Clinical trials: Botulinum Toxins, Type A
Upper and/or Lower Limb Focal Spasticity
A Study to Review Treatment Outcomes From Treatment With Dysport® Injections in Adults for Upper and/or Lower Limb Focal Spasticity
The aim of this retrospective study is to describe the real-world outcomes with the treatment of adult patients with Dysport® injections for focal upper limb spasticity (ULS) and/or focal lower limb spasticity (LLS) in NHS…
- Trial name
- DYSCOVER (NCT04604379)
- Where
- 3 sites in United Kingdom
- Volunteers
- 123 people
- Sponsor
- Ipsen
Graves Ophthalmopathy
Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction
Currently there are few therapeutic options for the treatment of lid retraction secondary to thyroid orbitopathy (TO) during the active stages of the disease.
- Trial name
- NCT01272414
- Testing
- Botulinum Toxin Type A, Saline injection
- Where
- Canada
- Sponsor
- University of Toronto
Oily Skin
BOTOX® Cosmetic and Skin Health.
This is a two cohort, randomized, double blind, single center study to evaluate the effects of Botox Cosmetic (BTX) on sebum protection.
- Trial name
- NCT05138835
- Testing
- Botox Cosmetic
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Andreas Nikolis
Overactive Bladder
OnabotulinumtoxinA (onaBoNT-A) Versus Oral Oxybutynin ER
Overactive bladder is a condition associated with symptoms of feeling the urge to urinate, urinating often, and may or may not be accompanied by leakage of urine.
- Trial name
- NCT01050114
- Testing
- onaBoNT-A, Oxybutynin ER
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Christopher Patrick Smith
Myofacial Pain Syndromes
Does Botulinum Toxin Type-A Injection an Effective Way of Relieving Pain in Myofascial Pain Syndrome Patients or Not
In this research prilocaine and botulinum toxin (BoNT-A) interventions prospectively compared to find out the effect of BoNT-A injection on myofascial pain syndrome (MPS).
- Trial name
- NCT06899438
- Testing
- Botulinum Toxin A Injection, Prilocaine HCl % 2 injectable solution
- Volunteers
- 38 people
- Sponsor
- Bursa City Hospital
Hyperhidrosis
Hyperhidrosis in Patients With Amputations-Botox
The objective is to establish and evidence base for hyperhidrosis treatment algorithm in amputees.This project will address a problem that has troubled Service members, Veterans, and civilians with amputations for decades…
- Trial name
- NCT03236012
- Testing
- Botulinum Toxin Type A (Botox)
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Utah
Cervical Dystonia
Clinical Trial to Compare the Safety and Efficacy of Botulax® Versus Botox® in Patients With Cervical Dystonia
To determine the efficacy and safety of Botulax® in treatment of cervical dystonia
- Trial name
- NCT04171258
- Testing
- Botulinum toxin type A injection, Botulinum Toxin Type A Injection [Botox]
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hugel
Mild to Moderate Temporal Atrophy, Moderate to Severe Glabellar Rhytids
Upper Facial Remodeling With Perlane-L and Dysport
The purpose of this study is to provide data to support combination treatment of the upper face with Perlane-L® and Dysport™. This study will assess the outcome of upper face rejuvenation in the temporal fossa; outcome of…
- Conditions
- Mild to Moderate Temporal Atrophy, Moderate to Severe Glabellar Rhytids, Moderate to Severe Periorbital Rhytids
- Trial name
- DPL-2010 (NCT01354743)
- Testing
- Dysport, Perlane L
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beer, Kenneth R., M.D., PA
Migraine Disorders
A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches
This is a 60 week study including a double-blind phase followed by an open-label phase.
- Trial name
- NCT00168428
- Testing
- Botulinum Toxin Type A
- Where
- 6 sites in United States, Canada and 4 more
- Volunteers
- 705 people
- Sponsor
- Allergan
Glabellar Lines
A Study to Assess the Adverse Events of Intramuscular Injections of AGN-151586 and OnabotulinumtoxinA in Adult Participants for the Change of Glabellar Lines (GL)
The objective of this Phase 1 study is to assess the safety and efficacy of single treatment of AGN-151586 and of OnabotulinumtoxinA in the glabellar complex of participants with moderate to severe glabellar lines (GL).
- Trial name
- NCT06834789
- Testing
- AGN-151586, OnabotulinumtoxinA
- Where
- 8 sites in United States
- Volunteers
- 132 people
- Sponsor
- AbbVie
Skin Aging
Efficacy and Safety of Botulinum Toxin Type A for Moderate to Severe Crow's Feet Lines
This study will confirm the efficacy and safety of a single topical administration of botulinum toxin type A compared to placebo control for the treatment of moderate to severe crow's feet lines
- Trial name
- NCT01940991
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Revance Therapeutics, Inc.
Proctalgia
Analgesic Effect of an Injection of Botulinum Toxin Type A in the Ganglion Impar in Patients With Chronic Proctalgia
The main objective is to evaluate the analgesic efficacy of botulinum toxin type A in refractory chronic proctalgia one month after a bilateral injection of 50 units of Botox ® in the ganglion Impar (total dose = 100 units)
- Trial name
- Impartox (NCT01331356)
- Testing
- Botox
- Where
- 2 sites in France
- Volunteers
- 18 people
- Sponsor
- Nantes University Hospital
BOTOX, Percutaneous Tibial Nerve Stimulation
IDB Injection Combined With PTNS for Managing Children With OAB Not Responding to Monotherapy
This study aimed to evaluate the outcome of simultaneous intradetrusor BOTOX (IDB) injection and Percutaneous tibial nerve stimulation (PTNS) for management of children with recurrent wetness since at least 6 months.
- Trial name
- NCT05911594
- Testing
- Solifenacin group, Percutaneous tibial nerve stimulation group, Intradetrusor BOTOX group
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Benha University
Oromandibular Dystonia, Electromyography
Botulinum Toxin A for Jaw Dystonia .
This study evaluates the effectiveness and safety of Electromyography (EMG)-guided Botulinum Toxin type A (BTX-A) injections in treating oromandibular dystonia (OMD) among a sample of Yemeni patients.
- Trial name
- OMD _ BTX-A (NCT07792798)
- Testing
- Botulinum Toxin Type A (BOTOX) Injection
- Where
- Yemen
- Volunteers
- 20 people
- Sponsor
- Sana'a University
Epicondylitis, Lateral Humeral, Tennis Elbow
Evaluation of Three Types of Injection for the Treatment of Lateral Epicondylalgia
The primary objective of this study is to compare the evolution of pain profiles among patients suffering from lateral epicondyalgia (tennis elbow) following three types of treatment: PRP-L injection versus type A botulinum toxin…
- Trial name
- LET (NCT02325063)
- Testing
- PRP-L Injection, Botox injection, Corticoid injection
- Where
- 2 sites in France
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Glabellar Rhytides
A Long-Term Safety Study of Repeat Treatment With PurTox® for Frown Lines Between the Eyebrows
The overall purpose of this study is to evaluate the long-term safety of repeat treatment with an intramuscular dose of Mentor Purified Toxin for the reduction of frown lines.
- Trial name
- PT-03c (NCT00752258)
- Testing
- Mentor Purified Toxin Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 576 people
- Sponsor
- Mentor Worldwide, LLC
Headache, Allodynia
Botulinum Toxin Type A in Treatment of Cranial Allodynia in Patients With Headache
The objective of this study is evaluated if the Botulinum Toxin Type A is superior to 0,9% saline in treatment of cranial Allodynia in patients with headache.
- Trial name
- NCT01357798
- Testing
- Botulinum toxin type A, 0,9% saline
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Bahia
Chronic Pain, Neuroma
Comparative Evaluation of Intraneuroma and Perineuroma Botulinum Toxin Type A Injection Techniques for Chronic Neuroma Pain After Combat-Related Amputation
Patients with combat-related amputations frequently experience chronic neuroma pain that may interfere with rehabilitation, prosthesis use, mobility, sleep, and quality of life.
- Conditions
- Chronic Pain, Neuroma, Botulinium Toxin-A, Combat Trauma
- Trial name
- IN-PERI NEUROM (NCT07624877)
- Testing
- Botulinum toxin type A injection
- Where
- 2 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Painful Bladder Syndrome, Interstitial Cystitis
Botox as a Treatment for Interstitial Cystitis in Women
Patients with interstitial cystitis have been well documented to have pelvic floor muscle tenderness as well as pain on bladder distension.
- Trial name
- NCT00194610
- Testing
- Botox, normal saline
- Volunteers
- 20 people
- Sponsor
- University of Washington
Wrinkles in Frontal Area
Field of Effects of Two Commercial Preparations of Botulinum Toxin Type A
The objective of this study is to compare the field of effects of the botulinum toxins (Dysport® and Botox®) using two equivalence-ratios and to gather supportive information, such as more detailed data on the effectiveness in…
- Trial name
- NCT00989768
- Testing
- Botulinum Toxin Type A (Dysport®), Botulinum Toxin Type A/Botox®, Botulinum Toxin Type A/Dysport®
- Where
- Brazil
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic