Clinical trials: Botulinum Toxins, Type A
Excessive Gingival Display, Gingival Diseases
Botulinum Toxin Type A Versus Cross-Linked Hyaluronic Acid Filler Myomodulation for Non-Surgical Management of Excessive Gingival Display
This randomized controlled trial compared the clinical efficacy and patient satisfaction of two non-surgical treatments for excessive gingival display (gummy smile): botulinum toxin type A (BTX-A) and cross-linked hyaluronic acid…
- Conditions
- Excessive Gingival Display, Gingival Diseases, Gummy Smile, Esthetics, Dental
- Trial name
- NCT07715331
- Testing
- Botulinum Toxin Type A (Refinex®), Cross-Linked Hyaluronic Acid Filler (Juvéderm Voluma® with Lidocaine)
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Al-Azhar University
Drug-resistant Focal Seizure
BOTOX Effects on Seizure Severity and Susceptibility
The purpose of this research is to determine whether BOTOX injections will reduce seizure frequency and severity. We chose to test its effects on epilepsy because epilepsy and migraine have common features so, are often treated…
- Trial name
- NCT05605756
- Testing
- OnabotulinumtoxinA 145 UNT [Botox]
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Low-back Pain
Are Paraspinous Intramuscular Injections of Botulinum Toxin A (BoNT-A) Efficient in the Treatment of Chronic Low-back Pain (LBP)?
Studying the therapeutic effect of paravertebral injections of BoNT-A (botulinum toxin A) requires further studies to confirm the reported short-term therapeutic effect and to determine potential predictive factors of efficacy.
- Trial name
- BoNT-A (NCT03181802)
- Testing
- Botox
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Bordeaux
Spastic Diplegic Cerebral Palsy
Efficacy and Functional Outcomes of Botulinum Toxin A Injections to Hamstrings in Flexed Knee Gait in Cerebral Palsy
The study proposes to determine if injections of BTX-A to the hamstring muscles result in measurable physiologic changes not observed with normal saline injections in children with spastic diplegic cerebral palsy who walk with a…
- Trial name
- NCT00261131
- Testing
- Botulinum Toxin A
- Volunteers
- 250 people
- Sponsor
- Shriners Hospitals for Children
Spasticity
Retrospective Real-Life Study From One Brazilian Reference Center Assessing Long-Term Experience In The Treatment Of Adult Spasticity With AbobotulinumtoxinA
The aim of the study is to describe the long-term use of abobotulinumtoxinA (Dysport®) in adult subjects affected with upper limb spasticity (ULS) +/- lower limb spasticity (LLS) who received treatment with Dysport® for a minimum…
- Trial name
- RETURN (NCT04446702)
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ipsen
Spastic Foot
Botulinum Toxin A & Weekly Serial Casting in ABI Inpatients With Lower Extremity Spasticity
Effects of Chemodenervation (Botulinum Toxin A) and Serial Casting vs Botulinum Toxin A and without serial casting in Lower Limb Spasticity following ABI.
- Trial name
- ChemoCast (NCT03903653)
- Testing
- Botulinum toxin type A, Serial Casting
- Sponsor
- Hamilton Health Sciences Corporation
Cervical Dystonia
Botox for Cervical Dystonia Following EMG Mapping
The purpose of this study is to determine how to improve treatment of patients with cervical dystonia who have not been helped with standard Botox injections.
- Trial name
- NCT00773253
- Testing
- Botulinum toxin A
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Post-operative Excessive Scarring
Botulinum Toxin is a Potential Prophylactic Therapy for Minimizing Post-excisional Scarring (Allergan Botox Scar Study)
Dermatological surgeons wear many hats to care for subjects with skin cancer. While their role in cancerous tissue removal results in superior cure rates, there is also a need for skilled excisional repair and effective wound…
- Trial name
- NCT02623829
- Testing
- Botulinum Toxin, Saline
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Adolescent Idiopathic Scoliosis
Dysport ® as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis
This study evaluates the combined effect of botulinum toxin A (administered as Dysport® (Ipsen Pharmaceuticals)) and bracing in children with adolescent idiopathic scoliosis.
- Trial name
- NCT03935295
- Testing
- AbobotulinumtoxinA, Custom Thoracolumbosacral Orthosis
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Dry Eye Syndromes
Paralysis of the Orbicularis Muscle of the Eye in the Treatment for Dry Eye
This is a prospective, comparative, contralateral eye study. Patients older than 18 years who have had treatment with topical lubricants for at least 1 month and persist with symptoms of dry eye and corneal staining with…
- Trial name
- NCT02403219
- Testing
- Botulinum toxin type A injection, Saline solution injection
- Volunteers
- 20 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Sexual Dysfunction, Erectile Dysfunction
Botulinum Toxin for Erectile Dysfunction
To evaluate the safety and efficacy of intra-cavernosal Botulinum toxin injection as an alternative line of treatment in patients with erectile dysfunction - not responding to oral PDE5i - through cavernosal smooth muscle…
- Trial name
- NCT03102762
- Testing
- Botulinum Toxin Type A, Normal saline
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Migraine
Efficacy and Safety Study of Dysport® Used for Migraine Prophylaxis
The purpose of this study is to evaluate the efficacy of botulinum toxin type A (Dysport®) injections into pericranial muscles compared to placebo to prevent migraine attacks.
- Trial name
- NCT00301665
- Testing
- Botulinum toxin type A
- Where
- 9 sites in Czechia, Poland and 1 more
- Volunteers
- 138 people
- Sponsor
- Ipsen
Spinal Stenosis With Nocturnal Calf Cramps
Botulinum Toxin Type A Injection Into the Gastrocnemius Muscle for Treatment of Nocturnal Calf Cramps in Patients With Lumbar Spinal Stenosis
Nocturnal calf cramps is a common complaint in patients with lumbar spinal stenosis. The purpose of this study is to evaluate the effect of botulinum toxin A injection into the gastrocnemius muscle in lumbar spinal stenosis…
- Trial name
- NCT02444351
- Testing
- botulinum toxin type A (Nabota®) injection into the gastrocnemius muscle, no intervention
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Urinary Incontinence, Stress, Urinary Incontinence, Urge
Sling vs Botox for Mixed Incontinence
The primary aim is to compare the effectiveness of intradetrusor injection of 100 unit injection of Botulinum toxin A to mid-urethral sling for change in MUI symptoms 6 months following treatment.
- Trial name
- MUSA (NCT04171531)
- Testing
- Botox® injection, Mid-urethral sling
- Where
- 8 sites in United States
- Volunteers
- 150 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Upper Limb Injury
CARegiver BURden, Effectiveness and Other Health Care Measures on Functional Disability, in Patients Treated With Abobotulinumtoxin A for Upper Limb Spasticity
The aim of this study is to perform, in real world clinical practice, a three-dimensional assessment from patient's, caregiver's and physician's perspectives, of the impact of AboBoNT-A on caregiver burden, functional disability…
- Trial name
- CARBUR (NCT06245772)
- Where
- 27 sites in France
- Volunteers
- 113 people
- Sponsor
- Ipsen
Overactive Bladder, Urinary Urge Incontinence
Over Active Bladder Instillation Study - Botox
The purpose of this study is to determine whether women with overactive bladder (OAB) who receive direct instillation via a catheter of a Botulinum-A Toxin (Botox) with Dimethyl Sulfoxide (DMSO) solution experience significantly…
- Conditions
- Overactive Bladder, Urinary Urge Incontinence, Urinary Incontinence, Detrusor Hyperreflexia
- Trial name
- NCT00667095
- Testing
- Botox Instillation, DMSO Instillation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Nocturnal Bruxism
Botulinum Toxin A Injectable Solution in the Management of Bruxism: A Clinical Trial Study
A Clinical Trial Study to investigate the potential performance of BTXA on masseter muscle on patient with nocturnal bruxism and to check the pain scale and share this clinical experience.
- Trial name
- NCT03827122
- Testing
- onabotulinumtoxinA
- Where
- Saudi Arabia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Multiple Sclerosis
Botulinum Toxin in Patients With Spastic Lower Limb Paresis Associated With Multiple Sclerosis
Spastic paraparesis is one of the most disabling functional deficits in the population with multiple sclerosis between 18 and 80 years of age and at any functional level.
- Trial name
- NCT04595045
- Testing
- Botulinum toxin type A infiltrations
- Where
- 2 sites in Spain
- Volunteers
- 84 people
- Sponsor
- Aránzazu Vázquez Doce
Urinary Bladder, Overactive
Urinary Retention Rates in Clinical Practice After Treatment With OnabotulinumtoxinA for Idiopathic Overactive Bladder
This study is a retrospective chart review of patients treated with BOTOX® for idiopathic Overactive Bladder (OAB) as standard of care in clinical practice.
- Trial name
- NCT02557971
- Testing
- onabotulinumtoxinA
- Where
- 7 sites in United States
- Volunteers
- 315 people
- Sponsor
- Allergan
Levator Ani Syndrome With Pain and/or Constipation Symptoms.
Comparison of Biofeedback vs. Botox Injection to Treat Levator Ani Syndrome
Purpose: To assess whether EMG directed biofeedback therapy or Botulinum toxin type A injection of the levator ani muscles has any effect on pain from the levator ani syndrome, and, in addition, to what extent either treatment is…
- Trial name
- NCT00564707
- Testing
- Biofeedback therapy, Botulinum Toxin Type A Injection
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
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