Clinical trials: Botulinum Toxin, Type A
Cerebral Palsy
Efficacy of Intermittent Serial Casting on Spastic Wrist Flexion Deformity
Spastic wrist flexion deformity is a very common problem in children with CP. Although serial casting (SC) is one of the commonly used interventions in addition to botulinum toxin A (BoNT-A) injections and physical therapy for…
- Trial name
- NCT03306212
- Testing
- Botulinum toxin A, Occupational Therapy, Intermittent serial casting
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Kocaeli University
Direct Brow Lift, Scarring
Onabotulinum Toxin A in Direct Brow Lift
The brow lift is a surgical procedure that has been practiced for several decades. A typical indication is brow ptosis, which can be secondary to involutional changes or facial nerve palsies.
- Trial name
- NCT04383912
- Testing
- Botox Injectable Product
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Peyronie's Disease
H-22411: BOTOX® for Peyronie's Disease
Peyronie's disease is a condition in which a plaque, or hard lump, forms on the penis. It causes hardened tissue, pain, and an abnormal bending in the penis. These symptoms are more severe during an erection.
- Trial name
- NCT00812838
- Testing
- 100 units of Botulinum Toxin Type A, Preservative free normal saline, 100 units Botulinum Toxin A
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mohit Khera
Esotropia, Exotropia
Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone
Two different treatments were given to large angle horizontal strabismus (eso and exotropia) adult patients who agree to participate of the study. Inform consents were required for participants.
- Trial name
- NCT01460355
- Testing
- Botulinum Toxin Type A, saline solution
- Where
- Brazil
- Volunteers
- 23 people
- Sponsor
- University of Campinas, Brazil
Moderate to Severe Glabellar Lines
Safety and Efficacy Study of ATGC-100 for the Treatment of Moderate to Severe Glabellar Lines in Adult Subjects
Phase I/II clinical trial will be integrated and conducted. In phase I clinical trial, subjects with moderate to severe glabellar lines at maximum frown are enrolled and safety is assessed after 12 weeks of administration of 20U…
- Trial name
- NCT03970876
- Testing
- ATGC-100, Botox®
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- EuBiologics Co.,Ltd
Glabellar Frown Lines
Efficacy and Safety Study of MT10107 in the Treatment of Glabella Line
This study design is a parallel, active drug controlled, double blind, randomized, multi-centered, phase III clinical trial to compare the efficacy and safety of MT10107 versus BOTOX® in treatment of glabella line.
- Trial name
- NCT03908008
- Testing
- Botox (Botulinum toxin type A), MT10107 (Botulinum toxin type A)
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Medy-Tox
Glabellar Frown Lines
The Safety and Efficacy Study of PROTOXIN in Subjects With Moderate to Severe Glabellar Lines
This study will be conducted in Phase I/II clinical trials. In Phase I, subjects with moderate to severe glabellar lines are enrolled and those who are judged to be eligible for this study will be injected with the "PROTOXIN" at…
- Trial name
- NCT04996810
- Testing
- PROTOXIN, Botox®
- Where
- 2 sites in South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Protox Inc.
Scar Keloid, Hypertrophic Scar
Botulinum Toxins Intralesional Injection for Scar Pain
Botulinum toxins has been approved by the FDA to treat chronic migraine. Botox had been shown to inhibiting the release of inflammatory mediators and peripheral neurotransmitters from sensory nerve to treat neuropathic pain.
- Trial name
- NCT03982862
- Testing
- Triamcinolone, Lidocaine, Botulinum toxin A
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Kaohsiung Medical University
Overactive Bladder, Urinary Incontinence
Botulinum-A Toxin Injection for Detrusor Hyperreflexia in Spinal Cord Injury: A Non-Surgical Approach.
The purpose of the study is to determine whether Botulinum-A toxin injected in the bladder muscle will help prevent the frequency and degree of urinary incontinence in Spinal Cord Injured and Multiple Sclerosis patients.
- Trial name
- NCT00262496
- Testing
- Botox
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Ischemia, Vasopressor
Treatment of Vasopressor-induced Ischemia With Botulinum Toxin A
The goal of this project is to determine if performing a "chemical sympathectomy" by injecting botulinum toxin A in critically ill patients on vasopressors can treat digital ischemia.
- Trial name
- NCT01483209
- Testing
- Injection of botulinum toxin A
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Duke University
Chronic Migraine More than15 Days Per Month, and Lasting 4 Hours a Day or Longer.
ASIS for Botox in Chronic Migraine
Botox acts on nerve endings, yet there are no nerve endings inside the muscle, where they are typically injected. All nerves terminate on the fascia, where ASIS device can precisely deliver Botox by creating that subdermal…
- Trial name
- ASISinCM (NCT02074163)
- Testing
- Gadolinium, Efficacy of Botox intramuscularly at Week 6, Efficacy of Botox intramuscularly at Week 12
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- ASIS Corporation
Athletic Pubalgia
Intra-muscular Botulinum Toxin A in Chronic Athletic Pubalgia
Chronic athletic pubalgia is a frequent sport condition in which the effectiveness of medical treatment has not been proven. Intra-muscular injection of botulinum toxin A may have positive effects on pain in some chronic…
- Trial name
- PUBATOX (NCT05430893)
- Testing
- Botulinum Toxin A
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type A Botulinum Toxin, Tennis Elbow
Comparison Between Type A Botulinum Toxin Injection and Corticosteroid Injection in the Treatment of Tennis Elbow
Humeral lateral epicondylitis or tennis elbow is a common painful elbow disorder. The cause of tennis elbow is the chronic overload of bone-tendon junction.
- Trial name
- NCT00395616
- Testing
- Botox (drug)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- E-DA Hospital
Excessive Gingival Display
The Effect of Botulinum Toxin A In Patients With Excessive Gingival Display With And Without Zinc Supplementation
It has been noted since the start of using botulinum toxin for both medical and cosmetic indications that some patients simply don't achieve the responses to the drug that others do, leading to increased dose requirements and…
- Trial name
- NCT03717987
- Testing
- Botulinum toxin type A, Zinc supplementation
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Scar
A Dosage-dependent Manner of Botulinum Toxin Type A on the Prevention of Postoperative Scars of Various Anatomic Regions of the Body
Each year, millions of burn, trauma, or surgical patients worldwide suffer from scarring that severely affects their quality of life and social functioning.
- Trial name
- NCT06349733
- Testing
- Botulinum toxin type A
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Erectile Dysfunction With Diabetes Mellitus
Evaluation of Efficacy of Botulinum Toxin A Plus Oral Tadalafil 5 mg in Diabetic Men With Erectile Dysfunction
Study is aiming to evaluate safety, efficacy and durability of intracavernosal injection (ICI) of Botulinum toxin A plus oral tadalafil in controlled diabetic men with refractory Erectile Dysfunction.
- Trial name
- NCT06583590
- Testing
- Botulinum toxin A, Tadalafil 5mg
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Aswan University Hospital
Spasticity
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
The purpose of the study is to assess the safety and efficacy of increasing doses of Corabotase (also known as IPN10200) with the aim to evaluate the Pharmacodynamics (PD) profile of Corabotase and to establish the total…
- Trial name
- LANTIMA (NCT04752774)
- Testing
- Corabotase, Dysport
- Where
- 81 sites in United States, Austria and 12 more
- Volunteers
- 240 people
- Sponsor
- Ipsen
CRPS (Complex Regional Pain Syndromes), CRPS (Complex Regional Pain Syndrome) Type I
Perineural Incobotulinumtoxin-A for Complex Regional Pain Syndrome - An Open-label Feasibility Study
Complex Regional Pain Syndrome (CRPS) is a chronic pain condition characterized by severe regional pain, sensory disturbances, and functional impairment.
- Conditions
- CRPS (Complex Regional Pain Syndromes), CRPS (Complex Regional Pain Syndrome) Type I, CRPS Type II
- Trial name
- PINCom (NCT07473635)
- Testing
- Perineural Incobotulinumtoxin-A 200 U
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Bo Biering-Soerensen
Spinal Cord Injury, Pain
Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.
As clinicians, it is often a struggle to find effective pain control for a certain subgroup of patients with tetraplegia. These patients often have severe upper back, neck, and shoulder pain, limiting rehabilitation productivity…
- Trial name
- NCT00320281
- Testing
- botulinum toxin A
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Craig Hospital
Overactive Bladder Syndrome
Intravesical Injection of Botox for Treating Therapy Refractory Overactive Bladder in Females
The neurotoxin Botox (botulinum neurotoxin type A) is shown to be effective in the treatment of therapy refractory overactive bladder syndrome.
- Trial name
- NCT01042119
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich