Clinical trials: Botox Injection
Interstitial Cystitis
Efficacy of Botulinum Toxin Type A in Patients With Bladder Pain Syndrome/Intersticial Cystitis and Hunners' Lesions
The etiology of bladder pain syndrome is unknown. Therefore the management is directed to pain relief, as bladder pain is believed to drive both voiding frequency and nocturia.
- Trial name
- NCT01437579
- Testing
- intratrigonal injection of botulinum toxin, cystoscopy
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Moscow State University of Medicine and Dentistry
BOTOX, Percutaneous Tibial Nerve Stimulation
IDB Injection Combined With PTNS for Managing Children With OAB Not Responding to Monotherapy
This study aimed to evaluate the outcome of simultaneous intradetrusor BOTOX (IDB) injection and Percutaneous tibial nerve stimulation (PTNS) for management of children with recurrent wetness since at least 6 months.
- Trial name
- NCT05911594
- Testing
- Solifenacin group, Percutaneous tibial nerve stimulation group, Intradetrusor BOTOX group
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Benha University
Overactive Bladder
This is a Prospective, Randomized, Double-Blind Study Comparing Intravesical Injection of Botox® to Placebo.
The current study will investigate the comparative efficacy, safety and patient satisfaction of intradetrusor injections BOTOX® injections (200U) versus placebo (saline) injections in the treatment of OAB secondary to benign…
- Trial name
- BTX0621 (NCT00479596)
- Testing
- Botox
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Urological Sciences Research Foundation
Synkinesis
Botox Injections in Non-Cranial Nerve VII Innervated Muscles for Facial Synkinesis
Facial synkinesis is a condition that occurs following facial nerve (CN7) injury, typically secondary to Bell's palsy, trauma, surgery (e.g., acoustic neuroma resection), or malignancy.
- Trial name
- NCT07295288
- Testing
- Botulinum Toxin Type A Injection [Botox]
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Episodic Migraine
Study of BOTOX Injections in Prevention of Migraine in Adult Participants With Episodic Migraine
Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound (International Classification of Headache Disorders, 2018).
- Trial name
- NCT05028569
- Testing
- BOTOX
- Where
- 133 sites in United States, Canada and 7 more
- Volunteers
- 775 people
- Sponsor
- AbbVie
Esophageal Cancer Surgery, Esophagectomy
Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy
The goal of this pragmatic, registry-based, randomized clinical trial is to find out if using botulinum toxin (Botox) to help drain the stomach during an esophagectomy works as well as a pyloromyotomy in patients undergoing…
- Conditions
- Esophageal Cancer Surgery, Esophagectomy, Delayed Gastric Emptying Following Procedure, Esophageal Diseases
- Trial name
- EMPTY (NCT06721520)
- Testing
- Botulinum Toxin A (Botox ), Pyloromyotomy
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- The Cleveland Clinic
Anterior Disc Displacement
Injecting Lateral Pterygoid Muscle by Botulinum Toxin Type A With 2 Different Methods : 3D Guided Appliance and Electromyography (EMG) .
The goal of this study is to evaluate intra-oral botulinum toxin type A injection into lateral pterygoid muscle using a surgical guide synthesized by virtual planning based on CT with soft tissue window.
- Trial name
- NCT06633445
- Testing
- botulinum toxin type A injection in lateral pterygoid muscle, botox injection in lateral pterygoid muscle
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mahmoud Akram Khodir
Pain
Novel Technique for Botulinum Toxin Injection to Minimize Patient Discomfort
This single blinded randomized pilot study was performed on 21 Caucasian females to determine if injections through follicular openings were less painful than traditional injections for cosmetic botulinum toxin type A injections.
- Trial name
- NCT00628472
- Testing
- botulinum type a
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Cerebral Palsy
The Effect of Botox Injection on Postural Stability of Cerebral Palsy (CP) Children
Children suffer from Cerebral Palsy that willing to participate in the study will be tested with well-established measuring techniques of Balance control using force plate before 2 month after BOTOX injection in the movement and…
- Trial name
- NCT00651339
- Testing
- botox
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Soroka University Medical Center
Overactive Bladder, Urinary Incontinence
Botulinum-A Toxin Injection for Detrusor Hyperreflexia in Spinal Cord Injury: A Non-Surgical Approach.
The purpose of the study is to determine whether Botulinum-A toxin injected in the bladder muscle will help prevent the frequency and degree of urinary incontinence in Spinal Cord Injured and Multiple Sclerosis patients.
- Trial name
- NCT00262496
- Testing
- Botox
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Stroke, Hemiparesis
Botulinum Toxin Type A (BT-A) in Hemiplegic Shoulder Pain Versus Steroid
The aim of this study is to confirm the efficacy and safety of the intra-articular injection of BT-A in a multicentric double blind randomised study.
- Conditions
- Stroke, Hemiparesis, Shoulder Pain
- Trial name
- NCT01473277
- Testing
- BT-A (Dysport 500U), Triamcinolone acetonide
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- The Foundation Institute San Raffaele G. Giglio of Cefalù
Blepharospasm of Both Eyelids, Blepharospasm of Left Eyelid
DaxibotulinumtoxinA for Blepharospasm
This study aims to provide real-world information about the duration, safety, and overall benefit of DaxibotulinumtoxinA (also called DAXI) treatment for adults living with blepharospasm (BSP), a condition that causes…
- Conditions
- Blepharospasm of Both Eyelids, Blepharospasm of Left Eyelid, Blepharospasm of Right Eyelid, Blepharospasm, Benign Essential
- Trial name
- BLEXI (NCT07489430)
- Testing
- Botulinum Neurotoxin Type A
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Dystonia, Cervical
Exercise Program for Patients With Cervical Dystonia Who Are Treated With Botulinum Toxin Type A
Dystonia is involuntary movements characterized by posture abnormalities or repetitive movements as a result of continuous or intermittent simultaneous contraction of opposing muscle groups.
- Trial name
- NCT05502718
- Testing
- Stretching and Strengthening Exercises, Breathing and Rhythmic Coordination Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Prof. Dr. Şehim Kutlay
BPH, Intravesical Botox
Prostate Enucleation With Intravesical Botox Injections in Treating BPH and Bladder Overactivity
The aim of this study is to evaluate the effect of intravesical Botox injections on lower urinary tract symptoms (LUTS) when administered during Bipolar prostate enucleation surgery in patients with bladder outlet obstruction…
- Conditions
- BPH, Intravesical Botox, Bipolar Enucleation of the Prostate, Overactive Bladder
- Trial name
- BPH Botox (NCT05910983)
- Testing
- Bipolar enucleation of the prostate (BipolEP), Intravesical Botox injection
- Volunteers
- 100 people
- Sponsor
- Menoufia University
Vulvodynia
Placebo-controlled RCT of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia
Women with provoked vestibulodynia (PVD) suffer from severe dyspareunia and often present a hyperactivity of the pelvic floor muscles (PFM) which maintain the dyspareunia.
- Trial name
- NCT02773641
- Testing
- Botulinum Toxin Type A, Sterile Saline Solution
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Adductor Spasmodic Dysphonia, Voice Disorders
DaxibotulinumtoxinA Injection for Treatment of Adductor Spasmodic Dysphonia
Spasmodic Dysphonia (SD) is a neurologic condition causing inappropriate contraction of the laryngeal musculature, leading to abnormal voicing.
- Conditions
- Adductor Spasmodic Dysphonia, Voice Disorders, Spasmodic Dysphonia
- Trial name
- NCT05158166
- Testing
- DaxibotulinumtoxinA
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Francisco
Moderate to Severe Glabellar Lines
Efficacy and Safety of Recombinant Botulinum Toxin Type A (Eveotox) for Injection to Treat Moderate to Severe Glabellar Lines
This is a Phase 3 clinical study to evaluate the efficacy, safety, and immunogenicity of single/repeated injections of Eveotox in the treatment of moderate to severe glabellar lines.
- Trial name
- NCT06937944
- Testing
- Rcombinant botulinum toxin type A for injection（Eveotox), OnabotulinumtoxinA (Botox)
- Where
- 15 sites in China
- Volunteers
- 669 people
- Sponsor
- JHM BioPharma (Tonghua) Co. , Ltd.
Upper and/or Lower Limb Focal Spasticity
A Study to Review Treatment Outcomes From Treatment With Dysport® Injections in Adults for Upper and/or Lower Limb Focal Spasticity
The aim of this retrospective study is to describe the real-world outcomes with the treatment of adult patients with Dysport® injections for focal upper limb spasticity (ULS) and/or focal lower limb spasticity (LLS) in NHS…
- Trial name
- DYSCOVER (NCT04604379)
- Where
- 3 sites in United Kingdom
- Volunteers
- 123 people
- Sponsor
- Ipsen
N/A, as no Specific Medical Condition Will be Treated
A Study to Evaluate the Distribution of Botulinum Neurotoxin Type A Administered as Intradermal Injections, Comparing Different Doses, Concentrations, and Delivery Methods
The purpose of this study is to evaluate the distribution of IncobotulinumtoxinA (Xeomin) in healthy subjects at different volumes, concentrations and doses when administered intradermally and subcutaneously using different…
- Trial name
- NCT05585398
- Testing
- IncobotulinumtoxinA
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merz Pharmaceuticals GmbH
Hypertrophic Scars
Treatment of Hypertrophic Scars Using Fractional CO2 Laser Alone in Comparison With Adding Botulinum Toxin Either Through Intralesional Injection or Assisted Drug Delivery
The current study aimed to evaluate the effectiveness of fractional laser treatment alone and fractional laser combined with botulinum toxin A, delivered either through injections or topical application fractional laser-assisted…
- Trial name
- BTX and LADD (NCT07360483)
- Testing
- Botulinum toxin type A (Botox®, Allergan)
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Cairo University