Clinical trials: Bone and Bones
Sarcoma, Osteosarcoma
Machine Learning Applied to EHRs Data of Patients With Sarcoma
Application of computational statistics and machine learning methods to data derived from electronic health records of patients diagnosed with sarcoma.
- Conditions
- Sarcoma, Osteosarcoma, Ewing Sarcoma
- Trial name
- AMLAS (NCT07215728)
- Testing
- No intervention studied
- Volunteers
- 700 people
- Sponsor
- University of Milano Bicocca
Polycythemia Vera
Hematocrit to Hemoglobin Ratio and Red Blood Cell Distribution Width in Polycythemia Vera and Secondary Erythrocytosis.
Polycythemia vera (PV), a hematological neoplasm characterized by excessive erythropoiesis due to Janus kinase 2 (JAK2)- activating mutations.
- Trial name
- NCT05993065
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Aplastic Anemia, Paroxysmal Hemoglobinuria, Nocturnal
Study of High Dose Cyclophosphamide in Patients With Severe Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria
OBJECTIVES: I. Confirm the efficacy demonstrated in a pilot study using high dose cyclophosphamide in patients with severe aplastic anemia. II.
- Trial name
- NCT00004464
- Testing
- cyclophosphamide, filgrastim
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Acromegaly Due to Pituitary Adenoma
Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma
In this study, the investigators hypothesize that upfront gamma knife radiosurgery with drug therapy is superior in the treatment of growth hormone-secreting pituitary tumors after primary surgical treatment compared with the…
- Trial name
- MERGE (NCT03439709)
- Testing
- Gamma knife radiosurgery, Lanreotide 60Mg Solution for Injection
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Samsung Medical Center
Bilateral Hearing Loss
Evaluation of the Benefits of Bilateral Fitting in BAHS Users
The purpose of this study is to evaluate the benefit of bilateral implantation with bone-anchored hearing systems (BAHS), in terms of sound localization abilities, as well as auditory working memory.
- Trial name
- NCT04006132
- Testing
- Fitting of Ponto 3 SuperPower
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Oticon Medical
Cancers, Cardiovascular Diseases
Swedish Mammography Cohort
The Swedish Mammography Cohort began in 1987-1990, when 66,651 women living in two counties in central Sweden completed a mailed questionnaire that included items about their diet, parity, age at first child's birth, history of…
- Conditions
- Cancers, Cardiovascular Diseases, Cataract, Gastrointestinal Diseases
- Trial name
- SMC (NCT01127698)
- Volunteers
- 61,433 people
- Sponsor
- Karolinska Institutet
Ankylosing Spondylitis, Osteoporosis
Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS)
This prospective study will assess the effects of treatment with alendronate in osteoporotic patients with ankylosing spondylitis.
- Trial name
- NCT01104987
- Testing
- alendronate
- Where
- Sweden
- Volunteers
- 16 people
- Sponsor
- Göteborg University
Myelodysplastic Syndromes
Magrolimab + Azacitidine Versus Azacitidine + Placebo in Untreated Participants With Myelodysplastic Syndrome (MDS)
The primary objective of this study is to evaluate the efficacy of magrolimab in combination with azacitidine compared to that of azacitidine plus placebo in previously untreated participants with intermediate/high/very high risk…
- Trial name
- ENHANCE (NCT04313881)
- Testing
- Magrolimab, Azacitidine
- Where
- 169 sites in United States, Australia and 19 more
- Volunteers
- 539 people
- Sponsor
- Gilead Sciences
Accidental Falls/Prevention and Control, Osteoporosis
Prevention of Injury in Skilled Nursing Facilities Through Optimizing Medications
The goal of this clinical trial is to compare three care models for optimizing medications and preventing falls with broken bones in patients receiving rehabilitation after a hospitalization for a broken bone.
- Trial name
- PRISM (NCT06304428)
- Testing
- Deprescribing Care Model, Bone Health Service Model, Injury Prevention Service Model
- Where
- 2 sites in United States
- Volunteers
- 3,780 people
- Sponsor
- Duke University
Skin Carcinoma
Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Chest and Back
RATIONALE: Drugs used in chemotherapy, such as tazarotene, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00783965
- Testing
- tazarotene
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Scoliosis, Scoliosis Idiopathic
Investigation of the Effects of Exercise and Kinesiological Taping on Spinal Deformities and Serum Markers in Individuals With Scoliosis
The aim of this study is to investigate the effects of Schroth exercises and kinesiological taping on spinal deformities and serum markers in young adults with scoliosis.
- Conditions
- Scoliosis, Scoliosis Idiopathic, Musculoskeletal Deformity
- Trial name
- NCT06341465
- Testing
- Just Exercise, Exercise, Taping
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Alopecia Areata, Alopecia Totalis
The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic
The study series consists of three studies with the aim to assess the incidence, prevalence, risk factors, comorbidities and management of patients with alopecia areata in Czech Republic based on the patients and registry of a…
- Conditions
- Alopecia Areata, Alopecia Totalis, Alopecia Universalis, Alopecia Areata (& Ophiasis)
- Trial name
- NCT05098600
- Testing
- Exposure of interest
- Where
- Czechia
- Volunteers
- 123 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Lumbar Disc Herniation, Postoperative Rehabilitation
The Influence of the Timing of Postoperative Rehabilitation Intervention on the Clinical Efficacy of Unilateral Biportal Endoscopic Spine System in the Treatment of Lumbar Disc Herniation
This study focuses on the impact of the timing of postoperative rehabilitation intervention on the clinical efficacy of unilateral biportal endoscopic spine surgery in the treatment of lumbar disc herniation.
- Trial name
- NCT07161232
- Testing
- Standardized Postoperative Rehabilitation Protocol
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Li Xiang
Sickle Cell Anemia, Thalassemia
The Spleen in Sickle Cell Anemia and Sickle Cell Thalassemia
The spleen in Sickle Cell Anemia and Sickle Cell Thalassemia is usually enlarged in the first years of life but the immune protection provided is considered insufficient.
- Trial name
- NCT00971698
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- HaEmek Medical Center, Israel
Chronic Myeloproliferative Disorders, Leukemia
Flu Vaccine in Preventing Influenza Infection in Healthy Volunteers and in Patients Who Have Undergone Stem Cell Transplant
RATIONALE: Studying immune response to flu vaccine in patients who have undergone a stem cell transplant may help doctors plan the best treatment.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00964821
- Testing
- trivalent influenza vaccine, Immunoenzyme technique, Laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Osteoporosis
Study of AK156 in Primary Osteoporosis Patients
The purpose of this study is to investigate the efficacy and safety of AK156 in Japanese patients with primary osteoporosis.
- Trial name
- NCT01522521
- Testing
- AK156
- Where
- 20 sites in Japan
- Volunteers
- 600 people
- Sponsor
- Asahi Kasei Therapeutics Corporation
Axial Spondyloarthritis
Safety, Tolerability and PK of SHR1314 in axSpA
The main purpose of this study is to evaluate the safety, Tolerability and Pharmacokinetics (PK) of SHR1314 with axial spondyloarthritis.
- Trial name
- NCT03704428
- Testing
- SHR-1314
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Chronic Myeloid Leukemia
Safety and Efficacy of Imatinib in Combination With High Dose Chemotherapy for Acute Phase Chronic Myelogenous Patients
The aim of this phase I/II trial is to determine the dose of daunorubicine to be associated with cytarabine and Imatinib for induction therapy in patients with chronic myelogenous leukemia in myeloid acute phase.
- Trial name
- NCT00219765
- Testing
- Imatinib mesylate 600 mg, Cytarabine, Daunorubicine
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Poitiers University Hospital
Femur Fracture
Nutritional Support in Femur Fracture Rehabilitation
This randomized, observer-blinded trial tested the hypothesis that nutritional supplementation with muscle-target nutritional supplementation would increase the efficacy of a physical rehabilitation program in old adults with…
- Trial name
- NCT04306536
- Testing
- Fortifit®
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Barichella Michela
Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia
Combination Chemotherapy With or Without PSC 833, Peripheral Stem Cell Transplantation, and/or Interleukin-2 in Treating Patients With Acute Myeloid Leukemia
Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PSC 833 may increase the effectiveness of chemotherapy by making cancer cells more sensitive to the drugs.
- Conditions
- Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Erythroid Leukemia (M6), Adult Acute Megakaryoblastic Leukemia (M7)
- Trial name
- NCT00006363
- Testing
- cytarabine, daunorubicin hydrochloride, etoposide
- Where
- United States
- Volunteers
- 720 people
- Sponsor
- National Cancer Institute (NCI)
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