Clinical trials: Bone Turnover Markers
Bone Health, Osteoporosis
Mediterranean Diet and Progressive Resistance Training Effects on BMD and Bone Turnover in the Elderly
This randomized controlled trial was designed to investigate the effects of progressive resistance training (PRT) combined with a Mediterranean diet on bone mineral density (BMD) and bone turnover markers (BTMs) in older adults.
- Trial name
- MED-RES-BONE (NCT07584785)
- Testing
- Mediterranean Diet combined with Resistance Training
- Where
- Italy
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Sfax
Osteopenic Women
Effects of Turkish Traditional Dances on Postmenopausal Osteopenic Women
The aim of this study is to evaluate the effects of regular Turkish regional dances, in addition to conventional exercises given with a home program, on the quality of life, balance, aerobic capacity, bone mineral density…
- Trial name
- NCT07068113
- Testing
- DANCE GROUP, EXERCISE GROUP
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Ankara Etlik City Hospital
Anorexia Nervosa, Osteoporosis
Bone Mass Changes in Anorexia Nervosa Patient Followed During 4 Years
The mechanism of bone loss in anorexia nervosa is complex. Marrow adipose tissue seems to play a role in the regulation of bone metabolism.
- Trial name
- AMOS (NCT02891356)
- Testing
- DEXA
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Lille
Obesity
Relationships Between GLP-2 and Markers of Bone Turnover Following Feeding
This study has been designed to study differences bone turnover in relation to glucagon-like peptide-2 (GLP-2) following feeding in lean and obese premenopausal women.
- Trial name
- GLP-2 (NCT01531907)
- Testing
- Study visit procedures
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Bone Diseases, Osteomalacia
Study of the Diagnostic Value of Stable Calcium Isotope Profiling in Bone and Calcium Disorders
The purpose of this study is to determine whether mass spectrometry analysis of stable (non-radioactive) calcium isotopes in plasma or urine samples can help in the diagnosis of bone and calcium disorders.
- Conditions
- Bone Diseases, Osteomalacia, Osteoporosis
- Trial name
- eCaSIS (NCT02252679)
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lactation
Bone Accrual and Hormones in Response to Lactation
This is a prospective observational trial of healthy postpartum women to investigate changes in bone density and markers of bone turnover during lactation.
- Trial name
- NCT01563094
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Intestinal Failure, Osteoporosis
Bone Markers in Pediatric IF
Poor bone health is a well-recognized but poorly understood complication in children with intestinal failure (IF) who are dependent on parenteral nutrition (PN).
- Conditions
- Intestinal Failure, Osteoporosis, Metabolic Bone Disease
- Trial name
- NCT05909228
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- The Hospital for Sick Children
Osteoporosis
Changes in Biochemical Markers of Bone Turnover (Serum CTX and PlNP) After Initiation of a "Drug Holiday" From Bisphosphonates
Bisphosphonates (BP) are widely used in the prevention and treatment of osteoporosis in postmenopausal women and older men. Recently, there has been concern about the risk of adverse events after several years of using these…
- Trial name
- NCT02575157
- Testing
- No intervention
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Bone Health Alliance
Breast Cancer
An Observational Study in Patients With Breast Cancer and Bone Metastases Receiving Ibandronate (Bondronat)
This open non-randomized, single-arm, multicenter, observational study is designed to evaluate the correlation between bone turnover markers and the response to treatment in patients with breast cancer and bone metastases.
- Trial name
- NCT02553850
- Where
- 19 sites in Hungary
- Volunteers
- 442 people
- Sponsor
- Hoffmann-La Roche
Patients With Anorexia Nervosa
Bone Loss in Patients With Anorexia Nervosa
Nutritional deprivation of adolescent girls with anorexia nervosa (AN) reduces the bone mass acquisition. A better understanding of this process would improve the medical treatment of bone alteration and its long-term…
- Trial name
- NCT01907464
- Testing
- clinical parameters description, para clinical parameters description, hormonal parameters dosing
- Where
- France
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Bone Turnover Rate Disorder
Bone Turnover and Parenteral Nutrition
Evaluation of changes in biochemical markers of bone metabolism. Fat profile. Evaluation of the overall body development. Assessment of parenteral nutrition protocols.
- Trial name
- NCT03618394
- Testing
- MCT/ω-3-PUFA, Soybean Based
- Where
- Greece
- Volunteers
- 66 people
- Sponsor
- Iaso Maternity Hospital, Athens, Greece
Bone Mineral Density Quantitative Trait Locus 7
Antidepressants and Bone Mineral Density
The aim of this five arm randomized trial was thus to compare selective serotonin reuptake inhibitor (SSRI)sertraline and citalopram to a dual reuptake inhibitor venlafaxine, a nor-adrenaline reuptake inhibitor reboxetine and a…
- Trial name
- NCT02179268
- Testing
- sertraline, citalopram, venlafaxine
- Volunteers
- 203 people
- Sponsor
- Guiyang Medical University
Type 2 Diabetes Mellitus, Bone Fractures
Microarchitecture, Bone Strength and Fracture Risk in Type 2 Diabetes
This multicenter, prospective, observational cohort study will assess bone differences in women and men with type 2 diabetes mellitus (T2DM) with and without fragility fractures.
- Trial name
- DiabOS (NCT02551315)
- Where
- 5 sites in Switzerland
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Breast Cancer, Osteoporosis
Study of Bone Mineral Density in Women With Breast Cancer Treated With Triptorelin and Tamoxifen or Exemestane on Protocol IBCSG 25-02
RATIONALE: Gathering information over time from bone density and laboratory tests of women with breast cancer treated with triptorelin and tamoxifen or exemestane may help the study of breast cancer in the future.
- Trial name
- TEXT-Bone (NCT00963417)
- Testing
- laboratory biomarker analysis, dual x-ray absorptiometry
- Where
- 13 sites in Australia, Belgium and 1 more
- Volunteers
- 119 people
- Sponsor
- ETOP IBCSG Partners Foundation
Bone Remodeling Disorder, Child Development
Clinical and Genetic Markers of Bone Metabolism in Children Under One Year
The study of children under one year of age for molecular genetic testing-VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759) with the study of the frequency distribution of alleles and genotypes by polymorphisms, analysis…
- Conditions
- Bone Remodeling Disorder, Child Development, Genetic Change
- Trial name
- NCT05375331
- Where
- Kazakhstan
- Volunteers
- 245 people
- Sponsor
- West Kazakhstan Medical University
Type 1 Diabetes Mellitus
Glucose-Dependent Insulinotropic Polypeptide - Effects on Markers of Bone Turnover in Patients With Type 1 Diabetes
Investigate GIP effects on biomarkers involved in bone homeostasis
- Trial name
- NCT03195257
- Testing
- GIP, GLP-1, Saline
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mikkel Christensen
Non-Alcoholic Fatty Liver Disease, Osteoporosis
Effect of Fatty Liver Disease on Bone Density
Non Alcohlic Fatty Liver (NAFLD) is a spectrum of diseases that ranges from accumulation of fat in the liver (Hepatosteatosis) that may be accompanied by inflammation (Steatohepatitis) to necrosis, fibrosis and even cirrhosis…
- Trial name
- NCT04850547
- Volunteers
- 80 people
- Sponsor
- Sohag University
Chronic Kidney Disease, Bee Venom
Effect of Bee Venom on Chronic Kidney Disease-Mineral Bone Disorders in Hemodialysis Patients: a Randomized Controlled Trial
This study aims to evaluate the effectiveness of bee venom injections as a treatment for chronic kidney disease (CKD)-mineral bone disorder (MBD) in patients undergoing hemodialysis.
- Conditions
- Chronic Kidney Disease, Bee Venom, Hemodialysis
- Trial name
- BeeVenom-CKD (NCT06901102)
- Testing
- Bee Venom Injection, Standard Care for CKD-MBD
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Osteoporosis
Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis
Denosumab is an antibody against receptor-activator of nuclear factor kappa-B ligand that prevents recruitment and differentiation of mature osteoclasts.
- Trial name
- ZOLARMAB (NCT03087851)
- Testing
- Zoledronic Acid
- Where
- Denmark
- Volunteers
- 61 people
- Sponsor
- Aarhus University Hospital
Multiple Myeloma
Study of 4 Bone Turnover Markers in Patients With Multiple Myeloma Treated With Intravenous Bisphosphonate in Routine Care
The aim of this study is looking at the Kinetics of bone turnover markers (C-terminal telopeptides of type I collagene (CTX), amino-terminal telopeptide of type 1 collagen (NTX), Dickkopf-1 (DKK-1) and Sclerostin (SOST)) in serum…
- Trial name
- AMBROBiMM (NCT04111809)
- Testing
- Blood and urine collection
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris