Clinical trials: Botox
Antibiotic Stewardship, Overactive Bladder
Antibiotic Usage Prior to OnabotulinumtoxinA Injection
Intradetrusor injection of onabotulinumtoxinA, which is performed through a cystoscopic procedure, has been demonstrated to be efficacious in the treatment of both neurogenic and non-neurogenic overactive bladder (OAB), and is…
- Conditions
- Antibiotic Stewardship, Overactive Bladder, Onabotulinumtoxin A, UTI
- Trial name
- NCT04754737
- Testing
- No antibiotic, Prophylactic antibiotic, cystoscopic injection of onabotulinumtoxinA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Benaroya Research Institute
Urinary Incontinence, Urinary Incontinence, Urge
Prophylactic Analgesia for Bladder Botox Injections
The goal of this clinical trial is to learn more about using phenazopyridine (Pyridium) for pain control during bladder onabotulinumtoxinA ("botox") injections for surgical management of overactive bladder (OAB) for patients at…
- Conditions
- Urinary Incontinence, Urinary Incontinence, Urge, Overactive Bladder
- Trial name
- NCT06514430
- Testing
- Phenazopyridine, 1% lidocaine with sodium bicarbonate
- Where
- United States
- Sponsor
- Montefiore Medical Center
Skin Aging
To Evaluate the Safety and Efficacy of Botulax® Are Not Inferior to Those of Botox® in the Treatment of Glabellar Lines
To compare the safety and efficacy of Botulax® with Botox® in the improvement of moderate to severe glabellar lines.
- Trial name
- NCT01791920
- Testing
- Botulinum toxin type A(Botulax®), Botulinum toxin type A(Botox®)
- Where
- 6 sites in South Korea
- Volunteers
- 262 people
- Sponsor
- Hugel
Migraine, Chronic Migraine Headache
The Nordic Chronic Migraine Trial of CGRP Monoclonal Antibody and Onabotulinumtoxin A Dual Therapy Compared to CGRP mAbs Monotherapy
Migraine is characterized by attacks of throbbing, moderate or severe headache, often associated with nausea, vomiting, and/or sensitivity to light and/or sound.
- Trial name
- NorMig (NCT07040813)
- Testing
- CGRP mAbs and onabotulinumtoxin A
- Where
- 6 sites in Norway
- Volunteers
- 450 people
- Sponsor
- Oslo University Hospital
Hyperhidrosis
A Study Using Botulinum Toxin Type A in Patients With Axillary Hyperhidrosis
This is a three-year study in subjects with axillary hyperhidrosis involving injection of Botulinum Toxin Type A into the axilla to reduce sweating.
- Trial name
- NCT00168402
- Testing
- Botulinum Toxin Type A
- Volunteers
- 193 people
- Sponsor
- Allergan
Cerebral Palsy, Spastic Paraplegia and Hemiparesis
Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral Palsy
1. To assess the clinical and neurophysiological efficacy of Xeomin® vs. Botox® in children with spastic equine and equinovarus foot deformation in pediatric cerebral palsy 2.
- Conditions
- Cerebral Palsy, Spastic Paraplegia and Hemiparesis, Equine and Equinovarus Foot Deformation
- Trial name
- XEBEC (NCT02188277)
- Testing
- Xeomin, Botox®
- Where
- 3 sites in Russia
- Volunteers
- 64 people
- Sponsor
- Merz Pharmaceuticals GmbH
Nocturnal Bruxism
Botulinum Toxin A Injectable Solution in the Management of Bruxism: A Clinical Trial Study
A Clinical Trial Study to investigate the potential performance of BTXA on masseter muscle on patient with nocturnal bruxism and to check the pain scale and share this clinical experience.
- Trial name
- NCT03827122
- Testing
- onabotulinumtoxinA
- Where
- Saudi Arabia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Forehead Rhytides, Glabellar Rhytides
A Safety and Efficacy Study of OnabotulinumtoxinA in Forehead and Glabellar Facial Rhytides
This is a safety and efficacy study of onabotulinumtoxinA in subjects with forehead and glabellar facial rhytides (frown lines).
- Trial name
- NCT02261467
- Testing
- OnabotulinumtoxinA, Normal Saline
- Where
- 16 sites in United States, Canada and 1 more
- Volunteers
- 421 people
- Sponsor
- Allergan
Neck Muscle Issue
BoTox Into the Sternocleidomastoid Muscles (SCM)
Botulinum toxin injections have been used both in the face and neck for many years. However, injection into the sternocleidomastoid muscle (SCM) has only been done to treat neck spasms.
- Trial name
- NCT06903975
- Testing
- prabotulinumtoxinA-xvfs
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Myofascial Pain - Dysfunction Syndrome of TMJ
Efficiency of Botulinum Toxin type-a in the Management of the Myofascial Pain
Study Title: Investigation of the Relationship Between Clinical Outcomes and Pain Mediators in the Treatment of Masticatory Muscle Disorders Associated with Myospasm Using Onabotulinum Toxin A Study Importance: Temporomandibular…
- Trial name
- NCT06840730
- Testing
- Botulinum Toxin A (Botox )
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Hacettepe University
Spasticity/Paresis, Cerebral Palsy
Efficacy of Extracorporeal Shock Wave Therapy in Children With Cerebral Palsy
Spastic plantar and palmar flexion deformities are very common in children with cerebral palsy (CP). These deformities usually involve spasticity of the plantar or palmar muscle complexes, weakness of the antagonist dorsiflexor…
- Trial name
- NCT06128616
- Testing
- ESWT, Botulinum Toxin Type A, Serial Casting
- Volunteers
- 40 people
- Sponsor
- Kocaeli University
Wrinkles in Frontal Area
Comparison of Two Commercial Preparations of Botulinum Toxin Type A
The objective of this study is to compare the action halos of the botulinum toxins (Dysport® and Botox®) using two equivalence-ratios and to gather supportive information, such as more detailed data on the effectiveness in…
- Trial name
- NCT00959907
- Testing
- BOTULINUM TOXIN TYPE-A
- Where
- Brazil
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
Lateral Canthal Lines, Crow's Feet
Dose Finding Study In Subjects With Crow's Feet
The purpose of this study is to establish the therapeutic range of ANT-1401 in the treatment of Crow's Feet.
- Trial name
- NCT01951742
- Testing
- ANT-1401, Vehicle
- Where
- 10 sites in United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Anterios Inc.
Glabellar Frown Lines
Safety and Efficacy Study of Dysport RU and Glabellar Lines
The primary objective is to assess the dose response versus placebo of a single treatment of Dysport RU (Dysport RU, Ready to Use, for injection), for the improvement in appearance of moderate to severe glabellar lines at maximum…
- Trial name
- NCT01333397
- Testing
- Botulinum toxin type A
- Where
- 8 sites in France, Germany
- Volunteers
- 176 people
- Sponsor
- Ipsen
Overactive Bladder Syndrome
Role of Combination Therapy in Women With Refractory Overactive Bladder
Defined by the International Continence Society (ICS) as urinary "urgency, with or without urge incontinence, usually with frequency and nocturia", overactive bladder (OAB) presents as challenging syndrome to treat.
- Trial name
- NCT06438861
- Testing
- Vibegron 75mg
- Sponsor
- University of Alabama at Birmingham
Bruxism
Which is More Effective in Management of Bruxism: Botox or Occlusal Splints
The aim of this study is to compare the efficacy of Botulinum toxin (Botox) and traditional occlusal splints for the management of bruxism in edentulous patients rehabilitated with MIOD
- Trial name
- NCT04366869
- Testing
- overdenture, occlusal splint, Botox
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Injection Site Vesicles
The Interest of the Nitrous Oxide During Intravesical Injection of Botulinum Toxin A
Second line treatment for detrusor hyperreflexia is the intravesical BTX-A injections. First 300 units Botox are diluted with 30 ml of preservative-free saline.
- Trial name
- PROTOTOX (NCT00948103)
- Testing
- Nitrous Oxide, Oxygen
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Painful Bladder Syndrome, Interstitial Cystitis
Botox as a Treatment for Interstitial Cystitis in Women
Patients with interstitial cystitis have been well documented to have pelvic floor muscle tenderness as well as pain on bladder distension.
- Trial name
- NCT00194610
- Testing
- Botox, normal saline
- Volunteers
- 20 people
- Sponsor
- University of Washington
Botulism, Iatrogenic Botulism
Effect of Amifampridine on Neuromuscular Transmission in Patients Treated With OnabotulinumtoxinA
if amifampridine can improve neuromuscular transmission in muscles previously injected with OnabotulinumtoxinA (BTX-A)
- Trial name
- NCT05769478
- Testing
- Amifampridine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Wake Forest University Health Sciences
Skin Aging
Open Label Study to Assess Long-term Safety of Repeat Administration of Botulinum Toxin Type A for Moderate to Severe Crow's Feet Lines
This study will evaluate the long-term safety of botulinum toxin type A for the treatment of moderate to severe crow's feet lines after repeat application.
- Trial name
- NCT01818076
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- Revance Therapeutics, Inc.
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