Clinical trials: Botulinum Toxins, Type A
Interstitial Cystitis
Efficacy of Botulinum Toxin Type A in Patients With Bladder Pain Syndrome/Intersticial Cystitis and Hunners' Lesions
The etiology of bladder pain syndrome is unknown. Therefore the management is directed to pain relief, as bladder pain is believed to drive both voiding frequency and nocturia.
- Trial name
- NCT01437579
- Testing
- intratrigonal injection of botulinum toxin, cystoscopy
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Moscow State University of Medicine and Dentistry
Myelomeningocele, Bladder, Neurogenic
Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele
The purpose of this study is to examine how injection of botulinum toxin in the bladder affects bladder function. The trial is carried out in children born with malformation of the spinal cord and subsequent overactive bladders.
- Trial name
- NCT00175123
- Testing
- Botulinum A toxin
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
N/A, as no Specific Medical Condition Will be Treated
A Study to Evaluate the Distribution of Botulinum Neurotoxin Type A Administered as Intradermal Injections, Comparing Different Doses, Concentrations, and Delivery Methods
The purpose of this study is to evaluate the distribution of IncobotulinumtoxinA (Xeomin) in healthy subjects at different volumes, concentrations and doses when administered intradermally and subcutaneously using different…
- Trial name
- NCT05585398
- Testing
- IncobotulinumtoxinA
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merz Pharmaceuticals GmbH
Bite Force, Botulinum Toxins, Type A
Muscle Weakness Duration After Single Botulinum Toxin Injection in Masseter
This study aimed to evaluate the duration of a reduced maximal voluntary bite force after a botulinum toxin intervention. Methods: In an intervention group, 25 units of Xeomin® (Merz Pharma GmbH \& Co KGaA, Frankfurt am Main…
- Trial name
- NCT05309564
- Testing
- Botulinum toxin type A
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Region Västerbotten
Spasticity, Stroke
A Randomized, Double Blind, Multi-center, Active Drug Controlled, Phase III Clinical Trial to Compare the Safety and Efficacy of DWP450 Versus Botox® in Treatment of Post Stroke Upper Limb Spasticity
Purpose: This study is a Randomized, Double Blind, Multi-center, Active Drug Controlled, Phase III Clinical Trial to Compare the Safety and Efficacy of DWP450 Versus Botox® in Treatment of Post Stroke Upper Limb(wrist, finger…
- Trial name
- NCT01945684
- Testing
- Botulinum toxin type A
- Where
- South Korea
- Volunteers
- 197 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Trigeminal Neuropathy, Traumatic
Botulinum Toxin Injections for Oral Neuropathic Pain
Peripheral painful traumatic trigeminal neuropathy (PPTTN) are poorly relieved by existing treatments which in addition induce many adverse effects.
- Trial name
- TRIGTOX (NCT03555916)
- Testing
- BOTOX®, Allergan
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Facial Aging, Facial Wrinkles and Rhytides Reduction
Intradermal Microbotulinum Toxin for Sebum Reduction and Facial Pore Improvement
This study aims to evaluate the efficacy and safety of microdoses of botulinum toxin type A (microtoxin) for improving periocular skin quality and reducing fine wrinkles.
- Trial name
- MICROTOX-PORE (NCT07526870)
- Testing
- Botulinum Toxin Type A (Dysport®)
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Vaginismus
Injection of Botox in the Perineal Muscles in Resistant Cases of Vaginal Spasm
During the first visit, the couple will be acquainted with their condition. This will include the epidemiology of their condition, some sex education tips, as well as the therapeutic modalities available.
- Trial name
- VginsmsBOTOX (NCT01859507)
- Testing
- Botox
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Abdel-Maguid Ramzy
Upper Limb Spasticity
A Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in Multiple Treatments of Adult Upper Limb Spasticity
This is an open-label, multicenter, phase III clinical study to evaluate the long-term safety and efficacy of multiple treatments with recombinant botulinum toxin type A (YY001) for injection in adult upper limb spasticity
- Trial name
- NCT07478822
- Testing
- Recombinant botulinum toxin type A for injection (YY001)
- Where
- 16 sites in China
- Volunteers
- 300 people
- Sponsor
- Chongqing Claruvis Pharmaceutical Co., Ltd.
Glabellar Frown Lines
Study Comparing Treatment With Alluzience vs Reconstituted Toxin
This is a Phase IV, open-label, randomized, interventional, two-armed, multi-centre study to investigate subject treatment perception and Investigator treatment experience when using Alluzience or vacuum-dried botulinum…
- Trial name
- STAR (NCT05277337)
- Testing
- Alluzience, powder BoNT-A (BOTOX/Vistabel)
- Where
- 8 sites in Germany, United Kingdom
- Volunteers
- 150 people
- Sponsor
- Galderma R&D
Antibiotic Prophylaxis
Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinA
This study aims to show that lack of antibiotic prophylaxis to those undergoing bladder Botox injections is not significantly inferior to administering prophylaxis.
- Trial name
- NCT05519072
- Testing
- Nitrofurantoin
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Stroke, Hemiparesis
Botulinum Toxin Type A (BT-A) in Hemiplegic Shoulder Pain Versus Steroid
The aim of this study is to confirm the efficacy and safety of the intra-articular injection of BT-A in a multicentric double blind randomised study.
- Conditions
- Stroke, Hemiparesis, Shoulder Pain
- Trial name
- NCT01473277
- Testing
- BT-A (Dysport 500U), Triamcinolone acetonide
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- The Foundation Institute San Raffaele G. Giglio of Cefalù
Cerebral Palsy
Comparison of Tendon Transfer, Botox Injections and Ongoing Treatment in Hemiplegic Cerebral Palsy
Doctors use different treatments for people with Cerebral Palsy. Surgery is one option. Botulinum toxin injections are another option; these are given directly into spastic muscles to weaken them temporarily.
- Trial name
- UECP (NCT00250081)
- Testing
- Upper Extremity Tendon transfer, Botulinum Toxin injections in Upper Extremity, Regularly ongoing therapy
- Where
- 10 sites in United States
- Volunteers
- 38 people
- Sponsor
- Shriners Hospitals for Children
Bruxism, Myofascial Pain
Ultrasonographic Evaluation of Masseter Muscle Changes After Botulinum Toxin Injection in Bruxism Patients
This prospective pilot study aimed to evaluate short-term clinical and ultrasonographic changes in the masseter muscle following botulinum toxin injection in patients with bruxism.
- Conditions
- Bruxism, Myofascial Pain, Masseter Muscle Hypertrophy
- Trial name
- NCT07545200
- Testing
- Botulinum Toxin A (Botox )
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Overactive Bladder (OAB), Urinary Tract Infection (Diagnosis)
Methenamine Hippurate Following Intradetrusor OnabotulinumtoxinA Injection
The goal of this clinical trial is to compare methenamine hippurate prophylaxis to routine antibiotic prophylaxis following onabotulinumtoxinA (BOTOX-A) injections in women with overactive bladder (OAB).
- Trial name
- META (NCT06953271)
- Testing
- Methenamine Hippurate, Typically prescribed oral antibiotic prophylaxis
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Gingival Overgrowth
Evaluating Lip Repositioning for the Treatment of Excess Gingival Display With and Without Pretreatment With Botox
Since the introduction of the lip repositioning procedure by a number of modifications to the technique have been introduced. All these modifications were made to prevent the main complication of lip repositioning surgeries…
- Trial name
- NCT04030767
- Testing
- Botox Injectable Product
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Glabellar Lines
Long-Term Patient Satisfaction of Facial Aesthetic Treatment With BOTOX®
This is an observational study assessing patient satisfaction following at least 5 years of BOTOX® treatment for glabellar lines.
- Trial name
- NCT01608672
- Testing
- botulinum toxin Type A
- Where
- 5 sites in United States, Australia and 3 more
- Volunteers
- 207 people
- Sponsor
- Allergan
Glabellar Lines
Clinical Trial to Evaluate the Safety and Efficacy of JTM201 to Treat Moderate or Severe Glabellar Lines
This is Multicenter, Randomized, Double-blind, Placebo-controlled, Single-dose Study to evaluate Safety and Efficacy of JTM201 in patients with Moderate or Severe Glabellar Lines
- Trial name
- NCT06246552
- Testing
- JTM201
- Where
- United States
- Volunteers
- 480 people
- Sponsor
- Jetema USA Inc.
Essential Tremor
Kinematic-based BoNT-A Injections for Bilateral ET
The primary objective is to study the efficacy of botulinum toxin type A (Xeomin®) injected utilizing kinematically-based injection parameters for the treatment of upper extremity essential tremor (ET).
- Trial name
- NCT02551848
- Testing
- Botulinum toxin type A
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Western University, Canada
Cluster Headache
Botulinum Toxin Type A Block of the Otic Ganglion in Chronic Cluster Headache: Safety Issues
Cluster headache (CH) is the most common of the trigeminal autonomic cephalalgias and one of the most severe pains known to man, having a large impact on the sufferer's quality of life.
- Trial name
- NCT03066635
- Testing
- Botulinum Toxin Type A 25 IU, Botulinum Toxin Type A 12.5 IU
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Norwegian University of Science and Technology
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