Clinical trials: Botulinum Toxin, Type A
Psoriasis Vulgaris
Botox Versus Tacrolimus in Psoriasis Vulgaris
Psoriasis is a systemic chronic relapsing immune-mediated disease which often requires a long-term therapy. Psoriasis occurs in around 2-3% of the total global population.
- Trial name
- NCT06203470
- Testing
- Botulinum Toxin-A, Tacrolimus
- Volunteers
- 60 people
- Sponsor
- Assiut University
Skin Aging
Safety and Efficacy of Botulinum Toxin Type A Topical Gel for Lateral Canthal Lines
This is a safety and efficacy study of botulinum toxin type A in subjects with lateral canthal lines.
- Trial name
- REALISE 1 (NCT02580370)
- Testing
- Botulinum toxin type A
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Revance Therapeutics, Inc.
Post-stroke Spasticity, Spasticity Post-Traumatic Brain Injury
Dysport® Adult Lower Limb Spasticity Follow-on Study
The purpose of this research study is to assess the long term safety of Dysport® in hemiparetic subjects with lower limb spasticity due to stroke or traumatic brain injury over repeated treatment cycles.
- Trial name
- NCT01251367
- Testing
- Botulinum toxin type A
- Where
- 50 sites in United States, Australia and 9 more
- Volunteers
- 352 people
- Sponsor
- Ipsen
Acne Vulgaris
Safety and Efficacy of the Use of Botox on Acne
To determine the safety and efficacy of Botox Treatment in subjects with mild to moderate acne vulgaris defined by the Investigator's Global Assessment (IGA)
- Trial name
- NCT00765375
- Testing
- Botulinum Neurotoxin Type A, Bacteriostatic saline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- DeNova Research
Wrinkles
Study of BOTOX and JUVEDERM for Treatment of Moderate to Severe Facial Wrinkles and Folds
The purpose of this study is to see how well Juvederm Ultra XC or Juvederm Ultra Plus XC, and BOTOX Cosmetic, work compared to each other and when used together for the cosmetic treatment of age-associated wrinkles and folds of…
- Trial name
- JUVE_BTX (NCT01269801)
- Testing
- onabotulinumtoxinA, JUVÉDERM
- Where
- 3 sites in United States, Canada
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- AboutSkin Dermatology and DermSurgery, PC
Prostate Cancer
Neoadjuvant Intraprostatic OnabotulinumtoxinA Before Radical Prostatectomy for High-Risk Localized Prostate Cancer
This pilot randomized, single-blind, placebo-controlled study evaluates the feasibility, safety, and preliminary biological activity of neoadjuvant intraprostatic onabotulinumtoxinA (BOTOX®) administered before radical…
- Trial name
- NCT07796490
- Testing
- OnabotulinumtoxinA (BOTOX®)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Methodist Hospital Research Institute
Pain From onabotulinumtoxinA Injections
Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine
People find the injections used in onabotulinumtoxinA (Botox®) uncomfortable. This study will test whether putting a small piece of cotton soaked with 4% lidocaine (a numbing medicine) inside the front of each nostril for 5…
- Trial name
- NCT07571889
- Testing
- onabotulinumtoxinA prophylaxis with Lidocaine, OnabotulinumtoxinA prophylaxis with Saline
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Association of Migraine Disorders
Chronic Plantar Fasciitis
Study to Assess the Efficacy and Safety of Dysport® in the Treatment of Chronic Plantar Fasciitis
This study will investigate the hypothesis that the analgesic effect of a single injection of Dysport (200 MU) induces a significant reduction of symptoms in chronic cases of plantar fasciitis.
- Trial name
- NCT00447876
- Testing
- Botulinum toxin type A
- Where
- 6 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Ipsen
Cervical Dystonia, Blepharospasm
A Retrospective Chart Review of BOTOX® and Xeomin® for the Treatment of Cervical Dystonia and Blepharospasm
This study is a retrospective chart review to evaluate the doses of botulinum Type A toxins BOTOX® (onabotulinumtoxinA) and Xeomin® (incobotulinumtoxinA) used for the treatment of Cervical Dystonia and Blepharospasm in clinical…
- Trial name
- NCT01814774
- Testing
- No Intervention
- Where
- 2 sites in Norway, United Kingdom
- Volunteers
- 48 people
- Sponsor
- Allergan
Bladder Disorder, Neurogenic
Heart Rate Variability (HRV) in Patients With Neurogenic Detrusor Overactivity (NDO) Before and After Botulinum Neurotoxin Type A (BoNT/A) Intradetrusor Injections
Heart rate variability (HRV) is an important indicator of cardiac autonomic function and predictor of cardiac mortality and of all-cause mortality.
- Trial name
- HRV/Botox (NCT01337024)
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Glabellar Frown Lines
Efficacy and Safety of Botulinum Toxin Type A for Injection to Treat Glabellar Lines
This is a safety and efficacy study of botulinum toxin type A in subjects with glabellar frown lines.
- Trial name
- NCT02303002
- Testing
- Botulinum Toxin Type A, Active Comparator botulinum toxin
- Where
- Canada
- Volunteers
- 268 people
- Sponsor
- Revance Therapeutics, Inc.
Cerebral Palsy, Drooling
Treatment of Drooling With Type A Botulinum Toxin in Children With Cerebral Palsy
The purpose of this study is to evaluate the effectiveness of botulinum toxin injection to treat drooling in children with cerebral palsy, and to find the most appropriate dosage, duration of effect and side effects.
- Trial name
- NCT00173745
- Testing
- botulinum toxin A injection
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Cervical Dystonia
Study to Evaluate Safety, Efficacy of Botulinum Toxin Type A in Patients With Cervical Dystonia
Study is to investigate the use of the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) scale in a cervical dystonia population treated with botulinum toxin type A, and placebo.
- Trial name
- NCT00564681
- Testing
- botulinum toxin type A, botulinum toxin type A Formulation 2, Normal Saline
- Where
- 16 sites in United States, Canada and 14 more
- Volunteers
- 242 people
- Sponsor
- Allergan
Wrinkles
Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A
This study is being done to find out if the use of botulinum toxin prior to a medium strength combination chemical peel (Jessner's peel followed by 35% Trichloroacetic acid peel) will improve the appearance of crow's feet…
- Trial name
- NCT01586819
- Testing
- Botulinum Toxin, Chemical Peel Only
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Loyola University
Stroke, Muscle Spasticity
Safety Study of Botulinum Toxin Type A for the Treatment of Focal Upper Limb Poststroke Spasticity
The purpose of this study is to evaluate the safety of repeated doses of Botulinum Toxin Type A for the treatment of focal upper limb poststroke spasticity
- Trial name
- NCT00651729
- Testing
- Botulinum Toxin Type A
- Where
- 2 sites in United States, Canada
- Volunteers
- 279 people
- Sponsor
- Allergan
Urinary Incontinence, Overactive Bladder
A Safety and Efficacy Study of Botulinum Toxin Type A (BOTOX®) to Treat Urinary Incontinence Due to Neurogenic Detrusor Overactivity or Overactive Bladder in Korean Patients
This is a safety and efficacy study of BOTOX® (Botulinum Toxin Type A) in the Treatment of Adult Korean Patients with Urinary Incontinence due to Neurogenic Detrusor Overactivity or Overactive Bladder.
- Trial name
- NCT02601287
- Testing
- Botulinum Toxin Type A
- Where
- 5 sites in South Korea
- Volunteers
- 168 people
- Sponsor
- Allergan
Breast Cancer
A Randomized Controlled Trial To Evaluate The Use Of Botox In Breast Reconstruction With Tissue Expanders
Investigation of whether injection of the pectoralis muscle with 100 units botulinum toxin during breast reconstruction with tissue expanders results in decreased pain using a blinded, randomized, controlled trial.
- Trial name
- NCT01765309
- Testing
- Bilateral mastectomy with reconstruction
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
Stroke, Post-Stroke Spasticity
ESTIM-UL: FES for Upper Limb Recovery After Stroke
Stroke is a leading cause of long-term disability, frequently resulting in impaired upper limb motor function and spasticity. Although Botulinum Toxin Type A (BoNT-A) is effective in reducing focal spasticity, functional recovery…
- Conditions
- Stroke, Post-Stroke Spasticity, Post-Stroke Hemiparesis
- Trial name
- ESTIM-UL (NCT07513714)
- Testing
- Functional Electrical Stimulation (FES), Conventional Rehabilitation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Foggia
Spasticity
Vanderbilt University Spasticity Management Program Evaluation Plan
People with severe developmental disabilities frequently have comorbidities that make providing care to them more difficult. Spasticity is one such comorbidity.
- Trial name
- NCT00179114
- Testing
- Botulinum Toxin Type A, Intrathecal baclofen administered by the Medtronic SyncroMed(TM) pump (ITB)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University
Stroke, Spastic Hemiplegia
BTX-A and Mirror Therapy for Chronic Stroke Spasticity
Stroke is one of the leading causes of disability worldwide, particularly affecting the upper extremities and thus negatively impacting patients' activities of daily living and quality of life.
- Trial name
- NCT07331844
- Testing
- Botulinum toxin type A (Botox®, Allergan), Mirror Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital