Clinical trials: Botulinum Toxin, Type A
Stroke
Evaluation of BOTOX® With Rehabilitation Therapy for the Treatment of Wrist and Hand Spasticity in Post-Stroke Patients
The present study is designed to determine the safety and effectiveness of injections of BOTOX® in spastic muscles of the arm and hand compared with injections of saline (which would do nothing) when combined with rehabilitation…
- Trial name
- Botox/Rehab (NCT00565201)
- Testing
- Botox and rehab
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Emory University
Urinary Urge Incontinence
Efficacy of Botulinum Toxin Type A for the Treatment of Non-neurogenic Urinary Urge Incontinence
Non-neurogenic urinary urge incontinence (UUI) is a common quality of life disorder that causes people to feel an "urgent" need to urinate.
- Trial name
- NCT01226706
- Testing
- Botulinum Toxins, Type A
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Saskatchewan Health Authority - Regina Area
Hemifacial Spasm
Assessment of Effectiveness and Safety of Dysport® for the Treatment of Hemifacial Spasm
To compare the effectiveness and safety of Dysport® with the domestic Botulinum Toxin Type A (manufactured by Lanzhou Biologic Product Institute, P.R. China) for the treatment of hemifacial spasm.
- Trial name
- NCT00276315
- Testing
- Botulinum toxin type A
- Where
- 4 sites in China
- Volunteers
- 332 people
- Sponsor
- Ipsen
Sialorrhea
Botulinum Toxin-A for Sialorrhoea Treatment in Asian Adults With Neurological Diseases
The efficacy of Botulinum toxin A (BoNT-A) in Asian population has not been properly studied and there is no literature available on the most efficacious dose of BoNT-A for sialorrhoea treatment.
- Trial name
- NCT02425176
- Testing
- Botulinum toxin A (BoNT-A) 50U, Botulinum toxin A (BoNT-A) 100U, Botulinum toxin A (BoNT-A) 200U
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- University of Malaya
Overactive Bladder
Evaluate the Safety and Efficacy of Botulax® Versus Botox® in Patient With Overactive Bladder
To determine the efficacy and safety of Botulax® in treatment of Overactive Bladder
- Trial name
- NCT04186442
- Testing
- Botulinum toxin type A injection, Botulinum Toxin Type A Injection [Botox]
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Hugel
Neurogenic Bladder, Post-operative Urinary Tract Infections
Antibiotic Prophylaxis for Neurogenic Bladder Botox
Injection of Botox into the bladder is a procedure used to treat neurogenic overactive bladder at the Dianne and Irving Kipnes Urology Centre in the Kaye Edmonton Clinic.
- Trial name
- NCT04791579
- Testing
- Ciprofloxacin
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- University of Alberta
Platysmal Bands
Safety and Efficacy of AbobotulinumtoxinA for the Treatment of Platysmal Bands
Interventional phase 2 study to evaluate safety and efficacy of abobotulinumtoxinA for the treatment of platysmal bands.
- Trial name
- NCT04080882
- Testing
- AbobotulinumtoxinA dose 1, AbobotulinumtoxinA dose 2, AbobotulinumtoxinA dose 3
- Where
- 8 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Glabellar Frown Lines
A Phase 3 Clinical Study to Evaluate the Efficacy and Safety of Botulinum Toxin Type A for Injection (CU-20101)
This is a Phase 3 clinical study to evaluate the efficacy, safety, and immunogenicity of single/repeated injections of CU-20101 in the treatment of moderate to severe glabellar lines.
- Trial name
- NCT06585696
- Testing
- CU-20101 treatment for Moderate to Severe Glabellar Striae, BOTOX®
- Where
- China
- Volunteers
- 554 people
- Sponsor
- Cutia Therapeutics（Wuxi）Co.,Ltd
Botulinum Toxins, Type A
Injections of Botulinum Toxin A in Treatment of Patients With Detrusor Overactivity and Impaired Contractility
The objectives of this study is to evaluate and compare the efficacy and safety between 100 U of botulinum toxin A (BoNT-A) suburothelial injections and combined 50 U of BoNT-A suburothelial injections and 50 U urethral injection…
- Trial name
- NCT02135341
- Testing
- Botulinum toxin A
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Epiphora
Determination of the Optimum Delivery Route for Botulinum Toxin A in Patients With Epiphora
Epiphora or excessive tearing is a significant disability for many affected patients diminishing their quality of life. There is a growing consensus that injection of Botulinum Toxin A (BTX-A) into the lacrimal gland provides…
- Trial name
- NCT01282541
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Merbs, Shannath, M.D., Ph.D.
Glabellar Lines
Dysport in the Treatment of Glabellar Lines in Chinese Subjects
The objective of this study is to demonstrate the efficacy of Dysport for the improvement in appearance of moderate to severe glabellar lines and to assess the short term and long term safety of Dysport, used for the improvement…
- Trial name
- NCT02450526
- Testing
- Botulinum toxin type A
- Where
- 10 sites in China
- Volunteers
- 520 people
- Sponsor
- Ipsen
Stroke With Hemiparesis
Study of Botulinum Toxin and Recovery of Hand Function After Stroke
The purpose of this study is to determine whether injections of botulinum toxin (commonly known as BOTOX®) into the affected hand of Stroke patients, while targeting the muscles controlling the hand, will lead to improved use of…
- Trial name
- NCT01422161
- Testing
- Botulinum Toxin commonly known as BOTOX®
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- NYU Langone Health
Overactive Bladder
This is a Prospective, Randomized, Double-Blind Study Comparing Intravesical Injection of Botox® to Placebo.
The current study will investigate the comparative efficacy, safety and patient satisfaction of intradetrusor injections BOTOX® injections (200U) versus placebo (saline) injections in the treatment of OAB secondary to benign…
- Trial name
- BTX0621 (NCT00479596)
- Testing
- Botox
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Urological Sciences Research Foundation
Spasmodic Dysphonia
Zinc Supplementation Prior to Botox Injections for Spasmodic Dysphonia
One initial study has shown that Botulinum Toxin (BT) in combination with zinc supplementation may increase the duration of effects BT treatment. This initial study was in the context of facial aesthetics.
- Trial name
- NCT05892770
- Testing
- Zinc gluconate supplement, Botulinum toxin type A
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Florida
Glabellar Lines
Safety and Efficacy of Two Types of Botulinum Toxin Type A For the Treatment of Glabellar Lines
This study will evaluate the safety and efficacy of two different types of botulinum toxin type A for the treatment of glabellar frown lines.
- Trial name
- NCT01271452
- Testing
- botulinum toxin type A
- Where
- Germany
- Volunteers
- 224 people
- Sponsor
- Allergan
COPD
A Study to Evaluate Safety and Efficacy of BOTOX in Adults With Moderate COPD
The aim of this clinical trial to determine the safety and effectiveness of treating the COPD symptoms with subcutaneous BOTOX injections in participants with moderate COPD.
- Trial name
- NCT06003049
- Testing
- OnabotulinumtoxinA
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- RMW Testing
Prostatitis, Chronic Pain Syndrome
Botox for Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
The objective of this study is to evaluate the safety and efficacy of intraprostatic injection of Botox for the treatment of men diagnosed with chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CP/CPPS).
- Trial name
- NCT00529386
- Testing
- Botox
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Queen's University
Migraine Disorders, Chronic Disease
"Follow the Sutures". A New Procedure for Injection of Botulinum Toxin for Chronic Migraine
There is no doubt that chronic migraine is a large public health problem, which is both disabling and costly. Many patients and headache doctors see Botulinum toxin (Botox) treatment as a big stride forward, but it is a problem…
- Trial name
- NCT03543254
- Testing
- BoNT-A
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Norwegian University of Science and Technology
Knee Pain
Safety and Efficacy of Botulinum Toxin A Injection in Patients With Painful Artificial Knee Arthroplasty (TKA)
Primary Total Knee joint replacement surgery is highly successful surgery for relieving pain and improving function in patients with disabling arthritis.
- Trial name
- NCT00403273
- Testing
- Botulinum toxin A, Normal Saline
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Gummy Smile
Effect of Clinical Crown Lengthening Surgery and Botulinum Toxin A Injection in Gummy Smile Treatment
Background: The demand for beauty is increasing in society as everyone is looking for cosmetic improvement, including gummy smile correction.
- Trial name
- NCT05057286
- Testing
- Clinical crown lengthening surgery
- Where
- Vietnam
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City