Clinical trials: Botulinum Toxins, Type A
Chronic Migraine Headache
Effectiveness of Greater Occipital Nerve and Supratrochlear Nerve Pulsed Radiofrequency Versus Botulinum Toxin Type A Injection in Chronic Migraine
Migraine is a common chronic neurovascular disorder ranked among the leading causes of disability worldwide, and its global burden has continued to rise over the past three decades, with prevalence increasing substantially…
- Trial name
- NCT07780136
- Testing
- Ultrasound-guided pulsed radiofrequency (PRF), OnabotulinumtoxinA
- Volunteers
- 70 people
- Sponsor
- Assiut University
Overactive Bladder, Urinary Incontinence
Long Term Follow-up Study of Safety and Efficacy of Botulinum Toxin Type A for the Treatment of Patients With Idiopathic Overactive Bladder With Urinary Incontinence
The purpose of this study is to assess the long term safety and effectiveness of botulinum toxin type A in treating patients with idiopathic overactive bladder with urinary incontinence.
- Trial name
- NCT00915525
- Testing
- botulinum toxin Type A
- Where
- 8 sites in United States, Belgium and 6 more
- Volunteers
- 829 people
- Sponsor
- Allergan
Post-Stroke Spasticity, Cerebrovascular Accident
Study of GSK1358820 In Patients With Post-Stroke Lower Limb Spasticity
This is a study to confirm the superior efficacy of GSK1358820 over placebo in patients with equinus deformity associated with post-stroke lower limb spasticity using the Modified Ashworth Scale (MAS) ankle score.
- Trial name
- NCT00460655
- Testing
- GSK1358820
- Where
- 20 sites in Japan
- Volunteers
- 120 people
- Sponsor
- GlaxoSmithKline
Glabellar Lines
Evaluate the Efficacy and Safety of INI101 Compared to BOTOX® in Subjects With Moderate to Severe Glabellar Lines.
To evaluate the efficacy and safety of botulinum toxin type A for injection INI101 compared to BOTOX® in subjects with moderate to severe glabellar lines.
- Trial name
- NCT07622004
- Testing
- Botulinum Toxin Type A Injection [INI101], Botulinum Toxin Type A Injection [Botox]
- Where
- South Korea
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- INIBIO Co., Ltd.
Stroke
The Effects of Early and Late Injection of Botulinum Toxin Type A on Upper Limb Function in Patients With Stroke
The aim of this study is to determine whether early use of OnabotulinumtoxinA is more effective to improve functional outcomes of upper limb in patients with stroke.
- Trial name
- NCT02580838
- Testing
- OnabotulinumtoxinA
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Cheng-Kung University Hospital
Smiling, Botulinum Toxins, Type A
Effects of Dose and Injection Site for Gummy Smile Treatment With Botulinum Type A
Botulinum type A (BTX-A) is an easy and efficacious treatment for gingival smile (GS). However, its dosage and injection sites effect among patients are controversial.The objective was to compare the reduction of gingival…
- Trial name
- NCT04820543
- Testing
- injection of Botulinum type A
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Peking University
Pelvic Floor Disorders
Botox for Chronic Pelvic Pain
The purpose of this research study is to find out if precise, targeted injection of botulinum neurotoxin (commonly known as Botox) provides better relief of pelvic floor hypertonicity and pain than the standard method being used.
- Trial name
- NCT06796985
- Testing
- Botulinum neurotoxin, High Density Surface Electromyographic, precision botulinum neurotoxin injection guidance medical device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Botulinum Toxins, Type A, Hernia
The Effects of Preoperative Botulinum Toxin A Injection on Respiratory System Function
Hernias are common complications post-abdominal surgeries, often leading to significant issues such as "loss of domain," where organs shift permanently, reducing abdominal cavity capacity.
- Trial name
- NCT06485440
- Testing
- Dysport 300 UNT Injection
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Swissmed Hospital
Myofascial Pain Syndromes
Study to Assess the Efficacy and Safety of Dysport® in Upper Back Myofascial Pain Syndrome
The main purpose of this study is to determine which is the best dose of a drug known as Dysport to give when treating one's type of upper back pain.
- Trial name
- NCT00134810
- Testing
- Botulinum toxin type A
- Where
- 22 sites in Czechia, Germany and 4 more
- Volunteers
- 381 people
- Sponsor
- Ipsen
Brow Ptosis
Brow Enhancement Study
Investigation into brow aesthetics using Botox in Conjunction with Juvederm XC as evaluated by patient satisfaction
- Trial name
- NCT01308593
- Testing
- Juvederm XC, Botox
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Skin Care and Laser Physicians of Beverly Hills
Neurogenic Bladder Dysfunction Nos, Spinal Cord Injury
Botox-A Injection to Improve Bladder Function in Early Spinal Cord Injury (#H-20344)
The purpose of this study is to see what the effect of Botox has on bladder function for those who have recently suffered spinal cord injury.
- Trial name
- NCT00711087
- Testing
- BOTOX-A, Saline injection
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Baylor College of Medicine
Pain, Cerebral Palsy, Spastic
Botulinum Toxin-A as a Treatment for Chronic Muscle-Related Pain in Adults With Spastic Cerebral Palsy: a Randomized Controlled Trial
The purpose of this double-blinded, placebo-controlled study is to test if treatment with Botulinum toxin-A is effective in reducing chronic muscle-related pain in adults with spastic cerebral palsy.
- Trial name
- BATCP (NCT02434549)
- Testing
- Dysport®, Normal saline
- Where
- 2 sites in Sweden
- Volunteers
- 16 people
- Sponsor
- Kristina Tedroff
Temporomandibular Joint Disorders, Temporomandibular Joint Dysfunction Syndrome
Arthrocentesis Versus Botulinum Toxin Injection in Patients With Temporomandibular Joint Disorders: A Randomized Controlled Trial
The goal of this clinical trial is to learn if arthrocentesis works as well as botulinum toxin (Botox) injection to treat pain and jaw dysfunction in adults with temporomandibular joint (TMJ) disorders.
- Conditions
- Temporomandibular Joint Disorders, Temporomandibular Joint Dysfunction Syndrome, Facial Pain
- Trial name
- RCT (NCT07736521)
- Testing
- Arthrocentesis, Botulinum Toxin-A
- Volunteers
- 66 people
- Sponsor
- Mudher MB Alsunbuli
Catocholamine Induced Finger Necrosis
Botulinum Toxin A for Treatment of Catocholamine Induced Finger Necrosis
Patients in the intensive care unit (ICU) often require blood pressure support of vasoactive drugs such as amines. Finger necrosis (so called "blue toe syndrome") is a well documented phenomena with incidence reaching as high as…
- Trial name
- NCT01500668
- Testing
- Botox
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Cervical Dystonia, Primary
The Effects of Waning of Botulinum Toxin in the Treatment of Cervical Dystonia
The main treatment for cervical dystonia is botulinum toxin injections. However, some patients receiving this treatment after many years tend to experience short duration of benefit.
- Trial name
- NCT06886750
- Testing
- Botulinum toxin type A injection
- Volunteers
- 45 people
- Sponsor
- Western University, Canada
Trigeminal Neuralgia
Botulinum Toxin Type A for Injection (HengLi®) in the Treatment of Trigeminal Neuralgia
To evaluate the efficacy of different dosing regimens of Botulinum Toxin Type A for Injection (HengLi®) in the treatment of trigeminal neuralgia (TN), so as to determine the optimal dosing regimen of the best administration…
- Trial name
- NCT06410859
- Testing
- Botulinum Toxin Type A for Injection,also known as "HengLi®"
- Where
- China
- Volunteers
- 240 people
- Sponsor
- LKGS_277
Chronic Migraine Headache, OnabotulinumtoxinA
Botulinum Toxin and/or Greater Occipital Nerve Block for Patients With Chronic Migraine
Chronic migraine is a debilitating neurological disorder that significantly affects patients' daily functioning, mental health, and quality of life.
- Conditions
- Chronic Migraine Headache, OnabotulinumtoxinA, Greater Occipital Nerve Block, Combination Therapy
- Trial name
- NCT07535723
- Testing
- OnabotulinumtoxinA, Greater Occipital Nerve Block (GONB)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Beni-Suef University
Glabellar Lines
A Study to Assess the Adverse Events of Intramuscular Injections of AGN-151586 and OnabotulinumtoxinA in Adult Participants for the Change of Glabellar Lines (GL)
The objective of this Phase 1 study is to assess the safety and efficacy of single treatment of AGN-151586 and of OnabotulinumtoxinA in the glabellar complex of participants with moderate to severe glabellar lines (GL).
- Trial name
- NCT06834789
- Testing
- AGN-151586, OnabotulinumtoxinA
- Where
- 8 sites in United States
- Volunteers
- 132 people
- Sponsor
- AbbVie
Hernia Abdominal Wall, Botox Injection
Preoperative BOTOX® Injection for Large Ventral Hernia Repair
This study is for adults who need open surgery to repair a very large abdominal (ventral) hernia. This study tests whether a one-time, image-guided injection of a medicine commonly known as "BOTOX®" (onabotulinumtoxinA) into the…
- Conditions
- Hernia Abdominal Wall, Botox Injection, Hernia Incisional Ventral, Hernia Repair With Compartment Syndrome
- Trial name
- PRETOX (NCT07220382)
- Testing
- OnabotulinumtoxinA Injection, OnabotulinumtoxinA, 0.9 % Normal Saline
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- The Cleveland Clinic
Interstitial Cystitis, Bladder Pain Syndrome
Bladder Instillations Versus Onabotulinumtoxin A for Treatment of Interstitial Cystitis/Bladder Pain Syndrome
Recognition of interstitial cystitis (IC)/bladder pain syndrome (BPS) is increasing. There is a dire need to develop effective treatment options for these patients as it manifests as more than a physical disease, affecting…
- Trial name
- NCT04401176
- Testing
- Heparin & Alkalinized Lidocaine Bladder Instillation, Onabotulinum Toxin A
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Walter Reed National Military Medical Center
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