Clinical trials: Bone Pain
Shoulder Pain, Bone Mineral Density
BFR After Bicep Tenodesis
A randomized controlled pilot study evaluating the effect of occlusion training on bone density and function of the upper extremity following a biceps tenodesis.
- Conditions
- Shoulder Pain, Bone Mineral Density, Muscle Strength
- Trial name
- NCT03437239
- Testing
- Delfi PTS II Portable Tourniquet System
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Pain, Bone Metastasis
Optimization of Radiotherapy in Treatment of Painful Bone Metastasis
Bone metastasis is one of the most frequent end complications of the cancer. Radiation therapy is the mainstay of treatment in this disease.
- Trial name
- bone mets (NCT00610272)
- Testing
- Radiotherapy
- Where
- 12 sites in Algeria, Brazil and 9 more
- Volunteers
- 650 people
- Sponsor
- International Atomic Energy Agency
Uterine Fibroids, Endometriosis
A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet in Women With Uterine Fibroids or Endometriosis
The purpose of this clinical trial to characterize changes in bone mineral density during continuous treatment with relugolix combination tablet for up to 48 months (4 years) and 1 year of post-treatment follow-up in…
- Trial name
- NCT05862272
- Testing
- Relugolix Combination Tablet
- Where
- 120 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
Hip Fractures, Femoral Neck Fractures
How TENS Affects Pain, Medication Use, and Muscle Function in Older Adults With Hip Fractures
The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation (TENS) can reduce perioperative pain in older adults with hip fractures.
- Conditions
- Hip Fractures, Femoral Neck Fractures, Intertrochanteric Femur Fracture
- Trial name
- TENS-HIP (NCT07567339)
- Testing
- Active Transcutaneous Electrical Nerve Stimulation (TENS)
- Volunteers
- 32 people
- Sponsor
- University of the Sinos Valley
Musculoskeletal Pain, Osteoarthritis
Clinical Outcomes of Autologous Bone Marrow Aspirate Concentrate Injections for Musculoskeletal Conditions
The use of Bone Marrow Autologous Collection (BMAC) in musculoskeletal conditions including osteoarthritis and tendon injuries has been growing. Outcome evidence continues to be sparse.
- Conditions
- Musculoskeletal Pain, Osteoarthritis, Tendinopathy, Sprains Strain
- Trial name
- NCT02981394
- Testing
- Bone Marrow Aspirate Concentrate Injection
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Prostate Cancer
A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) in Hormone Resistant Prostate Cancer With Bone Metastases
Enthuse M1 is a large phase III clinical trial studying the safety and efficacy of ZD4054 (Zibotentan) in patients with hormone resistant prostate cancer and bone metastases.
- Trial name
- ENTHUSE M1 (NCT00554229)
- Testing
- ZD4054
- Where
- 197 sites in United States, Argentina and 29 more
- Volunteers
- 896 people
- Sponsor
- AstraZeneca
Pain
A Pilot Study of TRV130 for the Treatment of Fracture Pain
The primary objective is to evaluate the analgesic efficacy of TRV130 for moderate to severe acute pain in patients presenting to the emergency department (ED) with a suspected/known, unilateral, closed long bone fracture.
- Trial name
- NCT02520297
- Testing
- TRV130
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Trevena Inc.
Axial Spondyloarthritis, Ankylosing Spondylitis (AS)
Effects of Pulmonary Rehabilitation Exercises in Patients With Axial Spondyloarthritis
This prospective, randomized, single-blind controlled study evaluates the effects of pulmonary rehabilitation exercises in patients with axial spondyloarthritis. Participants were randomized into two groups.
- Trial name
- NCT07847879
- Testing
- Pulmonary Rehabilitation Program, Conventional Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Pelvic Bone Injury, Pelvis Injury
RELIEVED (REgionaL anesthesIa PElVic fracturEs stuDy) Study. Regional Anesthesia (RA) Techniques for Pain Management in Pelvic Fractures: A Prospective, Monocentric, Pilot Cohort Study.
The goal of this observational clinical trial is to assess the impact of Regional Anesthesia (RA) techniques with the strongest anatomical and scientific support in controlling acute post-operative pain in pelvic/acetabular…
- Conditions
- Pelvic Bone Injury, Pelvis Injury, Acetabular Fractures, Acetabular Surgery
- Trial name
- RELIEVED (NCT07072286)
- Testing
- Regional Anesthesia, Multimodal analgesia
- Where
- Italy
- Volunteers
- 177 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Lumbar Disc Herniation
Comparison of the Efficacy of Thoracolumbar Interfascial Plane Block and Erector Spina Plane Block in Lumbar Discectomy
Patients who will undergo herniated disc surgery have serious pain after surgery. In order to minimise this pain and to ensure that they recover more quickly and use less morphine-derived painkillers, we aim to apply two types of…
- Trial name
- NCT05999253
- Testing
- Modified thoracolumbar plane block (mTLIP), Erector spinae plane block (ESP)
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Scoliosis
The Effect of Schroth Method on Pain, Body Awareness and Quality of Life in Adolescent Individuals With Idiopathic Scoliosis
This study was aimed to compare the effect of Schroth therapy method, which is a 3-dimensional scoliosis exercise method, and traditional exercises on pain, body awareness and quality of life in young individuals with idiopathic…
- Trial name
- NCT04689295
- Testing
- exercise programme 1, exercise programme 2
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Hip Fractures (ICD-10 72.01-72.2)
Traumatologic Acute Pain Management With Fentanyl Transdermal Therapeutic System (TTS)
Aim of the study is an examination whether a modified perioperative pain management system, that integrates the 2017 European Society of Anaesthesiology (ESA) guidelines for treatment of postoperative Delirium, can improve…
- Trial name
- NCT04026022
- Testing
- Fentanyl Transdermal System
- Where
- Austria
- Volunteers
- 145 people
- Sponsor
- Medical University of Graz
Degenerative Spondylolisthesis or Retrolisthesis, Spinal Stenosis
A Clinical Study of the Dynesys(R) Spinal System
This non-inferiority study will compare the clinical outcomes of subjects implanted with the Dynesys Spinal System versus the clinical outcomes of subjects implanted with an instrumented posterior lateral spinal fusion.
- Conditions
- Degenerative Spondylolisthesis or Retrolisthesis, Spinal Stenosis, Stenosing Lesion.
- Trial name
- NCT00759057
- Testing
- Posterior Pedicle Screw System
- Where
- 26 sites in United States
- Volunteers
- 399 people
- Sponsor
- Zimmer Biomet
Neck Pain
Investigation of the Relationship Between Neck Pain and Spinal Curvatures
Although it is known that the cervical, thoracic and lumbar regions of the spine are related with each other biomechanically, there are no studies examining the relationship between cervical pain and other regions of the spine.
- Trial name
- neck pain (NCT06884137)
- Volunteers
- 81 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Rib Fractures, Acute Pain
Comparison of Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Erector Spinae Plane Block for Acute Pain Management in Patients With Traumatic Rib Fractures
Traumatic rib fractures cause severe chest wall pain that can impair normal breathing, coughing, and lung function. While systemic opioids are commonly used to treat traumatic pain, their side effects, such as sedation and…
- Conditions
- Rib Fractures, Acute Pain, Thoracic Trauma
- Trial name
- NCT07827157
- Testing
- Dexmedetomidine with Bupivacaine in ESPB, Dexamethasone with Bupivacaine in ESPB
- Volunteers
- 100 people
- Sponsor
- Assiut University
Degenerative Disc Disease, Low Back Pain
VIA Disc Nucleus Pulposus Older Patients Pilot
VIA Disc NP is a non-surgical intervention intended to supplement the nucleus pulposus tissue in degenerated intervertebral discs.
- Conditions
- Degenerative Disc Disease, Low Back Pain, Disc Degeneration
- Trial name
- NCT05412277
- Testing
- VIA Disc Nucleus Pulposus Allograft
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- VIVEX Biologics, Inc.
Refractory Angina
Intramyocardial Delivery of Autologous Bone Marrow
A randomized study to assess the safety, feasibility and effectiveness of direct intramyocardial percutaneous delivery of autologous bone marrow-derived total mononuclear cells or selected CD34+ cells in patients with refractory…
- Trial name
- NCT00820586
- Testing
- Mononuclear bone marrow derived cells
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- IRCCS San Raffaele
Osteoarthritis, Knee, Arthroscopy
Evaluating the Effectiveness of Subchondroplasty for Treating Bone Marrow Lesions of the Knee
The primary objective of this randomized pilot study is to evaluate whether subchondroplasty combined with knee arthroscopy is more effective at reducing knee pain and improving knee function compared to knee arthroscopy alone.
- Conditions
- Osteoarthritis, Knee, Arthroscopy, Musculoskeletal Disease, Bone Marrow Edema
- Trial name
- NCT03699046
- Testing
- Subchondroplasty and Knee Arthroscopy, Knee Arthroscopy Alone, Subchondroplasty
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Calgary
Lumbar Disc Herniation, Chronic Low Back Pain
PTED Versus Radiofrequency Ablation for Lumbar Disc Herniation
Lumbar disc herniation (LDH) is a common and frequently-occurring disease giving rise to low back pain and (or) leg pain. There are about 1.5 million people with LDH-related pain, accounting for 10% of outpatients each year in…
- Trial name
- PTED (NCT03634046)
- Testing
- Percutaneous transforaminal endoscopic discectomy, Radiofrequency ablation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Refractory Angina
Study Protocol of Intramyocardial Injection of Autologous Bone Marrow Stem Cells for Refractory Angina
Therapeutic neovascularization is an innovative strategy for cardiac tissue recovery due to chronic, intense ischemia. Thus stem cell therapy has become a promising procedure for the large number of patients with refractory…
- Trial name
- ReACT (NCT01966042)
- Testing
- Local sedation, Bone Marrow Aspiration, Minithoracotomy
- Where
- Brazil
- Volunteers
- 13 people
- Sponsor
- CellPraxis Bioengenharia Ltda.
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