Clinical trials: Bone Microarchitecture
Osteoporosis
Bone Microarchitecture in Osteopenic Postmenopausal Women
The purpose of this trial is to compare the difference in bone microarchitecture of the distal radius at month 12 in postmenopausal osteopenic women treated with risedronate 150mg taken once a month compared to placebo.
- Trial name
- NCT00577395
- Testing
- risedronate
- Where
- 4 sites in United States, Argentina
- Volunteers
- 13 people
- Sponsor
- Warner Chilcott
Bone Demineralization, Hypoestrogenism
The Kampala Women's Bone Study
The primary objective of this study is to address critical safety questions with concurrent TDF-based PrEP and DMPA use. We hypothesize that young women using TDF-based PrEP and DMPA will have lower bone acquisition and altered…
- Conditions
- Bone Demineralization, Hypoestrogenism, Subclinical Kidney Injury, Bone Microarchitecture
- Trial name
- NCT03464266
- Testing
- FTC/TDF and DMPA, FTC/TDF, DMPA
- Where
- Uganda
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Washington
Anorexia Nervosa
Bone Microarchitecture Evaluation by HR-pQCT in Youngs Who Developed AN in Peri or Prepubertal Period.
The occurrence of anorexia nervosa (AN) during childhood or adolescence rapidly induces starvation, stop of growth and impaired mineralization of bone tissue together with an interruption of pubertal development.
- Trial name
- AMOS (NCT02526927)
- Testing
- HR-pQCT, DEXA, Blood samples
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Bone Density, Low, Bone Loss
Effects of Romosozumab on Bone Density in Women With Anorexia Nervosa
This protocol is a randomized, double-blind, placebo-controlled clinical trial which aims to investigate the effect of romosozumab on BMD in women with anorexia nervosa.
- Conditions
- Bone Density, Low, Bone Loss, Anorexia Nervosa, Eating Disorders
- Trial name
- NCT04779216
- Testing
- Romosozumab Prefilled Syringe, Zoledronic acid 5 mg
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Karen Klahr Miller, MD
Osteoporosis, Postmenopausal
A Study Using Imaging Technology to Measure Changes in Bone Structure After Treatment With Teriparatide
The purpose of this study is to use imaging technologies to demonstrate the effects of teriparatide on bone structure following 18 to 24 months of therapy in postmenopausal women with osteoporosis.
- Trial name
- NCT00557310
- Testing
- teriparatide
- Where
- 6 sites in United States, Canada
- Volunteers
- 35 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes
Type 2 Diabetes and Bone Microarchitecture
Type 2 diabetes is a major public health problem, associated with an increased risk of fractures. Diabetes even appears to be the most important predictor of low kinetic fractures in men and women, and the risk of hip fracture in…
- Trial name
- NCT04765631
- Testing
- Patients with Type 2 diabetes
- Where
- France
- Volunteers
- 582 people
- Sponsor
- Hospices Civils de Lyon
Primary Hyperparathyroidism, Bone Diseases, Metabolic
Radius Loading in Primary Hyperparathyroidism
The purpose of the study is to determine the effect of forearm exercise on forearm bone density in post-menopausal women with or without primary hyperparathyroidism.
- Conditions
- Primary Hyperparathyroidism, Bone Diseases, Metabolic, Osteoporosis, Postmenopausal, Bone Loss, Postmenopausal
- Trial name
- NCT01571843
- Testing
- Forearm exercise program, Walking program
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Columbia University
Osteoporosis
Teriparatide (PTH) and Bone Strength in Postmenopausal Women
This study will investigate the effects on bone quality of a medication (Teriparatide) used to treat people with severe osteoporosis.
- Trial name
- NCT01155245
- Testing
- Forteo
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Adult Onset Growth Hormone Deficiency
Bone Structure in Patients With Adult Onset Growth Hormone Deficiency Assessed Using High Resolution Peripheral Quantitative Computed Tomography
The aim of the study is to assess bone geometry, bone compartment specific volumetric densities and micro-architecture as well as to evaluate non-invasive estimates of bone strength in patients with adult onset growth hormone…
- Trial name
- NCT02218710
- Where
- 3 sites in Denmark
- Volunteers
- 45 people
- Sponsor
- Odense University Hospital
Postmenopause
Bone Microstructure in Nasal Salmon Calcitonin Treated Postmenopausal Women
Calcitonin has been used for many years for treating osteoporosis in postmenopausal women. Recent data from the 2 years placebo-controlled QUEST study have shown a preservation of microarchitecture as measured by high resolution…
- Trial name
- NCT00372099
- Testing
- Salmon calcitonin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rene Rizzoli
Osteoporosis
Analysis of Iliac Crest Biopsies From Patients Receiving Risedronate
This study analysed and reported on the study data from three similar, risedronate studies, 1996052, 2003073, and 2003096. The objective of the study was to determine the differences in the iliac crest bone histomorphometry and…
- Trial name
- NCT00837746
- Testing
- risedronate
- Where
- 8 sites in United States, Canada
- Volunteers
- 29 people
- Sponsor
- Warner Chilcott
Bone Alteration, Dietary Modification
Efficacy of a Once Daily Calcium and Vitamin D Fortified Food Product to Improve Bone Microarchitecture
The primary objective of this randomized, double-blind, placebo controlled trial is to determine the efficacy of a once per day calcium (1000mg) and vitamin D (1000IU) fortified food product on bone turnover markers, including…
- Trial name
- NCT02375503
- Testing
- Calcium/Vitamin D
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Osteoporosis
Risedronate in Osteopenic Postmenopausal Women
The primary objective of this study is to compare risedronate 35 mg and placebo with respect to the percent change at 12 months for distal radius trabecular bone volume (BV/TV) in osteopenic postmenopausal women, as measured by…
- Trial name
- OSMAUSE (NCT00345644)
- Testing
- risedronate
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Sanofi
Chronic Kidney Diseases, Hyperparathyroidism, Secondary
Analysis of Bone Microarchitecture With HR-pQCT of Patients With Chronic Kidney Disease (CKD) Candidates for Renal Transplantation
While the duration of renal transplant function has increased over the last decade kidney transplanted patients (KTP) still exhibit a fracture risk 4 times higher than in the general population.
- Trial name
- TRANSBONE (NCT02523209)
- Testing
- HR-pQCT, DEXA
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cystic Fibrosis
Bone Microarchitecture at the Radius: a Pilot Comparison Between Children With Cystic Fibrosis and Healthy Controls
Cystic fibrosis (CF) affects an estimated 30,000 people in the United States and is caused by a mutation in the gene encoding a protein called CF transmembrane regulator (CFTR).
- Trial name
- NCT01331980
- Testing
- Peripheral quantitative computed tomography (pQCT), Dual X-ray absorptiometry (DXA)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Rheumatoid Arthritis
Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease mediated by the production of several cytokines, which leads to the destruction of bone and cartilage tissue in multiple joints and to bone loss.
- Trial name
- REPAIR (NCT02765074)
- Testing
- subcutaneous tocilizumab
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Osteopenic Women
Bone Quality Lyon Orleans
QUALYOR is a prospective study on the predictive value for fragility fracture of various new techniques assessing bone quality, among postmenopausal women with low bone mass.
- Trial name
- QUALYOR (NCT01150032)
- Testing
- Bone quality complementary exams
- Where
- 2 sites in France
- Volunteers
- 1,605 people
- Sponsor
- Hospices Civils de Lyon
Dental Implant
Evaluation of Trabecular Microarchitecture of the Alveolar Bone by Micro-computed Tomography and of Osseointegration of Dental Implants by Resonance Frequency Analysis
Dental implants are a prosthetic rehabilitation device whose success depends of the bone morphology and quality, in more the surgical procedure.
- Trial name
- NCT03018457
- Testing
- ISQ
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Type 2 Diabetes Mellitus, Bone Fractures
Microarchitecture, Bone Strength and Fracture Risk in Type 2 Diabetes
This multicenter, prospective, observational cohort study will assess bone differences in women and men with type 2 diabetes mellitus (T2DM) with and without fragility fractures.
- Trial name
- DiabOS (NCT02551315)
- Where
- 5 sites in Switzerland
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Exercise, Healthy
Bone and Body Composition Adaptations to Physical Training
The goal of this clinical trial is to evaluate how different exercise programs alter bone density, structure, and strength in adults.
- Trial name
- BoBCAT (NCT06972862)
- Testing
- Osteogenic Index Optimized Exercise Training Program
- Where
- 2 sites in United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh