Clinical trials: Botulinum Toxin Injection
Cerebral Palsy
Music Therapy During Botulinum Injections
The primary objectives for this study are: 1. To demonstrate that music therapy can be an effective means of procedural support for children undergoing botox injections. 2.
- Trial name
- NCT00178217
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Rochester
Functional Popliteal Artery Entrapment Syndrome, Popliteal Artery Entrapment Syndrome
Botulinum Toxin Injection for Functional Popliteal Artery Entrapment Syndrome
Failure to adequately diagnose and treat patients with functional popliteal artery entrapment syndrome (PAES) leads to continued pain, loss of function and poor quality of life for many patients nationwide.
- Trial name
- NCT03631966
- Testing
- Dysport
- Where
- United States
- Sponsor
- Stanford University
Hemifacial Microsomia, Facial Nerve Paralysis
Treatment for "Asymmetric Crying Facies"
This study focuses on children with hemifacial microsomia (HFM), a common congenital craniofacial deformity caused by abnormal development of the first and second branchial arches.
- Trial name
- NCT07802639
- Testing
- Botulinium toxin type A injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaolei Jin
Vaginismus
Botulinum Toxin Injection for Treatment of Vaginismus
According to high rate of vaginismus (about 10 percent) which leads to unconsummated marriage (about 1 percent) and low efficacy for conventional treatments such as biofeedback therapy, analgesic drugs and pain killers and…
- Trial name
- NCT00638066
- Testing
- botulinum toxin, botulinum toxin A
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Stroke
Comparative Hybrid Effects of Combining BoNT-A With Robot-assisted or Mirror Therapy for U/E Spasticity Stroke Patients
The aim of this study will be to determine and compare the immediate and longer-term effects of combination of BoNT-A injection and mirror therapy vs combination of BoNT-A injection and robot-assisted therapy.
- Trial name
- NCT02749591
- Testing
- Botulinum Toxin Type A, Robot-assisted therapy, Mirror therapy
- Where
- Taiwan
- Volunteers
- 37 people
- Sponsor
- Chang Gung Memorial Hospital
Incisional Hernia
Botulinum Toxin A Facilitates Fascial Closure in Complex Incisional Hernias
Brief Study Description This prospective observational study evaluates the use of preoperative botulinum toxin A as part of a structured clinical pathway for patients undergoing elective repair of complex midline incisional…
- Trial name
- BRIDGE-HERNIA (NCT07349628)
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- Azienda Sanitaria Locale Napoli 2 Nord
Idiopathic Toe Walking
Trial of a Botulinum A Toxin (Botox) Injection in the Gastrocnemius Muscle in Children With Idiopathic Toe Walking
The purpose of this study is to compare the effect of Botox and casting to placebo and casting for reducing toe walking problems in children who are idiopathic toe walkers.
- Trial name
- NCT00175669
- Testing
- Botox injections
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Recalcitrant Alopecia Totalis, Recalcitrant Alopecia Universalis
The Randomized Double-blind Placebo-controlled Trial of Intralesional Botulinum Toxin A Injection for Recalcitrant Alopecia Totalis and Alopecia Universalis
The main purpose of this study is to determine the efficacy of intralesional botulinum toxin type A injection for recalcitrant alopecia totalis and alopecia universalis.
- Trial name
- NCT00997815
- Testing
- Botulinum toxin A, Normal saline injection
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Siriraj Hospital
Spastic Equinovarus
Treatment of Spastic Equinovarus Foot After Stroke
This study evaluates treatment for spastic foot after stroke using ankle foot orthosis with or without selective injection of BTA (Botox).
- Trial name
- NCT00199589
- Testing
- Botulinic toxin (Botox)
- Where
- 2 sites in France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Limoges
Overactive Bladder, Urinary Incontinence
Botulinum-A Toxin Injection for Detrusor Hyperreflexia in Spinal Cord Injury: A Non-Surgical Approach.
The purpose of the study is to determine whether Botulinum-A toxin injected in the bladder muscle will help prevent the frequency and degree of urinary incontinence in Spinal Cord Injured and Multiple Sclerosis patients.
- Trial name
- NCT00262496
- Testing
- Botox
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Trigeminal Neuropathy, Traumatic
Botulinum Toxin Injections for Oral Neuropathic Pain
Peripheral painful traumatic trigeminal neuropathy (PPTTN) are poorly relieved by existing treatments which in addition induce many adverse effects.
- Trial name
- TRIGTOX (NCT03555916)
- Testing
- BOTOX®, Allergan
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Upper Esophageal Sphincter
Cricopharyngeal Dysfunction in Adults
The objective of the study, after reviewing the recent literature, is to corroborate the thesis of the authors considering the injection of botulinum toxin as a gesture that is both diagnostic and therapeutic in the disorders of…
- Trial name
- NCT03598933
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Strasbourg, France
Eye Diseases
Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease
In active phase of thyroid eye disease some patients have obvious upper lid retraction , and sometimes exposure keratopathy .To date there is not any standard treatment for this situation .
- Trial name
- NCT00370734
- Testing
- Botulinum toxin A injection
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Facial Paralysis
Myofunctional Therapy in Facial Palsy
Objective: Quantify the benefits of myofunctional therapy associated to botulinum toxin injection in patients with long standing facial unilateral palsy.
- Trial name
- NCT00989209
- Testing
- Botulinum Toxin Type A, myofunctional therapy
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Glabellar Frown Lines
Depth of Botulinum Neurotoxin Injection for Treatment of Glabellar Lines
STUDY QUESTION: Does the depth of injection of onabotulinumtoxinA neurotoxin in the glabellar complex affect efficacy of the BoTN for the improvement of glabellar frown lines? STUDY AIM Primary objective: Compare the efficacy of…
- Trial name
- NCT05766683
- Testing
- onabotulinumtoxinA at a depth of 2mm, onabotulinumtoxinA at a depth of 4mm
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Synkinesis
Botox Injections in Non-Cranial Nerve VII Innervated Muscles for Facial Synkinesis
Facial synkinesis is a condition that occurs following facial nerve (CN7) injury, typically secondary to Bell's palsy, trauma, surgery (e.g., acoustic neuroma resection), or malignancy.
- Trial name
- NCT07295288
- Testing
- Botulinum Toxin Type A Injection [Botox]
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Stroke, Muscle Spasticity
The Effectiveness of Early Botulinum Toxin A Injection for Lower Limbs Spasticity in Subacute Stroke Adults
Botulinum toxin A (BoNT-A) injections are widely used to treat spasticity after stroke. Although this treatment is effective on muscle tone improvement, its effect on gait and ability of daily living on early stage of stroke…
- Trial name
- NCT02505802
- Testing
- BoNT-A injection
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Facial Aging, Melomental Folds
Botulinum Toxin Type A Injection Sites for Oral Commissure Ptosis
This multicenter, prospective, randomized parallel-controlled, assessor-blinded clinical trial aims to address the core clinical pain point of lack of high-level evidence and non-standardized operation in injection site selection…
- Conditions
- Facial Aging, Melomental Folds, Oral Commissure Ptosis
- Trial name
- NCT07646886
- Testing
- OnabotulinumtoxinA (Upper Depressor Anguli Oris Injection), OnabotulinumtoxinA (Lower Depressor Anguli Oris Injection)
- Volunteers
- 266 people
- Sponsor
- Peking University
Obstructed Defecation Syndrome (ODS)
Effects of Botox in Obstructed Defecation Syndrome
The purpose of this study is to determine if Botulinum Toxin-A (Botox) injection will improve symptoms of constipation in obstructed defecation syndrome (ODS).
- Trial name
- NCT02160288
- Testing
- Botulinum Toxin-A, Normal Saline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital
Moderate to Severe Glabellar Lines
Efficacy and Safety of Recombinant Botulinum Toxin Type A (Eveotox) for Injection to Treat Moderate to Severe Glabellar Lines
This is a Phase 3 clinical study to evaluate the efficacy, safety, and immunogenicity of single/repeated injections of Eveotox in the treatment of moderate to severe glabellar lines.
- Trial name
- NCT06937944
- Testing
- Rcombinant botulinum toxin type A for injection（Eveotox), OnabotulinumtoxinA (Botox)
- Where
- 15 sites in China
- Volunteers
- 669 people
- Sponsor
- JHM BioPharma (Tonghua) Co. , Ltd.