Clinical trials: Bone and Joint Infections
Reactive Arthritis
New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis
1. to investigate, whether one of the two alternative therapy strategies (antibiotic plus immunostimulation versus antibiotic plus immunosuppression) in chronic reactive arthritis is therapeutical superior to conventionel…
- Trial name
- NCT00244179
- Testing
- interferon-gamma, infliximab, dmard
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Spondylarthritis, Spondylarthropathies; Spondylitis, Ankylosing
Effects of a Digital Exercise Intervention on Sleep and Physical Activity in Patients With Spondyloarthritis
The goal of this clinical trial is to assess whether a tailored digital Adapted Physical Activity (APA) program can improve physical activity levels and sleep quality in adults diagnosed with spondyloarthritis (SpA).
- Trial name
- ASPIRE (NCT07034404)
- Testing
- Digital Adapted Physical Activity, Control (Standard treatment)
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Grenoble
Sarcoidosis, Tuberculosis
The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis
This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.
- Trial name
- uveitis (NCT02627209)
- Testing
- spectrophotometric assay, radial immunodiffusion
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Ozlem Sahin
Inflammatory Rheumatism, Psoriatic Arthritis
Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)?
TWEAK (TNF weakly inducer of apoptosis) is a type II-transmembrane protein, member of the TNF ligand superfamily that can be cleaved to function as a soluble cytokine.
- Conditions
- Inflammatory Rheumatism, Psoriatic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT02164214
- Testing
- etanercept Treatment
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Bone or Joint Infection
Study to Assess Safety, Tolerability and Efficacy of Afabicin in The Treatment of Participants With Bone or Joint Infection Due to Staphylococcus
This is a randomized, active-controlled, open-label study to assess the safety, tolerability and efficacy of Afabicin in the treatment of participants with bone or joint infection due to Staphylococcus aureus [both…
- Trial name
- NCT03723551
- Testing
- Afabicin, Cefazolin, Vancomycin
- Where
- 19 sites in Georgia, South Africa and 1 more
- Volunteers
- 67 people
- Sponsor
- Debiopharm International SA
Spondylitis, Spondylitis, Ankylosing
A Pilot Study of MSCs Iufusion and Etanercept to Treat Ankylosing Spondylitis
The purpose of this study is to evaluate the safety and clinical effect of mesenchymal stem cells (MSCs) derived from human bone marrow at a dose of 1.0E+6 MSC/kg in subject for the therapy of Ankylosing spondylitis (AS) and to…
- Conditions
- Spondylitis, Spondylitis, Ankylosing, Ankylosis, Arthritis
- Trial name
- NCT02809781
- Testing
- Intravenous infusion of MSCs, Etanercept
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Osteoarthritis, Osteoporosis
Development of a Non-invasive Assessment of Human Bone Quality Using Spatially Offset Raman Spectroscopy
In this study spatially offset Raman spectroscopy (SORS), which allows the collection of Raman spectra through turbid media, is being applied to collect Raman spectra of bone.
- Conditions
- Osteoarthritis, Osteoporosis, Osteogenesis Imperfecta, Rickets / Osteomalacia
- Trial name
- NCT02814591
- Testing
- spatially offset Raman spectrometer (SORS)
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University College, London
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Fractures, Bone, Stroke
Tele-Rehabilitation Pilot Evaluation Study
A proof of concept randomized controlled trial (RCT) only evaluated the National University of Singapore's (NUS) T-Rehab tele-rehabilitation (TR) system at a home setting where rehabilitation was provided on an individual level.
- Conditions
- Fractures, Bone, Stroke, Lower Limb Joint Replacement (Hip or Knee), Lower Limb Amputation
- Trial name
- NCT03409354
- Testing
- Tele-rehabilitation, Usual care
- Where
- Singapore
- Volunteers
- 14 people
- Sponsor
- National University of Singapore
Spondyloarthritis, Rheumatoid Arthritis
SarS-Cov-2 Viral Infection (COVID-19) in Patients With Chronic Inflammatory Rheumatism
The purpose of this study is to assess whether immunosuppressive therapies used by patients with chronic inflammatory rheumatic diseases have an impact on the viral load and the humoral and cellular responses during viral…
- Conditions
- Spondyloarthritis, Rheumatoid Arthritis, Covid19
- Trial name
- COVIRIC (NCT04584541)
- Testing
- blood tests, Nasopharyngeal swabs, Stools
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spondyloarthropathy
Clinical Characteristics of Importance to Outcome in Patients With Spondyloarthritis
The objective of the study is to investigate extra-articular manifestations, pain mechanisms, patient-reported outcomes, comorbidities and association between these conditions in patients with spondyloarthropathy (SpA) treated…
- Trial name
- NCT02948608
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Svendborg Hospital
Osteomyelitis Acute, Septic Arthritis
Initial Oral Antibiotics for Bone and Joint Infections in Children
Initial oral antibiotic treatment for children and adolescents with uncomplicated bone and joint infections (BJI) has been found non-inferior to initial IV antibiotics in one randomized controlled trial (RCT).
- Conditions
- Osteomyelitis Acute, Septic Arthritis, Bone Infection, Joint Infection
- Trial name
- NCT06827496
- Testing
- Oral antibiotic treatment
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ankylosing Spondyloarthritis
Study of Apremilast to Treat Subjects With Active Ankylosing Spondylitis
Apremilast is a new, orally available, small molecule drug that specifically inhibits phosphodiesterase 4 (PDE4), an enzyme that modulates inflammatory cytokines.
- Trial name
- POSTURE (NCT01583374)
- Testing
- Apremilast tablet 20 mg, Apremilast tablet 30 mg BID
- Where
- 103 sites in United States, Australia and 16 more
- Volunteers
- 490 people
- Sponsor
- Amgen
Bone Infection, Joint Infection
Performances of DendrisCHIP®OA in Bone and Joint Infections
Bone and joint infections (BJI) with and without prosthetic material (knee, hip and shoulder) are complex to diagnose and treat, justifying the creation of expert centers by the French Ministry of Health (CRIOAc).
- Conditions
- Bone Infection, Joint Infection, Molecular Diagnostic
- Trial name
- DENDRIS (NCT06132347)
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Radius Fracture Distal, Surgery
Volar Locking Plate Versus External Fixation for Distal Radius Fracture - a Longterm Follow up
A 10-year follow up of a fusion of two earlier published randomized controlled trials. 203 patients with displaced distal radius fractures were randomized to surgery with a volar locking plate or external fixation.
- Conditions
- Radius Fracture Distal, Surgery, Surgery--Complications, Treatment Complication
- Trial name
- EXTEND (NCT05371938)
- Testing
- Volar locking plate, external fixation
- Where
- Sweden
- Volunteers
- 203 people
- Sponsor
- Olof Skoldenberg
Bone and Joint Infection
Lyon PJI Retrospective Cohort Study
Bone and joint infections (BJI), although infrequent (prevalence of 70 per 100,000 in France), have a significant economic and clinical impact.
- Trial name
- NCT04722926
- Testing
- PJI
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon
Bone Diseases, Infectious, Musculoskeletal Diseases
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health.
- Conditions
- Bone Diseases, Infectious, Musculoskeletal Diseases, Joint Diseases, Osteoarthritis
- Trial name
- MVMS_MRI (NCT04536103)
- Testing
- MRI
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Xiaojuan Li
COVID-19, Systemic Lupus Erythematosus
Prevalence and Seroconversion of COVID-19 in Autoimmune Diseases in Europe
The coronavirus disease 2019 (COVID-19) pandemic is a potentially fatal disease that represents a great global public health concern.
- Conditions
- COVID-19, Systemic Lupus Erythematosus, Sjogren's Syndrome, Axial Spondyloarthritis
- Trial name
- Euro-COVIMID (NCT04397237)
- Where
- France
- Volunteers
- 3,100 people
- Sponsor
- Pitié-Salpêtrière Hospital
Staphylococcus Aureus Infection, Bone and Joint Infection
Recurrent S. Aureus Infections in Osteoarticular Infections
Staphylococcus aureus osteoarticular infections, in particular those associated with the presence of implant, relapse in 20% of cases.
- Trial name
- RELAPSTAPH (NCT04712123)
- Testing
- relapse due to S. aureus
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Chronic Inflammatory Rheumatism
COVID-19 in Rheumatic Inflammatory Diseases Under Immuno-suppressive Drugs
Accurate knowledge of the humoral immune responses induced by SARS-CoV-2 in patients undergoing immunosuppressive therapy is essential to guide recommendations for infected patients and for vaccination policy for uninfected…
- Trial name
- COVIDRIC-2 (NCT04530682)
- Testing
- Biological samples
- Where
- France
- Volunteers
- 163 people
- Sponsor
- University Hospital, Montpellier