Clinical trials: Botulinum Toxin, Type A
Tension-Type Headache
Botulinum Toxin A in Frequent and Chronic Tension-type Headache
Chronic tension-type headache (CTTH) is an underestimated disabling condition that affects a large number of patients. The treatment options for both episodic tension-type headaches, but especially CTTH are few.
- Trial name
- BACT (NCT04857671)
- Testing
- Botulinum Toxin Type A in saline water, Isotone saline water
- Where
- Norway
- Volunteers
- 66 people
- Sponsor
- Helse Nord-Trøndelag HF
HIV Posterior Cheek Enlargement
HIV Posterior Cheek Enlargement
Altered contour of the lower face is a frequent complication of human immunodeficiency virus (HIV). HIV facial lipoatrophy or loss of facial fat commonly results from antiretroviral therapy.
- Trial name
- NCT01635504
- Testing
- Botulinum toxin A
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of British Columbia
Overactive Bladder
Comparative Efficacy and Safety if Intravesical Botulinum Toxin A Versus Platelet-Rich Plasma in the Management of Refractory Overactive Bladder : A 2 Year Study
The goal of this clinical trial is to compare the efficacy and safety of intravesical Botulinum Toxin A versus intravesical Platelet-Rich Plasma (PRP) in adults with refractory overactive bladder who have not responded adequately…
- Trial name
- NCT07693192
- Testing
- Intravesical Botulinum Toxin A (100U), Intravesical Platelet-Rich Plasma
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mahmoud Mohamed Farag Ali
Overactive Bladder Syndrome (OABS)
Effect of BT and PFET on Urinary Symptoms and Quality of Life in Patients With OABS
The aim of this study was to examine the effects of bladder training and pelvic floor exercise training programs given in addition to Botulinum Toxin-A (BTx-A) application on urinary symptoms and quality of life in patients with…
- Trial name
- OABS/BT/PFET (NCT06209333)
- Testing
- Standard Patient Education, bladder training, pelvic floor exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Cervical Dystonia, Blepharospasm
A Retrospective Chart Review of BOTOX® and Xeomin® for the Management of Cervical Dystonia and Blepharospasm
This study is a retrospective chart review to evaluate the doses of botulinum Type A toxins BOTOX® (onabotulinumtoxinA) and Xeomin® (incobotulinumtoxinA) used for the treatment of Cervical Dystonia and Blepharospasm in clinical…
- Trial name
- NCT02245958
- Testing
- No Intervention
- Where
- 2 sites in Mexico, United Kingdom
- Volunteers
- 44 people
- Sponsor
- Allergan
Urge Urinary Incontinence
Intravesical Instillation of Botulinum Toxin Type A to Patients With Urge Urinary Incontinence
A pilot study to examine efficacy and safety of intravesical botulinum toxin type A.
- Trial name
- NCT00770406
- Testing
- botulinum toxin type A
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Base-of-thumb Osteoarthritis
Efficacy of an Intra-articular Injection of Botulinum Toxin A Associated With Splinting for Base-of-thumb Osteoarthritis
The primary purpose of this study is to determine whether a single ultrasound-guided intra-articular injection of botulinum toxin A associated to splinting is effective in reducing pain at 3 months in base-of-thumb osteoarthritis.
- Trial name
- RHIBOT (NCT03187626)
- Testing
- botulinum toxin A, saline
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Excessive Gingival Display
The Effect Of Botox In Patients With Gummy Smile With And Without Zinc And Phytase Supplementation.
Participants with esthetic concern of excessive gingival display who meets the inclusion criteria, will be carried out including history taking, clinical examination and initial therapy.
- Trial name
- NCT06577285
- Testing
- zinc gluconate 50 mg with phytase supplement 176mg (800FTU), zinc gluconate 50 mg
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hyperhidrosis
A Study Using Botulinum Toxin Type A in Adolescents With Axillary Hyperhidrosis
A study using Botulinum Toxin Type A in adolescents with axillary hyperhidrosis.
- Trial name
- NCT00168415
- Testing
- Botulinum Toxin Type A
- Where
- 2 sites in United States, Canada
- Volunteers
- 144 people
- Sponsor
- Allergan
Gummy Smile Due to Hypermobile Upper Lip
Satisfaction Of Adult Patients With Gummy Smile Treated By Botulinum Toxin A Injection
The aim of the proposal study is to answer the question of how to manage gummy smiles due to hypermobile upper lip with less invasive and low risk level procedure .
- Trial name
- NCT03186547
- Testing
- Botulinum Toxin A Injection, Modified Lip Repositioning Surgery
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hand-burned Children
Comparative Study Between Botulinum Toxin-A Injection and Shock Waves on Hypertrophic Scars in Hand-burned Children
PURPOSE: The study aims to compare study between Botulinum toxin-A injection and shock waves therapy on hypertrophic scars in hand-burned children.
- Trial name
- NCT06174155
- Testing
- physical therapy treatment, Botulinum toxin-A injection in addition to physical therapy program, shock wave therapy in addition to physical therapy program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Equinovarus; Acquired
Assessment of Gait After Dysport Treatment
This pilot study will aim to understand the potential benefit of the assessment of walking using video slow motion for muscle selection and the development of an image catalogue guide of the potential results of injection of…
- Trial name
- NCT03501043
- Testing
- Dysport
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Albert Einstein Healthcare Network
Chronic Migraine, Headache
Open Label, 6-month Study for High Frequency and Chronic Migraine,
This is a prospective, multi-center, unblinded study in patients with migraine (≥ 8 MMDs/month) requiring preventive treatment. Enrolled patients will receive DAX administered subcutaneously using an established, published…
- Trial name
- NCT06133491
- Testing
- Daxibotulinumtonix A
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Ki Health Partners. LLC
Overactive Bladder, Incontinence, Daytime Urinary
Botulinum Neurotoxin Type A (BoNT-A) in Paediatric Non-neurogenic Therapy Resistant Overactive Bladder (OAB)
A non-intervention cohort study on the use of Botulinum Neurotoxin Type A (BoNT-A) in Paediatric Non-neurogenic Therapy Resistant Overactive Bladder (OAB). Primary endpoint was the reduction of urinary incontinence.
- Conditions
- Overactive Bladder, Incontinence, Daytime Urinary, Incontinence, Nighttime Urinary
- Trial name
- NCT06569342
- Testing
- Intradetrusor BoNT-A
- Where
- Denmark
- Volunteers
- 43 people
- Sponsor
- University of Aarhus
Gingival Recession
Effect of Botulinum Toxin a Injection in Treatment of Recession RT1 and RT2
The goal of this study type: clinical trial] is to learn the effect of Botulinum Toxin _A injection in treatment of RT1andRT2 Gingival recession in lower anterior teeth . Primary outcome is keratinzed tissue width.
- Trial name
- NCT06842290
- Testing
- Botulinum toxin-A injection, Coronally advanced flap
- Volunteers
- 28 people
- Sponsor
- Cairo University
Traumatic Brain Injury
Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)
The purpose of this research is to understand and treat Traumatic Brain Injury (TBI) associated photophobia (light sensitivity) and its impact on visual function.
- Trial name
- NCT06293300
- Testing
- BoNT A
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Myofascial Pain Syndrome (MPS)
Botulinum Toxin Type A Versus Triamcinolone for Facial Myalgia
This single-blind randomized controlled trial aims to compare the therapeutic effects of Botulinum Toxin Type A and triamcinolone injections in adults with facial myofascial pain syndrome.
- Trial name
- NCT07867379
- Testing
- Botulinum Toxin A (Botox ), Triamcinolone Acetonide
- Where
- Saudi Arabia
- Volunteers
- 56 people
- Sponsor
- Riyadh Elm University
Myofascial Pain Syndromes, Myofascial Trigger Point Pain
Injection With OnabotulinumtoxinA (Botox) for the Treatment of Chronic Pelvic Pain
This research study because is looking at woman with symptoms of chronic pelvic pain caused by short, tight, and tender pelvic floor muscles (Myofascial Pelvic Pain syndrome).
- Conditions
- Myofascial Pain Syndromes, Myofascial Trigger Point Pain, Trigger Point Pain, Myofascial
- Trial name
- BotoxMPP (NCT02173405)
- Testing
- OnabotulinumtoxinA
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- University Hospitals Cleveland Medical Center
Depression
Botulinum Toxin for the Treatment of Depression
Depression is frequently accompanied by a specific sad facial expression. This expression is in part mediated by the same muscle activity that produces frown lines.
- Trial name
- NCT00934687
- Testing
- clostridium botulinum toxin type A neurotoxin complex, 0.9% NaCl solution
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland
Cerebral Palsy, Muscle Contraction
The Muscle in Children With Cerebral Palsy - Longitudinal Exploration of Microscopic Muscle Structure.
Cerebral palsy (CP) is a motor impairment due to a brain malformation or a brain lesion before the age of two. Spasticity, hypertonus in flexor muscles, dyscoordination and an impaired sensorimotor control are cardinal symptoms.
- Conditions
- Cerebral Palsy, Muscle Contraction, Muscle Spasticity
- Trial name
- CPBiopsyBTX (NCT05497609)
- Testing
- no intervention. Care as ususal
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Eva Ponten