Clinical trials: Botulinum Toxin, Type A
Cervical Dystonia
Single Treatment of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-1)
This is a randomized, double-blind, placebo-controlled, parallel group, multi-center trial of two doses of daxibotulinumtoxinA (DAXI) for injection (high-dose; low-dose in adult subjects with isolated (primary) cervical dystonia…
- Trial name
- ASPEN-1 (NCT03608397)
- Testing
- DaxibotulinumtoxinA for injection
- Where
- 75 sites in United States, Austria and 7 more
- Volunteers
- 301 people
- Sponsor
- Revance Therapeutics, Inc.
Intrinsic Aging of Skin, Solar Elastosis
Onabotulinum Toxin Type A and Abobotulinum Toxin Type A Crow's Feet Rhytid Study
The objective of the study is to compare the time to onset of Dysport® versus Botox® in the treatment of lateral orbital rhytids ("crow's feet").
- Trial name
- NCT01529788
- Testing
- Right lateral orbital injection of Botox Cosmetic or Dysport, Left lateral orbital injection of Botox Cosmetic or Dysport
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Maas Clinic
Cerebral Palsy, Muscle Spasticity
Dysport® Pediatric Lower Limb Spasticity Study
The purpose of this research study is to determine whether Dysport® is effective in the treatment of increased stiffness of the calf muscles and to evaluate the safety of this treatment in children with Cerebral Palsy.
- Conditions
- Cerebral Palsy, Muscle Spasticity, Children
- Trial name
- NCT01249417
- Testing
- Botulinum toxin type A
- Where
- 29 sites in United States, Chile and 4 more
- Volunteers
- 241 people
- Sponsor
- Ipsen
Glabellar Lines, Glabellar Frown Lines
A Non-inferiority Clinical Trial to Compare Efficacy and Safety of Abobotulinumtoxin A (Espad Pharmed) Versus AbobotulinumtoxinA (Dysport®, Ipsen Co.) for Correction of Moderate to Severe Glabellar Lines
The aim of this study is to evaluate the efficacy and safety of AbobotulinumtoxinA (produced by Espad Pharmed Darou Co.) for correction of moderate to severe glabellar lines.
- Trial name
- NCT06946160
- Testing
- Abobotulinumtoxin A (Espad Pharmed Darou Co.), Abobotulinumtoxin A (Ipsen Co.)
- Where
- Iran
- Volunteers
- 146 people
- Sponsor
- Espad Pharmed
Chronic Migraine
Trip-Tox, Effectiveness of Triptans Before and After Onabotulinumtoxin A Treatment in Chronic Migraine
Observational, longitudinal, prospective, prospective, comparative study of the effectiveness of triptans before and after onabotulintoxin A initiation in a single group of chronic migraine patients.
- Trial name
- NCT04871152
- Testing
- OnabotulinumtoxinA
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Chronic Migraine
A Study to Evaluate Botulinum Toxin Type A for Injection（HengLi®）for Prophylactic Treatment of Chronic Migraine
A study, multi-center, randomized, double-blind, placebo parallel-controlled method, will be carried out to evaluate the safety and efficacy of Botulinum Toxin Type A for injection (HengLi®) for prophylactic treatment with…
- Trial name
- NCT02291380
- Testing
- Botulinum Toxin Type A for Injection
- Volunteers
- 288 people
- Sponsor
- Lanzhou Institute of Biological Products Co., Ltd
Stroke
Botulinum Toxin Type A and Kinesitherapy of Post-stroke Patients
The objective of this study is to assess if the association of botulinum toxin type A and kinesitherapy is superior to kinesitherapy and 0,9% saline for the functional performance in post-stroke patients.
- Trial name
- NCT00999180
- Testing
- Botulinum toxin type A and kinesiotherapy, Saline and Kinesiotherapy
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Bahia
Hemifacial Paralysis
Onabotulinumtoxin A and Hyaluronic Acid Fillers in the Treatment of Facial Paralysis
Social interaction via facial mimic expression is crucial in human relationship and communication. Neural function disorder in this mechanism therefore affects human communication and social interaction.
- Trial name
- NCT05012566
- Testing
- Juvederm, Vistabex
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Upper and/or Lower Limb Focal Spasticity
A Study to Review Treatment Outcomes From Treatment With Dysport® Injections in Adults for Upper and/or Lower Limb Focal Spasticity
The aim of this retrospective study is to describe the real-world outcomes with the treatment of adult patients with Dysport® injections for focal upper limb spasticity (ULS) and/or focal lower limb spasticity (LLS) in NHS…
- Trial name
- DYSCOVER (NCT04604379)
- Where
- 3 sites in United Kingdom
- Volunteers
- 123 people
- Sponsor
- Ipsen
Vulvodynia
Botulinum Toxin A as a Treatment for Provoked Vestibulodynia
Women with provoked vestibulodynia (PVD) suffer from severe dyspareuni and often present a hyperactivity of the pelvic floor muscles (PFM) which maintain the dyspareunia.
- Trial name
- NCT04057755
- Testing
- botulinum toxin A, NaCl
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Botulinum Toxins, Type A, Hernia
The Effects of Preoperative Botulinum Toxin A Injection on Respiratory System Function
Hernias are common complications post-abdominal surgeries, often leading to significant issues such as "loss of domain," where organs shift permanently, reducing abdominal cavity capacity.
- Trial name
- NCT06485440
- Testing
- Dysport 300 UNT Injection
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Swissmed Hospital
Catocholamine Induced Finger Necrosis
Botulinum Toxin A for Treatment of Catocholamine Induced Finger Necrosis
Patients in the intensive care unit (ICU) often require blood pressure support of vasoactive drugs such as amines. Finger necrosis (so called "blue toe syndrome") is a well documented phenomena with incidence reaching as high as…
- Trial name
- NCT01500668
- Testing
- Botox
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Urinary Incontinence, Overactive Bladder
A Safety and Efficacy Study of BOTOX® (Botulinum Toxin Type A) in Patients With Urinary Incontinence Due to Neurogenic Detrusor Overactivity or Overactive Bladder in India
This is a Post-Marketing Surveillance study in India to evaluate safety and efficacy of BOTOX® (Botulinum Toxin Type A) in the treatment of patients with urinary incontinence due to neurogenic detrusor overactivity or overactive…
- Trial name
- NCT02590250
- Testing
- botulinum toxin Type A
- Where
- 12 sites in India
- Volunteers
- 250 people
- Sponsor
- Allergan
Chronic Pain, Chronic Pelvic Pain Syndrome
BTA vs Baclofen for Pelvic Myofascial Pain Syndrome
The aim of the study is to test the hypothesis that oral taking of baclofen in therapeutic dosage for 60 days is equally effective as injection of botulinum toxin type "A" in the area of trigger points of the pelvic muscles.
- Conditions
- Chronic Pain, Chronic Pelvic Pain Syndrome, Myofascial Pain Syndrome, Myofascial Trigger Point Pain
- Trial name
- BvsB (NCT05617118)
- Testing
- Baclofen 10mg, Botulinum toxin type A
- Where
- Russia
- Volunteers
- 52 people
- Sponsor
- Saint Petersburg State University, Russia
Stress Urinary Incontinence
Feasibility of BOTOX Injection on Improving Female Stress Urinary Incontinence
The purpose of this study is to assess the effect of onabotulinumtoxin A (BOTOX) injection into the detrusor muscle on increasing bladder compliance to reduce urinary leakage in women suffering from stress urinary incontinence…
- Trial name
- NCT04984317
- Testing
- onabotulinumtoxin A
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Platysma Prominence
A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Platysma Prominence
The purpose of the study is to evaluate the safety and effects of onabotulinumtoxinA (BOTOX) for the temporary improvement in the appearance of platysma prominence.
- Trial name
- NCT04994535
- Testing
- OnabotulinumtoxinA
- Where
- 34 sites in United States, Belgium and 3 more
- Volunteers
- 426 people
- Sponsor
- AbbVie
Chronic Low Back Pain
Botulinum Toxin A for the Treatment of Chronic Lumbar Back Pain
This study will assess the efficacy and the duration of efficacy of Botulinum toxin A (Botox®) injected into the lumbar paraspinal muscles for reducing pain and disability in subjects suffering from chronic low back pain of six…
- Trial name
- NCT00404417
- Testing
- Botulinum Toxin A / Botulinum Toxin A
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Blepharospasm, Hemifacial Spasm
Pretarsal Versus Preseptal Botulinum Toxin for Patients With Eyelid Spasm
A triple-masked placebo-controlled trial assessing the efficacy and safety of pretarsal versus preseptal botulinum toxin for patients with eyelid spasm.
- Conditions
- Blepharospasm, Hemifacial Spasm, Botulinum Toxins, Type A
- Trial name
- NCT03508882
- Testing
- Botulinum Toxin Type A 100Unit/Vial (Product), Saline Solution for Injection
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Urgency Urinary Incontinence
Reduction in Number of Botox Injections for Urgency Urinary Incontinence
The overall objective of this study is to determine if a reduced injection site protocol (5 injection sites) using an equivalent amount of Botox provides comparable relief of Urgency Urinary Incontinence (UUI) symptoms compared…
- Trial name
- NCT04731961
- Testing
- Standard of care (15 Botox injections), Experimental Arm (5 Botox injections)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Virginia
Myofascial Pelviperineal Pain
Multicenter Randomized Double-blind Study Evaluating the Effects of Botulinum Toxin A Associated With ropivacaïne Versus ropivacaïne Alone in the Treatment of the Myofascial Pelviperineal Pain
Myofascial pains are frequently found during the clinical examination of the patients presenting a painful chronic syndrome of the pelvis or the perineum.
- Trial name
- MYOTOX (NCT01967524)
- Testing
- botulinum toxin A + ropivacaïne, Ropivacaïne
- Where
- 6 sites in France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital