Clinical trials: Bone and Bones
Osteoporosis Pseudoglioma Syndrome
Growth Hormone for Osteoporosis Pseudoglioma Syndrome
Osteoporosis pseudoglioma (OPPG) syndrome is a rare autosomal recessive condition of childhood osteoporosis and congenital blindness for which new treatments are needed.
- Trial name
- GHOPPG (NCT01614171)
- Testing
- Human recombinant growth hormone
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Leukemia, Myelodysplastic Syndromes
Genomically Profiling, Collecting, Archiving and Distributing Hematologic Malignancy Specimens
This research study is a genomic profiling and repository study for children and young adults who have leukemia, myelodysplastic syndrome (MDS) or myeloproliferative syndrome (MPS).
- Conditions
- Leukemia, Myelodysplastic Syndromes, Myeloproliferative Syndrome
- Trial name
- NCT04968834
- Testing
- Genomic profiling
- Where
- 8 sites in United States
- Volunteers
- 300 people
- Sponsor
- Dana-Farber Cancer Institute
Stress Response
Comparison of the Escape Room and Storytelling Methods in Learning the Stress Response
The goal of this randomised controlled study is to evaluate the effects of storytelling and escape room methods on the level of learning about stress response of nursing students and students' opinions about these methods.
- Trial name
- NCT05865509
- Testing
- Escape room, Storytelling
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Healing Wound, Alveolar; Wound
Ultrasound for Socket Healing Evaluation
The design is a single blinded, dual comparative study of ultrasound versus micro-CT/LASCA in one study group. Up to a total of 140 subjects registered will be recruited.
- Conditions
- Healing Wound, Alveolar; Wound, Alveolar Bone Loss, Image
- Trial name
- NCT06017193
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Chronic Kidney Disease Mineral and Bone Disorder
The Effect of REgulation of PArathyroId hoRmone in Patients With Chronic Kidney Disease to Investigate the Change in Bone Mineral Density
The prevalence of chronic kidney disease (CKD) in the adult population is estimated to 10%. CKD increases risk of bone fractures, cardiovascular disease and death.
- Trial name
- REPAIR-CKD (NCT07171216)
- Testing
- Treat to target
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Herlev Hospital
Spinal Stenosis, Low Back Pain
Effects of Maitland and Mulligan Spinal Mobilizations Along With Canal Enlargement Exercises in Lumbar Spinal Stenosis
This randomised controlled trial will evaluate the comparative effects of Maitland versus Mulligan spinal mobilization techniques, when combined with canal enlargement exercises, in patients with lumbar spinal stenosis (LSS).
- Trial name
- NCT07080073
- Testing
- Maitland Mobilization Group, Mulligan Mobilization Group
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Hip Fracture, Femoral Neck Fracture
The Hip Fracture Surgical Approach Trial
The HIFSAT study will compare the standard direct lateral approach to hemiarthroplasty to a new muscle sparing approach (SPAIRE) in femoral neck fracture patients.
- Trial name
- HIFSAT (NCT06146205)
- Testing
- Direct lateral approach, SPAIRE
- Where
- Norway
- Volunteers
- 476 people
- Sponsor
- Diakonhjemmet Hospital
Knee Osteoarthritis
Post Market Clinical Follow-Up Study- EVOLUTION® Revision CCK
Sponsor is conducting this post market clinical follow-up (PMCF) study to evaluate the safety and efficacy of its EVOLUTION® Revision CCK Tibia and EVOLUTION® Revision CCK Femur with EVOLUTION® CCK Tibial inserts.
- Trial name
- NCT04145401
- Testing
- Revision Knee implants
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- MicroPort Orthopedics Inc.
Low Back Pain
A Prospective Study of the InterFuse T(tm),
The purpose of this post-approval study is to demonstrate that the InterFuse T modular lumbar interbody device is at least equal in safety and efficacy to other (standard of care) TLIF devices.
- Trial name
- NCT02678130
- Testing
- InterFuse T, Standard of Care TLIF (Stryker AVS Unilif)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vertebral Technologies, Inc.
Femoral Fracture
A Post-Market Clinical Evaluation of the Treatment of Femur Fractures With the Femoral Nail GT
This investigation is a prospective, multi-center clinical investigation. It is anticipated that a total of 50 subjects will be enrolled.
- Trial name
- NCT04015128
- Testing
- Femoral Nail GT of the T2 Alpha Femur Antegrade GT/PF Nailing System
- Where
- 6 sites in United States
- Volunteers
- 66 people
- Sponsor
- Stryker Trauma and Extremities
Bone Healing, Sinus Membrane Osteoginicity
Osteogenic Potential of Schneiderian Membrane
Maxillary sinus augmentation is commonly performed by creating a space below the Schneiderian membrane which is further filled using autografts, bone graft substitutes, or a combination of both to allow for new bone formation.
- Trial name
- NCT06766292
- Testing
- primary intervention, open sinus lifting with xenograft only
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- rehab soliman
Ewing Sarcomas, Chondrosarcomas
A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas
INDICATION: Metastatic bone sarcomas: conventional high grade osteosarcoma, Ewing sarcoma of bone, intermediate or high-grade chondrosarcomas and chordomas and either bone or soft tissue metastatic CIC-rearranged sarcomas
- Conditions
- Ewing Sarcomas, Chondrosarcomas, Osteosarcomas, Chondroma
- Trial name
- REGOBONE (NCT02389244)
- Testing
- Regorafenib
- Where
- 19 sites in France
- Volunteers
- 163 people
- Sponsor
- UNICANCER
Bone Loss
The Use of CoreBone Coral Particles vs. Cones for Preservation of Alveolar Bone
Normally, dentists do not graft the socket after extraction of teeth. When they do graft they use particulate graft devices. The purpose of this study is to examine whether coral particles of 300-450um in comparison to coral…
- Trial name
- CoreBone (NCT02632734)
- Testing
- CoreBone Cone device, CoreBone 500 device
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Proximal Humeral Fracture
Perioperative Complications in Reversed Shoulder Arthroplasties
Retrospective observational study of reversed shoulder arthroplasties by proximal humeral fracture. Analysis of preoperative risk factors as well as minor and major complications at the first week, 90 days and 1 year.
- Trial name
- NCT03243409
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Lumbar Spondylolisthesis
Free Hand Lumbar Pedicular Screw Fixation
Background: Different methods for lumbar pedicular screw insertion have been advocated, however each technique has its cons and pros.
- Trial name
- NCT03327298
- Testing
- pedicle screw fixation
- Volunteers
- 32 people
- Sponsor
- Zagazig University
Fractured Neck of Femur
10 Year Review of the Experience of the PFNA ,TFNA the Affixus Nail
The aim of this study was to investigate the clinical effects of design changes from the use of three different IM nail designs in the management of extracapsular hip fractures.
- Trial name
- NCT03493893
- Testing
- Intermedullary nail
- Volunteers
- 800 people
- Sponsor
- Princess Alexandra Hospital, Brisbane, Australia
Osteoporosis or Osteopenia
What is the Best Policy to Prevent Osteoporotic Fracture?
This study aims to conduct a cost-effectiveness analysis (CEA) among the programs for preventing osteoporotic fracture. The main comparison will be made among the effects of three programs for preventing osteoporotic fractures…
- Trial name
- NCT00173693
- Testing
- exercise for strength, balance, health education
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Bariatric Surgery, Osteoporosis
Skeletal Health in Bariatric Surgery Patients
The investigators propose a prospective cohort trial that will help to understand the impact of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in pre- and post-menopausal female bariatric patients.
- Conditions
- Bariatric Surgery, Osteoporosis, Fractures, Bone, Roux En-Y Gastric Bypass
- Trial name
- NCT03331536
- Testing
- Roux en Y Gastric Bypass Pre-menopausal, Roux en Y Gastric Bypass Post-menopausal, Sleeve Gastrectomy Pre-menopausal
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Adult Acute Promyelocytic Leukemia (M3), Blastic Phase Chronic Myelogenous Leukemia
PS-341 in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia in Blast Phase, or Myelodysplastic Syndrome
Phase I trial to study the effectiveness of PS-341 in treating patients who have refractory or relapsed acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia in blast phase, or myelodysplastic syndrome.
- Conditions
- Adult Acute Promyelocytic Leukemia (M3), Blastic Phase Chronic Myelogenous Leukemia, Previously Treated Myelodysplastic Syndromes, Recurrent Adult Acute Lymphoblastic Leukemia
- Trial name
- NCT00005064
- Testing
- bortezomib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Acute Myeloid Leukaemia (AML), Myelodysplastic Syndromes (MDS)
Panobinostat Maintenance After HSCT fo High-risk AML and MDS
Aim of this prospective randomized trial is to compare maintenance treatment with panobinostat interspersed with donor lymphocyte infusions (DLI) versus the standard approach of pre-emptive DLI alone in patients with poor-risk…
- Trial name
- NCT04326764
- Testing
- Panobinostat
- Where
- 19 sites in Germany, Netherlands
- Volunteers
- 52 people
- Sponsor
- Goethe University
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