Clinical trials: Botox
Cerebral Palsy
The Effect of Botox on Children With Cerebral Palsy
Botulinum toxin injections are a common form of treatment for children with cerebral palsy to help reduce muscle tightness and help them walk without resorting to surgery.
- Trial name
- NCT00503620
- Testing
- Botulinum Toxin A
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Peripheral Neuropathy Due to Chemotherapy
Botulinum Toxin A for the Treatment of Chemotherapy Induced Peripheral Neuropathy
Chemotherapy induced peripheral neuropathy (CIPN) is a common side effect of taxanes and platinum derivative based chemotherapeutic agents, common in breast cancer treatment regimens.
- Trial name
- NCT03571334
- Testing
- IncobotulinumtoxinA (Xeomin®, Merz) (INA), Normal saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
Keloid
Examining the Therapeutic Potential of Botulinum Toxin Type A in the Treatment of Keloids
Keloids are a common form of hypertrophic scars that by definition last beyond 6 months and grow beyond the site of initial injury.
- Trial name
- NCT05330078
- Testing
- Botulinum toxin type A, Vehicle
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Benign Prostatic Hyperplasia, Lower Urinary Track Symptoms
Effectiveness of onaBoNT-A vs Oral Tamsulosin in Men With BPH and LUTS
Benign prostatic hyperplasia (BPH) and its related symptoms are a common condition that affects nearly half of men over age 50 and 90% of men over 80.
- Trial name
- NCT01589263
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Surgical Wound Healing, Botulinum Toxin, Type A
Botulinum Toxin Type A for Wound Healing After Laparoscopic Colectomy
This study aims to evaluate the efficacy and safety of botulinum toxin type A (BTX-A) injection as an adjunct to surgical wound healing in patients undergoing laparoscopic colectomy.
- Trial name
- NCT07795463
- Testing
- Botulinum toxin type A (Botox®, Allergan)
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Pham Ngoc Thach University of Medicine
Erectile Dysfunction, Botulinum Toxin
Intracavernosal Injection of Botulinum Toxin Type A (50 and 100 Unit) in the Treatment of Erectile Dysfunction
purpose: The aim of this study is to compare the safety, efficacy and durability of different doses of BTX-A (50 and 100 unit) in the treatment of Vasculogenic Erectile Dysfunction after failure of other ICI therapy.
- Trial name
- NCT03355963
- Testing
- saline injection, Botulinum toxin type A 50 units, Botulinum toxin type A 100 units
- Volunteers
- 200 people
- Sponsor
- Benha University
Masseter Muscle Prominence
BOTOX® Treatment for Adults With a Wide Lower Face Due to Masseter Muscle Prominence
This study is designed to evaluate the safety and effectiveness of administering BOTOX for the treatment of Masseter Muscle Prominence (MMP) in adults.
- Trial name
- NCT04073303
- Testing
- Botulinum Toxin Type A
- Where
- 21 sites in Canada, China and 1 more
- Volunteers
- 377 people
- Sponsor
- AbbVie
Atopic Dermatitis (AD)
The Impact of Botox on Neuroimmune Interactions in Atopic Dermatitis
The purpose of this study is to understand cellular and molecular interactions in the skin of participants with mild-to-moderate AD, and how botulinum toxin alters these interactions.
- Trial name
- AD (NCT06928246)
- Testing
- Onabotulinum Toxin Type A - Phase 1b, Onabotulinum Toxin Type A - Phase 2
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Daniel Kaplan
Jawline and Neck Appearance
Study to Assess Participant Satisfaction After Jawline and Neck Treatment
The goal of this study is to evaluate overall participant satisfaction with the jawline and neck. Participants will receive select Juvéderm products and onabotulinumtoxinA in the jaw area and neck per eligibility criteria.
- Trial name
- AURA (NCT07794891)
- Testing
- OnabotulinumtoxinA, SKINVIVE, VOLUX
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- AbbVie
Dysphonia
BOTOX® Drug Use Investigation (Spasmodic Dysphonia)
This study is a drug use investigation program of BOTOX. The objective of this investigation is to collect and assess information on the safety and efficacy of BOTOX injections in subjects with a diagnosis of spasmodic dysphonia…
- Trial name
- NCT03543150
- Testing
- BOTOX
- Where
- Japan
- Volunteers
- 400 people
- Sponsor
- GlaxoSmithKline
Keratoconus
Botulinum Toxin A for the Treatment of Keratoconus
The purpose of this study is to associate the use of botulinum toxin type A for patients with keratoconus to demonstrate that tension eyelid has an important role in disease progression.
- Trial name
- NCT01691651
- Testing
- Subcutaneous injection of botulinum toxin type A, Botulinum Toxin Type A
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Hyperhidrosis
A Study Using Botulinum Toxin Type A in Patients With Axillary Hyperhidrosis
This is a three-year study in subjects with axillary hyperhidrosis involving injection of Botulinum Toxin Type A into the axilla to reduce sweating.
- Trial name
- NCT00168402
- Testing
- Botulinum Toxin Type A
- Volunteers
- 193 people
- Sponsor
- Allergan
Stroke
Comparative Hybrid Effects of Combining BoNT-A With Robot-assisted or Mirror Therapy for U/E Spasticity Stroke Patients
The aim of this study will be to determine and compare the immediate and longer-term effects of combination of BoNT-A injection and mirror therapy vs combination of BoNT-A injection and robot-assisted therapy.
- Trial name
- NCT02749591
- Testing
- Botulinum Toxin Type A, Robot-assisted therapy, Mirror therapy
- Where
- Taiwan
- Volunteers
- 37 people
- Sponsor
- Chang Gung Memorial Hospital
Obstructed Defaecation Syndrome
Biofeedback Therapy Versus Botox Injection in Treatment of Dyssynergic Defecation.
assessment the Improvement symptoms of obstructed defecation after biofeedback training versus botulinum toxin injection
- Trial name
- NCT06724250
- Testing
- Biofeedback therapy, Botulinum Toxin A (Botox )
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Mansoura University
Spasticity, Muscle, Stroke Sequelae
Valuation of the Evolution of Passive Mobility in the Spastic Upper Limb After Injection of Abobotulinumtoxin(Dysport®)
Assessing the objective measurement of passive joint mobility (ROM) in the spastic upper limb with Jost's pattern III in patients with post-stroke spasticity after infiltration with BoNT-A allows to objectify the increase in…
- Conditions
- Spasticity, Muscle, Stroke Sequelae, Movement Disorders
- Trial name
- ROM-ICTUS (NCT05151874)
- Testing
- Abobotulinum toxin A
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Urinary Bladder, Overactive, Urinary Incontinence
Evaluation of an Alternative Injection Paradigm for OnabotulinumtoxinA (BOTOX®) in the Treatment of Overactive Bladder in Patients With Urinary Incontinence
This study will evaluate the efficacy and safety of onabotulinumtoxinA 100 U (BOTOX®), compared to placebo, when injected into the bladder using an alternative injection paradigm in reducing the number of daily urinary…
- Trial name
- LO-BOT (NCT03052764)
- Testing
- onabotulinumtoxinA
- Where
- 31 sites in United States
- Volunteers
- 120 people
- Sponsor
- Allergan
Obstructed Defecation Syndrome (ODS)
Effects of Botox in Obstructed Defecation Syndrome
The purpose of this study is to determine if Botulinum Toxin-A (Botox) injection will improve symptoms of constipation in obstructed defecation syndrome (ODS).
- Trial name
- NCT02160288
- Testing
- Botulinum Toxin-A, Normal Saline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital
Depressive Disorder, Major
OnabotulinumtoxinA as Treatment for Major Depressive Disorder in Adult Females
This study will evaluate the safety and efficacy of onabotulinumtoxinA (BOTOX®) compared with placebo as treatment for major depressive disorder (MDD) in adult females.
- Trial name
- NCT02116361
- Testing
- onabotulinumtoxinA, Normal Saline
- Where
- 35 sites in United States
- Volunteers
- 258 people
- Sponsor
- Allergan
Pediatrics, Muscle Spasticity
BOTOX® Treatment in Pediatric Upper Limb Spasticity
This study will evaluate the safety and efficacy of BOTOX® (botulinum toxin Type A) in pediatric patients with upper limb spasticity.
- Conditions
- Pediatrics, Muscle Spasticity, Cerebral Palsy, Stroke
- Trial name
- NCT01603602
- Testing
- botulinum toxin Type A
- Where
- 45 sites in United States, Canada and 7 more
- Volunteers
- 235 people
- Sponsor
- Allergan
Antibiotic Prophylaxis
Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinA
This study aims to show that lack of antibiotic prophylaxis to those undergoing bladder Botox injections is not significantly inferior to administering prophylaxis.
- Trial name
- NCT05519072
- Testing
- Nitrofurantoin
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
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