Clinical trials: Botulinum Toxin, Type A
Non-relaxing Puborectalis Syndrome
Ultrasound and EMG Guided Botox Injection for the Treatment of Non-Relaxing Puborectalis Syndrome
Our study aims to determine the efficacy of ultrasound and EMG guided Botox injections into the puborectalis muscle in women with non-relaxing puborectalis syndrome.
- Trial name
- NCT01780636
- Testing
- botulinum toxin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Karen Noblett
Post-stroke Spasticity of the Lower Limb
Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Spasticity in the Leg After a Stroke
The purpose of this study is to determine whether injections of Botulinum toxin type A into muscles of the leg are effective in treating patients with increased muscle tension/uncontrollable muscle stiffness (spasticity) after a…
- Trial name
- PLUS (NCT01464307)
- Testing
- IncobotulinumtoxinA (400 Units)
- Where
- 53 sites in United States, Canada and 7 more
- Volunteers
- 290 people
- Sponsor
- Merz Pharmaceuticals GmbH
Glabellar Frown Lines
Duration of Botox Using OLD Versus COLD for Treatment of Glabellar Lines
This is a blinded, randomized study in the US to compare the duration response of two different concentrations of BOTOX in healthy female subjects with moderate to severe dynamic glabellar lines on maximum frown.
- Trial name
- NCT05083286
- Testing
- OnabotulinumtoxinA
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Clinical Testing of Beverly Hills
Facial Aging, Facial Wrinkles and Rhytides Reduction
Intradermal Microbotulinum Toxin for Sebum Reduction and Facial Pore Improvement
This study aims to evaluate the efficacy and safety of microdoses of botulinum toxin type A (microtoxin) for improving periocular skin quality and reducing fine wrinkles.
- Trial name
- MICROTOX-PORE (NCT07526870)
- Testing
- Botulinum Toxin Type A (Dysport®)
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Dyssynergic Defaecation, Evacuation Disorder
Infracoccygeal Botox for Dyssynergia
Background: Constipation is a common problem, affecting up to 20% of the population during their lifetime. Some patients respond poorly to standard treatments such as laxatives.
- Conditions
- Dyssynergic Defaecation, Evacuation Disorder, Anismus, Defecation Disorder
- Trial name
- NCT04879524
- Testing
- Percutaneous infracoccygeal Botulinum toxin injection to puborectalis
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Queen Mary University of London
Urinary Tract Infections
Comparison of Pre-procedural PCR and Culture-based UTI Assessment Prior to Intravesical Botox Injection
This study is a retrospective record review to determine whether a novel multiplex PCR assay can be utilized as a screening method for UTI in patients receiving Botox injection to treat overactive bladder (OAB).
- Trial name
- NCT04817865
- Testing
- Multiplex-PCR with Pooled Antibiotic Susceptibility Testing (M-PCR/P-AST), Urine Culture
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pathnostics
Knee Osteoarthritis
Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis
Introduction: Osteoarthritis of the knee is a very common disease. However there are few treatment options for these patients. Botulinum toxin type A is an option for chronic pain.
- Trial name
- NCT02829281
- Testing
- Botulinum Toxin Type A, Triamcinolone hexacetonide, Saline
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- Federal University of São Paulo
Ankle Osteoarthritis
Effects of Intraarticular Botulinum Toxin A in Ankle Osteoarthritis
The purpose of this study is to compare the effects of intraarticular Botulinum Toxin A versus intraarticular hyaluronate plus rehabilitation exercise in patients with ankle osteoarthritis.
- Trial name
- NCT01760577
- Testing
- Botulinum Toxin A (Allergan, Inc, Irvine CA), Hyalgan (Hyalgan, Fidia , Italy)
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Platysma Bands
Dysport Dose-Ranging Treatment of Platysmal Bands
This is a double-blinded, dose-ranging study in the US to assess the efficacy, safety, and duration of response of abobotulinumtoxinA for the treatment of moderate to severe platysmal bands.
- Trial name
- NCT04886167
- Testing
- AbobotulinumtoxinA
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clinical Testing of Beverly Hills
Migraine Disorders
BOTOX® (Botulinum Toxin Type A) as Headache Prophylaxis in Chinese Participants With Chronic Migraine
This study will evaluate the efficacy and safety of BOTOX® (Botulinum Toxin Type A) compared with placebo as headache prophylaxis in Chinese participants with chronic migraine.
- Trial name
- NCT03193346
- Testing
- botulinum toxin Type A
- Sponsor
- Allergan
Bilateral Blepharospasm (BEB)
Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Abnormal Contraction or Twitch of the Eyelid
This phase 3 study will serve to collect efficacy and safety data of two different doses of NT 201 in subjects suffering from Bilateral Blepharospasm (BEB) who are BTX treatment-naïve.
- Trial name
- NCT01896895
- Testing
- IncobulinumtoxinA (Xeomin), 25 Units, IncobotulinumtoxinA (Xeomin), 12.5 Units, IncobotulinumtoxinA (Xeomin), 35 Units
- Where
- 11 sites in Greece, Malaysia and 1 more
- Volunteers
- 61 people
- Sponsor
- Merz Pharmaceuticals GmbH
Cervical Dystonia
Open Label Safety/Immunogenicity Study of MYOBLOC (Neurobloc; Botulinum Toxin Type B) in Patients With Cervical Dystonia
Open label study to evaluate the safety and immunogenicity of MYOBLOC (Botulinum Toxin Type B) in adult patients with a clinical diagnosis of Cervical Dystonia (CD).
- Trial name
- NCT00702754
- Testing
- Botulinum Toxin Type B
- Volunteers
- 502 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of US WorldMeds, LLC
Carpal Tunnel Syndrome
BOTOX® (Onabotulinumtoxin A) Injection(s) as a Treatment for Carpal Tunnel Syndrome
This study will be a prospective double blind controlled randomized trial of ten patients diagnosed with Carpal Tunnel Syndrome (CTS). The study will be completed at offices of medical practices in Arizona.
- Trial name
- NCT02070302
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Benjamin Sucher
Smiling, Botulinum Toxins, Type A
Higher Doses of Botulinum Toxin in the Treatment of Gummy Smile
Botulinum type A (BTX-A) is an easy and efficacious treatment for gingival smile (GS). However, the necessary for higher-doses among patients are controversial.
- Trial name
- NCT05127018
- Testing
- injection of Botulinum type A
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Peking University
Stroke, Pain
Botulinum Toxin A for Shoulder Pain After Stroke
Shoulder pain after stroke is a very common, causing significant morbidity disease. Subacromial and subdeltoid (SASD) bursitis are common causes of pain or disability of the shoulder joint in stroke patients.
- Trial name
- NCT02618603
- Testing
- Botulinum toxin A, Triamcinolone Acetonide
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sir Run Run Shaw Hospital
Scar
Forehead Scars Following Mohs Micrographic Surgery and Reconstruction for Skin Cancer
This study will test if the use of DysportTM (abobotulinumtoxinA) improves wound healing and scarring after Mohs surgery. Research in the laboratory as well as previous studies in humans have shown improved wound healing and…
- Trial name
- NCT01459666
- Testing
- Dysport (abobotulinumtoxinA), Bacteriostatic 0.9% Sodium Chloride (vehicle)
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- University Hospitals Cleveland Medical Center
Bruxism
Which is More Effective in Management of Bruxism: Botox or Occlusal Splints
The aim of this study is to compare the efficacy of Botulinum toxin (Botox) and traditional occlusal splints for the management of bruxism in edentulous patients rehabilitated with MIOD
- Trial name
- NCT04366869
- Testing
- overdenture, occlusal splint, Botox
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Thoracic Outlet Syndrome
Botulinum Toxin Injections for Thoracic Outlet Syndrome
Botulinum toxin type A injected into the anterior and middle scalene muscles will reduce the irritation on the neurovascular structures at the interscalene triangle in subjects with TOS.
- Trial name
- NCT01405482
- Testing
- Botulinum Toxin Type A, Normal Saline injection
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Cerebral Palsy
Safety on Switching Between Different Botulinum Toxin-A
Clinical guidelines recommend the use of Botulinum Toxin-A (BoNT-A) for localized/segmental spasticity in children with cerebral palsy.
- Trial name
- NCT03234413
- Testing
- Botulinum toxin type A
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people
- Sponsor
- Nigar Dursun
Spasticity as Sequela of Stroke
Observational Longitudinal Study on the Outbreak and Management of Stroke Related Spasticity
Stroke is one of the leading cause of death and disability worldwide. Post-stroke spasticity (PSS) is outbreak after a stroke and is featured by disabling muscle stiffness.
- Trial name
- COLOSSEO (NCT05379413)
- Testing
- Botulinum toxin type A
- Where
- 4 sites in Italy
- Volunteers
- 960 people
- Sponsor
- Campus Bio-Medico University