Clinical trials: Bone Turnover Markers
Bone Remodeling, Energy Metabolism
Retrospective Monocentric Evaluation of Biomarkers Associated With Bone, Muscle and Energy Metabolism
Bone is a metabolically active tissue undergoing continuous remodeling through the coordinated actions of osteoclasts (resorption), osteoblasts (formation), and osteocytes (regulation).
- Trial name
- OVAD (NCT07454252)
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Hyperparathyroidism; Secondary, Renal
Bone Markers and Bone Density Changes in Hyperperparathyroid Dialysis Patients Under Cinacalcet Treatment
Chronic kidney disease related mineral and bone disorders (CKD-MBDs) and secondary hyperparathyroidism (SHPT) are observed in most patients with chronic kidney disease on dialysis (CKD-5D).
- Trial name
- NCT04637360
- Testing
- Cinacalcet Tablets, calcitriol
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Min-Sheng General Hospital
Parkinson's Disease
Study of Factors Associated With the Volumetric and Areal Bone Mineral Density and Bone Strength in Parkinson's Disease
Studies show that patients with idiopathic Parkinson's disease (IPD) have an increased risk of fracture, particularly hip fracture whose complications and postoperative mortality appear to be higher than in the general…
- Trial name
- PAFOS (NCT02930512)
- Testing
- DXA scan, pQCT scan
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
Vitamin D Deficiency
The Effect of Vitamin D Supplements on Vitamin D Status, Cardiometabolic Health and Immune Defense in Danish Children
The main purpose of this study is to investigate whether and in which doses vitamin D intake is needed in order to maintain an adequate vitamin D status in 4-8 year-old Danish children during wintertime.
- Trial name
- ODIN Junior (NCT02145195)
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- Denmark
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Osteoporosis, Postmenopausal, Statin Therapy
Therapeutic Prospects of HMG-CoA Reductase Inhibitors, Atorvastatin and Rosuvastatin, in Osteoporotic Patients
Osteoporosis is one of the most common chronic skeletal disorders, particularly among postmenopausal women, and is associated with an increased risk of fragility fractures, disability, and reduced quality of life.
- Trial name
- statins on BMD (NCT07717788)
- Testing
- Alendronate 70 mg tablets, Atorvastatin, Rosuvastatin
- Where
- Iraq
- Volunteers
- 65 people
- Sponsor
- Alkufa university\\collage of pharmacy
Postmenopausal Osteopenia
The Effect of Aerobic Exercise on Bone Turnover Markers in Postmenopausal Patients
The aim of the study was to evaluate the effect of light-moderate aerobic exercise on BMD in postmenopausal osteopenic women using bone formation-resorption markers.
- Trial name
- NCT06866561
- Testing
- aerobic exercise, cholecalciferol, calcium carbonate
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Scoliosis, Vitamin D
6 Years Study on Changes in Bone Quality, Bone Turnover and Curve Severity in AIS With and Without Calcium and Vit-D Supplementation
The study aimed to: 1. To investigate and compare the changes in bone mineral density (BMD), trabecular bone micro-architecture, bone strength, and curve severity at a mean of 6 years longitudinal follow up in AIS girls with low…
- Conditions
- Scoliosis, Vitamin D, Bone
- Trial name
- NCT02904421
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Chinese University of Hong Kong
Osteoporosis
Effects of Clinical Pilates and Whole Body Vibration Exercises in Postmenopausal Osteoporotic Women
The aim is to compare the effects of clinical pilates and whole body vibration exercises in postmenopausal osteoporotic women on strength, flexibility, balance, bone turnover markers and quality of life.
- Trial name
- NCT04259697
- Testing
- Clinical pilates, Whole body vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Dokuz Eylul University
Postmenopausal Women
Creatine on Bone Mass in Postmenopausal Women
Animal, in vitro and small-scale studies have suggested that creatine supplementation may augment bone mass. This clinical trial aims to investigate the effects of a 2-year creatine supplementation protocol on bone mass in…
- Trial name
- NCT01472393
- Testing
- Creatine supplementation
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Class I Malocclusion, Other Periodontal Diseases
A Biotype Enhancing Strategy For The Patient Undergoing Accelerated Orthodontics
Numerous treatment protocols geared towards accelerating orthodontic treatment have emerged in the past few years as an appealing alternative for patients and practitioners.
- Conditions
- Class I Malocclusion, Other Periodontal Diseases, Thin Gingival Biotype
- Trial name
- NCT02866929
- Testing
- Decortication, Orthodontics, Mucograft
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CES University
Energy Supply; Deficiency, Carbohydrate Availability
Endocrinological and Physiological Responses to Short-term Reduced Carbohydrate Availability in Males
Using a randomised crossover design, nine weight-stable men, aged 18 - 40 years old, will be recruited via convenience sampling from the staff and student body of LJMU and local area.
- Trial name
- NCT05551455
- Testing
- Nutritional/dietary intake manipulation ('Normal'), Nutritional/dietary intake manipulation ('Low')
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Post Menopausal Osteoporosis
A Study of Bone Turnover Markers in Post-Menopausal Women With Osteoporosis Treated With Monthly Boniva (Ibandronate)
This study will determine the rapidity of suppression of the bone resorption marker sCTX in post-menopausal women with osteoporosis.Other bone turnover markers will also be evaluated.
- Trial name
- NCT00303485
- Testing
- Vitamin D and calcium supplementation, ibandronate [Bonviva/Boniva]
- Where
- 10 sites in United States, Puerto Rico
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Osteoporosis, Osteoporosis, Steroid Induced
Dynamics in Bone Turnover Markers During and After Short-term Glucocorticoid Treatment in Patients With an Inflammatory Joint Disease
Bone turnover markers (BTMs) are recommended as an important tool in follow-up of osteoporosis treatment. However, there is a lack of knowledge in the reliability of BTMs during and after glucocorticoid treatment.
- Conditions
- Osteoporosis, Osteoporosis, Steroid Induced, Inflammatory Rheumatism
- Trial name
- BOOGIE (NCT06395883)
- Testing
- Glucocorticoid Effect
- Where
- 2 sites in Norway
- Volunteers
- 160 people
- Sponsor
- Diakonhjemmet Hospital
Osteoporosis, Duchenne Muscular Dystrophy
Effects of Low-level Mechanical Vibration on Bone Density in Ambulant Children Affected by Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (DMD) is a X-linked recessive disorder due to a mutation of the dystrophin gene (Xp21). Dystrophin is a sarcolemmal protein of skeletal and cardiac muscle, and its absence causes progressive muscle…
- Trial name
- NCT05281120
- Testing
- Low-level mechanical vibrations WITH vertical sinusoidal acceleration, Low-level mechanical vibrations WITHOUT vertical sinusoidal acceleration
- Volunteers
- 20 people
- Sponsor
- Istituto Auxologico Italiano
Osteoporosis, Postmenopausal
Effect of Alendronate 70mg Formulation on Bone Turnover Markers and Patient Reported Outcomes
Compare the data obtained with two formulations of alendronate 70 mg (tablets vs effervescent tablet for buffered solution) on the change in bone turnover markers, on gastric tolerance and on treatment adherence (including…
- Trial name
- NCT03435094
- Testing
- Binosto 70Mg Effervescent Tablet, Fosamax 70Mg Tablet
- Where
- 2 sites in Switzerland
- Volunteers
- 80 people
- Sponsor
- Labatec Pharma SA
Type 1 Diabetes
Evaluation of Some Biochemical Markers of Bone Turnover in Childern and Adolescents With Type 1 Diabetes
Type 1 diabetes is associated with many longterm complications as retinopathy,neuropathy and nephropathy. Recently, several studies have linked type 1 diabetes to bone fragility.Studies conducted on patients with type 1 diabetes…
- Trial name
- NCT05892848
- Testing
- serum ostecalcin,serum sclerostin and parathroid profile
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Disorder of Bone Density and Structure, Unspecified
Effects of rhIGF-1 on Bone Metabolism in Adolescent Girls With Anorexia Nervosa
Adolescents and young adults with anorexia nervosa (AN) are at high risk for low bone mineral density at a time when healthy adolescents are rapidly accruing bone, with implications for peak bone mass and fracture risk in later…
- Trial name
- 814 (NCT00720122)
- Testing
- Recombinant human insulin like growth factor-1 (rhIGF-1)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Massachusetts General Hospital
Kaposi Sarcoma, KSHV Associated Multicentric Castleman Disease
Assessment of Bone Mineral Density in People Living With HIV and KSHV Associated Malignancies: A Retrospective Longitudinal Analysis
Background: Some people with human immunodeficiency virus (HIV) are on antiretroviral therapy (ART). Their cells have shown to age faster than expected.
- Conditions
- Kaposi Sarcoma, KSHV Associated Multicentric Castleman Disease, Primary Effusion Lymphoma, IL-6 Related KSHV Associated Cytokine Syndrome
- Trial name
- NCT04742387
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
Anastrozole and Letrozole
Aromatase Inhibitors (AI) are effective for secondary prevention of breast cancer and may soon replace tamoxifen as first-line therapy in the treatment of hormone-sensitive breast cancer.
- Trial name
- NCT00762294
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- UConn Health
Bone Disease, Metabolic, Physical Activity
Metabolic Profile of Bone in Professional Athletes
Physical activity is a key stimulus for bone metabolism through both direct mechanisms (e.g., as a result of the applied load and/or impact) and indirect mechanisms (e.g., the activation of several metabolic pathways and the…
- Trial name
- SportMarkers (NCT03386981)
- Testing
- blood and saliva tests
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio