Clinical trials: Bone Mass
Osteoporosis
A Study That Will Compare the Effect of Two Drugs on Participants With Low Bone Mass and a Recent Hip Fracture
This study will evaluate whether teriparatide is superior to the active comparator in the change from baseline of lumbar spine BMD (bone mineral density) in men and postmenopausal women with low bone mass and a recent…
- Trial name
- MOVE (NCT00887354)
- Testing
- Teriparatide, Risedronate, Calcium
- Where
- 28 sites in United States, Canada and 10 more
- Volunteers
- 224 people
- Sponsor
- Eli Lilly and Company
Ankylosing Spondylitis
Biomarkers Identification of Anti-tumor Necrosis Factor (TNF) α Agent's Efficacy in Ankylosing Spondylitis Patients
To identify new candidate genes and proteins that are differentially expressed in responders' vs non-responders to anti-TNF alpha therapy at the several time points the investigators will use the transcriptomic and proteomic…
- Trial name
- NCT02492217
- Testing
- Adalimumab
- Where
- Portugal
- Volunteers
- 69 people
- Sponsor
- Universidade Nova de Lisboa
Epilepsy
Bone Mineral Density in Pediatric Epilepsy
What are the effects of the currently used AEDs on bone mineralization in children and adolescents between the ages of 8 to 18? This is a pilot observational study using DEXA scans to measure bone mineral density in 100 patients…
- Trial name
- NCT00204815
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Wisconsin, Madison
Hypopituitarism, Hypogonadism
Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients
This study will determine the prevalence of endocrine-related side effects in children who have been treated for cancer and establish a database and registry organized according to cancer diagnosis, treatments and endocrine side…
- Conditions
- Hypopituitarism, Hypogonadism, Thyroid Dysfunction, Bone Diseases, Metabolic
- Trial name
- NCT00504218
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Low Bone Mineral Density, Postmenopausal Osteoporosis
Romosozumab (AMG 785) in Postmenopausal Women With Low Bone Mineral Density
The primary objective was to determine the effect of treatment with romosozumab versus placebo at month 12 on the percent change from baseline in bone mineral density (BMD) at the lumbar spine in postmenopausal women with low…
- Trial name
- NCT00896532
- Testing
- Alendronate, Teriparatide, Romosozumab
- Volunteers
- 419 people
- Sponsor
- Amgen
Endometriosis, Dysmenorrhea
Treatment of Endometriosis With Norethindrone Acetate ( NA) VS. Gonadotropin- Releasing Hormone (GnRH) Agonist (Lupron Depot 11.25 mg)
(A) Major 1) to compare the effectiveness of norethindrone acetate (NA) with GnRH agonist (Lupron-Depot-3) in relieving symptoms of endometriosis, 2) to compare bone density in the two treated groups in order to demonstrate that…
- Conditions
- Endometriosis, Dysmenorrhea, Dyspareunia
- Trial name
- NCT00458458
- Testing
- Norethindrone Acetate (NA), GnRH Agonist (Lupron Depot)
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Femoral Neck Fractures, Pertrochanteric Fracture
Bone Intake Proteins and Muscle Mass Deficiency in Proximal Femur Fractures
The aim of this clinical trial is to compare serum concentration of bone intake proteins [ sex hormone-binding globulin (SHBG), cross linked C-telopeptide of type I collagen (CTX-I)] and muscle atrophy marker [creatine kinase…
- Conditions
- Femoral Neck Fractures, Pertrochanteric Fracture, Bone Resorption, Bone Loss
- Trial name
- NCT05804604
- Testing
- Surgical treatment of proximal femur fracture and blood sample test, Blood sample test
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Breast Cancer
Effects of Zometa and Physical Activity on Bone Density in Women Receiving Chemotherapy for Breast Cancer
The purpose of this study is to evaluate the effect of zoledronic acid and physical activity on preventing bone loss in women aged 40 - 55 who are receiving chemotherapy for breast cancer.
- Trial name
- NCT00202059
- Testing
- Zoledronic acid, Physical activity intervention
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- HealthPartners Institute
Low Bone Density, Osteoporosis
Effects of DHEA and Exercise on Bone Marrow Fat in Postmenopausal Women
Bone strength -the main determinant of bone fracture- is a function not only of bone mineral density (BMD) and microstructure, but also of its microenvironment, including bone marrow fat (BMF).
- Trial name
- NCT05316272
- Testing
- Exercise, DHEA
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Colorado, Denver
Psoriasis
Analysis of Influence Factors on Osteopenia in Different Treatment of Psoriasis
This clinical study aims to evaluate and compare changes in bone mineral density (BMD) and bone metabolism markers in patients with moderate-to-severe psoriasis treated with either Secukinumab or Adalimumab.
- Trial name
- NCT07140666
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chongli Yu
Hypogonadism, Diabetes
Effects of Aromatase Inhibition Versus Testosterone in Older Men With Low Testosterone: Randomized-Controlled Trial.
Background: Men≥65 years often produce lower levels of testosterone, meaning there is less testosterone circulating to the tissues of the body.
- Conditions
- Hypogonadism, Diabetes, Sarcopenia, Osteoporosis
- Trial name
- NCT00104572
- Testing
- Androgel (Testosterone Gel), Anastrozole (Aromatase Inhibitor), Calcium Cardone 500mg with vitamin D 400 IU
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Osteoporosis
Phase 2 Safety and Efficacy Study of a Vitamin D Compound (DP001) in Postmenopausal Women With Low Bone Mineral Density
This study will evaluate the effect of a 1-year administration of the vitamin D analog 2-methylene-19-nor-(20S)-1alpha, 25-dihydroxyvitamin D3 (DP001) on bone mineral density (BMD), safety, and tolerability.
- Trial name
- 2MD-3H-2B (NCT00715676)
- Testing
- DP001
- Where
- 9 sites in United States
- Volunteers
- 157 people
- Sponsor
- Deltanoid Pharmaceuticals
Eosinophilic Esophagitis
Eosinophilic Esophagitis Steroid Safety Study
This observational study will follow pediatric patients with eosinophilic esophagitis who are scheduled to begin topical steroid treatment, from the initiation of treatment longitudinally to determine the safety profile of the…
- Trial name
- EESY (NCT04416217)
- Where
- 4 sites in Greece, Israel and 1 more
- Volunteers
- 55 people
- Sponsor
- Rabin Medical Center
Bone Densitometry
Performance of REMS Bone Densitometry in a British Population
Radiofrequency echographic multispectrometry (REMS) is a recently developed technology that uses ultrasound to assess bone density and bone quality.
- Trial name
- NCT06151353
- Testing
- REMS
- Where
- United Kingdom
- Volunteers
- 2,500 people
- Sponsor
- OsteoscanUK Ltd
Amputation of Lower Limb Below Knee, Amputation, Traumatic
REsistance and LOADing Exercise for Bone Health
Lower limb amputation, often resulting from military conflict and road traffic accidents, is associated with reduced hip bone mineral density (BMD) and increased risk of hip fractures.
- Conditions
- Amputation of Lower Limb Below Knee, Amputation, Traumatic, Amputation, Limb Loss
- Trial name
- RELOAD (NCT07817381)
- Testing
- Resistance and high-impact exercise training
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Defence Medical Rehabilitation Centre, UK
Breast Cancer
Study of Oral Bisphosphonate for Osteopenic Women Treated With Adjuvant Aromatase Inhibitors
A single--blind, randomized, placebo--controlled phase II study to evaluate the impact of oral bisphosphonate treatment on bone mineral density in osteopenic women receiving aromatase inhibitors as adjuvant treatment.
- Trial name
- BONADIUV (NCT02616744)
- Testing
- Ibandronic acid
- Where
- Italy
- Volunteers
- 171 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Osteoporosis, Bone Loss, Age Related
Osteoporosis Choice Decision Aid for Use of Bisphosphonates in Postmenopausal Women
To develop a decision aid to support the decision to use (or not use) bisphosphonates in postmenopausal women at risk for osteoporotic fractures, and to assess the impact of the decision aid on start and six month adherence to…
- Conditions
- Osteoporosis, Bone Loss, Age Related, Postmenopausal Bone Loss, Postmenopausal Osteoporosis
- Trial name
- NCT00578981
- Testing
- Osteoporosis Choice Decision Aid
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Osteoporosis, Chronic Kidney Disease
Denosumab for Prevention of Osteoporosis in Renal Transplant Recipients
The primary objective of the study is to examine the effect of denosumab on lumbar spine bone mineral density (BMD) after one year of treatment in newly transplanted renal allograft recipients.
- Trial name
- POSTOP (NCT01377467)
- Testing
- Denosumab (Prolia)
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- Rudolf Wuethrich
Bone Loss
BONE: STAR (Switching to TAF Based Anti-Retroviral Therapy) Study
The primarily objective of this study is to assess the effect of switching from Tenofovir Disoproxil Fumurate (TDF) to TAF based ART on bone mass and turnover among women on DMPA for contraception.
- Trial name
- BONE:STAR (NCT03916328)
- Testing
- B/F/TAF, TDF/3TC/EFV or DTG or NVP, DMPA
- Where
- Uganda
- Volunteers
- 330 people
- Sponsor
- MU-JHU CARE
Sedentary Lifestyle, Postmenopausal Women
Health Benefits of a 6-month Brisk Walking Program in Sedentary Postmenopausal Women
Community-dwelling women aged 55 or over are recruited at public meetings aimed at promoting physical activity in postmenopausal women.
- Trial name
- ACTIMARCH (NCT02094144)
- Testing
- Brisk walking program, physical activity habit
- Where
- France
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.