Clinical trials: Bone Substitute
Chronic Periodontitis
Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects
The present clinical trial included 20 patients (11 females and 9 males, aged 36 to 56 years) suffering from moderate or advanced chronic periodontitis.
- Trial name
- NCT04643288
- Testing
- open flap debridement, n-HA bone graft
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Weam Ahmed Elbattawy
Knee Deformity
Clinical Study to Evaluate Adaptos®Ortho Wedge Bone Graft Substitute in High Tibial Osteotomy
The aim of this study is to obtain performance and safety data of the new investigational device, dual-part Adaptos®Ortho Wedge, for its intended use in orthopaedic surgery.
- Trial name
- NCT05570760
- Testing
- Adaptos®Ortho Wedge (bone grafting surgery), OWHTO without bone grafting, chronOS® Wedge (bone grafting surgery)
- Where
- 6 sites in Finland, Hungary
- Volunteers
- 87 people
- Sponsor
- Biomendex Oy
Fractures, Bone
Prospective Registry to Evaluate Outcomes of NanoBone® Bone Graft in Acute Trauma
This multicenter prospective patient registry was developed with the aim of documenting how orthopedic surgeons are utilizing the NanoBone products in acute trauma cases along with relevant patient outcomes.
- Trial name
- ARTIST (NCT06256458)
- Testing
- NanoBone® Bone Graft
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Artoss Inc.
Tooth-loss
The Use of Platelet-rich Fibrin (PRF) Membranes in Lateral Alveolar Ridge Augmentation When Jaw Bone is Missing Before Dental Implant Installation. A Study Comparing an Autogenous Bone Block Graft Covered Either by a (PRF) Membrane (Test) or Bone Substitute and a Barrier Membrane (Control)
Tooth loss can in many cases be treated with an artificial titanium root (dental implant) and subsequent manufacture of a porcelain crown.
- Trial name
- NCT04350749
- Testing
- PRF is added in the test group.
- Where
- Denmark
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cancer of Bone, Trauma
Mg OSTEOCRETE Post-Treatment Outcomes
Mg OSTEOCRETE is a bone substitute used to fill a defect in bone caused by excision of a tumor, orthopaedic hardware that has become loosened, or a trauma-related condition.
- Conditions
- Cancer of Bone, Trauma, Aseptic Loosening of Orthopaedic Hardware
- Trial name
- NCT06720142
- Testing
- Mg OSTEOCRETE as a bone void filler
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Santiago Lozano-Calderon
Tooth Loss, Partial-edentulism
Retrospective Evaluation of a Novel Biomimetic Synthetic Bone Substitute (Creos® Syntogain)
Guided bone regeneration (GBR) is a commonly performed technique, using autogenous grafts, allografts, xenografts, or synthetic bone grafts (SBG).
- Conditions
- Tooth Loss, Partial-edentulism, Tooth Fracture, Edentulous Alveolar Ridge
- Trial name
- NCT06473545
- Where
- 2 sites in Spain
- Volunteers
- 173 people
- Sponsor
- International dentistry Research Group
Maxillary Sinus Floor Augmentation, Dental Implant
Evaluation of Sinus Augmentation Bone Healing Using Autograft and Xenograft Compared to Xenograft Alone
To evaluate bone healing at 4 months after lateral sinus augmentation with a 4:1 ratio of autologous bone and xenograft or xenograft alone. A radiographic volumetric, histomorphometric, and histologic analysis.
- Conditions
- Maxillary Sinus Floor Augmentation, Dental Implant, Bone Substitute, Autogenous Bone Graft
- Trial name
- NCT06247098
- Testing
- Sinus Lift augmentation, Cone-beam computed tomography systems (CBCT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tufts University
Flatfoot
Calcaneal Neck Lengthening Osteotomy With Artificial Bone Graft
In this foot deformity (plano valgus) surgery may be indicated. The deformity is corrected with an osteotomy at the heelbone. In most cases bone graft material has to be obtained from the iliac crest to support the osteotomy.
- Trial name
- NCT01645267
- Testing
- Hydroxyapatite
- Volunteers
- 10 people
- Sponsor
- Aarhus University Hospital
Bone Disease, Fracture Bone
Calcium Phosphate Cement Registry (CPC Registry)
CPC REGISTRY is a multi-center, international, prospective, open-label, observational study on the use of injectable calcium phosphate cements for the treatment of bone defects in adults.
- Conditions
- Bone Disease, Fracture Bone, Bone Cyst
- Trial name
- CPC (NCT02575352)
- Where
- 11 sites in France, Germany and 3 more
- Volunteers
- 500 people
- Sponsor
- Graftys SA
Osteoarthritis of the Knee
Autograft Versus Calcium Phosphate Macroporous Bioceramics as Bone Substitute for Tibial Valgus Osteotomy
The aim of the study is to compare radiological behavior of blocks of macroporous phosphocalcium as bone substitute in comparison with iliac crest autograft in tibial valgus osteotomy.
- Trial name
- NCT00200603
- Testing
- calcium phosphate macroporous bioceramics
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Nantes University Hospital
Platelet-rich Fibrin, Bone Substitutes
Horizontal Bone Augmentation of Alveolar Ridge
The objective of this randomized controlled clinical trial was to evaluate the effects of particulate xenogeneic bone grafts associated with autogenous bone graft or Leukocyte-and-Platelet-Rich Fibrin (L-PRF) for horizontal…
- Conditions
- Platelet-rich Fibrin, Bone Substitutes, Atrophic Maxilla, Cone-beam Computed Tomography
- Trial name
- NCT06420713
- Testing
- Horizontal Bone Augmentation of Alveolar Ridge, Groups, Dental Implants
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- University of Sao Paulo
Edentulous Jaw
Horizontal Augmentation With Deproteinized Bovine Bone Mineral Alone or in Combination With Particulate Autogenous Bone
Background: Placement of oral implants is frequently compromised due to atrophy of the alveolar process. Lateral ridge augmentation with an autogenous bone block is frequently necessary to increase the width of the alveolar…
- Trial name
- NCT04755166
- Testing
- Lateral ridge augmentation
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- NU-Hospital Organization, Sweden
Alveolar Bone Loss, Denture Complete Immediate
Interest of Bone Substitute Material in Immediate Complete Denture
More than 2 million French people suffer from the widespread disability of edentulism, with large consequences on function, nutrition, aesthetics and well-being. Complete denture is a common therapeutic strategy.
- Conditions
- Alveolar Bone Loss, Denture Complete Immediate, Bone Substitute, Replacement Material
- Trial name
- PANORAMIX (NCT02120053)
- Testing
- Conventional protocol, Bone substitute material group
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intrabony Defect
Effect of Autogenous Demineralized Dentin as a Bone Graft Substitute in Management of Periodontal Intrabony Defects
one of the ultimate goals in periodontology is to achieve periodontal regeneration and change the prognosis of questionable or hopeless teeth to maintainable.Bone substitutes have been actively used to reconstruct bony defects.
- Trial name
- NCT05445102
- Testing
- autogenous demineralized dentin graft as bone substitute in treatment of intrabony defect
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Furcation Defects, Periodontal Disease
Conventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matrix Derivative and Anorganic Bovine Bone - a Randomized Controlled Clinical Trial.
This clinical study compared a conventional surgical technique (CST) and a minimally invasive surgical technique (MIST) in the regenerative treatment of mandibular furcation defects.
- Trial name
- NCT02102360
- Testing
- Anorganic Bovine Bone, Enamel Matrix Derivative
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontitis, Furcation Defects
Use of a Bone Substitute Material in the Surgical Therapy of Furcation Defects
The aim of this randomized clinical trial is to evaluate the potential benefit of the use of a bone substitute material in the treatment of furcation degree II-involved molars.
- Trial name
- NCT06270303
- Testing
- Access flap & surgical debridement, Application of bone substitute material (BioOss Collagen)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Göteborg University
Platelet-Rich Fibrin, Dental Implantation
Influence of Human Platelet Derivatives on Dental Implant
The goal of this randomized controlled trial is to evaluate the benefit of PRF membrane on bone around dental implant in patients who need treatment with dental implant.
- Conditions
- Platelet-Rich Fibrin, Dental Implantation, Bone Substitute
- Trial name
- NCT06044246
- Testing
- PRF membrane
- Where
- Iraq
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Alveolar Ridge Augmentation
Allograft Ridge Augmentation: 3D Analysis of CAD/CAM Custom Milled and Prefabricated Conventional Allogeneic Bone Blocks and Dental Implant Follow-up
To rehabilitate patients after the loss of their own teeth, dental implants are nowadays the therapy of choice if the indication is suitable.
- Trial name
- NCT06027710
- Testing
- Extensive alveolar ridge augmentation with allogeneic bone blocks; dental implant insertion in allogeneic bone graft
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Wisdom Tooth, Socket Preservation
Soft and Hard Tissue Healing Following Alveolar Ridge Preservation of Mandibular Third Molar Extraction Socket Filled With Auto Tooth Bone Graft or Alloplastic Graft
This study compared two bone graft materials: 1. Auto Tooth Bone (ATB) (made from the patient's own extracted tooth) and 2. EthOss® a synthetic alternative.
- Trial name
- AutoToothGraft (NCT07723183)
- Testing
- auto tooth graft material
- Where
- Malaysia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Sinus Floor Elevation
Histomorphometric and Radiographic Evaluation of Bone Following Maxillary Sinus Augmentation
Two groups of patients with posterior vertical deficient maxillary alveolar ridge with pneumatized sinus and needing dental implant .
- Trial name
- NCT06700772
- Testing
- mixing bone marrow aspirate concentrate from maxillary tuberosity with bovine bone, mixing autogenous bone with bovine bone
- Where
- 2 sites in Egypt
- Volunteers
- 26 people
- Sponsor
- Cairo University