Clinical trials: Botulinum Toxins, Type A
Essential Axillary Hyperhidrosis
Unicentric Comparing Study of Suction Curettage With Standard BOTOX Injection in the Treatment of Patients With Essential Axillar Hyperhidrosis: Comparing of Efficacy, Duration of Effectiveness, and Adverse Events.
Part 1: patients with essential hyperhidrosis are treated one time with suction curettage in both axillae. Part 2: patients with axillary hyperhidrosis receive one treatment with suction curettage in one axilla, and at the same…
- Trial name
- NCT00669474
- Testing
- Suction curettage, Treatment with Botox
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- University Hospital, Ghent
Hemifacial Spasm
Assessment of Effectiveness and Safety of Dysport® for the Treatment of Hemifacial Spasm
To compare the effectiveness and safety of Dysport® with the domestic Botulinum Toxin Type A (manufactured by Lanzhou Biologic Product Institute, P.R. China) for the treatment of hemifacial spasm.
- Trial name
- NCT00276315
- Testing
- Botulinum toxin type A
- Where
- 4 sites in China
- Volunteers
- 332 people
- Sponsor
- Ipsen
Neuropathic Pain
Intraoral Administration of Botox in Patients With Dentoalveolar Neuropathic Pain
Onabotulinum toxin type A (BoNT-A) is a potent neurotoxin that has been reported to have an effect on afferent (sensory) neurons independent of its action on muscle tone and secretory glands at the periphery.In human studies, the…
- Trial name
- NCT03848143
- Testing
- onabotulinum toxin A
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Isabel Moreno Hay
Erectile Dysfunction
Intracavernous Injection of Botox 100 U for Treatment of PDE5Is Inconvenient Patients With ED
There is a new emerging concept that Botulinum Toxin Type A may have a potential role in treatment of erectile dysfunction with a longer duration of action.
- Trial name
- NCT04172558
- Testing
- OnabotulinumtoxinA, Trimix
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Benha University
Groin Injury, Tendinopathy
Pubalgia and Adductor Tendinopathies Refractory to Medical Treatment
Pubalgia is a pain syndrome located in the groin area. This syndrome is mainly described in young male athletes and typically affect the superficial muscles defining the boundaries of the femoral triangle, i.e.
- Trial name
- PETRA (NCT03496649)
- Testing
- Dysport 500 Unit Powder for Injection
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Bordeaux
Skin Cancer Excision Site, Basal Cell Carcinoma
Impact of Dysport on PMFF Donor Scar
The purpose of this research study is to investigate the effect of pre-operative injections of Dysport (Abobotulinumtoxin-A, commonly known as "Botox") on the cosmetic appearance of and overall satisfaction with study…
- Conditions
- Skin Cancer Excision Site, Basal Cell Carcinoma, Squamous Cell Carcinoma, Melanoma
- Trial name
- NCT07720726
- Testing
- Abobotulinumtoxin-A, Control- Saline injection
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
Systemic Sclerosis Patients With Digital Ulcers
Effect and Safety of Local Injection of Botulinum Toxin Type B Against Digital Ulcer in Systemic Sclerosis
Efficacy and safety of local infusion of botulinum toxin type B in patients with systemic sclerosis (SSc) with digital ulcer is evaluated by a randomized, double-blind study.
- Trial name
- NCT03007004
- Testing
- Botulinum toxin type B (2500 units / vial), Physiological saline
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- Gunma University
Torticollis
Comparative Trial of Botox in the Management of Children With Congenital Muscular Torticollis
The primary purpose is to investigate the effect of Botox on the treatment of congenital muscular torticollis (CMT). The investigators' hypothesis is that a Botox injection will be an effective treatment when used in conjunction…
- Trial name
- NCT00175604
- Testing
- Botox
- Where
- Canada
- Sponsor
- University of British Columbia
Interstitial Cystitis, Bladder Pain Syndrome
Bladder Instillations Versus Onabotulinumtoxin A for Treatment of Interstitial Cystitis/Bladder Pain Syndrome
Recognition of interstitial cystitis (IC)/bladder pain syndrome (BPS) is increasing. There is a dire need to develop effective treatment options for these patients as it manifests as more than a physical disease, affecting…
- Trial name
- NCT04401176
- Testing
- Heparin & Alkalinized Lidocaine Bladder Instillation, Onabotulinum Toxin A
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Walter Reed National Military Medical Center
Idiopathic Overactive Bladder, Postoperative Urinary Tract Infection
Antibiotic Prophylaxis for Bladder Botox
Injection of Botox into the bladder is a common treatment for overactive bladder. Postoperative bladder infection is one of the more frequently reported complications of this procedure.
- Trial name
- NCT04444440
- Testing
- Ciprofloxacin
- Where
- Canada
- Volunteers
- 202 people
- Sponsor
- University of Alberta
Gummy Smile Due to Hypermobile Upper Lip
Effect of Cross-linked Hyaluronic Acid Filler Versus Botulinum Toxin Type A (Botox) in Management of Gummy Smile
A smile is supposed to express one's feelings and expressions, for that there has been an awakening concern for the appearance of gummy smile. Gummy smile is the appearance of about 2mm or more of the gingiva during smiling.
- Trial name
- NCT06952218
- Testing
- Injection of cross linked hyaluronic acid filler
- Where
- 2 sites in Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Facial Rhytides
A Study of Subject Satisfaction With BOTOX® Cosmetic Treatment in Facial Rhytides
This is a safety and efficacy study of BOTOX® in subjects with facial rhytides (glabellar lines and crow's feet lines).
- Trial name
- NCT01777620
- Testing
- onabotulinumtoxinA, Normal Saline
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- Allergan
Peripheral Neuropathy Due to Chemotherapy
Botulinum Toxin A for the Treatment of Chemotherapy Induced Peripheral Neuropathy
Chemotherapy induced peripheral neuropathy (CIPN) is a common side effect of taxanes and platinum derivative based chemotherapeutic agents, common in breast cancer treatment regimens.
- Trial name
- NCT03571334
- Testing
- IncobotulinumtoxinA (Xeomin®, Merz) (INA), Normal saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
Erectile Dysfunction, Botulinum Toxin
Intracavernosal Injection of Botulinum Toxin Type A (50 and 100 Unit) in the Treatment of Erectile Dysfunction
purpose: The aim of this study is to compare the safety, efficacy and durability of different doses of BTX-A (50 and 100 unit) in the treatment of Vasculogenic Erectile Dysfunction after failure of other ICI therapy.
- Trial name
- NCT03355963
- Testing
- saline injection, Botulinum toxin type A 50 units, Botulinum toxin type A 100 units
- Volunteers
- 200 people
- Sponsor
- Benha University
Equinus Foot Deformity in Children With Cerebral Palsy
PerLE (Peroneus Longus Evaluation): A Study Evaluating the Efficacy of Injection of Dysport in Peroneus Longus in Equinus Foot Deformity in Children With Cerebral Palsy
A recent publication (Boulay et al. 2012) highlighted the role of the peroneus longus (PL) muscle in equinus foot deformity in children with hemiplegia.
- Trial name
- PerLE (NCT02856321)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Overactive Bladder Syndrome, Urinary Urge Incontinence
Platelet-Rich Plasma Versus Botulinum Toxin for Refractory Overactive Bladder: A Randomized Trial
Overactive bladder is a common condition that causes sudden urges to urinate, frequent urination, night-time urination, and sometimes leakage of urine.
- Conditions
- Overactive Bladder Syndrome, Urinary Urge Incontinence, Detrusor Overactivity
- Trial name
- NCT07184307
- Testing
- Platelet-Rich Plasma, Intravesical Botulinum Toxin Injection
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Benha University
Chronic Migraine, Headache
Onabotulinumtoxin Type A Reconstitution With Preserved Versus Preservative-free Saline in Chronic Migraine.
A growing body of literature on the cosmetic use of OnabotulinumtoxinA has suggested that the use of preserved saline exerts a local anesthetic effect, and reduces the procedure discomfort when used in reconstitution in lieu of…
- Trial name
- B-RECON (NCT03698409)
- Testing
- Preserved saline in reconstitution of Botox
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- State University of New York - Upstate Medical University
Spinal Cord Injury, Neuropathic Pain
Neuropathic Pain Study With Botulinum Toxin A in Spinal Cord Injury Patients
The purpose of this study is to determine whether botulinum toxin A is effective in the treatment of neuropathic pain in spinal cord injury patients.
- Trial name
- NCT01579500
- Testing
- Botulinum toxin type A, normal saline
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Catholic University of Korea Saint Paul's Hospital
Cerebral Palsy
Safety on Switching Between Different Botulinum Toxin-A
Clinical guidelines recommend the use of Botulinum Toxin-A (BoNT-A) for localized/segmental spasticity in children with cerebral palsy.
- Trial name
- NCT03234413
- Testing
- Botulinum toxin type A
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people
- Sponsor
- Nigar Dursun
Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders
Arthrocentesis-PRF Versus Botulinum Toxin for Management of ADDwR
Temporomandibular joint (TMJ) internal derangement is a common cause of temporomandibular disorders and is often associated with pain, restricted mandibular movement, joint sounds, and functional limitations during mastication…
- Conditions
- Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders, Temporomandibular Disorders (TMD), TMJ Pain
- Trial name
- NCT07385742
- Testing
- Injectable Platelet-Rich Fibrin (I-PRF) Injection, Botulinum Toxin Type A (BOTOX) Injection
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
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