Clinical trials: Bone and Bones
Hepatitis B
Utilization and Efficacy of Tenofovir DF in Adolescents With Chronic Hepatitis B Virus Infection
The primary objective of this study is to characterize the long term (ie, 96 weeks of follow up) bone safety profile of open-label tenofovir disoproxil fumarate (tenofovir DF) treatment in CHB-infected adolescents.
- Trial name
- NCT02479880
- Testing
- Tenofovir DF, DEXA Scan
- Where
- 11 sites in Belgium, France and 5 more
- Volunteers
- 30 people
- Sponsor
- Gilead Sciences
Rheumatoid Arthritis
Comparing the Efficacy of Periarticular Bone Structure in Patients Treated With Either Tocilizumab or Tumor Necrosis Factor Blockers
Comparing the structural effects of TNFi and tocilizumab on the periarticular bone by performing a comprehensive analysis of the periarticular bone changes in RA patients treated with either TNFi or tocilizumab in a longitudinal…
- Trial name
- Re-Bone (NCT02778789)
- Testing
- Tocilizumab, TNF-alpha Inhibitor
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Osteoporosis, Postmenopausal, Bone Loss, Age-related
Effect of Blueberries on Bone Turnover
This study uses a bone labeling calcium tracer methodology to compare the dose-response effect of blueberry consumption on calcium retention and bone loss.
- Trial name
- NCT02630797
- Testing
- Blueberry Baseline, Blueberry Low, Blueberry Medium
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Purdue University
Acromegaly
Growth Hormone, IGF-1 and Medical Treatment in Acromegaly: Are There Effects on Gut Hormone Physiology and Postprandial Substrate Metabolism?
Acromegaly is a rare hormonal disorder leading to increased morbidity and mortality. In the vast majority of cases, a pituitary somatotroph cell adenoma causes excess growth hormone (GH) secretion, leading to hepatic…
- Trial name
- NCT02152124
- Where
- Belgium
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Flap Advancement, Primary Wound Closure
Flap Advancement Techniques in Ridge Augmentation
Different augmentation techniques has been proposed to resolve problem of hard and/or soft tissue ridge defects to enable dental implant placement.
- Trial name
- NCT03071523
- Testing
- coronally advanced lingual flap, periosteal releasing incision
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Cairo University
Bone Marrow Transplant, Sickle Cell Disease
Screening for Subjects to Participate in Studies of Blood Disorders
This study will determine eligibility for participation in research studies on blood disorders conducted by the National Heart, Lung and Blood Institute and the National Institute of Diabetes, Digestive, and Kidney Diseases.
- Conditions
- Bone Marrow Transplant, Sickle Cell Disease, G-CSF
- Trial name
- NCT00695123
- Where
- United States
- Volunteers
- 816 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Study of Haplo-HSCT + Rivogenlecleucel vs Haplo-HSCT + Post Transplant Cyclophosphamide in Patients With AML or MDS
This study compares the safety and effectiveness of giving rivogenlecleucel (BPX-501 T cells) to patients with AML or MDS post haploidentical hematopoietic stem cell transplant compared to post-transplant cyclophosphamide.
- Trial name
- THRIVE (NCT03699475)
- Testing
- rivogenlecleucel, rimiducid, Cyclophosphamide
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Bellicum Pharmaceuticals
Spinal Diseases, Other Biomechanical Lesions of Cervical Region
Cervical Spine Biomechanics During Endotracheal Intubation
Current methods for endotracheal intubation in the presence of cervical spine (c-spine) instability are not evidence-based. This is so because the relationships between the forces applied during intubation (by the laryngoscope)…
- Conditions
- Spinal Diseases, Other Biomechanical Lesions of Cervical Region, Tracheal Intubation Morbidity
- Trial name
- NCT01369381
- Testing
- Endotracheal intubation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Iowa
Plagiocephaly, Craniosynostosis
Hanger Helmet Study
The purpose of this study is to examine a group of patients requiring helmet therapy (either patients with plagiocephaly or post-surgical patients) to compare outcomes of infants treated with the Hanger helmet (Hanger, Inc.) to…
- Trial name
- NCT02561728
- Testing
- Hangar Helmet, P-Pod Helmet
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Degenerative Disc Disease
A Pilot Study of rhBMP-2/ACS/Allograft Bone Dowel for Anterior Lumbar Interbody Fusion in Patients With Symptomatic Degenerative Disc Disease
The purpose of this pilot clinical trial is to evaluate the device design as a method of facilitating spinal fusion.
- Trial name
- NCT01494428
- Testing
- rhBMP-2/ACS/allograft bone dowel, Autogenous bone/allograft bone dowel
- Volunteers
- 46 people
- Sponsor
- Medtronic Spinal and Biologics
Osteoarthritis Shoulder, Rotator Cuff Syndrome of Shoulder and Allied Disorders
FX Shoulder Prospective Clinical Study
Prospective Multi-Center Registry on study subjects with implanted devices marketed and legally commercialized in the USA by FX Shoulder Solutions.
- Conditions
- Osteoarthritis Shoulder, Rotator Cuff Syndrome of Shoulder and Allied Disorders, Fracture, Shoulder
- Trial name
- NCT06078865
- Testing
- FX Artificial Shoulder Prosthesis
- Where
- 4 sites in United States
- Volunteers
- 600 people
- Sponsor
- FX Shoulder Solutions
Distal Humerus Fracture
Elbow Hemiarthroplasty Versus Total Elbow Arthroplasty for Irreparable Distal Humeral Fractures
Distal humeral fractures can be difficult to treat, in particular when the joint surface is affected (intra-articular fractures).
- Trial name
- NCT03596736
- Testing
- Elbow Hemiarthroplasty, Total Elbow Arthroplasty
- Where
- 3 sites in Sweden
- Volunteers
- 42 people
- Sponsor
- Linkoeping University
Chronic Limb-threatening Ischemia, Diabetes Mellitus
Bone Marrow Mononuclear Cells vs Mesenchymal Stem Cells in Diabetic Patients With Chronic Limb Ischemia
Patients in the severe stages of Chronic limb-threatening ischemia (CLTI) are prone to amputation and death, leading to poor quality of life and a great socioeconomic burden.
- Trial name
- NCT05631444
- Testing
- Cell-based therapy
- Where
- Colombia
- Volunteers
- 24 people
- Sponsor
- Fundación Oftalmológica de Santander Clínica Carlos Ardila Lulle
Rib Fractures, Spirometry
Evaluation of Serratus Plane Block on the Respiratory Pattern in Patients With Multiple Rib Fractures
In patients admitted following a trauma, the incidence of multiple rib fractures is reported to be 9,7%, and this can be even higher in high energy trauma like motor vehicle accidents (1).
- Trial name
- NCT05105399
- Testing
- Serratus plane block (continuous or single-shot)
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Niguarda Hospital
Periodontitis, Bruxism
Trabecular Bone Changes After Periodontal Treatment in Patients With and Without Bruxism
This prospective observational cohort study evaluated changes in the trabecular bone structure around teeth after nonsurgical periodontal treatment in patients with periodontitis, with and without bruxism.
- Trial name
- NCT07904455
- Testing
- Bruxism Status
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Mustafa Kemal University
Chronic Myeloproliferative Disorders, Secondary Myelofibrosis
CC-4047 in Treating Patients With Myelofibrosis
RATIONALE: Biological therapies, such as CC-4047, may stimulate the immune system in different ways and stop cancer cells from growing. CC-4047 may also stop the growth of cancer cells by blocking blood flow to the cancer.
- Trial name
- NCT00669578
- Testing
- CC-4047
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Mayo Clinic
Primary Breast Cancer
Zoledronic Acid in the Treatment of Breast Cancer With Minimal Residual Disease in the Bone Marrow
Metastatic bone disease is an important prognostic factor for survival which will in median be close to two years after first diagnosis of osseous metastases.
- Trial name
- MRD-1 (NCT00172068)
- Testing
- Zoledronic acid + Calcium/Vitamin D
- Where
- 4 sites in Germany
- Volunteers
- 96 people
- Sponsor
- Novartis Pharmaceuticals
Arthritis, Psoriatic
Psoriatic Arthritis Dose Ranging Study for BMS-945429 in Subjects Who Are Not Responding to NSAIDs or Non-biologic Disease Modifying Anti-rheumatic Drugs (DMARDs) Therapy
The purpose of this study is to characterize the safety, efficacy and dose response of BMS-945429 in subjects with active Psoriatic Arthritis and an inadequate response to Nonsteroidal anti-inflammatory drugs (NSAIDs) and…
- Trial name
- NCT01490450
- Testing
- BMS-945429
- Where
- 49 sites in United States, Argentina and 11 more
- Volunteers
- 165 people
- Sponsor
- CSL Behring
Compressive Implants
Immediate Loading of Four Single Piece Compressive Implants for Bar Retained Mandibular Overdenture
this study was done to evaluate clinically and radiographically four single piece inter-foraminal compressive implant connected via digitally designed co-cr milled bar with distal cantilever supporting mandibular overdenture.
- Trial name
- NCT06514391
- Testing
- compressive single piece dental implant
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Kyphosis, Kyphosis Thoracic
Impact of Kinesio Taping on Kyphosis and Quality of Life in Adolescents
Kyphosis, a posture disorder, is excessive curvature of the thoracic area in the spine. In a healthy person, there is a normal kyphosis angulation in the thoracic and sacral areas in the sagittal plane.
- Conditions
- Kyphosis, Kyphosis Thoracic, Kyphosis Postural Thoracic
- Trial name
- kinesio (NCT06246474)
- Testing
- physical therapy program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.