Clinical trials: Botulinum Toxins, Type A
Urinary Tract Disease
Antibiotic Strategy and Asymptomatic Bacteriuria in the Context of Intra-vesical Botulinum Toxin A Injections.
The study aims to demonstrate that the "thrifty antibiotic strategy" applied to MS or SCI patients with asymptomatic bacteriuria prior to BoNTA intravesical injections does not increase the rate of symptomatic post-injection UTIs…
- Trial name
- ANTIBIOBONTA (NCT05534399)
- Testing
- Intra-vesical BoNTA injections
- Where
- France
- Volunteers
- 526 people
- Sponsor
- University Hospital, Lille
Skin Aging
Efficacy and Safety Study of Botulinum Toxin Type A for Moderate to Severe Crow's Feet Lines
This study will evaluate the efficacy and safety of botulinum toxin type A compared to placebo control for the treatment of moderate to severe crow's feet lines.
- Trial name
- RADIANT (NCT01776606)
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 247 people
- Sponsor
- Revance Therapeutics, Inc.
Plantar Fasciitis
DaxibotulinumtoxinA for Injection for the Treatment of Plantar Fasciitis
This is a randomized, double-blind, placebo-controlled, parallel group, multi-center trial of a single administration of DaxibotulinumtoxinA (DAXI) (high-dose; low-dose) for injection versus placebo for the management of Plantar…
- Trial name
- NCT03825315
- Testing
- DAXI 80 U, DAXI 120 U
- Where
- 20 sites in United States
- Volunteers
- 155 people
- Sponsor
- Revance Therapeutics, Inc.
Upper Limb Spasticity
A Clinical Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in The Treatment of Upper Limb Spasticity in Adults
This is a randomized, double-blind, multi-center phase II/III study to evaluate the efficacy and safety of Recombinant Botulinum Toxin Type A (YY001) for injection in the treatment of upper limb spasticity in adults
- Trial name
- NCT06783114
- Testing
- Recombinant Botulinum Toxin Type A for injection (YY001), BOTOX®
- Where
- 24 sites in China
- Volunteers
- 254 people
- Sponsor
- Chongqing Claruvis Pharmaceutical Co., Ltd.
Parkinson's Disease, Overactive Bladder
Safety and Efficacy of Botulinum Toxin A for Treatment of Overactive Bladder in Parkinson's Disease
A randomized controlled trial is to be conducted to confirm the efficacy and safety of intramuscular injection of botulinum toxin in the treatment of Parkinson's bladder overactivity.
- Conditions
- Parkinson's Disease, Overactive Bladder, Onabotulinumtoxin A
- Trial name
- NCT05997043
- Testing
- oral anti-Parkinson drugs and injection of botulinum toxin, oral anti-Parkinson's drugs
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhujiang Hospital
Acne Vulgaris
Clinical Trial To Evaluate ANT-1207 In Subjects With Acne
The purpose of this study is to provide evidence of the safety, tolerance, and efficacy of ANT-1207 in the treatment of acne.
- Trial name
- NCT01293552
- Testing
- ANT-1207, Vehicle
- Where
- 15 sites in United States
- Volunteers
- 72 people
- Sponsor
- Anterios Inc.
Skin Aging
Open Label Study to Assess Long-term Safety of Repeat Administration of Botulinum Toxin Type A for Moderate to Severe Crow's Feet Lines
This study will evaluate the long-term safety of botulinum toxin type A for the treatment of moderate to severe crow's feet lines after repeat application.
- Trial name
- NCT01818076
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- Revance Therapeutics, Inc.
Cerebrovascular Accident
A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of GSK1358820 (Botulinum Toxin Type A) in Chinese Subjects With Post-stroke Upper Limb Spasticity
This trial is a multicenter, double-blind, randomized, placebo-controlled study to compare GSK1358820 (Botulinum Toxin Type A, also known as "OnabotulinumtoxinA" or "Botox") with placebo on the efficacy and safety of treatment in…
- Trial name
- NCT01153815
- Testing
- GSK1358820(Botulinum toxin type A)
- Where
- 13 sites in China
- Volunteers
- 170 people
- Sponsor
- GlaxoSmithKline
Bruxism
Botulinum Toxin-A for Bruxism Using Digital Occlusal Analysis
Bruxism is a repetitive jaw-muscle activity that may lead to tooth wear, muscle pain, headaches, and functional limitations. Current diagnostic approaches mainly rely on self-reported symptoms and clinical examination findings…
- Trial name
- NCT07640035
- Testing
- Botulinum Toxin-A injection
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Bilecik Seyh Edebali Universitesi
Lower Urinary Tract Discomfort, Stent Pain
Randomization of Botox for Stent Pain and Irritative Voiding Symptoms
Botulinum toxin type A (Botox A) has shown great success in treating certain urologic conditions. A recent study has documented that Botox injected around the ureteral orifice (or place where the tube that connects the kidney to…
- Trial name
- NCT02078895
- Testing
- Botox
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Stroke, Hemiplegia, Spastic
The Effect of Extracorporeal Shock Wave Therapy After Botulinum Toxin Type A Injection for Post-stroke Spasticity
There are few studies on whether botulinum toxin treatment and extracorporeal shock wave therapy are more effective than botulinum toxin alone treatment for post-stroke spasticity.
- Conditions
- Stroke, Hemiplegia, Spastic, Muscle Spasticity
- Trial name
- NCT05889026
- Testing
- Extracorporeal shock wave therapy, Botulinum toxin treatment
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Korea University Guro Hospital
Catocholamine Induced Finger Necrosis
Botulinum Toxin A for Treatment of Catocholamine Induced Finger Necrosis
Patients in the intensive care unit (ICU) often require blood pressure support of vasoactive drugs such as amines. Finger necrosis (so called "blue toe syndrome") is a well documented phenomena with incidence reaching as high as…
- Trial name
- NCT01500668
- Testing
- Botox
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Sialorrhea, Amyotrophic Lateral Sclerosis
Toxin Treatment for Amyotrophic Lateral Sclerosis (ALS) Related Sialorrhea
Evaluation of the decrease of the secretion of saliva in patients with amyotrophic lateral sclerosis by a local ultrasound-guided bilateral injection of botulinum toxin type A in parotids and submandibular glands.
- Trial name
- ALS-TOX (NCT01551940)
- Testing
- Botox injection
- Where
- 13 sites in France
- Volunteers
- 18 people
- Sponsor
- Hospices Civils de Lyon
Obesity, Weight Loss
Intra-gastric Fundal and Body Injection of Botulinum Toxin A for Weight Loss, a Randomized Controlled Trial
This is a randomized controlled trial to compare intra-gastric injection of Botulinum Toxin A (Botox; Allergan Inc. Irvine, Ca, USA) against non-surgical management for obesity (i.e. exercise/diet).
- Trial name
- NCT04274608
- Testing
- Botulinum toxin type A, Weight Management Program
- Where
- Singapore
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Facial Rhytides
A Study of Subject Satisfaction With BOTOX® Cosmetic Treatment in Facial Rhytides
This is a safety and efficacy study of BOTOX® in subjects with facial rhytides (glabellar lines and crow's feet lines).
- Trial name
- NCT01777620
- Testing
- onabotulinumtoxinA, Normal Saline
- Where
- Canada
- Volunteers
- 125 people
- Sponsor
- Allergan
Myelomeningocele, Bladder, Neurogenic
Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele
The purpose of this study is to examine how injection of botulinum toxin in the bladder affects bladder function. The trial is carried out in children born with malformation of the spinal cord and subsequent overactive bladders.
- Trial name
- NCT00175123
- Testing
- Botulinum A toxin
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Post-Operative Atrial Fibrillation
Botulinum Toxin Type A (AGN-151607) for the Prevention of Post-operative Atrial Fibrillation in Adult Participants Undergoing Open-chest Cardiac Surgery (NOVA)
This was a multi-center, randomized, double-blind, placebo-controlled, parallel group, dose-ranging study to evaluate the efficacy and safety of botulinum toxin type A (AGN-151607) injections into the epicardial fat pads, foci of…
- Trial name
- NCT03779841
- Testing
- AGN-151607
- Where
- 32 sites in United States, Austria and 7 more
- Volunteers
- 323 people
- Sponsor
- AbbVie
Skin Aging
Efficacy and Safety Study of Botulinum Toxin Type A to Treat Glabellar Lines
The purpose of this study is to test the hypothesis that the efficacy and safety of Meditoxin® are not inferior to Botox®'s in the treatment of glabellar lines.
- Trial name
- NCT01237977
- Testing
- Botulinum Toxin Type A(Meditoxin®), Botulinum Toxin Type A(Botox®)
- Where
- 6 sites in South Korea
- Volunteers
- 314 people
- Sponsor
- Medy-Tox
Stroke, Muscle Spasticity
Upper-limb Active Function and Botulinum Toxin A
This study in an observational, prospective and longitudinal study. The aim of the study is to evaluate the effect of botulinum toxin type A (BTX) injections into the elbow flexors on the reduction of spastic co-contractions…
- Conditions
- Stroke, Muscle Spasticity, Upper Extremity Paralysis
- Trial name
- ULAFBoT-Stroke (NCT03783572)
- Testing
- Clinical evaluation, Clinical evaluation and Instrumental evaluation
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Lower Limb Spasticity
Effectiveness and Safety of Dysport® (abobotulinumtoxinA) in Paediatric Lower Limb Spasticity
The purpose of this study is to assess the longitudinal attainment of subject centred and functional related goals (cumulated Goal Attainment Scale Total (GAS T) score) after abobotulinumtoxinA injection (including following…
- Trial name
- NCT03017729
- Testing
- Botulinum toxin type A
- Where
- 27 sites in United States
- Volunteers
- 242 people
- Sponsor
- Ipsen
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