Clinical trials: Botulinum Toxin, Type A
Temporomandibular Disorders
Peripheral TMD Pain Mechanisms and the Effect by Botulinum Toxin A
The goal of this clinical trial is to investigate the effect of botulinum toxin on neurons' plasticity in the masseter muscle in humans with and without painful myogenous temporomandibular disorders (TMDM).
- Trial name
- NCT05720065
- Testing
- Botulinum toxin type A, Isotonic saline 0,9%
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Neuralgia
Botulinum Toxin Type A for Neuropathic Pain in Patients With Diabetic Peripheral Polyneuropathy
The purpose of this study is to determine whether botulinum toxin A is effective in the treatment of neuropathic pain in patients with diabetic peripheral polyneuropathy.
- Trial name
- BTXADMPPNP (NCT02460107)
- Testing
- Botulinum toxin type A, Normal saline
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Catholic University of Korea Saint Paul's Hospital
Post Stroke Spasticity
Relation Between Dose and Time to Reinjection of Botulinum Toxin-A in Patient With Poststroke Spasticity From a Real-world Healthcare Insurance Database.
Determining the mean/median time between botulinum toxin-A injection within the treatment of patients with spasticity after stroke in relation to the botulinum toxin dose from a healthcare insurance database in the Netherlands.
- Trial name
- Relax (NCT04649632)
- Where
- Netherlands
- Volunteers
- 451 people
- Sponsor
- Ipsen
Stroke, Muscle Spasticity
Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung Function
The purpose of this study is to evaluate the safety of injections of botulinum toxin Type A in patients with reduced lung function and focal upper limb poststroke spasticity
- Conditions
- Stroke, Muscle Spasticity, Motor Neuron Disease
- Trial name
- NCT00076687
- Testing
- botulinum toxin Type A, saline
- Where
- 4 sites in United States, Czechia and 2 more
- Volunteers
- 155 people
- Sponsor
- Allergan
Stroke
The Effects of Early and Late Injection of Botulinum Toxin Type A on Upper Limb Function in Patients With Stroke
The aim of this study is to determine whether early use of OnabotulinumtoxinA is more effective to improve functional outcomes of upper limb in patients with stroke.
- Trial name
- NCT02580838
- Testing
- OnabotulinumtoxinA
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Cheng-Kung University Hospital
Pain, Postoperative
Investigating Temporalis and Masseter Botox Injection Before Orthognathic Surgery to Improve Postoperative Pain
Jaw surgery has become a very successful way to improve the appearance and functional needs of patients. Like any surgery, jaw surgery comes with a host of possible issues that patients may experience during their recovery.
- Trial name
- NCT04794504
- Testing
- Botox 100 UNT Injection, 0.9% Saline Injection
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Kingsway Oral & Maxillofacial Surgery
Blepharospasm
Safety and Efficacy of NABOTA in Treatment of Essential Blepharospasm
The purpose of this study is to evaluate the Efficacy and Safety of NABOTA in treatment of essential blepharospasm
- Trial name
- NCT02947815
- Testing
- Clostridium Botulinum Toxin Type A
- Where
- South Korea
- Volunteers
- 234 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Cerebral Palsy, Spastic, Physical Therapy
Effect of Botulinum Toxin Type A Associated With Physical Therapy on Children With Spastic Cerebral Palsy
Purpose: The aim of this study was investigate the effects of botulinum toxin type A (BoNT-A) associated with physical therapy on the functional capacity of children with spastic cerebral palsy (CP).
- Conditions
- Cerebral Palsy, Spastic, Physical Therapy, Botulinum Toxin
- Trial name
- NCT03704155
- Testing
- Botulinum toxin type A, Physical Therapy
- Volunteers
- 24 people
- Sponsor
- University of Nove de Julho
Moderate to Severe Glabellar Lines
A Phase III Study to Evaluate the Efficacy and Safety of Recombinant Botulinum Toxin Type A for Injection in the Treatment of Moderate to Severe Glabellar Lines
This is a randomized, double-blind, placebo- and active-controlled parallel-group multi-center phase III study to evaluate the efficacy and safety of Rcombinant botulinum neurotoxin type A for injection (YY001)) in the treatment…
- Trial name
- NCT06499688
- Testing
- Rcombinant botulinum neurotoxin type A for injection (YY001), OnabotulinumtoxinA
- Where
- 16 sites in China
- Volunteers
- 529 people
- Sponsor
- Chongqing Claruvis Pharmaceutical Co., Ltd.
Stroke, Muscle Spasticity
Assessment and Management of Post-Stroke Spasticity With Botulinum Toxin-A
Within the first year after stroke, approximately 38% of stroke survivors experience an increased resistance to movement, also called spasticity.
- Trial name
- NCT01751373
- Testing
- Optimal muscle activation therapy, Standard Therapy
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Sunnybrook Health Sciences Centre
Glabellar Lines
The Safety and Efficacy Study of HU-014 Versus Botox® in Subject With Moderate to Severe Glabellar Lines
A Phase I/Ⅱ Clinical Trial to Compare the Safety and Efficacy of HU-014 versus Botox® in Subject with Moderate to Severe Glabellar Lines
- Trial name
- NCT02961673
- Testing
- HU-014 Inj, Botox Inj
- Where
- South Korea
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Huons Co., Ltd.
Pain Due to Certain Specified Procedures, Neuropathic Pain
Early Administration of Botox® in Neuropathic Pain Due to Thoracoscopy or Thoracotomy
Botulinum toxin type A has been reported to inhibit the release of various pain neurotransmitters (SP, CGRP, glutamate) responsible for neurogenic inflammation, a process that results from the sensitization of C-fiber nociceptors…
- Trial name
- APTODON (NCT01325090)
- Testing
- BOTOX
- Where
- France
- Sponsor
- University Hospital, Limoges
Multiple Sclerosis, Spasticity, Muscle
" Treating MS Patients With Lower Extremity Spasticity Using Dysport"
The purpose of this study is to determine whether Dysport® (abobotulinumtoxinA) injections for lower extremity spasticity showed a significant reduction of lower extremity spasticity after being injected with Dysport®…
- Trial name
- NCT03585569
- Testing
- Abobotulinumtoxin A
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Neurology Center of New England P.C.
Stroke
Improving Holding Function of the Hemiplegic Hand
Relevant to patients with spastic hemiparesis in the hand and upper limb, this pilot project proposes to measure the effects of botulinum toxin injections through observation of performance on a functional task known as 'hand as…
- Trial name
- NCT02459951
- Testing
- clenched fist
- Volunteers
- 10 people
- Sponsor
- Nathaniel Mayer
Hyperhidrosis
A Study Using Botulinum Toxin Type A in Patients With Axillary Hyperhidrosis
This is a three year open-label study in subjects with axillary hyperhidrosis.
- Trial name
- NCT00168480
- Testing
- Botulinum Toxin Type A
- Where
- 4 sites in United States, Germany and 2 more
- Volunteers
- 424 people
- Sponsor
- Allergan
Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders
Arthrocentesis-PRF Versus Botulinum Toxin for Management of ADDwR
Temporomandibular joint (TMJ) internal derangement is a common cause of temporomandibular disorders and is often associated with pain, restricted mandibular movement, joint sounds, and functional limitations during mastication…
- Conditions
- Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders, Temporomandibular Disorders (TMD), TMJ Pain
- Trial name
- NCT07385742
- Testing
- Injectable Platelet-Rich Fibrin (I-PRF) Injection, Botulinum Toxin Type A (BOTOX) Injection
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Tennis Elbow
Effectiveness of Botulinum Toxin Injection in the Tennis Elbow Treatment
Some studies valued the effectiveness of botulinum toxin. Results are contradictory and we need more studies. The purpose of the study is to compare the effectiveness of botulinum toxin injection with placebo in the treatment of…
- Trial name
- TBA (NCT00437762)
- Testing
- Botulinum Toxin A Injection
- Where
- France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Bordeaux
Temporomandibular Disorder, Bruxism
Botulinum Toxin Administration on Masticatory Performance
This study aimed to evaluate the effect of botulinum toxin type A (BTX-A) injection on masticatory performance and nutritional status in temporomandibular disorder patients with bruxism caused by both intra-articular and…
- Trial name
- NCT05562531
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marmara University
Overactive Bladder (OAB), Urinary Tract Infection (Diagnosis)
Methenamine Hippurate Following Intradetrusor OnabotulinumtoxinA Injection
The goal of this clinical trial is to compare methenamine hippurate prophylaxis to routine antibiotic prophylaxis following onabotulinumtoxinA (BOTOX-A) injections in women with overactive bladder (OAB).
- Trial name
- META (NCT06953271)
- Testing
- Methenamine Hippurate, Typically prescribed oral antibiotic prophylaxis
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Cervical Dystonia
Post-marketing Surveillance of Administration of Botulinum Toxin Type B(NerBloc)-Investigation of the Clinical Condition in Patients With Change From Botulinum Toxin Type A
Investigation of the clinical condition in patients with cervical dystonia by Toronto Western Spasmodic Torticollis Scale (TWSTRS)
- Trial name
- NCT02175719
- Where
- 2 sites in Japan
- Volunteers
- 150 people
- Sponsor
- Eisai Co., Ltd.