Clinical trials: Botulinum Toxins, Type A
Rhytides
Spread of PrabotulinumtoxinA-xvfs Versus OnabotulinumtoxinA in the Treatment of Forehead Rhytides
Ten subjects will be enrolled in the study. Each subject will have their left and right forehead randomly assigned to receive 4 units of PrabotulinumtoxinA-xvfs or OnabotulinumtoxinA.
- Trial name
- NCT05807412
- Testing
- PrabotulinumtoxinA-Xvfs, OnabotulinumtoxinA
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Lupo Center for Aesthetic and General Dermatology
Overactive Bladder Syndrome
Intravesical Injection of Botox for Treating Therapy Refractory Overactive Bladder in Females
The neurotoxin Botox (botulinum neurotoxin type A) is shown to be effective in the treatment of therapy refractory overactive bladder syndrome.
- Trial name
- NCT01042119
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University of Zurich
Hallux Valgus
Effect of Botulinum Toxin to Hallux Valgus in Addition to Total Contact Insole
The investigators propose a new therapeutic approach by injecting Botulinum Toxin Type A (BTA) to the oblique and transverse heads of adductor muscle of the great toe.
- Trial name
- NCT01501500
- Testing
- BOTOX, Normal Saline (0.9% NaCl)
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Chang Gung Memorial Hospital
Vocal Weakness(Post-BOTOX Injection)
Firdapse for Post-BOTOX Vocal Weakness
Botox injections into the thyroarytenoid muscle are a predictable and effective treatment for SD, but typically result in transient symptoms of voice weakness and breathiness during the first 2-3 weeks after injection.
- Trial name
- NCT05123053
- Testing
- Amifampridine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Augusta University
Scrotum Disease, Chronic Pain
Evaluation of Botox Treatment on Chronical Scrotal Pain
The aim of the study is to evaluate the effect of botox injections at the spermatic cord in patients with chronical scrotal pain. A lot of patients experiences depressive symptoms and a lot feel isolated.
- Trial name
- NCT05112081
- Testing
- Botulinum toxin type A, Sterile saline
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Nicolai Skov Schiellerup
Post Stroke Arm Spasticity
Study to Document the Effectiveness of Dysport in Patients Suffering From Upper Limb Spasticity (ULS) After Stroke
The objective of this non-interventional study is to evaluate clinical effectiveness and cost effectiveness of Dysport within the reimbursement scheme called "drug programme" funded by Polish National Health Fund (NHF) for…
- Trial name
- PSAS REGISTRY (NCT02444494)
- Where
- 6 sites in Poland
- Volunteers
- 108 people
- Sponsor
- Ipsen
Obstructed Defecation Syndrome (ODS)
Effects of Botox in Obstructed Defecation Syndrome
The purpose of this study is to determine if Botulinum Toxin-A (Botox) injection will improve symptoms of constipation in obstructed defecation syndrome (ODS).
- Trial name
- NCT02160288
- Testing
- Botulinum Toxin-A, Normal Saline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital
Overactive Bladder Syndrome
Use of Repris Needle in Bladder Injection
Treatment of overactive bladder (OAB) has been treated successfully by the injection of Botox. The Repris injection needle has a deflection that may assist in injection difficult to reach with standard straight needles.
- Trial name
- NCT04982120
- Testing
- Repris Needle
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Uro-1 Medical
Aging
Evaluation of the Safety and Efficacy of OnabotulinumtoxinA to the Depressor Anguli Oris
Single Center, Double Blind, Placebo- Controlled Study of 20 subjects with 10 active drug/10 placebo Standardized baseline/pre-treatments and follow-up images will be taken.
- Trial name
- NCT04240535
- Testing
- OnabotulinumtoxinA 50 UNT [Botox Cosmetic]
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Amir Moradi MD, MBA
Glabellar Frown Lines
Safety Study of DWP-450 (Botulinum Toxin, Type a) to Treat Glabellar Lines - EV-006
The primary objective is to demonstrate the safety of multiple doses of DWP-450 purified Botulinum neurotoxin, Type A, in treatment of moderate to severe glabellar lines associated with corrugator and procerus muscle activity in…
- Trial name
- EV-006 (NCT02428608)
- Testing
- DWP-450 (Botulinum purified neurotoxin, Type A)
- Where
- United States
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- Evolus, Inc.
Facial Flushing
Treatment of Facial Flushing With Botulinum Toxin A Injections
The purpose of this study is to find out if botulinum toxin A (botox®) can be used to treat facial flushing. This study is a pilot study designed to determine feasibility of these procedures.
- Trial name
- NCT02216838
- Testing
- botulinum toxin A, Saline Control
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Premature (Early) Ejaculation
Dual-Site Botulinum Toxin Type A Injection for Lifelong Premature Ejaculation
Premature ejaculation is a common sexual condition that can cause distress for men and their partners. Different treatments are available, but some men do not respond well to standard therapies.
- Trial name
- DUAL - PE (NCT07426640)
- Testing
- BoNT-A
- Where
- Saudi Arabia
- Volunteers
- 150 people
- Sponsor
- Al Mouwasat Hospital
Interstitial Cystitis
Efficacy of Botulinum Toxin Type A in Patients With Bladder Pain Syndrome/Intersticial Cystitis and Hunners' Lesions
The etiology of bladder pain syndrome is unknown. Therefore the management is directed to pain relief, as bladder pain is believed to drive both voiding frequency and nocturia.
- Trial name
- NCT01437579
- Testing
- intratrigonal injection of botulinum toxin, cystoscopy
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Moscow State University of Medicine and Dentistry
Keloid Scars
The Effectiveness of Intralesional Botulinum Toxin A and Triamcinolone Acetonide Injections in Keloid Treatment
Keloids are benign fibrous tissue overgrowths that extend beyond the boundaries of the original wound and tend to recur after therapy.
- Trial name
- NCT06814288
- Testing
- Botulinum toxin A, Triamcinolone Acetonide
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- Universitas Padjadjaran
Overactive Bladder, Bladder Pain Syndrome
Bladder Botox UTI Antibiotic Prophylaxis
Overactive bladder (OAB) is a common condition with a prevalence of 17% in the general population that significantly affects quality of life.
- Trial name
- NCT06387329
- Testing
- Nitrofurantoin 100 MG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders
Arthrocentesis-PRF Versus Botulinum Toxin for Management of ADDwR
Temporomandibular joint (TMJ) internal derangement is a common cause of temporomandibular disorders and is often associated with pain, restricted mandibular movement, joint sounds, and functional limitations during mastication…
- Conditions
- Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders, Temporomandibular Disorders (TMD), TMJ Pain
- Trial name
- NCT07385742
- Testing
- Injectable Platelet-Rich Fibrin (I-PRF) Injection, Botulinum Toxin Type A (BOTOX) Injection
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Vasculogenic Erectile Dysfunction
Intracavernosal Injection of Botulinum Toxin Type A in the Treatment of Vascular Erectile Dysfunction
Evidence has been arising that Botulinum toxin injections can relax smooth muscles fibers in the treatment of obesity and hyperactive bladder.
- Trial name
- NCT02584686
- Testing
- Botulinum Toxin Type A, Normal Saline
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Migraine
OnaBotulinumtoxin-A in Chronic Migraine Patients With Short or Long Disease History (the BACH Study)
The goal of this observational prospective multicentric study, 12 months duration is to investigate whether the history of Chronic Migraine and, more precisely, its duration for over or less than 10 years, can predict OBT-A…
- Trial name
- BACH (NCT06537700)
- Testing
- OnabotulinumtoxinA OBT-A
- Where
- 6 sites in Italy
- Volunteers
- 115 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Spasticity
Vanderbilt University Spasticity Management Program Evaluation Plan
People with severe developmental disabilities frequently have comorbidities that make providing care to them more difficult. Spasticity is one such comorbidity.
- Trial name
- NCT00179114
- Testing
- Botulinum Toxin Type A, Intrathecal baclofen administered by the Medtronic SyncroMed(TM) pump (ITB)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University
Urinary Incontinence
A Multi-Center Trial of Botox for Severe Urge Urinary Incontinence
The purpose of the study is to determine how effective Botox is in reducing the amount of urine leaked and which dose of Botox is more effective and safe in those who have urinary urge incontinence.
- Trial name
- NCT00345332
- Testing
- Botox
- Where
- 3 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Rochester
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