Clinical trials: Botulinum Toxin, Type A
Urinary Bladder, Overactive, Pelvic Organ Prolapse
BOTOX® at the Time of Prolapse Surgery for OAB
The purpose of the study will be to assess the efficacy and safety of bladder BOTOX® for overactive bladder symptoms, such as urinary urgency and frequency, given at the time of prolapse surgery.
- Trial name
- NCT04807920
- Testing
- OnabotulinumtoxinA 100 UNT, Injectable saline
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Walter Reed National Military Medical Center
Migraine Disorders
Efficacy and Safety Study of BOTOX® Compared to Topiramate for the Prevention of Chronic Migraine in Adults
This study will evaluate the efficacy, safety and tolerability of prophylactic (preventative) treatment with BOTOX® (onabotulinumtoxinA) compared to topiramate in adults with chronic migraine.
- Trial name
- NCT02191579
- Testing
- onabotulinumtoxinA, Topiramate
- Where
- 32 sites in United States
- Volunteers
- 282 people
- Sponsor
- Allergan
Facial Pain
Botox Injections for Patients With Persistent Facial Pain
The main objective of this study is to investigate efficacy and safety of injecting botulinum toxin towards the sphenopalatine ganglion using MultiGuide in patients with persistent idiopathic facial pain
- Trial name
- NCT03462290
- Testing
- botulinum toxin type A
- Where
- Norway
- Volunteers
- 31 people
- Sponsor
- Norwegian University of Science and Technology
Interstitial Cystitis
Intravesical Botulinum Toxin A Injections in Treatment of Interstitial Cystitis Refractory to Conventional Treatment
This study was designed in a multicenter, randomized, double-blind, placebo controlled trial to test the actual therapeutic effects of intravesical BoNTA injection.
- Trial name
- NCT01969773
- Testing
- Botulinum toxin A, Normal saline instillation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Cervical Dystonia
Efficacy and Safety of DYSPORT® Using 2mL Dilution in Adults With Cervical Dystonia.
The purpose of the protocol is to evaluate the efficacy and safety of Dysport® using 2 mL dilution compared with placebo for the treatment of Cervical Dystonia.
- Trial name
- NCT01753310
- Testing
- Botulinum toxin type A
- Where
- 42 sites in United States
- Volunteers
- 134 people
- Sponsor
- Ipsen
Cluster Headache
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache
Cluster headache is a primary headache condition characterized by clusters of one-sided, high-intensity pain attacks. The headache may be episodic or chronic. Treatment options are limited and their effects unsatisfactory.
- Trial name
- BASIC (NCT03944876)
- Testing
- Botulinum toxin type A
- Where
- 5 sites in Germany, Italy and 3 more
- Volunteers
- 112 people
- Sponsor
- Norwegian University of Science and Technology
Buerger Disease, Raynaud Syndrome
Evaluation of Botulinum TOXin Type A in the Treatment of Buerger's Disease
The main objective is to assess the feasibility of treatment by injecting botulinum toxin A into the hand or foot of patients with signs of critical ischemia secondary to Buerger's disease.
- Trial name
- BETOX (NCT05698979)
- Testing
- BOTOX INJECTION
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Toulouse
Stroke
The Impact of Botox® During Robotic Rehabilitation of the Wrist Following Stroke
The purpose of this study is to see whether treating subjects for wrist rehabilitation following stroke with Botox® and robotic therapy is more effective than treatment with robotic therapy alone and no Botox®.
- Trial name
- NCT01088230
- Testing
- Botox®, saline solution
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New York Presbyterian Hospital
Cervical Dystonia
Long-Term Safety and Efficacy of Repeat Treatments of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-OLS)
Phase 3, open-label, multi-center trial to evaluate the long-term safety, efficacy, and immunogenicity of up to four continuous treatment cycles of daxibotulinumtoxinA (DAXI) for injection.
- Trial name
- ASPEN-OLS (NCT03617367)
- Testing
- daxibotulinumtoxinA for injection
- Where
- 65 sites in United States, Austria and 7 more
- Volunteers
- 357 people
- Sponsor
- Revance Therapeutics, Inc.
Migraine Disorders, Headache, Migraine
Effectiveness of Onabotulinumtoxin A (Botox) in Pediatric Patients Experiencing Migraines: A Study in the Pediatric Pain Population
The purpose of the research is to examine the outcomes of pediatric patients receiving Botulinum toxin type A (Botox ®) for the treatment of migraine.
- Conditions
- Migraine Disorders, Headache, Migraine, Pediatrics
- Trial name
- NCT03055767
- Testing
- OnabotulinumtoxinA
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of California, Irvine
Obesity
Outcome of Combined Botulinum Toxin A Injection and Gastric Balloon Implantation in Obesity Treatment
Obesity, which is defined as the accumulation of fat in the body to a degree that impairs health, is defined as a serious public health problem and it is estimated that 13% (approximately 650 million) of the entire world…
- Trial name
- NCT05872932
- Testing
- gastric balloon implantation, botulinum toxin A injection
- Where
- Turkey (Türkiye)
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Sebahattin Celik MD
Wrinkle, Glabellar Frown Lines
Head-to-Head Comparison of All Botulinum Neurotoxin Type A Products for Glabellar Rhytides
Study Type: This is a multicenter, triple-blind, randomized controlled trial. Purpose: The goal of this clinical trial is to compare the effectiveness and safety of all commercially available Botulinum Neurotoxin Type A (BoNT-A)…
- Conditions
- Wrinkle, Glabellar Frown Lines, Glabellar Furrowing
- Trial name
- NCT06448676
- Testing
- Botulinum toxin type A
- Where
- 3 sites in Netherlands
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Upper Extremity Spasticity, Stroke
Efficacy of Functional Electrical Stimulation (FES) in Persons Receiving Botulinum Neurotoxin for Upper Extremity Spasticity
FES is a form of treatment with a device to aid movement in people who have had damage to their brain or spinal cord. Small electrical impulses are used to excite/stimulate the nerves that supply paralyzed muscles.
- Conditions
- Upper Extremity Spasticity, Stroke, Acquired Brain Injury
- Trial name
- Botox + FES (NCT00462449)
- Testing
- Functional Electrical Stimulation (FES) through the Ness H200
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pittsburgh
Post-Stroke Spasticity, Cerebrovascular Accident
Study of GSK1358820 In Patients With Post-Stroke Lower Limb Spasticity
This is a study to confirm the superior efficacy of GSK1358820 over placebo in patients with equinus deformity associated with post-stroke lower limb spasticity using the Modified Ashworth Scale (MAS) ankle score.
- Trial name
- NCT00460655
- Testing
- GSK1358820
- Where
- 20 sites in Japan
- Volunteers
- 120 people
- Sponsor
- GlaxoSmithKline
Glabellar Lines, Wrinkles
Comparison of Dysport Reconstitution at 1.5 mL and 2.5 mL for the Treatment of Moderate to Severe Glabellar Lines
This study is designed to evaluate the safety, efficacy, and subject and investigator satisfaction of 2 different injection volumes of Dysport in the glabellar lines. 1.
- Trial name
- NCT02718118
- Testing
- Dysport reconstituted at 1.5 mL (0.05 mL/injection), Dysport reconstituted at 2.5 mL (0.08 mL/injection)
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Benign Prostatic Hyperplasia
A Study Evaluating the Effect of Botulinum Toxin Type A on Semen Quality in Patients With Benign Prostatic Hyperplasia
This is a 24 week study evaluating the effects of botulinum toxin Type A on semen quality in patients with signs and symptoms of Benign Prostatic Hyperplasia (BPH).
- Trial name
- NCT00894517
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Allergan
Chronic Migraine
A Study to Evaluate the Tolerability of Botox and Topiramate or Botox and Placebo and Effect on Cognitive Efficiency
The purpose of this study is to evaluate sustained tolerability, quality of life, and change in cognitive efficiency following treatment with OnabotulinumtoxinA and daily topiramate vs.
- Trial name
- NCT01700387
- Testing
- onabotulinumtoxinA, Topiramate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cady, Roger, M.D.
Chronic Brain Injury, Cerebral Stroke
Qualitative Study Patient & Physician Experiences Botox COVID-19
During the COVID-19 pandemic and subsequent series of Lockdowns, clinic out-patient spasticity services were replaced with video based tele-consultation appointments, in order to reduce the potential risk of virus transmission…
- Conditions
- Chronic Brain Injury, Cerebral Stroke, MS (Multiple Sclerosis)
- Trial name
- QualBotoxCov (NCT05435404)
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Sphenopalatine Block, BOTOX
Sphenopalatine Block Versus BOTOX in Management of Chronic Migraine
This trial compares the efficacy and safety of sphenopalatine ganglion block (SPGB) and intramuscular BOTOX injection in chronic migraine.
- Conditions
- Sphenopalatine Block, BOTOX, Chronic Migraine
- Trial name
- NCT06974617
- Testing
- Sphenopalatine block, Botulinum Toxin Type A
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Cairo University
Urologic Diseases, Overactive Bladder Syndrome
Trigonal vs Non Trigonal Botox Injection in OAB.
The investigators attend to conduct a prospective randomized study to assess safety and efficacy of trigonal-involved vs. trigonal-sparing botox injection technique, quality of life measurement and post-injection anticholinergics…
- Conditions
- Urologic Diseases, Overactive Bladder Syndrome, Quality of Life, Anticholinergic Syndrome
- Trial name
- NCT03533062
- Testing
- botulinum toxin A
- Volunteers
- 80 people
- Sponsor
- Mansoura University