Clinical trials: Bone Remodeling
Breast Cancer, Osteoporosis
Study of Bone Mineral Density in Women With Breast Cancer Treated With Triptorelin and Tamoxifen or Exemestane on Protocol IBCSG 25-02
RATIONALE: Gathering information over time from bone density and laboratory tests of women with breast cancer treated with triptorelin and tamoxifen or exemestane may help the study of breast cancer in the future.
- Trial name
- TEXT-Bone (NCT00963417)
- Testing
- laboratory biomarker analysis, dual x-ray absorptiometry
- Where
- 13 sites in Australia, Belgium and 1 more
- Volunteers
- 119 people
- Sponsor
- ETOP IBCSG Partners Foundation
Socket Preservation
The Local Effect of Vitamin K2 on Bone Remodeling in Socket Preservation
This study is a randomized controlled trial comparing the effects of socket grafting with crushed vitamin K2 (menaquinone)capsules versus no grafting on bone density and socket dimensions following tooth extraction.
- Trial name
- NCT06707909
- Testing
- Menaquinone
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Bone Remodeling, Vitamin D
Bone Turnover Markers and Vitamin D Survey Among Health Professionals in Taiwan
This study will provide the first national overview of BTM and vitamin D utilization among healthcare professionals in Taiwan. The findings are expected to inform educational strategies, optimize clinical implementation, and…
- Trial name
- NCT07387458
- Where
- Taiwan
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Metastatic Cancer, Prostate Cancer
Paricalcitol in Treating Patients With Advanced Prostate Cancer and Bone Metastases
RATIONALE: Paricalcitol may help prostate cancer cells become more like normal cells, and to grow and spread more slowly. It may also stop the growth of tumor cells in bone.
- Trial name
- NCT00634582
- Testing
- paricalcitol, immunoenzyme technique, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Wake Forest University Health Sciences
Osteoporosis, Frailty
Effects of DHEA/Exercise on Bone, Muscle and Balance
The purpose of this study is to examine whether muscle strength and balance will improve in women with frailty selected for dehydroepiandrosterone sulfate (DHEAS) levels below 550 ng/dl treated with DHEAS supplementation and…
- Trial name
- NCT00664053
- Testing
- DHEA, Yoga, Aerobics
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)
Bone, Growth
Zinc and Bone Turnover Study in Adolescent Females
The purpose of the study is to determine the effects of zinc supplementation on bone growth over four weeks. Participants will agree to attend two visits to our laboratory and at each will complete blood and urine samples…
- Conditions
- Bone, Growth, Osteoporosis
- Trial name
- NCT01892098
- Testing
- Zinc Sulfate
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Unspecified Disorder of Bone Density and Structure
Mg Induced Changes From Day 0 to Day 28 on Serum and Urine Bone Metabolic Parameters in 70 y Old Females (no 50).
Calcium and vitamin D substitution has for a long time been used to improve osteoporosis.The main storage place for magnesium is in the bone.
- Trial name
- parathormon (NCT02549521)
- Testing
- Oral magnesium substitution
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Marginal Bone Level Change
A Clinical Study on Implants With TiUltra Technology and Associated Prosthetic Components
This is a multicenter, prospective, non-interventional study in which a total of 1000 subjects in need of a single, multiple or full arch restoration in any region of the mouth (healed or extracted) will be treated in up to 30…
- Trial name
- NCT04737421
- Testing
- NobelActive TiUltra implant, NobelParallel CC TiUltra implants, NobelReplace CC TiUltra implants
- Where
- 32 sites in United States, Australia and 12 more
- Volunteers
- 1,000 people
- Sponsor
- Nobel Biocare
Bone Diseases, Osteomalacia
Study of the Diagnostic Value of Stable Calcium Isotope Profiling in Bone and Calcium Disorders
The purpose of this study is to determine whether mass spectrometry analysis of stable (non-radioactive) calcium isotopes in plasma or urine samples can help in the diagnosis of bone and calcium disorders.
- Conditions
- Bone Diseases, Osteomalacia, Osteoporosis
- Trial name
- eCaSIS (NCT02252679)
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Incretins, Osteoporosis
The Role of Incretins in Bone Remodeling in Humans
The role of incretins (GIP and GLP-1) on cells and bone tissue has been shown in cellular and animal studies. In humans, the role of these hormones is mainly studied in the pathophysiology of diabetes, their effect on bone is…
- Conditions
- Incretins, Osteoporosis, Bone Remodeling, Healthy
- Trial name
- INCREMOS (NCT03966261)
- Testing
- blood sample
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Dental Implants, Sinus Floor Augmentation
Osteotome Sinus Floor Elevation With or Without Grafting
The osteotome sinus floor elevation (OSFE) technique has been proved to be a predictable procedure for successful implant placement in posterior maxillae with limited bone height under sinus.
- Conditions
- Dental Implants, Sinus Floor Augmentation, Bone Remodeling
- Trial name
- NCT01619956
- Testing
- SLA dental implants, Osteotome sinus floor elevation, Bone grafting
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Osteoporosis
Teriparatide Treatment in Patients With Inherited Osteoporosis
The purpose of this study is to analyse efficacy of teriparatide treatment in patients with new forms of inherited low-turnover osteoporosis.
- Trial name
- NCT01360424
- Testing
- Teriparatide
- Where
- Finland
- Volunteers
- 6 people
- Sponsor
- Helsinki University Central Hospital
HIV Infections
Vitamin D Reabsorption in Adolescents and Young Adults With HIV Infection
The purpose of this study is to test the effects of Vitamin D on renal phosphate and bone loss, which are common in HIV infected adolescents and young adults being treated with tenofovir.
- Trial name
- NCT00490412
- Testing
- Vitamin D supplement
- Where
- 15 sites in United States, Puerto Rico
- Volunteers
- 207 people
- Sponsor
- University of North Carolina, Chapel Hill
Primary Hyperparathyroidism, Osteoporosis, Postmenopausal
Circulating miRNA in Primary Hyperparathyroidism
The goal of this study is to: 1. Analyze the expression levels of circulating (serum) miRNAs in primary hyperparathyroidism patients with and without osteoporosis, and patients with osteoporosis undergoing thyroidectomy, and to…
- Trial name
- NCT03931109
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Pennsylvania
Primary Aldosteronism
The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary Aldosteronism
Primary aldosteronism (PA) is a disorder of the adrenal gland causing an autonomous overproduction of mineralocorticoids, leading to arterial hypertension. Although rare, it is the most frequent cause of secondary hypertension.
- Trial name
- NCT02216721
- Where
- Malaysia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Malaysia Sarawak
Type 2 Diabetes
Bone Turnover in Type 2 Diabetes Patients
Background: Incretin hormones are hormones produced by the gut in response to food intake. These hormones help the body to control the metabolism of glucose (sugar).
- Trial name
- NCT00732121
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Vermont
Type 1 Diabetes Mellitus
Glucose-Dependent Insulinotropic Polypeptide - Effects on Markers of Bone Turnover in Patients With Type 1 Diabetes
Investigate GIP effects on biomarkers involved in bone homeostasis
- Trial name
- NCT03195257
- Testing
- GIP, GLP-1, Saline
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mikkel Christensen
Polyostotic Fibrous Dysplasia
Alendronate to Treat Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome
This study will evaluate the effectiveness of alendronate in treating the bone abnormality in polyostotic fibrous dysplasia and McCune-Albright syndrome.
- Trial name
- NCT00001728
- Testing
- Fosamax (Alendronate)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Osteoporosis, Duchenne Muscular Dystrophy
Effects of Low-level Mechanical Vibration on Bone Density in Ambulant Children Affected by Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (DMD) is a X-linked recessive disorder due to a mutation of the dystrophin gene (Xp21). Dystrophin is a sarcolemmal protein of skeletal and cardiac muscle, and its absence causes progressive muscle…
- Trial name
- NCT05281120
- Testing
- Low-level mechanical vibrations WITH vertical sinusoidal acceleration, Low-level mechanical vibrations WITHOUT vertical sinusoidal acceleration
- Volunteers
- 20 people
- Sponsor
- Istituto Auxologico Italiano
To Assess the Changes in Markers of Bone Turnover Over a Six Month Period After Epidural Steroid Inject, To Assess the Changes in Bone Mineral Density
Effect of Epidural Steroid Injection on Bone Mineral Density in Postmenopausal Women
To evaluate for the effect of corticosteroid epidural injections on bone mineral density in postmenopausal women. Candidates for the study: Post menopausal women between the ages of 55 and 80. No history of bone disease.
- Trial name
- NCT00941473
- Testing
- Triamcinilone (kenalog)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System