Clinical trials: Bowel; Ischemic
Diagnoses Disease, Acute Mesenteric Ischemia
The Detrimental Course of Acute Intestinal Ischemia
Rationale: Acute intestinal ischemia is a life-threatening condition with a short-term mortality that can range up to 80%. Medical diagnosis and treatment have remained troublesome, due to the clinical presentation which is…
- Conditions
- Diagnoses Disease, Acute Mesenteric Ischemia, Intestinal Disease
- Trial name
- TACTIC (NCT05194527)
- Testing
- Biomarker validation and VOC profile identification
- Where
- 6 sites in Belgium, Netherlands
- Volunteers
- 120 people
- Sponsor
- Maastricht University
NEC, Atresia
Safety and Feasibility of Indocyanine Green Fluorescence for Intraoperative Assessment of Intestinal Perfusion in Young Infants and Neonates
The goal of this clinical trial is to test the use of the SPY-PHI device for the purpose of ICG-mediated intestinal perfusion visualization during gastrointestinal surgery in neonates and young infants (<3 months old) undergoing…
- Conditions
- NEC, Atresia, Malrotation, Intestinal Perforation
- Trial name
- IMAGINE (NCT05734118)
- Testing
- Perfusion assessment by means of the SPY-PHI camera
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Peptic Ulcer, Ulcer Complications
Peptic Ulcer Disease in Ischemic Heart Patients Taking Aspirin and Clopidogrel With or Without Proton Pump Inhibitor
Studies showed that combined use of clopidogrel and aspirin had a 25 % reduction of risk on myocardial infarction and stroke in patients who undergone percutaneous coronary intervention (PCI) when compared with use of aspirin…
- Trial name
- NCT00854776
- Testing
- lansoprazole, aluminum hydroxide 334 mg and Mg hydroxide 166 mg
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia
Perioperatively Assessed Biomarker I-FABP Level for Prediction of Acute Mesenteric Ischemia and Its Correlation With Acute Kidney Injury, Followed by Extracorporeal Circulation (aMIKI)
Acute mesenteric ischemia (AMI) is a severe condition that might occur after cardiovascular surgery. Several risk factors for AMI, such as multimorbidity, the use of vasopressors, and an increase in inflammatory markers have been…
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia, Acute Kidney Injury, Non-Occlusive Mesenteric Ischaemia
- Trial name
- aMIKI (NCT06365827)
- Testing
- observational study
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Giessen
Bowel Obstruction Small
Diagnostic Performance of Arterial Time for CT Assessment of Parietal Enhancement Defect for the Diagnosis of Ischemia in Mechanical Small Bowel Occlusions: a Comparative Study With Portal Time
Intestinal obstruction is a frequent cause of emergency room visits and represents about 4-7% of the causes of acute abdominal pain syndrome and up to 30% in adults over 60 years old.
- Trial name
- PORTOGRELE (NCT04880421)
- Where
- France
- Volunteers
- 158 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Mesenteric Vein Thrombosis
Acute Mesenteric Venous Thrombosis.. in Assiut University Hospital Management Controversies
Initial treatment in the management of acute mesenteric vein thrombosis (MVT) is controversial. Some authors have proposed a surgical approach, whereas others have advocated medical therapy (anticoagulation).
- Trial name
- NCT03483207
- Testing
- Warfarin, MVT with failure of anticoagulation therapy, Heparin
- Volunteers
- 30 people
- Sponsor
- Assiut University
Colon Cancer, Fragility
Prehabilitation of Frail Surgical Cancer Patients Using Remote Ischemic Preconditioning
This project will examine the efficacy of a simple, cost-effective, non-invasive intervention, called remote ischemic preconditioning (RIPC), to reduce frailty in pre-surgical, frail, elderly patients with colon cancer.
- Conditions
- Colon Cancer, Fragility, Prehabilitation, Surgery
- Trial name
- Prehab (NCT03853473)
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Medical College of Wisconsin
Ischemia
Biomagnetic Signals of Intestinal Ischemia
The lack of blood flow to the small intestine causes mesenteric ischemia. Using a Superconducting QUantum Interference Device (SQUID) which measures the magnetic field of the small intestine, we are hoping to identify…
- Trial name
- NCT00285545
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Colitis, Ulcerative, Gastrointestinal Diseases
Remote Ischemic Conditioning in Patients With Ulcerative Colitis
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease (IBD). At the time of diagnosis it is not possible to predict the course of the disease, which can range from a few flares in a lifetime to uncontrollable…
- Conditions
- Colitis, Ulcerative, Gastrointestinal Diseases, Pathologic Processes, Intestinal Diseases
- Trial name
- NCT02445365
- Testing
- AutoRIC device
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- Odense University Hospital
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
Necrotizing Enterocolitis of Newborn, Bowel Ischemic
CEUS Evaluation of Bowel Perfusion in Necrotizing Enterocolitis
There is no bedside imaging technique that can quantify dynamic bowel perfusion with high soft tissue contrast and sensitivity in necrotizing enterocolitis (NEC).
- Trial name
- NCT03549507
- Testing
- Sulfur hexafluoride lipid-type A microspheres
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital of Philadelphia
Intestinal Ischemia, Critical Illness
Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Injury in Critically Ill Patients
This study aims to address the challenges of enteral nutrition support in critically ill ICU patients with varying gastrointestinal function.
- Conditions
- Intestinal Ischemia, Critical Illness, Enteral Nutrition Feeding, Hemodynamics
- Trial name
- NCT07001943
- Testing
- enteral nutrition
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking Union Medical College Hospital
Chronic Mesenteric Ischemia, Ischemia, Mesenteric
Translesional PRESSURE Measurements to Assess Clinical Relevance of a Mesenteric Artery Stenosis (PRESSURE-study)
Chronic mesenteric ischemia (CMI) is an incapacitating disease with a vast impact on quality of life due to severe abdominal pain after a meal, resulting in fear of eating and subsequent weight loss.
- Trial name
- PRESSURE (NCT07059520)
- Where
- 3 sites in Netherlands
- Volunteers
- 125 people
- Sponsor
- Erasmus Medical Center
Acute Mesenteric Ischemia
The Feasibility of a Radiological Score Based on CT Signs for Recognizing Salvageable Bowel in Acute Mesenteric Ischemia
Computed tomography (CT) is the standard modality for scanning patients with critical acute abdominal conditions, including suspected acute mesenteric ischemia (AMI).
- Trial name
- AMESIradiol (NCT06445660)
- Where
- Estonia
- Volunteers
- 200 people
- Sponsor
- University of Tartu
Ischemic Bowel Disease
Clinical Application and Mechanism of Cord Blood Mononuclear Cells in the Treatment of Ischemic Bowel Disease
Ischemic bowel disease, also known as ischemic bowel disease (IBD), is a type of disease that causes the blood supply to a certain intestinal segment to be reduced or stopped by various reasons such as hypovolemia, shock or…
- Trial name
- NCT05560672
- Testing
- Human Umbilical Cord blood mononuclear cells
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qianfoshan Hospital
Acute Mesenteric Ischemia
Acute Mesenteric Ischemia, Reality in Catalonia
Acute mesenteric ischaemia (AMI) is a notorious disease with a high mortality, the diagnostic and management is truly multidisciplinary, but not very extended.
- Trial name
- AMI_CAT (NCT06428240)
- Volunteers
- 50 people
- Sponsor
- Hospital del Mar
Stroke, Ischemic, Dysbiosis
A Randomized Double Blinded Placebo Controlled Study on the Effects of Dietary Supplementation With a Probiotic on Stroke Patients
The aim of this study is to determine the effects of an intervention using a commercially available probiotic in a cohort of acute stroke patients.
- Trial name
- PRISE (NCT04954846)
- Testing
- OMNi-BiOTiC SR-9
- Where
- Germany
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Acute Mesenteric Ischemia
Analysis of the Acute Mesenteric Ischemia in a Single Institution Over 10 Years
Acute mesenteric ischemia (AMI) is a notorious disease with a high mortality, the diagnostic and management is truly multidisciplinary, but it is not the reality in many Hospitals.
- Trial name
- AMI_HMAR (NCT06310395)
- Volunteers
- 100 people
- Sponsor
- Hospital del Mar
Acute Mesenteric Ischemia, Bowel Necrosis
Plasma i-FABP as Predictor for Irreversible Bowel Ischemia
In the FARAMIS study, we aim to investigate the longitudinal course of intestinal plasma fatty acid binding protein (i-FABP) in patients with acute mesenteric ischemia (AMI) undergoing primary percutaneous angiographic…
- Trial name
- FARAMIS (NCT01788904)
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital Regensburg
Mesenteric Ischemia
Predictive Factors of Intestinal Infraction in Acute Mesenteric Ischemia
The study aims to identify several factors that can accurately predict the incident of intestinal infraction in patients with mesenteric vascular occlusion or ischemia.
- Trial name
- NCT02645240
- Testing
- Heparin injection
- Where
- Egypt
- Volunteers
- 97 people
- Sponsor
- Mansoura University