Clinical trials: Borderline Personality Disorder, active
Borderline Personality Disorder
Testing Interventions for Borderline Personality Disorder.
Borderline personality disorder (BPD) is a life-threatening, costly public health crisis affecting ~1-3% of North Americans, with 10% dying by suicide and annual healthcare costs of ~$63k (Canadian Dollars)/patient.
- Trial name
- NCT06458933
- Testing
- Sage, Supportive Individual Psychotherapy
- Where
- Canada
- Volunteers
- 304 people
- Sponsor
- York University
Self Harm, Borderline Personality Disorder
Predictors of Clinical Course and Treatment Response in DBT Programmes
The project is a collaboration between The National Centre for Suicide Research and Prevention (NSSF) and clinical units with Dialectical Behaviour Therapy (DBT) programmes.
- Trial name
- NCT04318899
- Testing
- Dialectical Behaviour Therapy adapted for adolescents (DBT-A), Dialectical Behaviour Therapy - Standard version (DBT)
- Where
- 5 sites in Norway
- Volunteers
- 250 people
- Sponsor
- Oslo University Hospital
Borderline Personality Disorder
A Novel Drug for Borderline Personality Disorder
Borderline Personality Disorder (BPD) is one of the most prevalent psychiatric disorders with high morbidity and mortality. It affects the lives of millions worldwide and is often highly incapacitating, leading to significant…
- Trial name
- NCT02097706
- Testing
- NMDA receptor antagonist (active drug), Lactose packed capsule (inert/inactive arm)
- Where
- Australia
- Volunteers
- 150 people
- Sponsor
- The Alfred
Borderline Personality Disorder (BPD)
A Pilot Trial of One-Day Accelerated TMS and D-cycloserine in Suicidal Patients With Borderline Personality Disorder
This study tests a new treatment for people with borderline personality disorder (BPD). The treatment combines a medication called D-cycloserine with one day of transcranial magnetic stimulation (TMS).
- Trial name
- ONE-D BPD (NCT07460947)
- Testing
- TMS, D-Cycloserine (DCS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mclean Hospital
Borderline Personality Disorder (BPD), PTSD - Post Traumatic Stress Disorder
Pilot Study for the Evaluation of a New Psychotherapeutic Treatment for Borderline Personality Disorder Patients With Post-traumatic Stress Symptoms
Borderline Personality Disorder (BPD) is a serious mental health condition that often co-occurs with Complex PTSD (CPTSD), making treatment more challenging.
- Trial name
- MBT-TF (NCT07305155)
- Testing
- Standard Mentalization-Based Treatment, Trauma-Focused Mentalization-Based Treatment
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Eva Rüfenacht
Borderline Personality Disorder
SHame prOpensity in bOrderline Personality Disorder
Borderline Personality Disorder (BPD) is a common psychiatric disorder occurring in 2 to 6% of the population. 70% of patients with BPD do at least one Suicide Attempt (SA) in their lives.
- Trial name
- SHOO (NCT03994510)
- Testing
- Clinical and biological assessments - a 5 Years follow-up
- Where
- France
- Volunteers
- 688 people
- Sponsor
- University Hospital, Montpellier
Borderline Personality Disorder
MDMA in Borderline Personality Disorder
The purpose of this study is to test the effects of MDMA (3,4-methylenedioxymethamphetamine) on social cognition in adults with Borderline Personality Disorder.
- Trial name
- MDMA in BPD (NCT06683014)
- Testing
- MDMA
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Self-harm, Personality Disorder, Borderline
Self-harm Behaviour Among the Most At-risk Adolescents
In the proposed study, three objectives will be pursued: 1. To develop a method to identify more effectively the acute and long-term risk of adolescents with the most threatening self-harm behaviours. 2.
- Conditions
- Self-harm, Personality Disorder, Borderline, Epigenetic Disorder, Non-Suicidal Self Injury
- Trial name
- SH-MARA (NCT05765864)
- Testing
- Enrollment questionnaire, General questionnaire1, General questionnaire2, General questionnaire3, Columbia Suicide Severity Rating Scale (CSSRS), The Brief Non-Suicidal Self-Injury Assessment Tool (B-NSSI-AT)
- Where
- 2 sites in Slovenia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana, Faculty of Medicine
Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD Group, Diagnosis of ADHD Using the KSADS-PL for the ADHD Group
ADOLESCENTS IMAGING USING fMRI: Feasibility Study
Impaired social cognition and cognitive control associated with borderline personality disorder (BPD) remain less explored. Recent Franco-Canadian study, has shown the feasibility of a neuroimaging tests in Quebec adolescents…
- Conditions
- Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD Group, Diagnosis of ADHD Using the KSADS-PL for the ADHD Group, Absence of Pathology on the CBCL and Ab-DIB for the Healthy Control Group, All Participants Were Euthymic at the Time of Task Administration
- Trial name
- ADO IMAGE (NCT07540429)
- Testing
- functional magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Etablissement Public de la Sante Mentale de la Somme
Borderline Personality Disorder
rTMS-enhanced Psychotherapy for Borderline Personality Disorder
This project assesses the effectiveness and lasting impact of combining Dialectical Behavioral Therapy (DBT) with prefrontal repetitive transcranial magnetic stimulation (rTMS) in patients with borderline personality disorder.
- Trial name
- rTMS-DBT (NCT06259851)
- Testing
- Dialectical behavioral therapy program, Prefrontal rTMS treatment
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Masarykova Univerzita
Borderline Personality Disorder, Borderline Personality Disorder (BPD)
Conceptualizing Borderline Personality Disorder as a Relationship Use Disorder
This study aims to explore a novel conceptualization of Borderline Personality Disorder (BPD) as a "Relationship Use Disorder." The research proposes that BPD shares key features with behavioral addictions, specifically addiction…
- Conditions
- Borderline Personality Disorder, Borderline Personality Disorder (BPD), Bipolar Disorder (BD)
- Trial name
- TLUR (NCT07337889)
- Testing
- Relationship-use questionnaire
- Where
- France
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Self Harm, Suicide, Attempted
Emotional Dysregulation in Para-suicidal Behavior
This is a naturalistic cohort pre-post study investigating aspects of emotional processing and how possible changes in emotional processing is related to the successful treatment of non-suicidal self-injury and suicidal ideation…
- Conditions
- Self Harm, Suicide, Attempted, Emotional Instability, Borderline Personality Disorder
- Trial name
- NCT03846375
- Testing
- Psychotherapy, Pre-intervention testing
- Where
- Norway
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
SCHIZOPHRENIA 1 (Disorder), Borderline Personality Disorder
Disorders of the Sense of Self and Physical Activity
Schizophrenia (SZ) patients with metabolic syndrome, patients with vestibular syndrome, and patients with borderline personality disorder, would benefit from physical activity (PA).
- Conditions
- SCHIZOPHRENIA 1 (Disorder), Borderline Personality Disorder, Vestibular Syndromes
- Trial name
- sensdesoi (NCT06817980)
- Testing
- Physical activity
- Where
- France
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Borderline Personality Disorder (BPD)
The Role of Gender in Borderline Personality Disorder
This study is a mixed-methods, single-arm cross-sectional study comprising 1) a qualitative, exploratory, critical-constructivist content analysis examining the significance of gender in relationship experiences and…
- Trial name
- BPD-G (NCT07639957)
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University Hospital Heidelberg
Borderline Symptoms, Borderline Personality Disorder
The Effectiveness of Group Schema Therapy in the Treatment of Borderline Symptoms in Adolescents
The goal of this randomized and controlled trial is to assess the effectiveness of group schema therapy in the treatment of adolescents with borderline symptoms.
- Trial name
- NCT06606002
- Testing
- Group schema therapy, Treatment as Usual (TAU)
- Where
- Finland
- Volunteers
- 64 people
- Sponsor
- Turku University Hospital
Borderline Personality Disorder
Cognitive Reappraisal Training for Borderline Personality (BPD)
Previous work by the group convinced the researchers to pursue development of focused cognitive reappraisal training as a novel approach to treatment of BPD, either as stand-alone treatment or in concert with evidence-based…
- Trial name
- NCT06772831
- Testing
- Cognitive Reappraisal by Distancing, Downregulate condition
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Posttraumatic Stress Disorder, Family Members
Testing a Peer-led Trauma-focused Intervention for Significant Others of Those With BPD
This project involves developing and piloting a peer-led intervention focused on posttraumatic stress symptoms for the family members and significant others of people with borderline personality disorder.
- Conditions
- Posttraumatic Stress Disorder, Family Members, Spouses
- Trial name
- NCT06135090
- Testing
- Trauma Recovery Program (official title TBD)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- York University
Borderline Personality Disorder (BPD)
Combining Transcranial Magnetic Stimulation With Emotion Regulation Skills Training in Borderline Personality Disorder
Impaired emotion regulation is a core feature of borderline personality disorder (BPD) and a known driver of functional impairment, interpersonal difficulties, self-harm, and suicidality.
- Trial name
- NCT07714005
- Testing
- Transcranial Magnetic Stimulation (TMS), Emotion Regulation Skills Training
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Borderline Personality Disorder
PILOT Phase: BPD Study
This pilot study aims to identify the area of the brain best suited for the treatment of Borderline Personality disorder (BPD). The study investigators will test whether repetitiveTranscranial Magnetic Stimulation (rTMS), a…
- Trial name
- NCT07223619
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Emotionally Unstable Personality Disorder, Borderline Type
Exploring Equine-Assisted Psychotherapy as an Intervention for Those Who Have Received a Diagnosis of Emotionally Unstable Personality Disorder
The purpose of this research is for the multi-disciplinary team at an inpatient psychiatric hospital to investigate more innovative ways to engage service users in order to promote wellbeing and emotional regulation.
- Trial name
- NCT07261033
- Testing
- Equine-Assisted Psychotherapy
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Cygnet Healthcare