton University
Hyperparathyroidism
The Effects of Alendronate After Cure of Primary Hyperparathyroidism
We are investigating whether, after surgical cure of primary hyperparathyroidism, alendronate provides even greater beneficial skeletal effects than parathyroidectomy alone.
- Trial name
- AlenPostPara (NCT00359385)
- Testing
- Alendronate 70mg weekly
- Where
- United States
- Sponsor
- Columbia University
Osteoporosis
Diagnostic Performances of Mandibular CBCT in Osteoporosis
In the last decade, there has been a shift towards Cone-Beam Computed Tomography (CBCT - regarding its low-dose radiation profile) in Dentistry/Implantology fields because it presents a more conclusive insight in the bone…
- Trial name
- TOMOSTEOp (NCT05721118)
- Testing
- CBCT and DXA exams performed in current practice in Nantes University Hospital
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Diabetes Mellitus Type 1
The Effect of Supplementation With Two Different Doses of Vitamin D on Bone Mineral Density, Vitamin D Levels and Hand Grip Strength in Children With Diabetes Mellitus Type 1
The aim of the study is to assess the effect of 12 month supplementation with two different doses of vitamin D ( 500 vs 1000) on bone mineral density, serum 25 hydroxyvitamin D levels and hand grip strength in preadolescents with…
- Trial name
- NCT01277913
- Testing
- Vitamin D3
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Warsaw
Bone Mineral Density, Grip Strength
Reference Curve on Bone Mineral Density in Men
In men, the hope of lower life, the absence of equivalent of menopause and the existence of a higher peak bone mass are the three factors that explain the lower incidence of osteoporosis in men.
- Conditions
- Bone Mineral Density, Grip Strength, Physical Performance
- Trial name
- COURDO2 (NCT03400982)
- Testing
- Bone densitometry measurement
- Where
- 3 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Werner Syndrome
Phase 2, Open-Label Study to Evaluate the Safety and Tolerability of Progerinin in Werner Syndrome
This is a Phase 2, open-label study to A Phase 2, Open-Label Study to Evaluate the Safety and Tolerability of Progerinin for the Treatment of Bone Mineral Density (BMD) Loss in Subjects with Typical Werner Syndrome.
- Trial name
- NCT05847179
- Testing
- Progerinin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- PRG Science & Technology Co., Ltd.
Osteoporosis, Liver Steatosis
China Action on Spine and Hip Status
1. To determine the prevalences of osteoporotic fracture in elderly Chinese population. 2. To determine the prevalences of osteoporosis in elderly Chinese population using QCT BMD measurement. 3.
- Conditions
- Osteoporosis, Liver Steatosis, Metabolic Syndrome, Obesity
- Trial name
- CASH (NCT01758770)
- Where
- China
- Volunteers
- 3,457 people, healthy volunteers welcome
- Sponsor
- Beijing Jishuitan Hospital
Multiple Sclerosis
Effects of a Weight Based Training Program on MS Patients
Low bone density is a health risk in older adults and especially people with multiple sclerosis (MS) due to steroid treatments and less mobility. Bone density is a measurement of how dense or strong bones are.
- Trial name
- NCT04002492
- Testing
- Bodyweight training
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Holy Name Medical Center, Inc.
Osteoarthritis
A Comparison of the Design of Tibia Stems in Cemented Total Knee Arthroplasty - Wedge Stem Versus I-beam Stem.
The purpose of this study is to compare the early migration and periprosthetic bone changes of two cemented total knee arthroplasties with different tibial stem design.
- Trial name
- NCT00175136
- Testing
- Maxim TKA
- Where
- Denmark
- Volunteers
- 54 people
- Sponsor
- University of Aarhus
Osteoporosis, Vascular Calcification
Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification
The purpose of this study is to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women above that achieved by supplementation.
- Conditions
- Osteoporosis, Vascular Calcification, Inflammation
- Trial name
- NCT00183001
- Testing
- Vitamin K
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Osteoporosis, Osteopenia, Renal Transplant Recipient
Alendronate Versus Denosumab in Kidney Transplant Patients
The management of bone disease has often been neglected post-transplantation, when the clinical focus is on allograft function and immunological sequelae.
- Trial name
- NCT04169698
- Testing
- Denosumab 60 mg/ml [Prolia], Alendronate 70Mg Tab
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Osteoporosis
Efficacy of Zoledronic Acid in Osteoporosis
There has been no comparative data between Zoledronic acid and Zoledronic acid combined with active vitamin D in primary and secondary osteoporosis.
- Trial name
- NCT03183557
- Testing
- "Zoledronic acid", "Reclast®", "Zoledronic acid", "Reclast®" and "active vitamin D", "alfacalcidol®"
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Shinshu University
HIV-associated Co-morbidities
Vitamin D Supplements for HIV-positive Patients on cART
The ability of vitamin D to modulate the immune system and strengthen bones may mitigate the adverse medication consequences of HIV/AIDS, but little is known about either the health benefits of vitamin D supplements, or about the…
- Trial name
- NCT01295034
- Testing
- conventional vitamin D treatment, tiered/titrated vitamin D dosing
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Andrea Branch
Leukemia, Lymphoblastic, Acute, Osteoporosis
A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors
Research studies have shown that children who are long-term survivors of childhood leukemia may be at greater risk for early bone loss called osteoporosis.
- Trial name
- NCT00186901
- Testing
- Calcium carbonate (Tums), vitamin D
- Where
- 3 sites in United States
- Volunteers
- 429 people
- Sponsor
- St. Jude Children's Research Hospital
Asthma, Bone Density, Low
CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids
The goal of this study is to assess the feasibility of emerging CT-based tools to measure changes in central and peripheral bone density, micro-structure, and marrow adipose tissue (MAT) among patients treated with oral steroids.
- Conditions
- Asthma, Bone Density, Low, Oral Steroid-Dependent Asthma (Disorder)
- Trial name
- NCT04518722
- Testing
- CT Scan, DXA Scan, Steroid Intake Questionnaire
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Iowa
Lactation Bone Loss, Infant Bone Growth
Effect of Calcium Plus Vitamin D Supplementation on Adolescent Mother and Infant Bone Health
Pregnancy and lactation are periods of high calcium requirement. Inadequate maternal calcium intake and vitamin D insufficiency may adversely affect fetal and neonatal growth and maternal bone mass particularly in adolescent…
- Trial name
- NCT01732328
- Testing
- Calcium plus vitamin D
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Bone Mineral Density, Bone Strength
Vibration Intervention For Bone Enhancement In Childhood Cancer Survivors
Treatment for childhood cancer interferes with normal bone maturation such that maximal peak bone mass may never be attained by some survivors of childhood cancer.
- Trial name
- NCT01010230
- Testing
- LMHF mechanical stimulation active device
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- St. Jude Children's Research Hospital
Bone Mineral Density, Strength
Exercise and Prevention of Hip Fractures
The significance of this population-based study is in producing new information for planning interventions and rehabilitation programs for the elderly, planning education of health care personnel and planning national health…
- Conditions
- Bone Mineral Density, Strength, Balance, Osteoporosis
- Trial name
- NCT00655577
- Testing
- Exercise
- Where
- Finland
- Volunteers
- 160 people
- Sponsor
- University of Oulu
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